Abstract: A device for delivering an occlusive element includes an elongate sheath having a lumen therein. An elongate core member is disposed within the lumen and is formed from a proximal portion and distal portion connected via a joint. The distal portion of the elongate member includes a severable junction secured to the occlusive element. A marker coil is coaxially arranged around the distal portion of the elongate core member and is partially disposed inside the sheath lumen. A coil member is coaxially arranged around the distal portion of the elongate core member and coaxially arranged around at least a portion of the marker coil extending outside the lumen of the sheath. The coil member is secured at a distal end thereof to the distal portion of the elongate core member. The device resists axial compression while allowing for radial bending.

Abstract: A stent delivery system includes a delivery member, a frictional interfacing member disposed on a distal region of the delivery member, the frictional interfacing member comprising a plurality of perfusion channels, a self-expanding stent disposed over the respective frictional interfacing member and delivery member in a radially contracted configuration, and a sheath defining disposed over the respective self-expanding stent, frictional interfacing member, and delivery member, wherein the frictional interfacing member resists axial and/or rotational movement of the stent relative to the delivery member while the stent is in its radially contracted configuration, and wherein the perfusion channels permit fluid to flow from an interior region of the sheath proximal of the frictional interfacing member to an interior region of the sheath distal of the frictional interfacing member.

Abstract: Medical devices, such as endoprostheses, and methods of making the devices are disclosed. The medical device can include a composite cover formed of a deposited metallic film and one or more polymer layers. The polymer layers contribute to mechanical or biological properties of the endoprosthesis.

Abstract: A method and system are provided herein for forming microparticles from plastic and elastomeric materials that cannot be reduced in size by conventional methods. The system includes a high-pressure liquid nitrogen energy source, a feeder for providing a preferred constant and uninterrupted feed to a mill, a preferred integral injection device to meter the feed into a chamber for milling and/or classification, and a preferred exhaust system for collection of the milled product.

Abstract: Medical devices, such as endoprostheses, and methods of making the devices are disclosed. The medical device can include a composite cover formed of a deposited metallic film and one or more polymer layers. The polymer layers contribute to mechanical or biological properties of the endoprosthesis.

Abstract: A stent delivery system includes a delivery wire, a first stent, a second stent, and a sheath. The first stent may be disposed around a portion of a distal region of the delivery wire in a radially contracted configuration and the second stent may be disposed around a portion of the distal region of the delivery wire in a radially contracted configuration. In some cases, the first stent and the second stent may be disposed in a tandem arrangement with the first stent distal of the second stent. The sheath may be slidably disposed around the delivery wire, the first stent, and the second stent. The sheath may be retractable relative to the delivery wire to deploy the first stent and the second stent. In some embodiments, the first stent and the second stent may be sequentially deployed in an overlapping arrangement at the target site in the vessel.

Abstract: Medical devices, such as endoprostheses, and methods of making the devices are disclosed. The medical device can include a composite cover formed of a deposited metallic film and one or more polymer layers. The polymer layers contribute to mechanical or biological properties of the endoprosthesis.

Abstract: A self-expanding stent delivery assembly includes a shaft having a proximal end, a distal end, a distal region, a lumen, and a longitudinal axis. A retractable sheath having an outer surface, a proximal end and a distal end is co-axially disposed around the shaft distal region. A stent is disposed co-axially between the shaft and the retractable sheath. A tubular tapered tip is affixed to the retractable sheath distal end. The tubular tapered tip has an elongate region predisposed to fracturing. Methods of delivering a self-expanding stent are also described.

Abstract: A method and system are provided herein for forming microparticles from plastic and elastomeric materials that cannot be reduced in size by conventional methods. The system includes a high-pressure liquid nitrogen energy source, a feeder for providing a preferred constant and uninterrupted feed to a mill, a preferred integral injection device to meter the feed into a chamber for milling and/or classification, and a preferred exhaust system for collection of the milled product.

Abstract: A self-expanding stent delivery assembly includes a shaft having a proximal end, a distal end, a distal region, a lumen, and a longitudinal axis. A retractable sheath having an outer surface, a proximal end and a distal end is co-axially disposed around the shaft distal region. A stent is disposed co-axially between the shaft and the retractable sheath. A tubular tapered tip is affixed to the retractable sheath distal end. The tubular tapered tip has an elongate region predisposed to fracturing. Methods of delivering a self-expanding stent are also described.

Abstract: A process for the preparation of a purified monomer is disclosed which comprises the steps of reacting an impure monomer wherein R1 and R2 are independently hydrogen or alkyl groups containing from 1 to about 6 carbon atoms, with (B) a substantially aqueous solution of an oxide or hydroxide of the structure MO or MOH wherein M is a Group IA or Group IIA metal, or an amine of the structure NR3R4R5 wherein R3, R4 and R5 are independently hydrogen or alkyl, alkanol or alkoxy groups containing from 1 to about 12 carbon atoms, wherein the molar ratio of (A):(B) is from about 1:1-2 for Group IA metals, 2:1-2 for Group IIA metals or ratio of moles of (A) to nitrogens of (B) is from about 1:1-2 nitrogens to form a salt, wherein in order to prevent polymerization of (A), the purified monomer or both or prevent undesired side reactions, the reaction of (A) and (B) occurs at a temperature of between about −20 to 75° C. and at a pH between about 7 to about 12.