Patents by Inventor William D. Thomas, Jr.

William D. Thomas, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190002534
    Abstract: The invention provides human antibodies against rabies and methods of using the same.
    Type: Application
    Filed: August 12, 2016
    Publication date: January 3, 2019
    Applicants: University of Massachusetts, University of Massachusetts
    Inventors: William D. THOMAS, Jr., Yang WANG
  • Publication number: 20180208643
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: March 19, 2018
    Publication date: July 26, 2018
    Inventors: Donna M. AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, Jr., Hui-Fen ZHANG
  • Publication number: 20170226193
    Abstract: The invention provides anti-OspA antibodies and methods of using the same.
    Type: Application
    Filed: August 7, 2015
    Publication date: August 10, 2017
    Inventors: Yang WANG, William D. THOMAS, Jr., Naomi K. BOATRIGHT, Mark S. J. KLEMPNER
  • Publication number: 20160287689
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Application
    Filed: January 4, 2016
    Publication date: October 6, 2016
    Inventors: William D. THOMAS, JR., Paul J. GIANNASCA, Zhenxi ZHANG, Wende LEI, Thomas P. MONATH
  • Publication number: 20160152694
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: October 29, 2015
    Publication date: June 2, 2016
    Inventors: Donna M. AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, JR., Hui-Fen ZHANG
  • Patent number: 9226956
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: January 5, 2016
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: William D. Thomas, Jr., Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Patent number: 9217029
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: December 22, 2015
    Assignees: UNIVERSITY OF MASSACHUSETTS, E. R. SQUIBB & SONS, L.L.C.
    Inventors: Donna M. Ambrosino, Gregory J. Babcock, Teresa Broering, Robert Graziano, Hector Javier Hernandez, Israel Lowy, Robert Mandell, Deborah Molrine, William D. Thomas, Jr., Hui-Fen Zhang
  • Publication number: 20150315266
    Abstract: Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
    Type: Application
    Filed: December 2, 2014
    Publication date: November 5, 2015
    Inventors: William D. Thomas, JR., Donna M. Ambrosino, Robert Mandell, Susan Sloan, Gregory J. Babcock, Charles Rupprecht
  • Publication number: 20150030612
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Application
    Filed: October 10, 2014
    Publication date: January 29, 2015
    Inventors: William D. THOMAS, JR., Paul J. GIANNASCA, Zhenxi ZHANG, Wende LEI, Thomas P. MONATH
  • Publication number: 20140134175
    Abstract: Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
    Type: Application
    Filed: September 24, 2013
    Publication date: May 15, 2014
    Inventors: Donna M. AMBROSINO, William D. THOMAS, JR., Gregory J. BABCOCK, Teresa BROERING, Susan SLOAN
  • Publication number: 20140120614
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: November 14, 2013
    Publication date: May 1, 2014
    Applicants: MEDAREX, L.L.C., UNIVERSITY OF MASSACHUSETTS
    Inventors: Donna M. AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, JR., Hui-Fen ZHANG
  • Patent number: 8609111
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: December 17, 2013
    Assignees: University of Massachusetts, Medarex, L.L.C.
    Inventors: Donna M. Ambrosino, Gregory J. Babcock, Teresa Broering, Robert Graziano, Hector Javier Hernandez, Israel Lowy, Robert Mandell, Deborah Molrine, William D. Thomas, Jr., Hui-Fen Zhang
  • Patent number: 8551484
    Abstract: Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: October 8, 2013
    Assignee: University of Massachusetts
    Inventors: Donna M. Ambrosino, William D. Thomas, Jr., Gregory J. Babcock, Teresa Broering, Susan Sloan
  • Publication number: 20130177592
    Abstract: The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
    Type: Application
    Filed: April 27, 2012
    Publication date: July 11, 2013
    Applicant: Sanofi Pasteur Biologics, LLC
    Inventors: William D. Thomas, JR., Paul J. Giannasca, Zhenxi Zhang, Wende Lei, Thomas P. Monath
  • Publication number: 20130039926
    Abstract: Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
    Type: Application
    Filed: July 19, 2012
    Publication date: February 14, 2013
    Applicants: Center for Disease Control and Prevention, University of Massachusetts
    Inventors: William D. Thomas, JR., Donna M. Ambrosino, Robert Mandell, Susan Sloan, Gregory J. Babcock, Charles Rupprecht
  • Publication number: 20120288508
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Application
    Filed: June 7, 2012
    Publication date: November 15, 2012
    Applicants: MEDAREX, INC., UNIVERSITY OF MASSACHUSETTS
    Inventors: Donna AMBROSINO, Gregory J. BABCOCK, Teresa BROERING, Robert GRAZIANO, Hector Javier HERNANDEZ, Israel LOWY, Robert MANDELL, Deborah MOLRINE, William D. THOMAS, JR., Hui-Fen ZHANG
  • Publication number: 20120288510
    Abstract: Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
    Type: Application
    Filed: February 13, 2008
    Publication date: November 15, 2012
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Donna M. Ambrosino, William D. Thomas, JR., Gregory J. Babcock, Teresa Broering, Susan Sloan
  • Patent number: 8257709
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: September 4, 2012
    Assignees: University of Massachusetts, Medarex, Inc.
    Inventors: Donna M. Ambrosino, Gregory J. Babcock, Teresa Broering, Robert Graziano, Hector Javier Hernandez, Israel Lowy, Robert Mandell, Deborah Molrine, William D. Thomas, Jr., Hui-Fen Zhang
  • Patent number: 8236311
    Abstract: Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: August 7, 2012
    Assignees: University of Massachusetts, Medarex, Inc.
    Inventors: Donna M. Ambrosino, Gregory J. Babcock, Teresa Broering, Robert Graziano, Hector Javier Hernandez, Israel Lowy, Robert Mandell, Deborah Molrine, William D. Thomas, Jr., Hui-Fen Zhang
  • Patent number: 8226952
    Abstract: Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: July 24, 2012
    Assignees: University of Massachusetts, Centers for Disease Control and Prevention
    Inventors: William D. Thomas, Jr., Donna M. Ambrosino, Robert Mandell, Susan Sloan, Gregory J. Babcock, Charles Rupprecht