Patents by Inventor William John Kenneth LEWIS

William John Kenneth LEWIS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies with reduced binding to process impurities
    Patent number: 11254753
    Abstract: The present invention relates to variant antibodies and methods of generating said antibodies with a reduced level of binding to process impurities. In particular, the invention describes variant IgG4 antibodies which have been modified in the heavy chain constant region at any one or a combination of amino acids in the region between Kabat residues 203 and 256, wherein the variant IgG4 antibody has a reduced level of binding to host cell protein (HCP), compared to an unmodified IgG4 antibody. The invention also relates to compositions comprising said variant IgG4 antibodies.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: February 22, 2022
    Inventors: Hella Bosteels, Shugui Chen, Kayeleigh Farrow, Richard Kucia-Tran, William John Kenneth Lewis, Andrew S. Thomson, Mark Uden
  • Method of producing a recombinant protein
    Patent number: 11098312
    Abstract: The present invention relates to a recombinant signal sequence derived from E. coli. The invention also relates to a fusion protein comprising the signal sequence, a recombinant protein and methods of producing the recombinant protein. The recombinant signal sequence can be used to provide a method for controlling the viscosity of the fermentation, and/or controlling basal (pre-induction) expression of the recombinant protein.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: August 24, 2021
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: Robyn Alexandra Emmins, Gary Brian Finka, Michael Hoare, Alan Peter Lewis, William John Kenneth Lewis, Adam Daniel McInally, Mark Uden, Ioannis Voulgaris
  • ANTIBODIES WITH REDUCED BINDING TO PROCESS IMPURITIES
    Publication number: 20190225708
    Abstract: The present invention relates to variant antibodies and methods of generating said antibodies with a reduced level of binding to process impurities. In particular, the invention describes variant IgG4 antibodies which have been modified in the heavy chain constant region at any one or a combination of amino acids in the region between Kabat residues 203 and 256, wherein the variant IgG4 antibody has a reduced level of binding to host cell protein (HCP), compared to an unmodified IgG4 antibody. The invention also relates to compositions comprising said variant IgG4 antibodies.
    Type: Application
    Filed: October 3, 2017
    Publication date: July 25, 2019
    Inventors: Hella BOSTEELS, Shugui CHEN, Kayeleigh FARROW, Richard KUCIA-TRAN, William John Kenneth LEWIS, Andrew S. THOMSON, Mark UDEN
  • Method of Producing a Recombinant Protein
    Publication number: 20190177734
    Abstract: The present invention relates to a recombinant signal sequence derived from E. coli. The invention also relates to a fusion protein comprising the signal sequence, a recombinant protein and methods of producing the recombinant protein. The recombinant signal sequence can be used to provide a method for controlling the viscosity of the fermentation, and/or controlling basal (pre-induction) expression of the recombinant protein.
    Type: Application
    Filed: May 4, 2017
    Publication date: June 13, 2019
    Inventors: Robyn Alexandra EMMINS, Gary Brian FINKA, Michael HOARE, Alan Peter LEWIS, William John Kenneth LEWIS, Adam Daniel McINALLY, Mark UDEN, Ioannis VOULGARIS