Patents by Inventor William R. Wagner

William R. Wagner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170340432
    Abstract: A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
    Type: Application
    Filed: March 8, 2017
    Publication date: November 30, 2017
    Inventors: Mohammed S. El-Kurdi, J. Christopher Flaherty, Yi Hong, Jonathan McGrath, Lorenzo Soletti, John J. Stankus, David A. Vorp, William R. Wagner
  • Publication number: 20170326772
    Abstract: A system for electrospinning a fiber matrix on a tubular member includes at least one nozzle, a tubular member in a spaced relationship to the at least one nozzle, and a fluid source for pressurizing a lumen of the tubular member. An electrical potential is applied between the at least one nozzle and either the tubular member or fluid from the fluid source. The electrical potential draws at least one fiber from the at least one nozzle to the tubular member.
    Type: Application
    Filed: April 27, 2017
    Publication date: November 16, 2017
    Applicant: University of Pittsburgh - Of The Commonwealth System of Higher Education
    Inventors: Jon MCGRATH, Lorenzo SOLETTI, Mohammed S. EL-KURDI, William R. WAGNER, J. Christopher FLAHERTY
  • Patent number: 9808560
    Abstract: A method of forming an implantable article includes providing a biodegradable polymer including anti-thrombogenic groups along the length of the biodegradable polymer, biodegradable groups in the backbone of the biodegradable polymer and a plurality of functional groups adapted to react with reactive functional groups on a surface of the implantable article, and reacting at least a portion of the plurality of functional groups with the reactive functional groups on the surface of the implantable article.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: November 7, 2017
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Yi Hong, William R Wagner, Sang-Ho Ye
  • Publication number: 20170246350
    Abstract: Provided herein is a method of making an aligned ECM scaffold useful in refractive correction of the eye and repair of the cornea. Methods of use of the scaffold as well as a scaffold construct are provided.
    Type: Application
    Filed: March 2, 2017
    Publication date: August 31, 2017
    Inventors: Yiqin Du, James L. Funderburgh, William R. Wagner, Jian Wu
  • Patent number: 9656417
    Abstract: A system for electrospinning a fiber matrix on a tubular member includes at least one nozzle, a tubular member in a spaced relationship to the at least one nozzle, and a fluid source for pressurizing a lumen of the tubular member. An electrical potential is applied between the at least one nozzle and either the tubular member or fluid from the fluid source. The electrical potential draws at least one fiber from the at least one nozzle to the tubular member.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: May 23, 2017
    Assignees: Neograft Technologies, Inc., University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Jon McGrath, Lorenzo Soletti, Mohammed S. El-Kurdi, William R. Wagner, J. Christopher Flaherty
  • Patent number: 9597358
    Abstract: Provided herein is a method of making an aligned ECM scaffold useful in refractive correction of the eye and repair of the cornea. Methods of use of the scaffold as well as a scaffold construct are provided.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: March 21, 2017
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Yiqin Du, James L. Funderburgh, William R. Wagner, Jian Wu
  • Publication number: 20170049941
    Abstract: Provided herein are methods or making and using whole or partial organ ECM structures comprising an anticoagulant. Also provided are organ structures prepared according to those methods.
    Type: Application
    Filed: April 29, 2015
    Publication date: February 23, 2017
    Inventors: Alejandro SOTO-GUTIERREZ, Kentaro MATSUBARA, Ken FUKUMITSU, Kan HANDA, Jorge Guzman LEPE, William R. WAGNER, Sang Ho YE, Hiroshi YAGI, Yuko KITAGAWA
  • Publication number: 20170043360
    Abstract: A cartridge device is provided for applying a fiber matrix to a tubular member such as a saphenous vein graft. The cartridge includes a housing, a tubular member holder, a rotational drive, and a polymer delivery assembly. The housing defines a chamber which surrounds the tubular member holder. The rotational drive rotates the tubular member during the fiber application process.
    Type: Application
    Filed: August 4, 2016
    Publication date: February 16, 2017
    Applicant: University of Pittsburgh - of the Commonwealth System of Higher Education
    Inventors: Lorenzo SOLETTI, Mohammed S. EL-KURDI, Jon MCGRATH, Andrew ZIEGLER, J. Christopher FLAHERTY, William R. WAGNER, David VORP
  • Publication number: 20170028101
    Abstract: Provided are novel biocompatible copolymers, compositions comprising the copolymers, and methods of using the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.
    Type: Application
    Filed: April 14, 2015
    Publication date: February 2, 2017
    Inventors: Hongbin Jiang, William R. Wagner, Tomo Yoshizumi, Yang Zhu
  • Publication number: 20160325016
    Abstract: A biohybrid scaffold is provided that is useful in clinical applications for abdominal wall reconstruction, pelvic floor repair, breast reconstruction, as well as other soft tissue repairs. Methods of making and using the biohybrid scaffold are provided.
    Type: Application
    Filed: July 22, 2016
    Publication date: November 10, 2016
    Inventors: Nicholas J. Amoroso, Stephen Francis Badylak, Yi Hong, Alexander Huber, Keisuke Takanari, William R. Wagner
  • Publication number: 20160317280
    Abstract: A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
    Type: Application
    Filed: March 31, 2016
    Publication date: November 3, 2016
    Inventors: Mohammed S. El-Kurdi, Yi Hong, Lorenzo Soletti, John J. Stankus, David A. Vorp, William R. Wagner
  • Patent number: 9445874
    Abstract: A cartridge device is provided for applying a fiber matrix to a tubular member such as a saphenous vein graft. The cartridge includes a housing, a tubular member holder, a rotational drive, and a polymer delivery assembly. The housing defines a chamber which surrounds the tubular member holder. The rotational drive rotates the tubular member during the fiber application process.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: September 20, 2016
    Assignees: Neograft Technologies, Inc., University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Lorenzo Soletti, Mohammed S. El-Kurdi, Jon McGrath, Andrew Ziegler, J. Christopher Flaherty, William R. Wagner, David Vorp
  • Patent number: 9421307
    Abstract: A biohybrid scaffold is provided that is useful in clinical applications for abdominal wall reconstruction, pelvic floor repair, breast reconstruction, as well as other soft tissue repairs. Methods of making and using the biohybrid scaffold are provided.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: August 23, 2016
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Nicholas J. Amoroso, Stephen F. Badylak, Yi Hong, Alexander Huber, Keisuke Takanari, William R. Wagner
  • Patent number: 9408855
    Abstract: Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: August 9, 2016
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Kazuro Lee Fujimoto, Jianjun Guan, Zuwei Ma, William R. Wagner
  • Patent number: 9333068
    Abstract: A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: May 10, 2016
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Mohammed S. El-Kurdi, Yi Hong, Lorenzo Soletti, John J. Stankus, David A. Vorp, William R. Wagner
  • Patent number: 9237945
    Abstract: A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: January 19, 2016
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Mohammed S. El-Kurdl, Yi Hong, Lorenzo Soletti, John J. Stankus, David A. Vorp, William R. Wagner
  • Publication number: 20150314059
    Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.
    Type: Application
    Filed: November 27, 2013
    Publication date: November 5, 2015
    Inventors: William J. Federspiel, Brian Joseph Frankowski, James F. Antaki, Christian Andres Bermudez, Richard Garrett Jeffries, William R. Wagner
  • Publication number: 20150150673
    Abstract: A tubular tissue graft device is provided comprising a tubular tissue and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided.
    Type: Application
    Filed: January 21, 2015
    Publication date: June 4, 2015
    Inventors: Mohammed S. El-Kurdi, Yi Hong, Lorenzo Soletti, John J. Stankus, David A. Vorp, William R. Wagner
  • Publication number: 20150132251
    Abstract: Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The biodegradable elastomeric patch may be engineered to have mechanical properties similar to that of soft tissue and to provide mechanical support to the damaged tissue. The biodegradable elastomeric patch also may comprise therapeutic agents to aid in the healing process. Methods also are provided for using a biodegradable elastomeric patch for treating patients suffering from tissue damage or tissue deficiencies in the cardiac or cardiovascular system.
    Type: Application
    Filed: January 15, 2015
    Publication date: May 14, 2015
    Inventors: Kazuro Lee Fujimoto, Jianjun Guan, Bradley B. Keller, Kimimasa Tobita, William R. Wagner
  • Patent number: 8974542
    Abstract: Provided herein is a biodegradable elastomeric patch that can be implanted on a heart or other portions of the cardiovascular system to repair tissue deficiencies or tissue damage. The biodegradable elastomeric patch may be engineered to have mechanical properties similar to that of soft tissue and to provide mechanical support to the damaged tissue. The biodegradable elastomeric patch also may comprise therapeutic agents to aid in the healing process. Methods also are provided for using a biodegradable elastomeric patch for treating patients suffering from tissue damage or tissue deficiencies in the cardiac or cardiovascular system.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: March 10, 2015
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Kazuro Lee Fujimoto, Kimimasa Tobita, Jianjun Guan, William R. Wagner, Bradley Barth Keller