Patents by Inventor Wolfgang Wrasidlo

Wolfgang Wrasidlo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190308965
    Abstract: The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer and melanoma.
    Type: Application
    Filed: June 11, 2019
    Publication date: October 10, 2019
    Applicant: UCB Biopharma SPRL
    Inventors: Wolfgang WRASIDLO, Emily M. Stocking
  • Patent number: 10358443
    Abstract: The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer and melanoma.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: July 23, 2019
    Assignee: UCB Biopharma SPRL
    Inventors: Wolfgang Wrasidlo, Emily M. Stocking
  • Publication number: 20180222899
    Abstract: The present invention relates to certain bis-heteroaryl compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.
    Type: Application
    Filed: July 29, 2016
    Publication date: August 9, 2018
    Applicant: Neuropore Therapies, Inc.
    Inventors: Wolfgang WRASIDLO, Emily M. STOCKING, Adrian HALL, Malcolm MACCOSS
  • Publication number: 20180093979
    Abstract: The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer and melanoma.
    Type: Application
    Filed: August 1, 2017
    Publication date: April 5, 2018
    Applicant: Neuropore Therapies, Inc.
    Inventors: Wolfgang WRASIDLO, Emily M. STOCKING
  • Patent number: 9738635
    Abstract: The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer and melanoma.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: August 22, 2017
    Assignee: NEUROPORE THERAPIES, INC.
    Inventors: Wolfgang Wrasidlo, Emily M. Stocking
  • Patent number: 9527852
    Abstract: The present invention relates to certain phenyl-urea and phenyl-carbamate derivatives comprising a bicyclic heteroaryl group, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, and multiple system atrophy.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 27, 2016
    Assignee: NEUROPORE THERAPIES, INC.
    Inventor: Wolfgang Wrasidlo
  • Patent number: 9487524
    Abstract: The present invention relates to certain phenyl-urea and phenyl-carbamate derivatives comprising a bicyclic heteroaryl group, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, and multiple system atrophy.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 8, 2016
    Assignee: NEUROPORE THERAPIES, INC.
    Inventor: Wolfgang Wrasidlo
  • Publication number: 20160207912
    Abstract: The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer and melanoma.
    Type: Application
    Filed: December 29, 2015
    Publication date: July 21, 2016
    Inventors: Wolfgang Wrasidlo, Emily M. Stocking
  • Patent number: 9284309
    Abstract: The present invention relates to certain di- and tri-heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, and multiple system atrophy.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: March 15, 2016
    Assignee: NEUROPORE THERAPIES, INC.
    Inventor: Wolfgang Wrasidlo
  • Publication number: 20150216985
    Abstract: Provided herein in some embodiments is a composition that comprises (a) a nanoscale particle(s) or a microscale particle(s); and (b) a film-forming polymer. Also provided herein is a method for an immediate and sustained released formulation suitable for topical administration or administration to surfaces. Further provided herein in certain embodiments is a method of reducing the population of pathogenic microorganisms on skin or surfaces, wherein a method comprises applying to the skin or surface a composition, wherein the composition comprises (a) a nanoscale particle(s) or a microscale particle(s); and (b) a film-forming polymer.
    Type: Application
    Filed: February 5, 2015
    Publication date: August 6, 2015
    Inventors: John A. Macoviak, Wolfgang Wrasidlo, John Norton, Kristin Spivey, Steve Oldenberg, Aaron Saunders
  • Publication number: 20150197513
    Abstract: The present disclosure relates to certain aryl- or heteroaryl-substituted benzene derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.
    Type: Application
    Filed: August 8, 2013
    Publication date: July 16, 2015
    Inventors: Wolfgang Wrasidlo, Emily M. Stocking
  • Publication number: 20150183776
    Abstract: The present invention relates to certain di- and tri-heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, and multiple system atrophy.
    Type: Application
    Filed: July 16, 2013
    Publication date: July 2, 2015
    Applicant: NEUROPORE THERAPIES, INC.
    Inventor: Wolfgang Wrasidlo
  • Publication number: 20150166543
    Abstract: The present invention relates to certain phenyl-urea and phenyl-carbamate derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, and multiple system atrophy.
    Type: Application
    Filed: March 15, 2013
    Publication date: June 18, 2015
    Inventor: Wolfgang Wrasidlo
  • Patent number: 9050376
    Abstract: The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: June 9, 2015
    Assignee: The Regents of the University of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Wolfgang Wrasidlo, Christina C. N. Wu, Gregory A. Daniels
  • Patent number: 9045401
    Abstract: The invention provides novel compositions—lipopeptides and analogs, including somocystinamide A, and somocystinamide A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these lipopeptides and analogs are used to induce apoptosis in a cell, which can be a normal cell, a dysfunctional cell and/or a cancer (tumor) cell. In alternative embodiments, the compositions of the invention, including the lipopeptides and analogs of the invention, and the pharmaceutical compositions comprising them, are used to treat or ameliorate (including slowing the progression of) normal, dysfunctional (e.g., abnormally proliferating) and/or tumor associated blood vessels, including endothelial and/or capillary cell growth; including neovasculature related to (within, providing a blood supply to) a tumor.
    Type: Grant
    Filed: May 21, 2008
    Date of Patent: June 2, 2015
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: William Gerwick, Wolfgang Wrasidlo, Dennis Carson, Dwayne Stupack, Takashi Suyama
  • Patent number: 9019078
    Abstract: A method and apparatus for identifying and tracking surgical objects is disclosed. More specifically, a method and apparatus for identifying and tracking surgical objects such as needles, scalpels, blades, sponges and instruments in a medical industry using an identifier encoded on a fluorescent paint attached to the surgical object combined with detectors and software capable of retrieving the identifying information on the identifier.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: April 28, 2015
    Assignee: The Regents of the University of California
    Inventors: Thomas Hamelin, Niren Angle, Milan Makale, Wolfgang Wrasidlo, Sadik C. Esener
  • Publication number: 20140364610
    Abstract: The present invention relates to certain heteroaromatic compounds of Formula (Ia), or pharmaceutically acceptable salts thereof, and uses of such compounds in the treatment of synucleopathies.
    Type: Application
    Filed: August 21, 2014
    Publication date: December 11, 2014
    Inventors: Eliezer MASLIAH, Edward M. ROCKENSTEIN, Wolfgang WRASIDLO, Igor Flint TSIGELNY
  • Publication number: 20140302120
    Abstract: The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma.
    Type: Application
    Filed: June 19, 2014
    Publication date: October 9, 2014
    Inventors: Dennis A. Carson, Howard B. Cottam, Wolfgang Wrasidlo, Christina C.N. Wu, Gregory A. Daniels
  • Patent number: 8846682
    Abstract: The present invention relates to a compound of formula (I): Wherein R1 is a substituted or unsubstituted aromatic hetero- or homocyclic or a substituted or unsubstituted alicyclic hetero- or homocyclic group; R2 is an alkyl group with 1 to 18 carbon atoms or a substituted or unsubstituted cycloalkyl or aryl group; R3 is a substituted or unsubstituted aromatic hetero- or homocyclic or a substituted or unsubstituted alicyclic hetero- or homocyclic group; L is a single bond, an alkyl group having 1 to 6 carbon atoms, NHCO, O, S, NHCONH or NHCOO; X, Y and Z are independently O, N, NH, S or CH; W is a single bond or an alkyl group having from 1 to 6 carbon atoms; or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate of said compound or salt.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: September 30, 2014
    Assignee: Neuropore Therapies, Inc.
    Inventors: Eliezer Masliah, Edward M. Rockenstein, Wolfgang Wrasidlo, Igor Flint Tsigelny
  • Patent number: 8790655
    Abstract: The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: July 29, 2014
    Assignee: The Regents of The University of California
    Inventors: Dennis A. Carson, Howard B. Cottam, Wolfgang Wrasidlo, Christina C. N. Wu, Gregory A. Daniels