Patents by Inventor William J. McGahren

William J. McGahren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
    Patent number: 5606040
    Abstract: This disclosure describes disulfide analogs of the family of antibacterial and antitumor agents known collectively as the LL-E33288 complex.
    Type: Grant
    Filed: November 15, 1993
    Date of Patent: February 25, 1997
    Assignee: American Cyanamid Company
    Inventors: William J. McGahren, Martin L. Sassiver, George A. Ellestad
  • Targeted forms of methyltrithio antitumor agents
    Patent number: 5053394
    Abstract: This disclosure describes a method for constructing carrier-drug conjugates from the family of methyltrithio antibacterial and antitumor agents.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: October 1, 1991
    Assignee: American Cyanamid Company
    Inventors: George A. Ellestad, William J. McGahren, Martin L. Sassiver, Philip R. Hamann, Lois M. Hinman, Janis Upeslacis
  • Process for producing the antibiotic and antitumor agents LL-E33288.epsilon . .epsilon.-Br
    Patent number: 4996305
    Abstract: Processes for producing antibacterial and antitumor agents designated LL-E33288.epsilon.I and LL-E33288.epsilon.-Br using triphenylphosphine or a sulfhydryl-containing reagent are disclosed. Processes for producing reductively aromatized derivatives of other antibiotics are also disclosed.
    Type: Grant
    Filed: February 29, 1988
    Date of Patent: February 26, 1991
    Assignee: American Cyanamid Company
    Inventors: William J. McGahren, George A. Ellestad
  • Intermediate and process for producing the antibacterial and antitumor agents LL-E33288.epsilon.-I and LL-E33288Epsilon-Br
    Patent number: 4978748
    Abstract: Processes for producing antibacterial and antitumor agents designated LL-E33288.epsilon.-I and LL-E33288.epsilon.-Br using triphenylphosphine at ice bath temperature are disclosed. Novel intermediates prepared in the processes are also disclosed.
    Type: Grant
    Filed: February 29, 1988
    Date of Patent: December 18, 1990
    Assignee: American Cyanamid Company
    Inventors: George A. Ellestad, William J. McGahren
  • Antibacterial and antitumor agents LL-E33288EPSILON-I and LL-E33288EPSILON-BR
    Patent number: 4977143
    Abstract: Antibacterial and antitumor agents designated LL-E333288.epsilon.-I and LL-E33288.epsilon.-Br and their production by strains of Micromonospora echinospora ssp. calichensis designated NRRL-15839, NRRL-15975 and NRRL-18149, are disclosed.
    Type: Grant
    Filed: February 29, 1988
    Date of Patent: December 11, 1990
    Assignee: American Cyanamid Company
    Inventors: William J. McGahren, George A. Ellestad
  • Antibacterial antibiotic BM782
    Patent number: 4234717
    Abstract: This disclosure describes three new antibiotics designated BM782.alpha.1, BM782.alpha.2, and BM782.alpha.1a which are produced in a microbiological fermentation under controlled conditions using a new strain of an undetermined species of the genus Nocardia or mutants thereof. These new antibacterial agents are active against Mycobacterium tuberculosis as well as both gram-positive and gram-negative microorganisms and thus are useful for inhibiting the growth of such bacteria and bacilli wherever they may be found.
    Type: Grant
    Filed: March 2, 1979
    Date of Patent: November 18, 1980
    Assignee: American Cyanamid Company
    Inventors: Homer D. Tresner, Amedeo A. Fantini, Donald B. Borders, William J. McGahren
  • Novel hydroxy substituted 15-deoxy-5-cis-prostenoic acids and esters
    Patent number: 4179451
    Abstract: This disclosure describes certain hydroxy substituted 15-deoxy-5-cis-prostenoic acids and esters useful as hypotensive agents, anti-ulcer agents, bronchodilators, anti-microbial agents, anticonvulsants, or as intermediates.
    Type: Grant
    Filed: June 12, 1978
    Date of Patent: December 18, 1979
    Assignee: American Cyanamid Company
    Inventors: Middleton B. Floyd, Jr., Martin J. Weiss, William J. McGahren, Robert E. Schaub