Patents by Inventor William M. Clemons

William M. Clemons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240199677
    Abstract: The present invention relates to methods of treating bacterial infections and cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound provided herein.
    Type: Application
    Filed: February 1, 2023
    Publication date: June 20, 2024
    Inventors: William M. Clemons, Michio Kurosu
  • Publication number: 20230340006
    Abstract: Provided herein are compounds and methods of using these compounds to treat disorders related to DPAGT1 function, including cancer and bacterial infections.
    Type: Application
    Filed: June 30, 2021
    Publication date: October 26, 2023
    Inventors: Michio KUROSU, Katsuhiko MITACHI, William M. Clemons
  • Patent number: 11597743
    Abstract: The present invention relates to methods of treating bacterial infections and cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula I.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: March 7, 2023
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: William M. Clemons, Michio Kurosu
  • Patent number: 11545236
    Abstract: Membrane protein expression can be predicted using statistical frameworks to provide an enhanced subset of sequences, out of an initial larger set of potentially expressing sequences, by using features derived from sequences and a model parameterized through a dataset of known expression levels. Also, membrane protein experimentation protocols can be designed using the statistical frameworks in concert known outcomes to identify which laboratory conditions are most likely to produce successful results.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: January 3, 2023
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Shyam M. Saladi, William M. Clemons
  • Publication number: 20200361981
    Abstract: The present invention relates to methods of treating bacterial infections and cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound provided herein. Also provided are methods of inhibiting dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of any of the compounds or compositions described herein.
    Type: Application
    Filed: January 11, 2019
    Publication date: November 19, 2020
    Inventors: William M. Clemons, Michio Kurosu
  • Patent number: 10108776
    Abstract: Methods and systems are described to provide computerized trajectory-based methods to represent translocon-associated protein trajectories, provide proteins or protein sequences with desired translocon-associated biogenesis features, screening proteins or protein sequences to provide proteins or protein sequences with desired translocon-associated biogenesis features, screening translocon-associated biogenesis feature determinants to provide proteins or protein sequences with desired translocon-associated biogenesis features, identifying translocon-associated biogenesis feature determinants of a given protein sequence, computer-based protein sequence identification methods, computer-based methods for identifying correlations in a set of protein sequences, computer-based methods for identifying correlations between experimental data and computer-generated data in a protein sequence, and computer-based methods for determining which modifications of a protein sequence do not substantially affect a translocon-ass
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: October 23, 2018
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Thomas F. Miller, III, William M. Clemons, Jr., Stephen Marshall, Axel Mueller, Michiel Niesen, Bin Zhang
  • Patent number: 10013525
    Abstract: Methods and systems are described to provide computerized trajectory-based methods to represent translocon-associated protein trajectories, provide proteins or protein sequences with desired translocon-associated biogenesis features, screening proteins or protein sequences to provide proteins or protein sequences with desired translocon-associated biogenesis features, screening translocon-associated biogenesis feature determinants to provide proteins or protein sequences with desired translocon-associated biogenesis features, identifying translocon-associated biogenesis feature determinants of a given protein sequence, computer-based protein sequence identification methods, computer-based methods for identifying correlations in a set of protein sequences, computer-based methods for identifying correlations between experimental data and computer-generated data in a protein sequence, and computer-based methods for determining which modifications of a protein sequence do not substantially affect a translocon-ass
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: July 3, 2018
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Thomas F. Miller, III, William M. Clemons, Jr., Stephen Marshall, Axel Mueller, Michiel Niesen, Bin Zhang
  • Publication number: 20170249420
    Abstract: Membrane protein expression can be predicted using statistical frameworks to provide an enhanced subset of sequences, out of an initial larger set of potentially expressing sequences, by using features derived from sequences and a model parameterized through a dataset of known expression levels. Also, membrane protein experimentation protocols can be designed using the statistical frameworks in concert known outcomes to identify which laboratory conditions are most likely to produce successful results.
    Type: Application
    Filed: February 27, 2017
    Publication date: August 31, 2017
    Inventors: Shyam M. SALADI, William M. CLEMONS
  • Patent number: 9541558
    Abstract: A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also provided.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: January 10, 2017
    Assignee: California Institute of Technology
    Inventors: William M. Clemons, Kyoung-Soon Jang, Roger Nani, Sergiy Levin, Sarah Reisman
  • Publication number: 20140072981
    Abstract: A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also provided.
    Type: Application
    Filed: September 4, 2013
    Publication date: March 13, 2014
    Applicant: California Institute of Technology
    Inventors: William M. Clemons, Kyoung-Soon Jang, Roger Nani, Sergiy Levin, Sarah Reisman