Patents by Inventor William M. Keefe

William M. Keefe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED FGF-21 POLYPEPTIDES AND THEIR USES
    Publication number: 20210261637
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Application
    Filed: February 2, 2021
    Publication date: August 26, 2021
    Inventors: Thomas P. CUJEC, Roberto MARIANI, Anna-Maria A. HAYS PUTNAM, William M. KEEFE, Nick KNUDSEN, Lillian SKIDMORE, Jason PINKSTAFF, Vadim KRAYNOV
  • Modified FGF-21 polypeptides and their uses
    Patent number: 10961291
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: March 30, 2021
    Assignee: AMBRX, INC.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Skidmore, Jason Pinkstaff, Vadim Kraynov
  • MODIFIED FGF-21 POLYPEPTIDES AND THEIR USES
    Publication number: 20200031894
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Application
    Filed: June 17, 2019
    Publication date: January 30, 2020
    Inventors: Thomas P. CUJEC, Roberto MARIANI, Anna-Maria A. HAYS PUTNAM, William M. KEEFE, Nick KNUDSEN, Lillian SKIDMORE, Jason PINKSTAFF, Vadim KRAYNOV
  • Modified FGF-21 polypeptides comprising non-naturally encoding amino acids and their uses
    Patent number: 10377805
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: August 13, 2019
    Assignee: AMBRX, INC.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Skidmore, Jason Pinkstaff, Vadim Kraynov
  • MODIFIED FGF-21 POLYPEPTIDES AND THEIR USES
    Publication number: 20180298073
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Application
    Filed: April 13, 2018
    Publication date: October 18, 2018
    Inventors: Thomas P. CUJEC, Roberto MARIANI, Anna-Maria A. HAYS PUTNAM, William M. KEEFE, Nick KNUDSEN, Lillian SKIDMORE, Jason PINKSTAFF, Vadim KRAYNOV
  • Nucleic acids encoding modified FGF-21 polypeptides comprising non-naturally occurring amino acids
    Patent number: 9975936
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: May 22, 2018
    Assignee: AMBRX, INC.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Skidmore, Jason Pinkstaff, Vadim Kraynov
  • Modified FGF-21 polypeptides comprising non-naturally occurring amino acids
    Patent number: 9079971
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: January 2, 2013
    Date of Patent: July 14, 2015
    Assignee: AMBRX, INC.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Ho, Jason Pinkstaff, Vadim Kraynov
  • Methods of making FGF-21 mutants comprising non-naturally encoded phenylalanine derivatives
    Patent number: 8383365
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: February 26, 2013
    Assignee: AMBRX, Inc.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Skidmore (Nee Ho), Jason Pinkstaff, Vadim Kraynov
  • Modified FGF-21 polypeptides and their uses
    Patent number: 8012931
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: September 6, 2011
    Assignee: Ambrx, Inc.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Ho, Jason Pinkstaff, Vadim Kraynov
  • Modified FGF-21 Polypeptides and Their Uses
    Publication number: 20110172401
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Application
    Filed: March 18, 2011
    Publication date: July 14, 2011
    Applicant: AMBRX, INC.
    Inventors: Thomas P. CUJEC, Roberto MARIANI, Anna-Maria A. HAYS PUTNAM, William M. KEEFE, Nick KNUDSEN, Lillian Ho, Jason PINKSTAFF, Vadim KRAYNOV
  • Biosynthetic Polypeptides Utilizing Non-Naturally Encoded Amino Acids
    Publication number: 20100048871
    Abstract: Modified biosynthetic polypeptide molecules, methods for manufacturing, and uses thereof are provided.
    Type: Application
    Filed: November 4, 2009
    Publication date: February 25, 2010
    Applicant: AMBRX, INC.
    Inventors: Ho Sung CHO, Thomas O. DANIEL, Anna-Maria HAYS, Troy E. WILSON, David C. LITZINGER, Roberto MARIANI, Bruce E. KIMMEL, William M. KEEFE
  • Biosynthetic polypeptides utilizing non-naturally encoded amino acids
    Patent number: 7638299
    Abstract: Modified biosynthetic polypeptide molecules, methods for manufacturing, and uses thereof are provided.
    Type: Grant
    Filed: July 21, 2005
    Date of Patent: December 29, 2009
    Assignee: Ambrx, Inc.
    Inventors: Ho Sung Cho, Thomas O. Daniel, Anna-Maria Hays, Troy E. Wilson, David C. Litzinger, Roberto Mariani, Bruce E. Kimmel, William M. Keefe
  • Modified FGF-21 Polypeptides and Their Uses
    Publication number: 20080255045
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Application
    Filed: March 19, 2008
    Publication date: October 16, 2008
    Applicant: AMBRX, INC.
    Inventors: Thomas P. CUJEC, Roberto MARIANI, Anna-Maria A. HAYS PUTNAM, William M. KEEFE, Nick KNUDSEN, Lillian HO, Jason PINKSTAFF, Vadim KRAYNOV