Patents by Inventor Wolfgang Haap

Wolfgang Haap has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolidine derivatives
    Patent number: 7601752
    Abstract: The invention is concerned with novel pyrrolidine derivatives of formula (I) wherein X, Y, R1, R2 and R3 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
    Type: Grant
    Filed: November 6, 2006
    Date of Patent: October 13, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lilli Anselm, Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Jacques Himber, Bernd Kuhn, Narendra Panday, Fabienne Ricklin, Stefan Thomi
  • SOLID FORMS OF A PYRROLIDINE-3,4-DICARBOXAMIDE DERIVATIVE
    Publication number: 20090215826
    Abstract: The invention is concerned with crystalline forms or amorphous forms of a pyrrolidine-3,4-dicarboxamide derivative, which is useful as an active ingredient of medicaments for the diseases which can be treated by the coagulation factor Xa inhibitors.
    Type: Application
    Filed: February 19, 2009
    Publication date: August 27, 2009
    Inventors: Jean-Michel Adam, Andre Bubendorf, Annette Deynet-Vucenovic, Pascal Dott, Alexander Glomme, Olaf Grassmann, Wolfgang Haap, Martin Kuentz, Roland Meier
  • Benzodioxole derivatives
    Patent number: 7576088
    Abstract: The present invention relates to compounds of the general formula and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases such as obesity by selective modulation of CB1 receptors.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: August 18, 2009
    Assignee: Hoffman-La Roche Inc.
    Inventors: Alexander Alanine, Konrad Bleicher, Wolfgang Guba, Wolfgang Haap, Dagmar Kube, Thomas Luebbers, Jean-Marc Plancher, Olivier Roche, Mark Rogers-Evans, Gisbert Schneider, Jochen Zuegge
  • Pyrrolidine-3,4-dicarboxamide derivatives
    Patent number: 7550487
    Abstract: The invention is concerned with novel pyrrolidine-3,4-dicarboxamide derivatives of formula (I) wherein R1 to R9 and X are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
    Type: Grant
    Filed: March 9, 2005
    Date of Patent: June 23, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lilli Anselm, Katrin Groebke Zbinden, Wolfgang Haap, Jacques Himber, Christoph Martin Stahl, Stefan Thomi
  • NEW PYRIDINES AS FBPASE INHIBITORS FOR TREATMENT OF DIABETES
    Publication number: 20090143439
    Abstract: Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof wherein the residues have the significance given in claim 1 and which can be used in the form of pharmaceutical compositions.
    Type: Application
    Filed: November 24, 2008
    Publication date: June 4, 2009
    Inventors: Wolfgang Haap, Paul Hebeisen, Eric A. Kitas, Bernd Kuhn, Peter Mohr, Hans Peter Wessel
  • Dicarboxamide derivatives
    Patent number: 7501413
    Abstract: The invention is concerned with novel dicarboxamide derivatives of formula (I) wherein A, B, Rc, D and E are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: March 10, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Markus Boehringer, Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Jacques Himber, Roland Humm, Hans Iding, Dietmar Knopp, Narendra Panday, Fabienne Ricklin, Christoph Martin Stahl
  • Factor Xa inhibitors
    Patent number: 7417144
    Abstract: The invention is concerned with novel heteroaryl fused cyclic amines of formula (I) wherein A, X1 to X3, Y1 to Y3, Z, R1, R2, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit coagulation factor Xa and can be used as medicaments.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: August 26, 2008
    Assignee: Hoffman-La Roche Inc.
    Inventors: Markus Boehringer, Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Narendra Panday, Fabienne Ricklin
  • HETEROARYLACETAMIDE INHIBITORS OF FACTOR Xa
    Publication number: 20080146550
    Abstract: The invention is concerned with novel heteroarylacetamides of formula (I) R—C(O)—N(Re)—Rc—CH2—C(O)—N(Ra)(Rb) ??(I) wherein Ra to Re are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
    Type: Application
    Filed: February 4, 2008
    Publication date: June 19, 2008
    Inventors: Markus Boehringer, Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Narendra Panday, Fabienne Ricklin
  • NOVEL HETEROARYL CARBOXAMIDES
    Publication number: 20080103143
    Abstract: The invention is concerned with novel heteroaryl carboxamides of formula (I) wherein A, R1, R2, X, Y, Z and m are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used for the treatment or prevention of thrombotic disorders.
    Type: Application
    Filed: October 19, 2007
    Publication date: May 1, 2008
    Inventors: Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Bernd Kuhn, Narendra Panday, Fabienne Ricklin
  • Heteroarylacetamide inhibitors of factor Xa
    Patent number: 7361672
    Abstract: The invention is concerned with novel heteroarylacetamides of formula (I) Rd—C(O)—N(Re)—Rc—CH2—C(O)—N(Ra)(Rb)??(I) wherein Ra to Re are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: April 22, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Markus Boehringer, Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Narendra Panday, Fabienne Ricklin
  • Sulfonamide derivatives
    Publication number: 20080085928
    Abstract: Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein L, R1, R2, m and n have the meaning given in claim 1 and which can be used in the form of pharmaceutical compositions.
    Type: Application
    Filed: September 24, 2007
    Publication date: April 10, 2008
    Inventors: Wolfgang Haap, Paul Hebeisen, Eric Kitas, Philipp Kohler, Holger Kuehne, Armin Ruf
  • New FBPase inhibitors for diabetes
    Publication number: 20070281979
    Abstract: Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R3 have the significance given in the application and which can be used in the form of pharmaceutical compositions.
    Type: Application
    Filed: May 30, 2007
    Publication date: December 6, 2007
    Inventors: Marcel Gubler, Wolfgang Haap, Paul Hebeisen, Eric A. Kitas, Bernd Kuhn, Rudolf E. Minder, Brigitte Schott, Hans P. Wessel
  • Dicarboxamide derivatives
    Publication number: 20070249683
    Abstract: The invention is concerned with dicarboxamide derivatives of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used in pharmaceutical compositions.
    Type: Application
    Filed: April 11, 2007
    Publication date: October 25, 2007
    Inventors: Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Narendra Panday, Fabienne Ricklin
  • Carbocyclic fused cyclic amines
    Publication number: 20070112012
    Abstract: The invention is concerned with novel carbocyclyl fused cyclic amines of formula (I) wherein A, X1 to X3, Y1 to Y3, Z, R1, R2, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
    Type: Application
    Filed: November 1, 2006
    Publication date: May 17, 2007
    Inventors: Markus Boehringer, Katrin Zbinden, Wolfgang Haap, Narendra Panday, Fabienne Ricklin, Martin Stahl, Petra Schmitz
  • Pyrrolidine derivatives
    Publication number: 20070112001
    Abstract: The invention is concerned with novel pyrrolidine derivatives of formula (I) wherein X, Y, R1, R2 and R3 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
    Type: Application
    Filed: November 6, 2006
    Publication date: May 17, 2007
    Inventors: Lilli Anselm, Katrin Zbinden, Wolfgang Haap, Hans Hilpert, Jacques Himber, Bernd Kuhn, Narendra Panday, Fabienne Ricklin, Stefan Thomi
  • Factor Xa inhibitors
    Publication number: 20070049587
    Abstract: The invention is concerned with novel cycloalkane carboxamides of formula (I) wherein X, X1, Y, Y1, R1?, R1?, R2, R3, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
    Type: Application
    Filed: August 25, 2006
    Publication date: March 1, 2007
    Inventors: Katrin Zbinden, Wolfgang Haap, Hans Hilpert, Narendra Panday, Fabienne Ricklin
  • Factor Xa inhibitors
    Publication number: 20070015812
    Abstract: The invention is concerned with novel heteroaryl fused cyclic amines of formula (I) wherein A, X1 to X3, Y1 to Y3, Z, R1, R2, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit coagulation factor Xa and can be used as medicaments.
    Type: Application
    Filed: July 7, 2006
    Publication date: January 18, 2007
    Inventors: Markus Boehringer, Katrin Zbinden, Wolfgang Haap, Hans Hilpert, Narendra Panday, Fabienne Ricklin
  • Pyrrolyl-thiazole derivatives
    Patent number: 7135488
    Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of CB1 receptors.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: November 14, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wolgang Guba, Wolfgang Haap, Hans Peter Marty, Robert Narquizian
  • Cyclic amines
    Publication number: 20060247238
    Abstract: The invention is concerned with cyclic amines of formula (I) wherein X1 to X3, Y1 to Y3, R1?, R1? and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit coagulation factor Xa and can be used as medicaments and for treating diseases associated with coagulation factor Xa.
    Type: Application
    Filed: April 13, 2006
    Publication date: November 2, 2006
    Inventors: Katrin Zbinden, Wolfgang Haap, Hans Hilpert, Narendra Panday, Fabienne Ricklin, Beat Wirz
  • Antimicrobial method using a hydroxydiphenyl ether compound
    Patent number: 7105577
    Abstract: The present invention relates to the use of hydroxydiphenyl ether compounds as antimicrobially active substances, to certain new compounds of this type and to processes for the preparation of these compounds.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: September 12, 2006
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Werner Hölzl, Wolfgang Haap, Dietmar Ochs, Karin Puchtler, Marcel Schnyder, Surendra Umesh Kulkarni, Arakali Srinivasarao Radhakrishna, Mangesh Shivram Sawant, Asawari Bhikaji Mahtre