Abstract: Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with histone acetyltransferase (HAT).

Abstract: A computer-assisted device include an actuator and one or more processors. The computer-assisted device is configured to support an instrument having an end effector located at a distal end. To perform an operation with the instrument, the one or more processors are configured to operate the end effector according to a state machine having a first state and a second state. In the first state a velocity set point of the actuator is set to a first velocity. In the second state the velocity set point of the actuator is set to a second velocity lower than the first velocity. The state machine transitions from the first state to the second state when a force or torque applied by the actuator is above a first threshold and transitions from the second state to the first state when the force or torque applied by the actuator is below a second threshold.

Abstract: The inventive subject matter provides apparatus, systems and methods in which a high port count base station antenna uses an array of spherical lenses with multiple ports per frequency band, containing multiple frequency bands, and capable of multiple beam operation. In a preferred embodiment, the antenna system comprises a plurality of spherical, dielectric lenses, stacked vertically, where each lens is surrounded by four or more lower frequency radiating elements, or one circular element. The circular element can have multiple sub-elements, along with feed gaps.

Abstract: A surgical fixation system can include a fixation device, a loop connected to the fixation device, a graft carried by the loop, and a reinforcement material. Surgical fixation systems can be used in various tissue reconstruction procedures, including but not limited to, ACL and PCL reconstructions. The graft and the reinforcement material may be tensioned independently of one another to avoid stress shielding the graft.

Abstract: A method of operating a power plant is provided. The method includes generating, with the one or more power generators, a total plant power. The method further includes supplying, with a back up power source, a backup power output. The method further includes providing a first portion of the total plant power to one or more auxiliary devices to meet an auxiliary demand. The method further includes providing at least one of a second portion of the total plant power and the backup power output to the flexible firm skid to meet the flexible firm demand. The method further includes providing a third portion of the total plant power to a power grid outside of the power plant to meet a grid demand.

Abstract: The instant specification provides for evolved base editors which overcome deficiencies of those in art (including increased efficiency and/or decreased requirement for specific sequence-context at an editing site) and which are obtained a result of a phage-assisted continuous evolution (PACE) system. In particular, the instant specification provides for evolved cytidine base editors (e.g., based on APOBEC1, CDA, or AID cytidine deaminase domains) which overcome deficiencies of those in art (including increased efficiency and/or decreased requirement for specific sequence-context at an editing site) and which are obtained a result of a phage-assisted continuous evolution (PACE) system.

Abstract: A method of manufacturing a polymer film includes melting a resin, extruding the melted resin through a die to produce a polymer film, shaping the polymer film, cooling the polymer film, illuminating a surface with a light source, capturing an image of a shadow cast by the polymer film on the surface while the polymer film is between the light source and the surface, calculating a frequency spectrum of at least a portion of the captured image, and adjusting a process parameter of the melting, the extruding, the shaping, or the cooling based on the frequency spectrum.

Abstract: Data routing for efficient decompressor use is described. In accordance with the described techniques, a cache controller receives requests from multiple requestors for elements of data stored in a compressed format in a cache. The requests include at least a first request from a first requestor and a second request from a second requestor. A decompression routing system identifies a redundant element of data requested by both the first requestor and the second requestor and causes decompressors to decompress the requested elements of data. The decompression includes performing a single decompression of the redundant element. After the decompression, the decompression routing system routes the decompressed elements to the plurality of requestors, which includes routing the decompressed redundant element to both the first requestor and the second requestor.

Abstract: Methods and systems for managing distributed systems are disclosed. The distributed systems may include any number of data processing systems that may contribute to the functionality of the distributed system. To contribute to the functionality of the distributed system, each of the data processing systems may need to be configured to positively contribute to one or more functions. To manage configuration of data processing system, a distributed control plane may be utilized that vests decision making authority at different levels within a hierarchy. The distributed control plane may utilize an intermediate representation of intent of users and through which flexibility of implementation may be maintained.

Abstract: The present disclosure provides compositions and methods for producing a high-purity isoprenoid from an isoprenoid composition, wherein the method includes using chromatography to reduce the impurities in the isoprenoid composition to below parts per million levels. Further provided herein are compositions containing high-purity isoprenoids.

Abstract: A method, computer program product, and computer system for testing of robotic process automation robots that interact with user interfaces. The method includes obtaining analysis of commands in a robotic process automation script to determine interaction of the commands with one or more user interface applications. The method includes extracting a list of commands that interact with user interface controls and grouping the commands by user interface application. The method then generates a set of tests for each user interface application, with the set of tests including the commands for user interface control interactions and assertions of a state of each user interface control interacted with. The method provides a set of tests for a robot for each user interface application.

Abstract: A valve for regulating the flow of ferromagnetic peening materials, consisting of an arrangement of pole pieces, spacers, permanent magnets, and electrical coils. This arrangement uses an angular magnetic field to concentrate holding strength within the working gaps without sacrificing holding strength to the environment, increasing the valve's efficiency. Additionally, this valve covers a large range of flow rates by exchanging center bars and magnets of different sizes, without otherwise increasing the size of the valve.

Abstract: A biocontainer having a first film, the film having an interior and exterior side; articulating elements disposed on or within the first film, the articulating elements comprising at least one a folded hinge, a sealed joint, a thinned pathway, a bowed path, an embedded polymeric or metallic cylindrical fiber or rod; and a second film, optionally comprising articulating elements, joined to the first film, to form a biocontainer having a closed volume, wherein the articulating elements permit the biocontainer to expand and collapse along the articulating elements.

Abstract: The present disclosure generally relates to viewing and updating application views. A device receives a user input, the input, when received initiating display of a plurality of application views of a set of application views. The device, in response to receiving the user input, displays the plurality of application views of the set of application views, wherein the set of application views includes preselected application views and an adaptive view that corresponds to a most recently opened application that is not one of the preselected application views.

Abstract: The technology described herein identifies malicious URLs using a classifier that is both accurate and fast. Aspects of the technology are particularly well adapted for use as a real-time URL security analysis tool because the technology is able to quickly process a URL and produce a warning when a malicious URL is identified. The rapid processing speed of the technology described herein is produced, in part, by use of only a single input signal, which is the URL itself. The high accuracy produced by the technology described herein is achieved by analyzing the unstructured text on both a character-by-character level and a word-by-word level. The technology described herein uses both character-level and word-level information from the incoming URL.

Abstract: An attachment of a display for use in a vehicle is provided. The attachment comprising a rigid bracket having a first end with a connecting flange and a second end with two flat angle brackets. A display carrier configured to support a display. An adapter plate with a plurality of slots and fixation ears. Each fixation ear being fixedly mounted into a slot. The adapter plate is mounted on the display carrier, and at least a fixation ear cooperates with a flat angle bracket.