Patents by Inventor William G. Hawkins

William G. Hawkins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10072061
    Abstract: Fusion polypeptides comprising a TRAIL trimer and a targeting domain are disclosed. The targeting domain can be, in some embodiments, a sequence that binds MUC16, which is prevalent on some tumor cells such as pancreatic and ovarian tumor cells. A sequence that binds MUC 16 can be mesothelin or a MUC16-binding fragment thereof, such as amino acids 1-64 of mesothelin. A fusion polypeptide of the present teachings can induce apoptosis in a target cell such as a MUC16-expressing cancer cell. Also disclosed are nucleic acids encoding the fusion polypeptides, and methods of use of the fusion polypeptides and nucleic acids.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: September 11, 2018
    Assignee: Washington University
    Inventors: Dirk Spitzer, William G Hawkins
  • Publication number: 20180030109
    Abstract: Fusion polypeptides comprising a TRAIL trimer and a targeting domain are disclosed. The targeting domain can be, in some embodiments, a sequence that binds MUC16, which is prevalent on some tumor cells such as pancreatic and ovarian tumor cells. A sequence that binds MUC 16 can be mesothelin or a MUC16-binding fragment thereof, such as amino acids 1-64 of mesothelin. A fusion polypeptide of the present teachings can induce apoptosis in a target cell such as a MUC16-expressing cancer cell. Also disclosed are nucleic acids encoding the fusion polypeptides, and methods of use of the fusion polypeptides and nucleic acids.
    Type: Application
    Filed: October 11, 2017
    Publication date: February 1, 2018
    Applicant: Washington University
    Inventors: Dirk Spitzer, William G Hawkins
  • Patent number: 9815882
    Abstract: Fusion polypeptides comprising a TRAIL trimer and a targeting domain are disclosed. The targeting domain can be, in some embodiments, a sequence that binds MUC16, which is prevalent on some tumor cells such as pancreatic and ovarian tumor cells. A sequence that binds MUC 16 can be mesothelin or a MUC16-binding fragment thereof, such as amino acids 1-64 of mesothelin. A fusion polypeptide of the present teachings can induce apoptosis in a target cell such as a MUC16-expressing cancer cell. Also disclosed are nucleic acids encoding the fusion polypeptides, and methods of use of the fusion polypeptides and nucleic acids.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: November 14, 2017
    Assignee: Washington University
    Inventors: Dirk Spitzer, William G Hawkins
  • Publication number: 20170022263
    Abstract: Fusion polypeptides comprising a TRAIL trimer and a targeting domain are disclosed. The targeting domain can be, in some embodiments, a sequence that binds MUC16, which is prevalent on some tumor cells such as pancreatic and ovarian tumor cells. A sequence that binds MUC 16 can be mesothelin or a MUC16-binding fragment thereof, such as amino acids 1-64 of mesothelin. A fusion polypeptide of the present teachings can induce apoptosis in a target cell such as a MUC16-expressing cancer cell. Also disclosed are nucleic acids encoding the fusion polypeptides, and methods of use of the fusion polypeptides and nucleic acids.
    Type: Application
    Filed: July 13, 2015
    Publication date: January 26, 2017
    Inventors: Dirk Spitzer, William G Hawkins
  • Patent number: 9127081
    Abstract: Fusion polypeptides comprising a TRAIL trimer and a targeting domain are disclosed. The targeting domain can be, in some embodiments, a sequence that binds MUC16, which is prevalent on some tumor cells such as pancreatic and ovarian tumor cells. A sequence that binds MUC 16 can be mesothelin or a MUC16-binding fragment thereof, such as amino acids 1-64 of mesothelin. A fusion polypeptide of the present teachings can induce apoptosis in a target cell such as a MUC16-expressing cancer cell. Also disclosed are nucleic acids encoding the fusion polypeptides, and methods of use of the fusion polypeptides and nucleic acids.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: September 8, 2015
    Assignee: Washington University
    Inventors: Dirk Spitzer, William G Hawkins
  • Publication number: 20130302270
    Abstract: Fusion polypeptides comprising a TRAIL trimer and a targeting domain are disclosed. The targeting domain can be, in some embodiments, a sequence that binds MUC16, which is prevalent on some tumor cells such as pancreatic and ovarian tumor cells. A sequence that binds MUC 16 can be mesothelin or a MUC16-binding fragment thereof, such as amino acids 1-64 of mesothelin. A fusion polypeptide of the present teachings can induce apoptosis in a target cell such as a MUC16-expressing cancer cell. Also disclosed are nucleic acids encoding the fusion polypeptides, and methods of use of the fusion polypeptides and nucleic acids.
    Type: Application
    Filed: May 10, 2013
    Publication date: November 14, 2013
    Applicant: WASHINGTON UNIVERSITY
    Inventors: Dirk Spitzer, William G. Hawkins
  • Patent number: 8461311
    Abstract: Disclosed are TNF-related apoptosis-inducing ligand (TRAIL) trimers (TR3) and nucleic acids encoding covalently linked TRAIL trimers. A TRAIL trimer can have greater stability compared to native TRAIL, and can retain the native killing ability of TRAIL. Target specificity of a TR3 can be shown by blocking its activity with soluble death receptor 5 (DR5-Fc). Also disclosed are modified TRAIL trimers and nucleic. acids encoding them. These modifications include additional functional domains, such as antibody fragments (scFvs). A TR3 comprising an additional functional domain can allow for cell-specific delivery of the TR3. The inventors disclose TR3-decorated RBCs that target cell killing in a model of pancreatic cancer.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: June 11, 2013
    Assignee: Washington University
    Inventors: William G. Hawkins, Dirk Spitzer, Richard S. Hotchkiss
  • Patent number: 8143222
    Abstract: Pharmaceutical compounds, pharmaceutical compositions and methods of treatment are disclosed, wherein a compound comprises a targeting moiety which, in free form, binds a cell receptor with a dissociation constant Kd of less than about 10?7 M, and a pharmaceutically active moiety, wherein the targeting moiety is other than an oligopeptide, a polypeptide, a peptidomimetic, a protein or a protein domain, and wherein the targeting moiety and the pharmaceutically active moiety are covalently attached. In some aspects, the targeting moiety binds a sigma-2 receptor with high affinity and high specificity, and the pharmaceutically active moiety is a pro-apoptotic peptide moiety. Methods of cancer treatment are disclosed comprising administering a disclosed pharmaceutical compound to a subject in need of thereof. The treatments selectively induce apoptosis in cancer cells. These methods can further comprise co-administration of radiation therapy and/or an additional chemotherapeutic agent.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: March 27, 2012
    Assignee: Washington University
    Inventors: Jonathan E. McDunn, William G. Hawkins, Robert H. Mach, Richard A. Hotchkiss
  • Publication number: 20110300629
    Abstract: Disclosed are TNF-related apoptosis-inducing ligand (TRAIL) trimers (TR3) and nucleic acids encoding covalently linked TRAIL trimers. A TRAIL trimer can have greater stability compared to native TRAIL, and can retain the native killing ability of TRAIL. Target specificity of a TR3 can be shown by blocking its activity with soluble death receptor 5 (DR5-Fc). Also disclosed are modified TRAIL trimers and nucleic acids encoding them. These modifications include additional functional domains, such as antibody fragments (scFvs). A TR3 comprising an additional functional domain can allow for cell-specific delivery of the TR3. In some configurations, a modification such as the addition of a functional domain can be stoichiometrically controlled. In some configurations, a modification can be inconsequential with regard to the bioactivity of TRAIL. In various embodiments, a TR3, including a modified TR3, can be a cancer-selective drug.
    Type: Application
    Filed: June 8, 2011
    Publication date: December 8, 2011
    Applicant: Washington University
    Inventors: William G. Hawkins, Dirk Spitzer, Richard S. Hotchkiss
  • Publication number: 20090176705
    Abstract: Pharmaceutical compounds, pharmaceutical compositions and methods of treatment are disclosed, wherein a compound comprises a targeting moiety which, in free form, binds a cell receptor with a dissociation constant Kd of less than about 10?7 M, and a pharmaceutically active moiety, wherein the targeting moiety is other than an oligopeptide, a polypeptide, a peptidomimetic, a protein or a protein domain, and wherein the targeting moiety and the pharmaceutically active moiety are covalently attached. In some aspects, the targeting moiety binds a sigma-2 receptor with high affinity and high specificity, and the pharmaceutically active moiety is a pro-apoptotic peptide moiety. Methods of cancer treatment are disclosed comprising administering a disclosed pharmaceutical compound to a subject in need of thereof. The treatments selectively induce apoptosis in cancer cells. These methods can further comprise co-administration of radiation therapy and/or an additional chemotherapeutic agent.
    Type: Application
    Filed: October 22, 2008
    Publication date: July 9, 2009
    Applicant: Washington University
    Inventors: Jonathan E. McDunn, William G. Hawkins, Robert H. Mach, Richard A. Hotchkiss
  • Patent number: 7158823
    Abstract: A nuclear camera (10) includes a plurality of detector heads (12) which have collimators (14) for fixing the trajectory along which radiation is receivable. A rotating gantry (22) rotates the detector heads around the subject collecting less than 360° of data, e.g., 204° of data. A zero-filling processor (50) generates zero-filled projection views such that the actually collected projection views and the zero-filled projection views span 360°. A smoothing processor (56) smooths an interface between the zero-filled and actually collected projection views. The zero-filled and smoothed views are Fourier transformed (60) into frequency space, filtered with a stationary deconvolution function (62), and Fourier transformed (64) back into real space. The resolution recovered projection data sets in real space are reconstructed by a reconstruction processor (68) into a three-dimensional image representation for storage in an image memory (70).
    Type: Grant
    Filed: February 13, 2001
    Date of Patent: January 2, 2007
    Assignee: Koninklijke Philips Electroncis N.V.
    Inventor: William G. Hawkins
  • Patent number: 6905196
    Abstract: A fluid ejector includes a fluid channel having a resistive heater and terminating in a nozzle, a common bus formed transverse to the fluid channel and between the resistive heater and the nozzle, a connection line laterally adjacent to the fluid channel, and a connection structure for electrically connecting the common bus with the resistive heater and the connection line, the connection structure including a first set of one or more layers for electrical connection and a second set of one or more layers for covering the common bus and connection line. The first set of one or more layers includes a doped polysilicon layer on or overlaid by an optional tantalum-silicide layer. The second set of one or more layers includes a nitride layer on or overlaid by a tantalum layer.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: June 14, 2005
    Assignee: Xerox Corporation
    Inventors: Scott N. Seabridge, Alan D. Raisanen, Scott C. Warner, Thomas A. Tellier, Cathie J. Burke, William G. Hawkins
  • Publication number: 20040073109
    Abstract: A nuclear camera (10) includes a plurality of detector heads (12) which have collimators (14) for fixing the trajectory along which radiation is receivable. A rotating gantry (22) rotates the detector heads around the subject collecting less than 360° of data, e.g., 204° of data. A zero-filling processor (50) generates zero-filled projection views such that the actually collected projection views and the zero-filled projection views span 360°. A smoothing processor (56) smooths an interface between the zero-filled and actually collected projection views. The zero-tilled and smoothed views are Fourier transformed (60) into frequency space, filtered with a stationary deconvolution function (62), and Fourier transformed (64) back into real space. The resolution recovered projection data sets in real space are reconstructed by a reconstruction processor (68) into a three-dimensional image representation for storage in an image memory (70).
    Type: Application
    Filed: February 13, 2001
    Publication date: April 15, 2004
    Applicant: MARCONI MEDICAL SYSTEMS, INC.
    Inventor: William G. Hawkins
  • Patent number: 6719388
    Abstract: A method and Apparatus for protection of semiconductor micromechanical devices that use circuits with dynamic logic addressing is disclosed. In one exemplary embodiment of the invention, a fail-safe circuit is provided for an ink jet print head integrated circuit which prevents a catastrophic consequence of the dynamic logic addressed integrated circuit losing its charge.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: April 13, 2004
    Assignee: Xerox Corporation
    Inventors: Juan J. Becerra, William G. Hawkins, Christopher R. Morton, Yungran Choi
  • Publication number: 20030210301
    Abstract: A fluid ejector includes a fluid channel having a resistive heater and terminating in a nozzle, a common bus formed transverse to the fluid channel and between the resistive heater and the nozzle, a connection line laterally adjacent to the fluid channel, and a connection structure for electrically connecting the common bus with the reistive heater and the connection line, the connection structure including a first set of one or more layers for electrical connection and a second set of one or more layers for covering the common bus and connection line. The first set of one or more layers includes a doped polysilicon layer on or overlaid by an optional tantalum-silicide layer. The second set of one or more layers includes a nitride layer on or overlaid by a tantalum layer.
    Type: Application
    Filed: May 8, 2003
    Publication date: November 13, 2003
    Applicant: XEROX CORPORATION
    Inventors: Scott N. Seabridge, Alan D. Raisanen, Scott C. Warner, Thomas A. Tellier, Cathie J. Burke, William G. Hawkins
  • Publication number: 20030132976
    Abstract: A method and Apparatus for protection of semiconductor micromechanical devices that use circuits with dynamic logic addressing is disclosed. In one exemplary embodiment of the invention, a fail-safe circuit is provided for an ink jet print head integrated circuit which prevents a catastrophic consequence of the dynamic logic addressed integrated circuit losing its charge.
    Type: Application
    Filed: January 16, 2002
    Publication date: July 17, 2003
    Inventors: Juan J. Becerra, William G. Hawkins, Christopher R. Morton, Yungran Choi
  • Patent number: 6412938
    Abstract: Printing systems and methods that reduce inter-color bleeding between dark and light colored inks without losing productivity of a color ink jet printer by distributing the printing of a total amount of black ink required in a single swath over multiple passes while each of the color inks required for the same swath is printed in a single pass. For example, the print method may print a single swath by printing portions of the slow dry black ink in three passes while printing each of the fast dry color inks in single passes.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: July 2, 2002
    Assignee: Xerox Corporation
    Inventors: Roger Guy Markham, Yonglin Xie, William G. Hawkins
  • Patent number: 6339652
    Abstract: A method of ML-EM image reconstruction is provided for use in connection with a diagnostic imaging apparatus (10) that generates projection data. The method includes collecting projection data, including measured emission projection data and measured transmission projection data. Optionally, the measured transmission projection data is truncated. An initial emission map and attenuation map are assumed. The emission map and the attenuation map are iteratively updated. With each iteration, the emission map is recalculated by taking a previous emission map and adjusting it based upon: (i) the measured emission projection data; (ii) a reprojection of the previous emission map which is carried out with a multi-dimensional projection model; and, (iii) a reprojection of the attenuation map.
    Type: Grant
    Filed: November 10, 1999
    Date of Patent: January 15, 2002
    Assignee: Picker International, Inc.
    Inventors: William G. Hawkins, Daniel Gagnon
  • Patent number: 6315398
    Abstract: The new heater element design has a pit layer which protects the overglaze passivation layer, PSG step region, portions of the Ta layer and dielectric isolation layer and junctions or regions susceptible to the cavitational pressures. Further, the inner walls of the pit layer define the effective heater area and the dopant lines define the actual heater area. In alternative embodiments, the dopant lines define the actual and effective heater areas, and an inner wall and a dopant line define the actual and effective heater areas. Further, when the new heater element designs are incorporated into printheads having full pit channel geometry and open pit channel geometry, the operating lifetime of the printhead is extended because the added protection of the pit layer prevents: 1) passivation damage and cavitational damages of the heater elements; and 2) degradation of heater robustness, hot spot formations and heater failures well into the 109 pulse range.
    Type: Grant
    Filed: October 21, 1992
    Date of Patent: November 13, 2001
    Assignee: Xerox Corporation
    Inventors: Cathie J. Burke, Narayan V. Desphande, William G. Hawkins, Dale R. Ims, Michael P. O'Horo, Gary A. Kneezel, Thomas A. Tellier, Ivan Rezanka
  • Patent number: 6310968
    Abstract: A method of ML-EM image reconstruction is provided for use in connection with a diagnostic imaging apparatus (10) that generates projection data. The method includes collecting projection data, including measured emission projection data. An initial emission map and attenuation map are assumed. The emission map and the attenuation map are iteratively updated. With each iteration, the emission map is recalculated by taking a previous emission map and adjusting it based upon: (i) the measured emission projection data; (ii) a reprojection of the previous emission map which is carried out with a multi-dimensional projection model; and, (iii) a reprojection of the attenuation map. As well, with each iteration, the attenuation map is recalculated by taking a previous attenuation map and adjusting it based upon: (i) the measured emission projection data; and, (ii) a reprojection of the previous emission map which is carried out with the multi-dimensional projection model.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: October 30, 2001
    Assignee: Picker International, Inc.
    Inventors: William G. Hawkins, Daniel Gagnon