Patents by Inventor William J. Federspiel

William J. Federspiel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11298452
    Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.
    Type: Grant
    Filed: September 22, 2018
    Date of Patent: April 12, 2022
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon University
    Inventors: William J. Federspiel, Brian Joseph Frankowski, James F. Antaki, Christian Andres Bermudez, Richard Garrett Jeffries, William R. Wagner, Sang-Ho Ye
  • Publication number: 20220080095
    Abstract: A system for lung assist includes a plurality of fiber bundle sections. Each of the fiber bundle sections includes a fiber bundle housing defining a fiber bundle compartment therein and a fiber bundle positioned within the fiber bundle compartment. The fiber bundle includes a plurality of hollow gas permeable fibers configured to permit diffusion of gas between blood and an interior of the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers is positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment. Each fiber bundle is different in at least one property from each other fiber bundle.
    Type: Application
    Filed: January 15, 2019
    Publication date: March 17, 2022
    Inventors: William J. Federspiel, Shalv Madhani, Ryan A. Orizondo, Peter Drew Wearden, Brian Joseph Frankowski, Alexandra May, Gregory Burgreen
  • Publication number: 20210283324
    Abstract: An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment for pressurizing blood entering the pressurizing stator compartment from the blood flow inlet. The system further includes a fiber bundle positioned within the fiber bundle compartment. The fiber bundle includes a plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers is adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers. The plurality of hollow gas permeable fibers is positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment.
    Type: Application
    Filed: May 24, 2021
    Publication date: September 16, 2021
    Inventors: Shalv Madhani, Brian Joseph Frankowski, William J. Federspiel, Gregory Burgreen, James F. Antaki
  • Patent number: 11045597
    Abstract: An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment. The system further includes a fiber bundle within the fiber bundle compartment. A plurality of hollow gas permeable fibers of the fiber bundle extend generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: June 29, 2021
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon University, Mississippi State University
    Inventors: Shalv Madhani, Brian Joseph Frankowski, William J. Federspiel, Gregory Burgreen, James F. Antaki
  • Publication number: 20210077706
    Abstract: A system for lung assist includes a plurality of fiber bundle sections which includes a fiber bundle housing defining a fiber bundle compartment with a fiber bundle positioned within. The fiber bundle includes a plurality of hollow gas permeable fibers. The fiber bundle housing further includes a gas inlet in fluid connection with the fiber bundle housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers, a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers, and a blood outlet in fluid connection with a first end of the fiber bundle. The system further includes a base section including a housing including a pressurizing compartment, a pressurizing mechanism within the pressurizing compartment, a blood inlet in fluid connection with the pressurizing compartment and a conduit.
    Type: Application
    Filed: January 15, 2019
    Publication date: March 18, 2021
    Applicants: University of Pittsburgh - Of theCommonwealth System of Higher Education, Mississippi State University
    Inventors: William J. Federspiel, Shalv Madhani, Ryan A. Orizondo, Peter Drew Wearden, Brian Joseph Frankowski, Alexandra May, Gregory Burgreen
  • Patent number: 10549022
    Abstract: An extracorporeal gas exchange device includes a housing, a rigid shaft rotatable within the housing, a plurality of agitation mechanisms positioned on the rigid shaft, and a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between fluid flowing within the housing and an interior of the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers are positioned radially outward from the plurality of agitation mechanisms. The rotational speed of the rigid shaft is adjustable independent of the flow rate of fluid through the housing.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: February 4, 2020
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Richard Garrett Jeffries, William J. Federspiel, Brian Joseph Frankowski
  • Patent number: 10335530
    Abstract: An extracorporeal system for lung assist includes a system housing, which includes a blood flow inlet and a blood flow outlet and a fiber bundle housing movably positioned within the system housing. The fiber bundle housing includes a gas inlet and a gas outlet. A fiber bundle is in operative connection with the fiber bundle housing. The fiber bundle includes a plurality of hollow gas permeable fibers, wherein lumens of the plurality of hollow gas fibers are in fluid connection with the gas inlet at a first end thereof and in fluid connection with the gas outlet as a second end thereof. The system further includes an actuator to impart oscillatory motion to the fiber bundle housing and thereby to the fiber bundle.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: July 2, 2019
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Shalv Madhani, Brian Joseph Frankowski, William J. Federspiel
  • Patent number: 10322221
    Abstract: A method of reducing the concentration of carbon dioxide in blood plasma includes removing blood from a patient and treating or processing at least blood plasma of the blood by flowing the blood plasma on one side of at least one semi-permeable membrane and flowing a dialysate on the other side of the at least one semi-permeable membrane. The dialysate has a concentration of bicarbonate less than the concentration of bicarbonate in the blood plasma before treating the blood plasma and has a composition such that the blood plasma strong ion difference that results from treating the blood plasma in conjunction with an achieved reduction in blood plasma CO2 concentration results in a blood plasma pH that does not change by more than +/?0.5 during treatment.
    Type: Grant
    Filed: January 18, 2014
    Date of Patent: June 18, 2019
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: John Alston Kellum, Jr., Matthew Cove, William J. Federspiel
  • Patent number: 10258734
    Abstract: A method of modifying cells includes removing fluid including cells from a patient, contacting the removed fluid from the patient with at least one surface upon which at least one agent to interact at least one cell receptor is immobilized to modify cells in the fluid, and returning the fluid to the patient. The agent can, for example, be immobilized via covalent bonding or ionic bonding to the at least one surface. The fluid can, for example, be blood or a blood fraction. The agent can, for example, be an agonist, an antagonist or an inverse agonist.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: April 16, 2019
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: William J. Federspiel, John Alston Kellum, Kai Singbartl
  • Publication number: 20190022300
    Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.
    Type: Application
    Filed: September 22, 2018
    Publication date: January 24, 2019
    Inventors: William J. Federspiel, Brian Joseph Frankowski, James F. Antaki, Christian Andres Bermudez, Richard Garrett Jeffries, William R. Wagner, Sang-Ho Ye
  • Publication number: 20180353673
    Abstract: An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment for pressurizing blood entering the pressurizing stator compartment from the blood flow inlet. The system further includes a fiber bundle positioned within the fiber bundle compartment. The fiber bundle includes a plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers is adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers. The plurality of hollow gas permeable fibers is positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment.
    Type: Application
    Filed: June 23, 2016
    Publication date: December 13, 2018
    Inventors: Shalv Madhani, Brian Joseph Frankowski, William J. Federspiel, Gregory Burgreen, James F. Antaki
  • Patent number: 10080834
    Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: September 25, 2018
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, CARNEGIE MELLON UNIVERSITY
    Inventors: William J. Federspiel, Brian Joseph Frankowski, James F. Antaki, Christian Andres Bermudez, Richard Garrett Jeffries, William R. Wagner, Sang-Ho Ye
  • Publication number: 20180264184
    Abstract: An extracorporeal gas exchange device includes a housing, a rigid shaft rotatable within the housing, a plurality of agitation mechanisms positioned on the rigid shaft, and a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between fluid flowing within the housing and an interior of the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers are positioned radially outward from the plurality of agitation mechanisms. The rotational speed of the rigid shaft is adjustable independent of the flow rate of fluid through the housing.
    Type: Application
    Filed: January 20, 2016
    Publication date: September 20, 2018
    Inventors: Richard Garrett Jeffries, William J. Federspiel, Brian Joseph Frankowski
  • Publication number: 20180185567
    Abstract: An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment for pressurizing blood entering the pressurizing stator compartment from the blood flow inlet. The system further includes a fiber bundle positioned within the fiber bundle compartment. The fiber bundle includes a plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers is adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers. The plurality of hollow gas permeable fibers is positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment.
    Type: Application
    Filed: June 23, 2016
    Publication date: July 5, 2018
    Inventors: Shalv Madhani, Brian Joseph Frankowski, William J. Federspiel, Gregory Burgreen, James F. Antaki
  • Patent number: 9814821
    Abstract: A method for removal of at least a portion of carbon dioxide from an aqueous fluid such as a blood fluid includes placing a first surface of at least one membrane through which carbon dioxide and at least one acid gas other than carbon dioxide can pass in fluid in contact with the fluid. The membrane limits or prevent passage of the fluid therethrough. A carrier or sweep gas including the acid gas other than carbon dioxide is passed over a second surface (which is typically opposite the first surface) of the membrane so that the acid gas other than carbon dioxide can pass through the membrane into the fluid, and carbon dioxide from the fluid can pass from the liquid, through the membrane, and into the sweep gas.
    Type: Grant
    Filed: June 15, 2013
    Date of Patent: November 14, 2017
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: William J. Federspiel, David T. Arazawa, Jeremy D. Kimmel
  • Publication number: 20170173254
    Abstract: A method of modifying cells includes removing fluid including cells from a patient, contacting the removed fluid from the patient with at least one surface upon which at least one agent to interact at least one cell receptor is immobilized to modify cells in the fluid, and returning the fluid to the patient. The agent can, for example, be immobilized via covalent bonding or ionic bonding to the at least one surface. The fluid can, for example, be blood or a blood fraction. The agent can, for example, be an agonist, an antagonist or an inverse agonist.
    Type: Application
    Filed: March 8, 2017
    Publication date: June 22, 2017
    Inventors: WILLIAM J. FEDERSPIEL, JOHN ALSTON KELLUM, KAI SINGBARTL
  • Publication number: 20170100531
    Abstract: An extracorporeal system for lung assist includes a system housing, which includes a blood flow inlet and a blood flow outlet and a fiber bundle housing movably positioned within the system housing. The fiber bundle housing includes a gas inlet and a gas outlet. A fiber bundle is in operative connection with the fiber bundle housing. The fiber bundle includes a plurality of hollow gas permeable fibers, wherein lumens of the plurality of hollow gas fibers are in fluid connection with the gas inlet at a first end thereof and in fluid connection with the gas outlet as a second end thereof. The system further includes an actuator to impart oscillatory motion to the fiber bundle housing and thereby to the fiber bundle.
    Type: Application
    Filed: October 7, 2016
    Publication date: April 13, 2017
    Inventors: Shalv Madhani, Brian Joseph Frankowski, William J. Federspiel
  • Patent number: 9296990
    Abstract: An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are adapted to receiving and conveying red blood cells. There is another embodiment of an oxygen depletion device and method for removing oxygen from red blood cells.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: March 29, 2016
    Assignees: New Health Sciences, Inc., University of Pittsburgh-of the Commonwealth System of Higher Education
    Inventors: William J. Federspiel, Brian J. Frankowski, Tatsuro Yoshida, Paul J. Vernucci
  • Publication number: 20150335807
    Abstract: A method of reducing the concentration of carbon dioxide in blood plasma includes removing blood from a patient and treating or processing at least blood plasma of the blood by flowing the blood plasma on one side of at least one semi-permeable membrane and flowing a dialysate on the other side of the at least one semi-permeable membrane. The dialysate has a concentration of bicarbonate less than the concentration of bicarbonate in the blood plasma before treating the blood plasma and has a composition such that the blood plasma strong ion difference that results from treating the blood plasma in conjunction with an achieved reduction in blood plasma CO2 concentration results in a blood plasma pH that does not change by more than +/?0.5 during treatment.
    Type: Application
    Filed: January 18, 2014
    Publication date: November 26, 2015
    Inventors: John Alston Kellum, JR., Matthew Cove, William J. Federspiel
  • Publication number: 20150314059
    Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.
    Type: Application
    Filed: November 27, 2013
    Publication date: November 5, 2015
    Inventors: William J. Federspiel, Brian Joseph Frankowski, James F. Antaki, Christian Andres Bermudez, Richard Garrett Jeffries, William R. Wagner