Patents by Inventor William J. Muller

William J. Muller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adenoviruses for control of gene expression
    Patent number: 6974694
    Abstract: The invention claims a class of adenovirus vectors for delivering recombinases to a large number of cells of different origins, and methods for regulating the expression of a gene in transfected mammalian cells in culture and in cells of transgenic animals, comprising infecting said cells with an Ad vector encoding a recombinase whose target site is present at or adjacent to the gene, wherein the action of the recombinase regulates the expression of said gene.
    Type: Grant
    Filed: October 17, 2001
    Date of Patent: December 13, 2005
    Assignee: AdVec, Inc.
    Inventors: Frank L. Graham, Martina Anton, Silvia Bacchetti, Ping Wang, Michael A. Rudnicki, William J. Muller
  • Adenoviruses for control of gene expression
    Publication number: 20030100523
    Abstract: The invention claims a class of adenovirus vectors for delivering recombinases to a large number of cells of different origins, and methods for regulating the expression of a gene in transfected mammalian cells in culture and in cells of transgenic animals, comprising infecting said cells with an Ad vector encoding a recombinase whose target site is present at or adjacent to the gene, wherein the action of the recombinase regulates the expression of said gene.
    Type: Application
    Filed: October 17, 2001
    Publication date: May 29, 2003
    Inventors: Frank L. Graham, Martina Anton, Silvia Bacchetti, Ping Wang, Michael A. Rudnicki, William J. Muller
  • Adenoviruses for control of gene expression
    Patent number: 6120764
    Abstract: The invention claims a class of adenovirus vectors for delivering recombinases to a large number of cells of different origins, and methods for regulating the expression of a gene in transfected mammalian cells in culture and in cells of transgenic animals, comprising infecting said cells with an Ad vector encoding a recombinase whose target site is present at or adjacent to the gene, wherein the action of the recombinase regulates the expression of said gene.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 19, 2000
    Assignee: AdVec, Inc.
    Inventors: Frank L. Graham, Martina Anton, Silvia Bacchetti, Ping Wang, Michael A. Rudnicki, William J. Muller
  • Animal model for benign prostatic disease
    Patent number: 5175383
    Abstract: A male transgenic mouse containing germ cells and somatic cells which contain a recombinant gene which is a vertebrate gene in the int-2/FGF family which is capable of promoting benign prostatic hyperplasia or hypertrophy in said transgenic mouse, said gene being introduced into the mouse, or an ancestor of the mouse, at an embryonic stage.
    Type: Grant
    Filed: February 17, 1989
    Date of Patent: December 29, 1992
    Assignee: President and Fellows of Harvard College
    Inventors: Philip Leder, William J. Muller