Patents by Inventor William D. Voorhees, III
William D. Voorhees, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7550005Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.Type: GrantFiled: August 14, 2002Date of Patent: June 23, 2009Assignee: Cook IncorporatedInventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
-
Patent number: 7445628Abstract: Methods of making coated implantable medical devices are provided. The methods include positioning a first layer comprising a bioactive on at least a portion of a structure, and positioning at least one porous layer over the first layer. The at least one porous layer has a thickness adequate to provide a controlled release of the bioactive.Type: GrantFiled: April 14, 2003Date of Patent: November 4, 2008Assignees: Cook Incorporated, MED Institute, Inc.Inventors: Anthony O. Ragheb, Neal E. Fearnot, William D. Voorhees, III, Thomas G. Kozma, Brian L. Bates, Thomas A. Osborne
-
Patent number: 7410665Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.Type: GrantFiled: June 17, 2004Date of Patent: August 12, 2008Assignees: Cook Incorporated, MED Institute, Inc.Inventors: Anthony O. Ragheb, Brian L. Bates, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III, Anthony H. Gershlick
-
Patent number: 7056274Abstract: A catheter assembly for use in radiation therapy of a patient by insertion into a vessel, passageway or cavity to deliver radioactive material to a treatment site within the patient. The distal end of the catheter assembly (10) includes a noncompliant inner balloon (18) therearound that is inflatable with a non-radioactive fluid (such as CO2 or saline or contrast medium), and an outer balloon (16) therearound that is inflated with radioactive fluid (such as radiogas like xenon-133 ) and is noncompliant to conform the vessel wall to the balloon's shape at the treatment site for optimal distribution of dose. The inner balloon allows reduction in volume of the amount of radioactive fluid necessary to achieve a desired dose. The inner and outer balloons (112,108) may be affixed to inner and outer catheters (104,102), respectively.Type: GrantFiled: July 12, 2002Date of Patent: June 6, 2006Inventors: Marc G. Apple, William D. Voorhees, III
-
Patent number: 6774278Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.Type: GrantFiled: February 20, 1998Date of Patent: August 10, 2004Assignees: Cook Incorporated, MED Institute, Inc.Inventors: Anthony O. Ragheb, Brian L. Bates, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III, Anthony H. Gershlick
-
Patent number: 6730064Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer is includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.Type: GrantFiled: May 7, 2001Date of Patent: May 4, 2004Assignees: Cook Incorporated, Med Institute Inc.Inventors: Anthony O. Ragheb, Brian L. Bates, Neal E. Fearnot, William D. Voorhees, III, Thomas G. Kozma
-
Patent number: 6530951Abstract: A silver implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure 12 and the bioactive-material-free surface. Also included is a layer or impregnation of silver 45. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Silver is included as a base material, coating or included in a carrier, drug, medicament material utilized with the implantable stent.Type: GrantFiled: October 23, 1997Date of Patent: March 11, 2003Assignees: Cook Incorporated, MED Institute Inc.Inventors: Brian L. Bates, Neal E. Fearnot, Thomas G. Kozma, Thomas A. Osborne, Anthony O. Ragheb, Joseph W. Roberts, William D. Voorhees, III
-
Patent number: 6299604Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer is includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.Type: GrantFiled: August 20, 1999Date of Patent: October 9, 2001Assignees: Cook Incorporated, MED Institute Inc.Inventors: Anthony O. Ragheb, Brian L. Bates, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
-
Patent number: 6231598Abstract: A radially expandable stent (10) made from a cannula or sheet of biocompatible material that includes at least one longitudinal segment (14) comprised of a series of laterally interconnected closed cells (13). Each closed cell of a longitudinal segment is defined laterally by a pair of longitudinal struts (15, 16) that are interconnected at each end by a circumferentially adjustable member (19, 20). When the stent is expanded using a balloon (47), the opposing circumferentially adjustable members deform to allow circumferential expansion of the longitudinal segment, while the length of the segment, as defined by the longitudinal struts, is maintained. Self-expanding versions of the stent utilize a nickel-titanium alloy. Adjacent longitudinal segments are joined by flexible interconnection segments (21) that permit the stent to bend laterally. The flexible interconnection segment is comprised of curvilinear struts (22, 23) that form a series of serpentine bends (81) that distribute lateral bending forces.Type: GrantFiled: September 24, 1998Date of Patent: May 15, 2001Assignees: MED Institute, Inc., Cook IncorporatedInventors: Dale T. Berry, Coy M. Herald, Brian L. Bates, Scott E. Boatman, Michael C. Hoffa, Neal E. Fearnot, William D. Voorhees, III
-
Patent number: 6096070Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure (12) and the bioactive-material-free surface. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Also disclosed is the method of manufacture of the device 10, as well as a method of using it in medical treatments.Type: GrantFiled: May 16, 1996Date of Patent: August 1, 2000Assignees: MED Institute Inc., Cook Inc.Inventors: Anthony O. Ragheb, Brian L. Bates, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
-
Patent number: 5873904Abstract: A silver implantable medical device 29 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure (12) and the bioactive-material-free surface. Also included is a layer or impregnation of silver 45. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Silver is included as a base material, coating or included in a carrier, drug, medicant material utilized with the implantable stent.Type: GrantFiled: February 24, 1997Date of Patent: February 23, 1999Assignees: Cook Incorporated, MED Institute, Inc.Inventors: Anthony O. Ragheb, Brian L. Bates, Neal E. Fearnot, Thomas A. Osborne, Thomas G. Kozma, Joseph W. Roberts, William D. Voorhees, III
-
Patent number: 5824049Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure (12) and the bioactive-material-free surface. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Also disclosed is the method of manufacture of the device 10, as well as a method of using it in medical treatments.Type: GrantFiled: October 31, 1996Date of Patent: October 20, 1998Assignee: MED Institute, Inc.Inventors: Anthony O. Ragheb, Brian L. Bates, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
-
Patent number: 5380299Abstract: An intravascular medical device having a structure shaped and sized for introduction into the vascular system of a patient including a base material and a coating of a thrombolytic agent on the base material. The thrombolytic agent advantageously dissolves or breaks up the formation of thrombus on the surface of the structure when placed in the vascular system of a patient. The intravascular medical device also includes a antithrombogenic agent for inhibiting the formation of thrombus on the surface of the medical device. The method of treating a medical device with a thrombolytic agent includes providing a base material for the medical device along with a thrombolytic agent. The base material is dipped into the thrombolytic agent and then removed to allow the thrombolytic agent to dry on the surface thereof. The dipping and drying steps are repeated to increase the concentration or quantity of the thrombolytic agent on the device.Type: GrantFiled: August 30, 1993Date of Patent: January 10, 1995Assignee: MED Institute, Inc.Inventors: Neal E. Fearnot, Anthony O. Ragheb, William D. Voorhees, III
-
Patent number: 5092339Abstract: Cardiac output is measured using an injected substance (indicator) that changes the conducting property (electrical resistivity) of blood, provided the indicator has a different resistivity from that of blood. A new type of electrically compensated tetrapolar conductivity cell located at the distal end of an intravascular catheter is disclosed. The conductivity cell consists of four electrodes arranged across the end of a catheter at its tip. The outer electrodes used for current injection are enlarged to reduce the electrode-electrolyte interface impedance. Capacitance compensation of the cather/tetrapolar conductivity cell provides reliable and repeatable blood resistivity measurements. The catheter further includes a calibration resistor thereby eliminating a calibration step previously necessary in using such a catheter for measuring cardiac output.Type: GrantFiled: July 23, 1990Date of Patent: March 3, 1992Inventors: Leslie A. Geddes, Joe D. Bourland, William D. Voorhees, III, Neal E. Fearnot, Anthony C. Raghep, Frederick J. Shipko