Patents by Inventor William Joseph Zabrodski

William Joseph Zabrodski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6939923
    Abstract: A method for functionalizing a crosslinked polymer bead. The method comprises the steps of: (a) swelling the bead in a first solvent or solvent mixture to a volume from 200% to 310% of its volume when dry; and (b) contacting the bead with a functionalizing reagent in a second solvent or solvent mixture capable of swelling the bead to a volume from 200% to 310% of its volume when dry.
    Type: Grant
    Filed: August 7, 2003
    Date of Patent: September 6, 2005
    Assignee: Rohm and Haas Company
    Inventors: James Charles Bohling, Marlin Kenneth Kinzey, John Joseph Maikner, William Joseph Zabrodski
  • Publication number: 20040209999
    Abstract: The present invention relates to an improved process for making commercial quantities of a polypeptide or fragment thereof, e.g. a T-20 or a T-1249 composition, or a fragment of a T-20 or a T-1249 composition. One variant of a T-20 composition is known as Fuzeon™ enfuvirtide. The improvement includes using a low void space resin, a resin made from a copolymer having less than 5% organic extractables, a resin made using a chloride corrosion resistant filter, resin beads functionalized using a nitro-compound, resins made using jetting techniques, and resins made using seed expansion techniques. In yet other variants, the invention provides a composition made using the processes described herein.
    Type: Application
    Filed: February 25, 2004
    Publication date: October 21, 2004
    Inventors: James Charles Bohling, Biwang Jiang, Marlin Kenneth Kinzey, John Joseph Maikner, James Franklin Tate, William Joseph Zabrodski, Witold Andrew Ziarno
  • Publication number: 20040063856
    Abstract: A crosslinked polymer bead which, when: (i) functionalized with a 2-chlorotrityl chloride group; (ii) coupled with Leu to 0.65 mmol/g; and (iii) coupled with Glu(t-Bu); allows coupling of FMOC-Lys(BOC)-OH at an amount of 1.5 equivalents in the presence of 1.5 equivalents of HOBT, 1.5 equivalents of DIEA and 1.5 equivalents of HBTU, to be completed, as determined by the Kaiser test, in no more than 35 minutes.
    Type: Application
    Filed: September 16, 2003
    Publication date: April 1, 2004
    Inventors: James Charles Bohling, Martin Kenneth Kinzey, John Joseph Maikner, William Joseph Zabrodski
  • Publication number: 20040054203
    Abstract: The present invention relates to a method for converting a substituted or unsubstituted solid supported trityl alcohol to a substituted or unsubstituted solid supported trityl chloride.
    Type: Application
    Filed: August 19, 2003
    Publication date: March 18, 2004
    Inventors: James Charles Bohling, William Joseph Zabrodski
  • Publication number: 20040033918
    Abstract: The present invention relates to a resin cleaning method using fewer solvents.
    Type: Application
    Filed: August 19, 2003
    Publication date: February 19, 2004
    Inventors: James Charles Bohling, Marlin Kenneth Kinzey, John Joseph Maikner, William Joseph Zabrodski
  • Publication number: 20040034173
    Abstract: A method for functionalizing a crosslinked polymer bead. The method comprises the steps of: (a) swelling the bead in a first solvent or solvent mixture to a volume from 200% to 310% of its volume when dry; and (b) contacting the bead with a functionalizing reagent in a second solvent or solvent mixture capable of swelling the bead to a volume from 200% to 310% of its volume when dry.
    Type: Application
    Filed: August 7, 2003
    Publication date: February 19, 2004
    Inventors: James Charles Bohling, Marlin Kenneth Kinzey, John Joseph Maikner, William Joseph Zabrodski
  • Patent number: 5969200
    Abstract: Novel routes for the preparation of acetonylbenzamides are provided by the reaction of an amine and acyl chloride. Novel routes to various intermediates used in the manufacture of acetonylbenzamides are also disclosed.
    Type: Grant
    Filed: October 22, 1998
    Date of Patent: October 19, 1999
    Assignee: Rohm and Haas Company
    Inventors: Enrique Luis Michelotti, Heather Lynnette Rayle, Randall Wayne Stephens, William Joseph Zabrodski
  • Patent number: 5945565
    Abstract: Novel routes for the preparation of acetonylbenzamides are provided by the reaction of an amine and acyl chloride. Novel routes to various intermediates used in the manufacture of acetonylbenzamides are also disclosed.
    Type: Grant
    Filed: October 22, 1998
    Date of Patent: August 31, 1999
    Assignee: Rohm and Haas Company
    Inventors: Enrique Luis Michelotti, Heather Lynnette Rayle, Randall Wayne Stephens, William Joseph Zabrodski
  • Patent number: 5874466
    Abstract: Novel routes for the preparation of acetonylbenzamides are provided by the reaction of an amine and acyl chloride. Novel routes to various intermediates used in the manufacture of acetonylbenzamides are also disclosed.
    Type: Grant
    Filed: June 10, 1997
    Date of Patent: February 23, 1999
    Assignee: Rohm and Haas Company
    Inventors: Enrique Luis Michelotti, Heather Lynnette Rayle, Randall Wayne Stephens, William Joseph Zabrodski