Patents by Inventor William J. McGrath

William J. McGrath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10065989
    Abstract: The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: September 4, 2018
    Assignees: The Broad Institute Inc., President and Fellows of Harvard College, Rijksuniversiteit Groningen
    Inventors: Walter F. Mangel, Paul Blainey, Vito Graziano, Andreas Herrmann, William J. McGrath, Antonius Martinus Van Oijen, Xiaoliang Sunney Xie
  • Publication number: 20150210738
    Abstract: The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or engineered composition which may comprise a molecular sled, linkers and a molecular cargo connected to the sled via the linkers. Methods involving the use of molecular sleds and their cargoes and pharmaceutical compositions, methods for treating treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.
    Type: Application
    Filed: January 13, 2015
    Publication date: July 30, 2015
    Inventors: Walter F. MANGEL, Paul BLAINEY, Vito GRAZIANO, Andreas HERRMANN, William J. MCGRATH, Antonius Martinus VAN OIJEN, Xiaoliang Sunney XIE
  • Patent number: 4216462
    Abstract: The system is composed of a plurality of bedside stations, each in the vicinity of a hospitalized patient, and each interconnected to a central station for monitoring and controlling the bedside stations. The bedside stations contain a plurality of physiological sensing and data sending modules. Each bedside unit contains a central processor for controlling the flow and format of data from the module and to the central station. The central station includes peripheral display units for selectively displaying data from each of the bedside stations. A central processor controls the flow of data from each bedside station to the peripheral displays and for communicating with each bedside processor. Data links are provided for the analog data from the central stations and data links for serial asynchronous data transmission from the bedside station to the central station and for commands from the central station to the bedside station.
    Type: Grant
    Filed: March 6, 1978
    Date of Patent: August 5, 1980
    Assignee: General Electric Company
    Inventors: William J. McGrath, Regis P. DiGiacomo
  • Patent number: 4187714
    Abstract: A surface friction tester in the form of a friction sled which may be pulled over a surface to determine the coefficient of friction of that surface. The sled has a friction surface characterizing a vehicle tire tread attached to the bottom of a base plate. The base plate is a part of a sled frame which also has a tongue portion. A straight spring scale attached to the tongue is used to measure the force required to pull the sled over the surface. The friction sled is especially adapted for accident investigations in order to allow the investigator to determine the coefficient of friction of the surfaces upon which skid marks exist and, thus, calculate the vehicle velocity at the time of brake locking on the basis of the skid marks left by the sliding vehicle.
    Type: Grant
    Filed: October 10, 1978
    Date of Patent: February 12, 1980
    Assignee: Wright State University
    Inventors: Myron K. Cox, William J. McGrath, James E. Cantrill