Abstract: The present disclosure provides constructs that comprise (a) a TNF-related apoptosis-inducing ligand (TRAIL) trimer comprising three consecutive extracellular TRAIL domains fused together in a head-to-tail configuration; (b) an epitope binding agent, and (c) optionally one or more additional components, wherein the epitope binding agent competitively inhibits binding of P4-TR3 or HN1-TR3 to cell surface human mesothelin. Constructs of the present disclosure induce apoptosis in cells expressing human mesothelin and a death receptor (DR4 or DR5) on the cell's surface.

Abstract: A cycling computer includes a housing for enclosing an electronics package and a mount for removably securing the housing to the front of a bicycle. The housing has a wedge-shaped profile defined by a leading edge and a lower front surface extending rearward and downward to a bottom surface. The computer mount includes a cradle for removably receiving the housing. A bracket arm extends between the cradle and a mounting adapter which is used to connect to a handlebar or otherwise. The cradle further includes a curved underside surface extending rearward from a forward edge that is sized and shaped to align with the lower front surface of the computer housing to form a substantially smooth and continuous aerodynamic surface from the leading edge of the computer housing to a rear edge of the cradle.

Abstract: Systems and methods for providing online games, including various means of providing computer-implemented games using standard and non-standard tokens, and that operate in coordination with an online social network. Examples of standard tokens may include tokens associated with each card of a standard 52 card deck, units in a real-time strategy game, and the like. Non-standard tokens may represent digital tokens with specified attributes and associated digital rights management for use by specified users, such as users purchasing rights to a particular non-standard token. Non-standard tokens may also include tokens with different functionality across a number of different computer-implemented games.

Abstract: Systems and methods for providing online games, including trading card games played on a computer, and other mobile devices, are described using combinations of standard and non-standard digital tokens. The systems and methods provide the capability for games to allow users to acquire rights to digital tokens that have different functionality across a spectrum of computer-implemented games, and for computer-implemented games to combine variable-use digital tokens with other standard gaming tools and constructs, such as a standard 52 card deck.

Abstract: Systems and methods for providing online games, including various means of providing computer-implemented games using standard and non-standard tokens, and that operate in coordination with an online social network. Examples of standard tokens may include tokens associated with each card of a standard 52 card deck, units in a real-time strategy game, and the like. Non-standard tokens may represent digital tokens with specified attributes and associated digital rights management for use by specified users, such as users purchasing rights to a particular non-standard token. Non-standard tokens may also include tokens with different functionality across a number of different computer-implemented games.

Abstract: Systems and methods for providing online games, including trading card games played on a computer, and other mobile devices, are described using combinations of standard and non-standard digital tokens. The systems and methods provide the capability for games to allow users to acquire rights to digital tokens that have different functionality across a spectrum of computer-implemented games, and for computer-implemented games to combine variable-use digital tokens with other standard gaming tools and constructs, such as a standard 52 card deck.

Abstract: A distributed control system architecture (HSE) provides an open, interoperable solution optimized for integration of distributed control systems and other control devices in a high performance backbone, provides an open, interoperable solution that provides system time synchronization suitable for distributed control applications operable over a high performance backbone, and provides an open, interoperable solution that provides a fault tolerant high performance backbone as well as fault tolerant devices that are connected to the backbone. The distributed control system architecture comprises a High speed Ethernet Field Device Access (HSE FDA) Agent, which maps services of a distributed control system, e.g., a fieldbus System, to and from a standard, commercial off-the-shelf (COTS) Ethernet/Internet component.

Abstract: A new and improved control system architecture using a combination of standard function blocks and new flexible function blocks eliminates the need for expensive and difficult to maintain custom control software and special I/O gateways for discrete/hybrid/batch and PLC applications. The end user builds application-specific flexible function blocks by configuring the number and type of inputs and outputs, and the block algorithm. Flexible function blocks and gateway flexible function block interconnect and interoperate with each other and with standard function blocks in a distributed control architecture.

Abstract: The mapping of playing objects from one game to another. In one embodiment, generic attributes of an object may be mapped to game-specific attributes. The mapping may either change or maintain the look and feel of an object. For example, a fast but lightly-armed starship in one game may be mapped to a quick but weak warrior in another game.

Abstract: The mapping of playing objects from one game to another. In one embodiment, generic attributes of an object may be mapped to game-specific attributes. The mapping may either change or maintain the look and feel of an object. For example, a fast but lightly-armed starship in one game may be mapped to a quick but weak warrior in another game.

Abstract: A fishing rod holder and pivoting fishing device that in response to a bite from a fish automatically sets the hook by raising the fishing rod. The device comprises a frame assembly including a generally vertical support member which may be attached to a boat, into the ground or some other appropriate location. A generally horizontal member supports a rod holding bracket. Along the back end of the device a helical spring member under tension allows the device to pivot rapidly in a generally upward direction to set the hook once a fish strikes the line. Further, the amount of axial displacement necessary to spring the device and set the hook may be adjusted to account for various types of fish or fishing conditions. The device further includes an audio and visual strike indicator that is easily removed from the device, and allows rapid removal of the fishing rod from the device in order to initiate the manual manipulation of the fishing rod required to land the fish.