Abstract: The present invention pertains to novel immunogenic peptide sequences that can be used as vaccines in the treatment of cancer diseases such as brain cancers and specifically glioma. The cancer vaccines of the invention are designed based on the K27M mutated variant of the human Histone 3. Provided are further fusion proteins comprising the sequences of the cancer vaccines, nucleic acids encoding such vaccines, such as RNA vaccines, and vectors and host cells comprising these sequences. Furthermore the invention pertains to T cells and T cell receptors binding the cancer vaccines of the invention, preferably when presented by the human Major Histocompatibility Complex (MHC). The peptide immunogens of the invention elicit a HLA restricted immune response and therefore are of use in the treatment of cancer diseases, in particular glioma. Further aspects of the invention pertain to pharmaceutical compositions as well as diagnostic methods based on the immunogenic capacity of the disclosed peptides.

Abstract: Described is a pharmaceutical composition comprising (a) a parvovirus and (b) bevacizumab and the use of said composition for treatment of cancer, e.g., a solid tumor.

Abstract: The invention relates to a device for filling containers with filling material in powder form, comprising: at least one metering wheel (29); a metering chamber (28a, 28b); at least one container (27) for discharging into the metering chamber (28a, 28b) a filling material (21) to be metered; at least one filter (36) which is mounted on the metering chamber (28a, 28b), the filter (36) being non-permeable to the filling material (21) and permeable to a gaseous medium; at least one feed (46) for the gaseous medium, to influence the filling material (21) to be metered in the metering chamber (28a, 28b) by means of the gaseous medium via the filter (36), at least one transport means (43) being provided to displace the filter (36) such that a new region of the filter (36) reaches the underside of the metering chamber (28a, 28b).

Abstract: A method for fragrancing and/or deodorizing a cleaning appliance is disclosed. The method involves capturing first information or obtaining captured first information indicative of an odor load in the interior of the cleaning appliance, producing fragrancing and/or deodorizing information based at least in part on the captured or obtained first information or outputting the captured first information in order to produce fragrancing and/or deodorizing information of this type, and initiating fragrancing and/or deodorization by employing at least one actuator for releasing a fragrancing and/or deodorizing agent based on the fragrancing and/or deodorizing information produced. A corresponding dosing device, a device for carrying out and/or controlling the method, and a system with one or more devices for carrying out and/or controlling the method are also disclosed.

Abstract: The present invention concerns a pharmaceutical composition where a checkpoint inhibitor is combined with an oncolytic virus and the use of said combination for the treatment of cancer.

Abstract: The present invention concerns the field of tumor therapeutics and diagnostics. Specifically, it relates to a peptide comprising at least 8 amino acids in length which are present as contiguous amino acid sequence in the human Isocitratdehydrogenase Type 1 (IDH1), wherein said peptide has at least one amino acid exchange from R to H at a position corresponding to position 132, for use in preventing and/or treating cancer. Further contemplated is a medicament comprising the said peptide.

Abstract: The present invention relates to agents for use in the treatment of glioma, in particular astrocytoma WHO IF and 111°, as well as IV0 (glioblastoma), in a subject.

Abstract: The present invention pertains to novel immunogenic peptide sequences that can be used as vaccines in the treatment of cancer diseases such as brain cancers and specifically glioma. The cancer vaccines of the invention are designed based on the K27M mutated variant of the human Histone 3. Provided are further fusion proteins comprising the sequences of the cancer vaccines, nucleic acids encoding such vaccines, such as RNA vaccines, and vectors and host cells comprising these sequences. Furthermore the invention pertains to T cells and T cell receptors binding the cancer vaccines of the invention, preferably when presented by the human Major Histocompatibility Complex (MHC). The peptide immunogens of the invention elicit a HLA restricted immune response and therefore are of use in the treatment of cancer diseases, in particular glioma. Further aspects of the invention pertain to pharmaceutical compositions as well as diagnostic methods based on the immunogenic capacity of the disclosed peptides.

Abstract: The present invention pertains to a method for detecting antigen presentation via antigen presenting molecules such as major histocompatibility complex (MHC) class I or II. The invention deploys a first binding agent specific for the antigen epitope and a second binding agent specific for the antigen presenting molecule. The binding agents of the invention are coupled to proximity probes which upon antigen presentation elicit a detectable signal. The method of the invention allows detecting antigen presentation via MHC in-vitro and in a tissue sample in-situ. Thus the method of the present invention finds application as a new diagnostic tool, for example in the diagnosis of various diseases such as infectious diseases, immunological disorders, in particular autoimmune diseases, and proliferative disorders such as cancer.

Abstract: The present invention relates to the field of cancer therapeutics and treatment of cancer. In particular, it relates to a method for treating and/or preventing a natural AHR ligand-dependent cancer comprising administering to a subject suffering from said cancer a therapeutically effective amount of an AHR inhibitor. Moreover, contemplated is a AHR inhibitor for use in treating and/or preventing a natural AHR ligand-dependent cancer.

Abstract: The present invention concerns the field of tumor therapeutics and diagnostics. Specifically, it relates to a peptide comprising at least 8 amino acids in length which are present as contiguous amino acid sequence in the human Isocitratdehydrogenase Type 1 (IDH1), wherein said peptide has at least one amino acid exchange from R to H at a position corresponding to position 132, for use in preventing and/or treating cancer. Further contemplated is a medicament comprising the said peptide.

Abstract: The present invention relates to the field of cancer therapeutics and treatment of cancer. In particular, it relates to a method for treating and/or preventing a natural AHR ligand-dependent cancer comprising administering to a subject suffering from said cancer a therapeutically effective amount of an AHR inhibitor. Moreover, contemplated is a AHR inhibitor for use in treating and/or preventing a natural AHR ligand-dependent cancer.

Abstract: Liquid washing or cleaning agent preparations includes a) >5 wt. % of at least one active washing or cleaning enzyme; b) >5 wt. % of at least one organic solvent c) boric acid or a boric acid derivative d) a source of Ca or Mg ions and are characterized by a good phase and enzyme stability and good cleaning powers.

Abstract: The present invention relates to methods for the diagnosis of a brain tumor and for the estimation of a prognosis for patients having a brain tumor using the presence/absence of a particular IDH1 mutation as a marker.

Abstract: The invention relates to low-alkaline and bleach-free dishwasher detergents having a pH value (20° C.) between 8 and 12, comprising a) 10 to 60 wt % of citrate, b) 1.5 to 30 wt % anionic copolymer, comprising i) unsaturated monocarboxylic acid(s) A ii) unsaturated dicarboxylic acid(s) B, characterized by good cleaning action, particularly improved cleaning of tea.

Abstract: A method for operating an automatic dishwasher is disclosed. Provided are a dispenser, a cartridge with a chamber of rinse aid, a washing program including a cleaning program, and a sensor for measuring soil on the dishware or in the wash. The soiling is compared to a reference value and if less than reference, the temperature of the wash is held to ?65° C., and at the end of the cleaning program and/or the intermediate rinse cycle, rinse aid is dispensed and drying immediately follows the cleaning program and/or intermediate rinse cycle without execution of a rinse aid program.

Abstract: Liquid washing or cleaning agent preparations includes a) >5 wt. % of at least one active washing or cleaning enzyme; b) >5 wt. % of at least one organic solvent c) boric acid or a boric acid derivative d) a source of Ca or Mg ions and are characterized by a good phase and enzyme stability and good cleaning powers.

Abstract: Phosphate-free, bleach-free automatic dishwashing agents comprising 10 to 60 wt % citrate and from 1 to 30 wt % maleic acid are described, wherein the automatic dishwashing agents are characterized by good cleaning performance, particularly in the improved cleaning of tea stains.

Abstract: The invention relates to low-alkaline and bleach-free dishwasher detergents having a pH value (20° C.) between 8 and 12, comprising a) 10 to 60 wt % of citrate, b) 1.5 to 30 wt % anionic copolymer, comprising i) unsaturated monocarboxylic acid(s) A ii) unsaturated dicarboxylic acid(s) B, characterized by good cleaning action, particularly improved cleaning of tea.

Abstract: Multi-armed silyl polyalkoxylates of the formula (I), (H-A)n-Z-[A-B—Si(OR1)r(R2)3?r]m (I), where Z is an (m+n)-valent radical having at least three carbon atoms, A is a divalent polyoxyalkylene radical, B is a chemical bond or a divalent organic radical having 1 to 50 carbon atoms, OR1 is a hydrolysable group, R1 and R2 independently of one another are a linear or branched alkyl group having 1 to 6 carbon atoms and r is an integer from 1 to 3, and m is an integer ?1 and n is 0 or an integer ?1, and m+n has a value from 3 to 100, for reducing glass corrosion and/or for improving the drying performance during mechanical cleaning of a glass surface. Also compositions, in particular for the cleaning of glass surfaces, which compositions contain compounds of the formula (I).