Patents by Inventor William L. Warren

William L. Warren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Artificial immune system: methods of use
    Patent number: 9625444
    Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: April 18, 2017
    Assignees: SANOFI PASTEUR VAXDESIGN CORPORATION, THE SCRIPPS RESEARCH INSTITUTE, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH, MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY
    Inventors: William L Warren, Heather Fahlenkamp, Russell Higbee, Anatoly Kachurin, Conan Li, Mike Nguyen, Robert Parkhill, Guzman Sanchez-Schmitz, Darrell J. Irvine, Gwendalyn J. Randolph, Nir Hacohen, Bruce Torbett
  • Methods for testing an immune response using cultures of T cells, B cells, dendritic cells and follicular dendritic cells
    Patent number: 8962319
    Abstract: The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: February 24, 2015
    Assignees: Sanofi Pasteur Vaxdesign Corp., Virginia Commonwealth University
    Inventors: William L. Warren, Donald Drake, III, Janice Moser, Inderpal Singh, Haifeng Song, Eric Mishkin, John G. Tew
  • ARTIFICIAL IMMUNE SYSTEM: METHODS OF USE
    Publication number: 20140273209
    Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.
    Type: Application
    Filed: March 20, 2014
    Publication date: September 18, 2014
    Applicants: SANOFI PASTEUR VAXDESIGN CORPORATION, THE SCRIPPS RESEARCH INSTITUTE, MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY, THE WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: William L WARREN, Heather FAHLENKAMP, Russell HIGBEE, Anatoly KACHURIN, Conan LI, Mike NGUYEN, Robert PARKHILL, Guzman SANCHEZ-SCHMITZ, Darrell J. IRVINE, Gwendalyn J. RANDOLPH, Nir HACOHEN, Bruce TORBETT
  • METHODS FOR TESTING AN IMMUNE RESPONSE USING CULTURES OF T CELLS, B CELLS, DENDRITIC CELLS AND FOLLICULAR DENDRITIC CELLS
    Publication number: 20140248640
    Abstract: The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
    Type: Application
    Filed: November 4, 2011
    Publication date: September 4, 2014
    Applicants: VIRGINIA COMMONWEALTH UNIVERSITY, SANOFI PASTEUR VAXDESIGN CORPORATION
    Inventors: William L. WARREN, Donald DRAKE, III, Janice MOSER, Inderpal SINGH, Haifeng SONG, Eric MISHKIN, John G. TEW
  • Artificial immune system: methods of use
    Patent number: 8722402
    Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: May 13, 2014
    Assignees: Sanofi Pasteur Vaxdesign Corporation, Mount Sinai School of Medicine, The Whitehead Institute, Massachusetts Institute of Technology, The Scripps Research Institute
    Inventors: William L Warren, Heather Fahlenkamp, Russell Higbee, Anatoly Kachurin, Conan Li, Mike Nguyen, Robert Parkhill, Guzman Sanchez-Schmitz, Darrell J. Irvine, Gwendalyn J. Randolph, Nir Harcohen, Bruce Torbett
  • Methods for testing an immune response using cultures of T cells, B cells and dendritic cells
    Patent number: 8697371
    Abstract: The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: April 15, 2014
    Assignees: Sanofi Pasteur VaxDesign Corp., Virginia Commonwealth University
    Inventors: William L. Warren, Donald Drake, III, Janice Moser, Inderpal Singh, Haifeng Song, Eric Mishkin, John G. Tew
  • Methods for assaying responses to vaccines
    Patent number: 8669105
    Abstract: The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and other compounds. Development of an in vitro GC adds functionality to an AIS, in that it enables generation of an in vitro human humoral response by human B lymphocytes that is accurate and reproducible, without using human subjects. The invention also permits evaluation of, for example, vaccines, allergens, and immunogens, and activation of human B cells specific for a given antigen, which can then be used to generate human antibodies. In an embodiment of the present invention the function of the in vitro GC is enhanced by placing FDCs and other immune cells in a 3D ETC; FDCs appear more effective over a longer time (antibody production is sustained for up to about 14 days.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: March 11, 2014
    Assignees: Sanofi Pasteur Vaxdesign Corp., Virginia Commonwealth University
    Inventors: Selva Sukumar, Mohey Eldin M. El Shikh, John G. Tew, Guzman Sanchez-Schmitz, Donald Drake, III, Luis Mosquera, Conan Li, Anatoly M. Kachurin, Russell Higbee, Heather Fahlenkamp, Eric Mishkin, William L. Warren
  • ARTIFICIAL IMMUNE SYSTEM: METHODS OF USE
    Publication number: 20130078656
    Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.
    Type: Application
    Filed: September 10, 2012
    Publication date: March 28, 2013
    Applicants: SANOFI PASTEUR VAXDESIGN CORPORATION, THE WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: William L. WARREN, Heather FAHLENKAMP, Russell HIGBEE, Anatoly KACHURIN, Conan LI, Mike NGUYEN, Robert PARKHILL, Guzman SANCHEZ-SCHMITZ, Darrell J. IRVINE, Gwendalyn J. RANDOLPH, Nir HACOHEN, Bruce TORBETT
  • Methods of evaluating a test agent in a diseased cell model
    Patent number: 8298824
    Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the tissues of the immune system in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates and other materials in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system, coupled with disease models to provide a more complete representation of an immune response.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: October 30, 2012
    Assignee: Sanofi Pasteur Vaxdesign Corporation
    Inventors: William L. Warren, Heather Fahlenkamp, Russell G. Higbee, Eric M. Mishkin, Guzman Sanchez-Schmitz, Michael D. Rivard, Santosh Pawar
  • Methods for antibody production
    Patent number: 8298823
    Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.
    Type: Grant
    Filed: March 24, 2010
    Date of Patent: October 30, 2012
    Assignee: Sanofi Pasteur Vaxdesign Corporation
    Inventors: William L. Warren, Robert Parkhill, Michael N. Nguyen, Guzman Sanchez-Schmitz, Heather Fahlenkamp, Russell Higbee, Donald Drake, III, Anatoly Kachurin, David Moe
  • Artificial immune system: methods for making and use
    Patent number: 8288159
    Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.
    Type: Grant
    Filed: March 17, 2010
    Date of Patent: October 16, 2012
    Assignee: Sanofi Pasteur Vaxdesign Corp. et al.
    Inventors: William L Warren, Heather Fahlenkamp, Russell Higbee, Anatoly Kachurin, Conan Li, Mike Nguyen, Robert Parkhill, Guzman Sanchez-Schmitz, Darrell J. Irvine, Gwendalyn J. Randolph, Nir Harcohen, Bruce Torbett
  • Methods of evaluating an immune response to an antigen
    Patent number: 8247226
    Abstract: The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and other compounds. Development of an in vitro GC adds functionality to an AIS, in that it enables generation of an in vitro human humoral response by human B lymphocytes that is accurate and reproducible, without using human subjects. The invention also permits evaluation of, for example, vaccines, allergens, and immunogens, and activation of human B cells specific for a given antigen, which can then be used to generate human antibodies. In an embodiment of the present invention the function of the in vitro GC is enhanced by placing FDCs and other immune cells in a 3D ETC; FDCs appear more effective over a longer time (antibody production is sustained for up to about 14 days.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: August 21, 2012
    Assignee: Sanofi Pasteur Vaxdesign Corp.
    Inventors: Selva Sukumar, Mohey Eldin M. El Shikh, John G. Tew, Guzman Sanchez-Schmitz, Donald Drake, III, Luis Mosquera, Conan Li, Anatoly M. Kachurin, Russell Higbee, Heather Fahlenkamp, Eric Mishkin, William L. Warren
  • METHODS FOR TESTING AN IMMUNE RESPONSE USING CULTURES OF T CELLS, B CELLS AND DENDRITIC CELLS
    Publication number: 20120052517
    Abstract: The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
    Type: Application
    Filed: November 3, 2011
    Publication date: March 1, 2012
    Applicants: VIRGINIA COMMONWEALTH UNIVERSITY, SANOFI PASTEUR VAXDESIGN CORPORATION
    Inventors: William L. WARREN, Donald DRAKE, III, Janice MOSER, Inderpal SINGH, Haifeng SONG, Eric MISHKIN, John G. TEW
  • Disease model incorporation into an artificial immune system (AIS)
    Patent number: 8119403
    Abstract: The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising a three-dimensional matrix comprising lymphoid tissue, a three-dimensional matrix comprising epithelial and/or endothelial cells, and diseased cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: February 21, 2012
    Assignee: Sanofi Pasteur Vaxdesign Corp.
    Inventors: William L. Warren, Russell Higbee, Eric Mishkin, Guzman Sanchez-Schmitz, Heather Fahlenkamp, Michael Rivard
  • METHODS OF EVALUATING A TEST AGENT IN A DISEASED CELL MODEL
    Publication number: 20120009561
    Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the tissues of the immune system in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates and other materials in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system, coupled with disease models to provide a more complete representation of an immune response.
    Type: Application
    Filed: September 20, 2011
    Publication date: January 12, 2012
    Applicant: SANOFI PASTEUR VAXDESIGN CORP.
    Inventors: William L. WARREN, Heather FAHLENKAMP, Russell G. HIGBEE, Eric M. MISHKIN, Guzman SANCHEZ-SCHMITZ, Michael D. RIVARD, Santosh PAWAR
  • Method for determining the immunogenicity of an antigen
    Patent number: 8080416
    Abstract: The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: December 20, 2011
    Assignee: Sanofi Pasteur Vaxdesign Corp.
    Inventors: William L. Warren, Donald Drake, III, Janice Moser, Inderpal Singh, Haifeng Song, Eric Mishkin
  • Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS)
    Patent number: 8071373
    Abstract: The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: December 6, 2011
    Assignees: Sanofi Pasteur Vaxdesign Corp., Virginia Commonwealth University
    Inventors: William L. Warren, Donald Drake, III, Janice Moser, Inderpal Singh, Haifeng Song, Eric Mishkin, John G. Tew
  • Methods of evaluating a test agent in a diseased cell model
    Patent number: 8062889
    Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the tissues of the immune system in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates and other materials in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system, coupled with disease models to provide a more complete representation of an immune response.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: November 22, 2011
    Assignee: Sanofi Pasteur Vaxdesign Corp.
    Inventors: William L. Warren, Heather Fahlenkamp, Russel G. Higbee, Eric M. Mishkin, Guzman Sanchez-Schmitz, Michael D. Rivard, Santosh Pawar
  • METHODS FOR ASSAYING RESPONSES TO VACCINES
    Publication number: 20110269176
    Abstract: The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and other compounds. Development of an in vitro GC adds functionality to an AIS, in that it enables generation of an in vitro human humoral response by human B lymphocytes that is accurate and reproducible, without using human subjects. The invention also permits evaluation of, for example, vaccines, allergens, and immunogens, and activation of human B cells specific for a given antigen, which can then be used to generate human antibodies. In an embodiment of the present invention the function of the in vitro GC is enhanced by placing FDCs and other immune cells in a 3D ETC; FDCs appear more effective over a longer time (antibody production is sustained for up to about 14 days.
    Type: Application
    Filed: June 23, 2011
    Publication date: November 3, 2011
    Applicant: SANOFI PASTEUR VAXDESIGN CORPORATION
    Inventors: Selva SUKUMAR, Mohey Eldin M. EL SHIKH, John G. TEW, Guzman SANCHEZ-SCHMITZ, Donald DRAKE, III, Luis MOSQUERA, Eric MISHKIN, Anatoly M. KACHURIN, Russell HIGBEE, Conan LI, William L. WARREN, Heather FAHLENKAMP
  • METHODS OF EVALUATING AN IMMUNE RESPONSE TO AN ANTIGEN
    Publication number: 20110250620
    Abstract: The present invention incorporates germinal centers (GCs) into three-dimensional (3D) engineered tissue constructs (ETCs). In an embodiment, we have incorporated the GC in the design of an artificial immune system (AIS) to examine immune responses to vaccines and other compounds. Development of an in vitro GC adds functionality to an AIS, in that it enables generation of an in vitro human humoral response by human B lymphocytes that is accurate and reproducible, without using human subjects. The invention also permits evaluation of, for example, vaccines, allergens, and immunogens, and activation of human B cells specific for a given antigen, which can then be used to generate human antibodies. In an embodiment of the present invention the function of the in vitro GC is enhanced by placing FDCs and other immune cells in a 3D ETC; FDCs appear more effective over a longer time (antibody production is sustained for up to about 14 days.
    Type: Application
    Filed: June 23, 2011
    Publication date: October 13, 2011
    Applicant: SANOFI PASTEUR VAXDESIGN CORPORATION
    Inventors: Selva SUKUMAR, Mohey Eldin M. EL SHIKH, John G. TEW, Guzman SANCHEZ-SCHMITZ, Donald DRAKE, III, Luis MOSQUERA, Eric MISHKIN, Anatoly M. KACHURIN, Russell HIGBEE, Conan LI, William L. WARREN, Heather FAHLENKAMP