Abstract: A deagglomerator apparatus and method are provided for deagglomerating material such as micron-sized, dry medicament powder (M). The deagglomerator apparatus includes a horn member (HM) having a tip portion (TP, TP1) wherein the tip portion defines a recess (R1) for holding the material. A vibrator mechanism is attached to the horn member and is operable for utilizing power from a generator (G) for vibrating the horn member, tip portion and recess wherein the recess vibrates at a frequency suitable for deagglomeration of agglomerated material held by within the recess. In a preferred embodiment, the material is held by a substrate which can be positioned at least partially into the recess. The deagglomerator apparatus and method can be used for deagglomerating material such that it includes particles of a respirable size, preferably less than approximately ten (10) microns (when referenced to unit density of 1 gram/cm3).

Abstract: An apparatus (100) adapted for applying to a carrier (C) a suspension (S) comprising a suspending agent and a powdered medicament. The apparatus (110) includes a reservoir (110), a junction container (120) adapted to contain a liquid, an outlet line (130) extending from the reservoir (110) and through the junction container (120) to a pump (P), a nozzle (160) connected to the pump (P) and a sonicator (150) operatively connected to the junction container (120). The reservoir (110) is adapted to maintain the agent and the medicament admixed in suspension. The nozzle (160) is formed from an inner cylinder (161) disposed within an outer cylinder (162), thereby defining a space (X) therebetween, and includes a purge line (165) fluidly connected with the outer cylinder (162) for providing a gas jet to the space (X).