Patents by Inventor Xiang Fang
Xiang Fang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10504712Abstract: A mass spectrometry device comprises a reaction gas introduction device and a gas phase molecule-ion reaction mass spectrometry analysis device, wherein the reaction gas introduction device is connected to the gas phase molecule-ion reaction mass spectrometry analysis device; the reaction gas introduction device is configured to introduce reaction gas into the gas phase molecule-ion reaction mass spectrometry analysis device; and the gas phase molecule-ion reaction mass spectrometry analysis device is configured to enable molecules or ions to be subjected to a reaction and carry out mass spectrometry analysis on a reaction result. The reaction gas introduction device comprises a reaction gas container, the reaction gas container being configured to contain gas or volatile liquid or solid and generate gas molecules needed by a reaction; and a reaction gas quantitation device, configured to carry out flow control on the gas molecules.Type: GrantFiled: March 23, 2016Date of Patent: December 10, 2019Assignee: National Institute of Metrology, ChinaInventors: You Jiang, Xiang Fang, Xing-Chuang Xiong, Ze-Jian Huang
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Publication number: 20190347985Abstract: Local passive matrix displays and methods of operation are described. In an embodiment, the display includes a pixel driver chip coupled with a matrix of rows and columns of LEDs. The pixel driver chips may be arranged in rows across the display with separate portions to operate separate matrices of LEDs.Type: ApplicationFiled: February 11, 2019Publication date: November 14, 2019Inventors: Derek K. Shaeffer, Mahdi Farrokh Baroughi, Xiaofeng Wang, Sam S. Li, John T. Wetherell, Henry C. Jen, Xiang Lu, Hasan Akyol, Hopil Bae, Xiang Fang, Hjalmar Edzer Ayco Huitema, Tore Nauta
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Publication number: 20190317749Abstract: In a multiple interface, low power and lossy network comprising multiple nodes, a Network Management System (“NMS”) communicating firmware upgrades in each node of a network utilizing centralized scheduling and distributed dissemination of firmware blocks. A firmware update image is broken into blocks and transmitted throughout the network of nodes. In certain instances, every node does not receive every firmware block. The NMS receives a bitmap from the nodes indicating which of the blocks each node is missing from the update. The NMS identify particular nodes that are missing blocks and source nodes that have the blocks and are nearest to the particular recipient nodes. The NMS determines the route for the source node with the block to deliver the block to the recipient node that this missing a block. The source nodes that are identified and instructed to communicate a block to a recipient node.Type: ApplicationFiled: April 13, 2018Publication date: October 17, 2019Inventors: Die Hu, Kang Li, Huimin She, Xiang Fang
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Publication number: 20190221953Abstract: An electrical connector is used to be electrically connected to a circuit board. The circuit board has a sink plate groove, and the electrical connector is mounted in the sink plate groove. The sink plate groove has at least one groove wall, and the groove wall has at least one first contact area. The electrical connector includes: an insulating body; a plurality of terminals, accommodated in the insulating body; an inner shell, accommodated in the insulating body; and an outer shell, provided outside the inner shell and electrically connected with the first contact area.Type: ApplicationFiled: January 8, 2019Publication date: July 18, 2019Inventors: Zhi Lin Chen, Xiang Fang Lei
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Publication number: 20190177312Abstract: Provided are a preparation method for a crystalline form of the compound represented by formula (A), as well as a method for preparation thereof, a composition thereof, and an application thereof in preparing an angiotensin II receptor antagonist or an application in preparing a drug for preventing and/or treating hypertension, chronic heart failure and diabetic nephropathy.Type: ApplicationFiled: July 10, 2017Publication date: June 13, 2019Applicants: Wuhan LL Science and Technology Development Co., Ltd., Wuhan QR Pharmaceuticals Co., Ltd.Inventors: Sijun LEI, Xiang FANG, Yongkai CHEN, Wei FENG, Chaodong WANG
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Patent number: 10233439Abstract: The present invention discloses a directionally modified glucosamine synthase mutant and its application. The amino acid sequence of the glucosamine synthase mutant is as shown in sequence list SEQ ID No. 1, and the nucleotide sequence is as shown in sequence list SEQ ID No. 2. The genetic engineering bacteria of glucosamine synthase is successfully constructed. In order to improve the tolerance of recombinant bacteria against glucosamine, the glucosamine synthase is directionally modified. A glucosamine synthase mutant is selected from the mutant library via high-throughput screening method, the amino acid changes in the mutant induces the spatial conformational change in the enzyme, so as enlarged the region where the enzyme and substrate combines, therefor the combination efficiency of the enzyme and the substrate is increased. The glucosamine synthase of the present invention has various advantages, such as rich in raw material of glucose, and a convenient subsequent extraction.Type: GrantFiled: June 5, 2017Date of Patent: March 19, 2019Assignees: Yangzhou Rixing Bio-Tech Co., Ltd, Jiangnan UniversityInventors: Jinsong Shi, Zhenghong Xu, Chao Zhang, Jinsong Gong, Heng Li, Zhenzhong Ding, Xiang Fang, Wanhong Zhang
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Patent number: 10163618Abstract: The invention proposes a mass spectrometry apparatus for ultraviolet light ionization of neutral lost molecules, and a method for operating same. The mass spectrometry apparatus for ultraviolet light ionization of neutral lost molecules includes a quadrupole tandem special linear ion trap mass analyzer, a vacuum ultraviolet lamp, a lamp front shutter, a gradient vacuum system and other necessary components for the mass spectrometry apparatus. In addition, the invention also proposes a method for operating the apparatus to efficiently store ions, fragment and analyze the ions, perform ultraviolet efficient ionization on lost neutral molecules, and then analyze the ions.Type: GrantFiled: November 19, 2015Date of Patent: December 25, 2018Assignee: NATIONAL INSTITUTE OF METROLOGY CHINAInventors: Xingchuang Xiong, Xiang Fang, You Jiang, Xiaoyun Gong, Zejian Huang, Meiying Liu
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Publication number: 20180342167Abstract: The embodiments of the present invention disclose a method and apparatus for joint optimization of multi-UAV task assignment and path planning.Type: ApplicationFiled: April 16, 2018Publication date: November 29, 2018Inventors: He LUO, Guoqiang WANG, Zhengzheng LIANG, Xiaoxuan HU, Shanlin YANG, Huawei MA, Wei XIA, Peng JIN, Moning ZHU, Yanqiu NIU, Xiang FANG
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Patent number: 10140875Abstract: The embodiments of the present invention disclose a method and apparatus for joint optimization of multi-UAV task assignment and path planning.Type: GrantFiled: April 16, 2018Date of Patent: November 27, 2018Assignee: HEFEI UNIVERSITY OF TECHNOLOGYInventors: He Luo, Guoqiang Wang, Zhengzheng Liang, Xiaoxuan Hu, Shanlin Yang, Huawei Ma, Wei Xia, Peng Jin, Moning Zhu, Yanqiu Niu, Xiang Fang
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Publication number: 20180312829Abstract: The present invention discloses a directionally modified glucosamine synthase mutant and its application. The amino acid sequence of the glucosamine synthase mutant is as shown in sequence list SEQ ID No. 1, and the nucleotide sequence is as shown in sequence list SEQ ID No. 2. The genetic engineering bacteria of glucosamine synthase is successfully constructed. In order to improve the tolerance of recombinant bacteria against glucosamine, the glucosamine synthase is directionally modified. A glucosamine synthase mutant is selected from the mutant library via high-throughput screening method, the amino acid changes in the mutant induces the spatial conformational change in the enzyme, so as enlarged the region where the enzyme and substrate combines, therefor the combination efficiency of the enzyme and the substrate is increased. The glucosamine synthase of the present invention has various advantages, such as rich in raw material of glucose, and a convenient subsequent extraction.Type: ApplicationFiled: June 5, 2017Publication date: November 1, 2018Applicants: Yangzhou Rixing Bio-Tech Co.,Ltd, Jiangnan UniversityInventors: Jinsong Shi, Zhenghong Xu, Chao Zhang, Jinsong Gong, Heng Li, Zhenzhong Ding, Xiang Fang, Wanhong Zhang
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Publication number: 20180261443Abstract: The invention proposes a mass spectrometry apparatus for ultraviolet light ionization of neutral lost molecules, and a method for operating same. The mass spectrometry apparatus for ultraviolet light ionization of neutral lost molecules includes a quadrupole tandem special linear ion trap mass analyzer, a vacuum ultraviolet lamp, a lamp front shutter, a gradient vacuum system and other necessary components for the mass spectrometry apparatus. In addition, the invention also proposes a method for operating the apparatus to efficiently store ions, fragment and analyze the ions, perform ultraviolet efficient ionization on lost neutral molecules, and then analyze the ions.Type: ApplicationFiled: November 19, 2015Publication date: September 13, 2018Inventors: Xingchuang XIONG, Xiang FANG, You JIANG, Xiaoyun GONG, Zejian HUANG, Meiying LIU
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Publication number: 20180108523Abstract: A mass spectrometry device and analysis method for a gas phase molecule-ion reaction. The device comprises a reaction gas introduction device and a gas phase molecule-ion reaction mass spectrometry analysis device, wherein the reaction gas introduction device is connected to the gas phase molecule-ion reaction mass spectrometry analysis device; the reaction gas introduction device is configured to introduce reaction gas into the gas phase molecule-ion reaction mass spectrometry analysis device; and the gas phase molecule-ion reaction mass spectrometry analysis device is configured to enable molecules or ions to be subjected to a reaction and carry out mass spectrometry analysis on a reaction result. The reaction gas introduction device comprises a reaction gas container, the reaction gas container being configured to contain gas or volatile liquid or solid and generate gas molecules needed by a reaction; and a reaction gas quantitation device, configured to carry out flow control on the gas molecules.Type: ApplicationFiled: March 23, 2016Publication date: April 19, 2018Inventors: You JIANG, Xiang FANG, Xing-Chuang XIONG, Ze-Jian HUANG
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Publication number: 20170271137Abstract: The invention discloses a networking mass analysis method and device, and belongs to the field of mass spectrometer and ion mass analysis. The device comprises an ion source, an ion transporter, an ion deflector and multiple mass analyzers, wherein the ion transporter is connected with one of the multiple mass analyzers, the multiple mass analyzers are connected with the ion deflector respectively, the ion source produces the ions to be detected, the ions to be detected enter any of the mass analyzers connected with the ion deflector via the ion transporter for mass analysis, and the remaining ions to be detected are transported to the corresponding mass analyzers via the ion deflector for mass analysis. The invention can improve the mass analysis duty ratio of continuous ion sources and obtain more mass-to-charge ratio information of ion beams within each time slot.Type: ApplicationFiled: March 23, 2016Publication date: September 21, 2017Applicant: National Institute of Metrology, ChinaInventors: You JIANG, Xiang FANG, Xingchuang XIONG, Zejian HUANG
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Patent number: 9716001Abstract: A method for analyzing ionic structure, including: applying a radio frequency electric field on an ion mass analyzer to cause sample ions to be excited to a motion amplitude, the motion amplitude at this moment being recorded as a primary motion amplitude; continuously feeding carrier gas into the ion mass analyzer and keeping a certain degree of vacuum in the ion mass analyzer, the sample ions being collided with the carrier gas and the motion amplitude being decreased gradually, and collecting a time domain signal of an image current generated by the sample ions during the process; and analyzing the time domain signal through a time-frequency analysis method and obtaining time-varying characteristic curves indicating corresponding relations between the motion frequencies of the ions having corresponding sizes and the collision cross sectional areas of the ions and the carrier gas, thus distinguishing among ions having different sizes.Type: GrantFiled: September 5, 2014Date of Patent: July 25, 2017Assignee: BEIJING INSTITUTE OF TECHNOLOGYInventors: Wei Xu, Muyi He, Xiang Fang
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Patent number: 9679759Abstract: The present invention discloses a rectangular ion trap device and method for ion storage. The device comprises a front end cover including left electrode, middle layer insulator, and right electrode, wherein the left electrode and the right electrode are respectively positioned at both sides of the middle layer insulator; a rear end cover, wherein the rear end cover has the same axis as the front end cover, and the central position of the rear end cover electrode is penetrated; the front and rear electrodes and the upper and lower electrodes are symmetric along the axis of the front end cover, and these electrodes form a space region for ion storage about the axis between the front end cover and the rear end cover electrode. The present invention can increase the number of ions in storage within a unit time prominently.Type: GrantFiled: August 15, 2014Date of Patent: June 13, 2017Assignee: National Institute of Metrology, ChinaInventors: Xingchuang Xiong, You Jiang, Zejian Huang, Xiang Fang
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Publication number: 20160293396Abstract: The present invention discloses a rectangular ion trap device and method for ion storage. The device comprises a front end cover including left electrode, middle layer insulator, and right electrode, wherein the left electrode and the right electrode are respectively positioned at both sides of the middle layer insulator; a rear end cover, wherein the rear end cover has the same axis as the front end cover, and the central position of the rear end cover electrode is penetrated; the front and rear electrodes and the upper and lower electrodes are symmetric along the axis of the front end cover, and these electrodes form a space region for ion storage about the axis between the front end cover and the rear end cover electrode. The present invention can increase the number of ions in storage within a unit time prominently.Type: ApplicationFiled: August 15, 2014Publication date: October 6, 2016Applicant: NATIONAL INSTITUTE OF METROLOGY, CHINAInventors: Xingchuang XIONG, You JIANG, Zejian HUANG, Xiang FANG
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Publication number: 20160268115Abstract: Provided is an ion source system for an atmospheric pressure interface, comprising an atmospheric pressure ion source (1), wherein the atmospheric pressure ion source (1) is connected downstream to a vacuum ion source (2). Also provided is a mass spectrometer, using the present ion source system as an ion source. The present ion source system uses a combination of the atmospheric pressure ion source (1) and the vacuum ion source (2), is suitable for test sample having variety of forms, and performs secondary ionization on a sample to be tested, thus enhancing ion transmission efficiency. The present mass spectrometer significantly increases ion transmission efficiency, thus enabling continuous injection of samples and testing, and increasing the scanning speed of the spectrometer, particularly suitable for miniaturized mass spectrometer.Type: ApplicationFiled: October 16, 2014Publication date: September 15, 2016Inventors: Wei XU, Cunjuan BIAN, Yanbing ZHAI, Xiang FANG, Xingchuang XIONG, You JIANG
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Publication number: 20160247670Abstract: A method for analyzing ionic structure, including: applying a radio frequency electric field on an ion mass analyzer to cause sample ions to be excited to a motion amplitude, the motion amplitude at this moment being recorded as a primary motion amplitude; continuously feeding carrier gas into the ion mass analyzer and keeping a certain degree of vacuum in the ion mass analyzer, the sample ions being collided with the carrier gas and the motion amplitude being decreased gradually, and collecting a time domain signal of an image current generated by the sample ions during the process; and analyzing the time domain signal through a time-frequency analysis method and obtaining time-varying characteristic curves indicating corresponding relations between the motion frequencies of the ions having corresponding sizes and the collision cross sectional areas of the ions and the carrier gas, thus distinguishing among ions having different sizes.Type: ApplicationFiled: September 5, 2014Publication date: August 25, 2016Inventors: WEI XU, MUYI HE, XIANG FANG
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Patent number: 9368336Abstract: An ion trap-based device and method for analyzing and detecting bipolar ions is provided. The device includes multiple electrodes of an ion trap; a radio frequency voltage source configured to form a radio frequency electric field; a direct current voltage source configured to form a bias electric field, positive and negative ions in the ion trap being separated by the bias electric field; a first and second detectors, configured to detect the positive and negative ions, respectively. A bipole and quadrupole field direct current voltage detection modes may be employed. A single positive ion or negative ion operation mode in a conventional biological mass spectrometry method is improved, so that the positive and negative ion modes are performed simultaneously; without any resolution loss, the analysis speed is increased, the sample consumption is reduced, and the accuracy of quantitative analysis of the samples is improved.Type: GrantFiled: January 31, 2013Date of Patent: June 14, 2016Assignee: Beijing Institute of TechnologyInventors: Wei Xu, Muyi He, You Jiang, Zejian Huang, Xingchuang Xiong, Xiang Fang
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Publication number: 20150262801Abstract: The disclosure provides a device and a method for analyzing an ion structure, comprising: pre-processing a time domain signal of a mirror current of ions to be measured that are obtained from an ion mass analyzer, to obtain a signal to be measured; extracting information about a position a spectral signal of the signal to be measured through a Fourier transforming: modulating the spectral peak signal, to obtain a modulated signal; filtering the modulated signal, to obtain a filtered signal; estimating parameters of an ion motion model with respect to the filtered signal, to determine information on structural characteristics of the ions to be measured from the estimated parameters. According to the device and the method for analyzing an ion structure of the present disclosure, the ion structures may be analyzed by directly analyzing the time domain signal of the mirror current of the ion.Type: ApplicationFiled: February 26, 2015Publication date: September 17, 2015Inventors: Wei XU, Yi XIN, Yu CHEN, Li ZHENG, Xiang FANG