Patents by Inventor William K. Sonnenburg

William K. Sonnenburg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7842478
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: August 9, 2006
    Date of Patent: November 30, 2010
    Assignee: The Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, J. Kelley Bentley, Harry Charbonneau, William K. Sonnenburg
  • Patent number: 7122363
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: October 17, 2006
    Assignee: The Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Kelley J. Bentley, Harry Charbonneau, William K. Sonnenburg
  • Publication number: 20040126866
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Application
    Filed: October 30, 2003
    Publication date: July 1, 2004
    Inventors: Joseph A. Beavo, J. Kelley Bentley, Harry Charbonneau, William K. Sonnenburg
  • Patent number: 6642040
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: June 18, 2001
    Date of Patent: November 4, 2003
    Assignee: The Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Kelley J. Bentley, Harry Charbonneau, William K. Sonnenburg
  • Publication number: 20030054992
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Application
    Filed: April 3, 2002
    Publication date: March 20, 2003
    Applicant: ICOS Corporation
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
  • Publication number: 20020151024
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Application
    Filed: June 18, 2001
    Publication date: October 17, 2002
    Applicant: The Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, J. Kelley Bentley, Harry Charbonneau, William K. Sonnenburg
  • Patent number: 6037119
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 14, 2000
    Assignee: Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
  • Patent number: 6015677
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: January 18, 2000
    Assignee: The Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Kelley J. Bentley, Harry Charbonneau, William K. Sonnenburg
  • Patent number: 5955583
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Antibodies to the cGMP-binding, cGMP-stimulated phosphodiesterase are disclosed. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 21, 1999
    Assignees: ICOS Corporation, Board of Regents of the University of Washington, Vanderbilt University
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
  • Patent number: 5800987
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: September 1, 1998
    Assignee: The Board of Regents of The University of Washington
    Inventors: Joseph A. Beavo, J. Kelley Bentley, Harry Charbonneau, William K. Sonnenburg
  • Patent number: 5789553
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: August 4, 1998
    Assignee: The Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, J. Kelley Bentley, Harry Charbonneau, William K. Sonnenburg
  • Patent number: 5776752
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 7, 1998
    Assignee: The Board of Regents of The University of Washington
    Inventors: Joseph A. Beavo, J. Kelley Bentley, Harry Charbonneau, William K. Sonnenburg
  • Patent number: 5702936
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: December 30, 1997
    Assignees: ICOS Corporation, Vanderbilt University, Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
  • Patent number: 5652131
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 29, 1997
    Assignees: ICOS Corporation, Vanderbilt University, Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
  • Patent number: 5602019
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: February 11, 1997
    Assignee: The Board of Regents of The University of Washington
    Inventors: Joseph A. Beavo, Kelley J. Bentley, Harry Charbonneau, William K. Sonnenburg
  • Patent number: 5580771
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: December 3, 1996
    Assignee: The Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Harry Charbonneau, William K. Sonnenburg
  • Patent number: 5389527
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: April 20, 1992
    Date of Patent: February 14, 1995
    Assignee: The Board of Regents of The University of Washington
    Inventors: Joseph A. Beavo, Harry Charbonneau, William K. Sonnenburg