Patents by Inventor Xiangji Chen
Xiangji Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11548974Abstract: A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.Type: GrantFiled: December 4, 2020Date of Patent: January 10, 2023Assignee: Medtronic, Inc.Inventors: Kimberly A. Chaffin, Xiangji Chen, Matthew Jolly, SuPing Lyu, Peter L. Thor, Darrel F. Untereker, Zhaoxu Wang
-
Publication number: 20220299026Abstract: Provided are a vapor injection device and a compressor. The vapor injection device includes an injector valve plate, an injector plate, and an injector reed valve. One side of the injector plate facing toward the injector valve plate is provided with an avoidance groove. A guide post is disposed protruding from one side of the injector plate facing away from the injector valve plate. The guide post is inserted into a fixed scroll of the compressor and provided with an injection channel. A vapor injection inlet cavity is formed between the rear housing, the injector valve plate, and the fixed scroll. The injector reed valve is disposed between the injector valve plate and the injector plate and attaches to the injector valve plate, the injector reed valve is provided with a movable sheet, and the movable sheet, the injector valve plate and the avoidance groove form a one-way valve structure.Type: ApplicationFiled: July 2, 2021Publication date: September 22, 2022Inventors: Tao DING, Xiangji CHEN, Aijun LIU, Ao ZOU
-
Patent number: 11359050Abstract: A method for preparing tyrosine derived polyarylates includes combining a desaminotyrosyl-tyrosine ethyl ester, a desaminotyrosyl-tyrosine benzylester, succinic acid and a catalyst in a flask to produce a first mixture. Methylene chloride is added to the first mixture to produce a first suspension. Diisopropylcarbodiimide (DIPC) is added to the first mixture to produce a first solution. The first solution is added to a non-solvent to produce a precipitate. The precipitate is dissolved in methylene chloride to form a polymer solution. The polymer solution is blended with a slurry to produce polymer shreds. The polymer shreds are blended with a second slurry to produce a tyrosine derived polyarylate.Type: GrantFiled: July 23, 2020Date of Patent: June 14, 2022Assignee: MEDTRONIC, INC.Inventors: Satish Pulapura, Fatima Buevich, Xiangji Chen, Suping Lyu
-
Patent number: 11191878Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.Type: GrantFiled: July 1, 2020Date of Patent: December 7, 2021Assignee: MEDTRONIC, INC.Inventors: Xiangji Chen, Satish Pulapura
-
Patent number: 11168171Abstract: Disclosed is a segmented thermoplastic elastomer that can be a polyurethane, polyurea, or polyurethane-urea comprising soft segments and hard segments, wherein the soft segments are made of polyolefin diols or polyolefin diamine that may have 0 to 1000 carbon atoms in the main chain, wherein each carbon atom in the main chain may have 0 to 2 side chains and each side chain may have 0 to 30 carbon atoms, the hard segment is made of a diisocyante and a chain extender, the hard segments make up 10-60% of the elastomer and the soft segments make up the rest, the number-average molecular weight of the elastomer is 5×103-1000×103 g/mol, the ultimate elongation of the elastomer is 100-1000%, the Young's modulus is 1 to 3,000 MPa, and the ultimate tensile strength is 10-100 MPa. Also disclosed are a method for preparing the segmented thermoplastic elastomer and use of segmented thermoplastic elastomer.Type: GrantFiled: March 2, 2017Date of Patent: November 9, 2021Assignee: Medtronic, Inc.Inventors: Jing Chen, Haining Na, Jin Zhu, Suping Lyu, XiangJi Chen
-
Patent number: 11160907Abstract: A medical device, a method for preparation thereof, and use thereof are provided. The medical device comprises a thermoplastic elastomer that is composed of soft segments and hard segments. The method for preparing a medical device comprising a thermoplastic elastomer, comprises forming the thermoplastic elastomer into tubing or other shapes via extrusion, molding, or coating, assembling the tubing or other shapes with other parts including: cables, coils, coated cables, or coated coils, and bonding the tubing, cables, or coils with other components including: other tubing components, cables, coils, sleeves, electrical pulse generator, defibrillation shock generator, electrodes, sensors, or drug release components. The medical device is used for correcting cardiac rhythm, defibrillating, assisting hearts, sensing, stimulating neurological systems, gastrointestinal system, or skeletomuscular tissues or organs.Type: GrantFiled: March 2, 2017Date of Patent: November 2, 2021Assignee: Medtronic, Inc.Inventors: Suping Lyu, XiangJi Chen, Jing Chen, Haining Na, Jin Zhu
-
Publication number: 20210115182Abstract: A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.Type: ApplicationFiled: December 4, 2020Publication date: April 22, 2021Inventors: Kimberly A. Chaffin, Xiangji Chen, Matthew Jolly, SuPing Lyu, Peter L. Thor, Darrel F. Untereker, Zhaoxu Wang
-
Patent number: 10882945Abstract: A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.Type: GrantFiled: March 20, 2019Date of Patent: January 5, 2021Assignee: Medtronic, Inc.Inventors: Kimberly A. Chaffin, Xiangji Chen, Matthew Jolly, SuPing Lyu, Peter L. Thor, Darrel F. Untereker, Zhaoxu Wang
-
Publication number: 20200354514Abstract: A method for preparing tyrosine derived polyarylates includes combining a desaminotyrosyl-tyrosine ethyl ester, a desaminotyrosyl-tyrosine benzylester, succinic acid and a catalyst in a flask to produce a first mixture. Methylene chloride is added to the first mixture to produce a first suspension. Diisopropylcarbodiimide (DIPC) is added to the first mixture to produce a first solution. The first solution is added to a non-solvent to produce a precipitate. The precipitate is dissolved in methylene chloride to form a polymer solution. The polymer solution is blended with a slurry to produce polymer shreds. The polymer shreds are blended with a second slurry to produce a tyrosine derived polyarylate.Type: ApplicationFiled: July 23, 2020Publication date: November 12, 2020Applicant: MEDTRONIC, INC.Inventors: SATISH PULAPURA, FATIMA BUEVICH, XIANGJI CHEN, SUPING LYU
-
Publication number: 20200345901Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.Type: ApplicationFiled: July 1, 2020Publication date: November 5, 2020Applicant: Medtronic, Inc.Inventors: Xiangji Chen, Satish Pulapura
-
Patent number: 10793670Abstract: A method for preparing tyrosine derived polyarylates includes combining a desaminotyrosyl-tyrosine ethyl ester, a desaminotyrosyl-tyrosine benzylester, succinic acid and a catalyst in a flask to produce a first mixture. Methylene chloride is added to the first mixture to produce a first suspension. Diisopropylcarbodiimide (DIPC) is added to the first mixture to produce a first solution. The first solution is added to a non-solvent to produce a precipitate. The precipitate is dissolved in methylene chloride to form a polymer solution. The polymer solution is blended with a slurry to produce polymer shreds. The polymer shreds are blended with a second slurry to produce a tyrosine derived polyarylate.Type: GrantFiled: May 7, 2018Date of Patent: October 6, 2020Assignee: MEDTRONIC, INC.Inventors: Satish Pulapura, Fatima Buevich, Xiangji Chen, Suping Lyu
-
Patent number: 10767006Abstract: A method for hydrogenating tyrosine derived polyarylates includes dissolving a second polyarylate with DMF in a flask to produce a first solution. A catalyst is added to the first solution to produce a polymer solution. The polymer solution is filtered through a Celite bed to produce a filtrate. The filtrate is added to water and stirred to precipitate the polyarylate.Type: GrantFiled: May 7, 2018Date of Patent: September 8, 2020Assignee: MEDTRONIC, INC.Inventors: Satish Pulapura, Dan Thanh Le, Xiangji Chen, Suping Lyu, Fatima Buevich
-
Patent number: 10736998Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.Type: GrantFiled: May 9, 2019Date of Patent: August 11, 2020Assignee: Medtronic, Inc.Inventors: Xiangji Chen, Satish Pulapura
-
Patent number: 10632206Abstract: The invention generally relates to zwitterionic polymers (including zwitterionic copolymers), such as polymethacrylic structures, with pendent functional moieties, such as therapeutic or biologic moieties. More particularly, the invention relates to phosphorylcholine-substituted methacrylic polymers prepared by free radical polymerization and click chemistry, for example, and compositions and products comprising same, as well as related methods and uses of the compositions, for example, as biological or therapeutic agents and in drug delivery thereof.Type: GrantFiled: June 30, 2016Date of Patent: April 28, 2020Assignee: UNIVERSITY OF MASSACHUSETTSInventors: Todd Emrick, Xiangji Chen, Samantha Page
-
Patent number: 10472493Abstract: A composition, article, and method for increasing the hydrolytic stability of a polymer; wherein a composition includes: a polymer comprising functional groups having hydrolyzable bonds; a carbodiimide compound; and a weak base (or hindered amine); wherein the carbodiimide compound and weak base (or hindered amine) are used in amounts effective to decrease the rate and/or extent of hydrolytic degradation of the polymer relative to either used alone in the same amount with the polymer.Type: GrantFiled: April 26, 2017Date of Patent: November 12, 2019Assignee: Medtronic, Inc.Inventors: Patricia E. Dunn, Ronald A. Drake, Xiangji Chen, Samuel E. Owings
-
Patent number: 10442757Abstract: A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution. EDCI HCl is added to the first solution to produce a first mixture. Ethyl acetate is added to the first mixture to produce a second mixture. The second mixture is added to sodium chloride to produce a third mixture having layer separation. An aqueous layer is removed from the third mixture. The third mixture is extracted with reagents after the aqueous layer has been removed from the third mixture to produce a fourth mixture. Magnesium sulfate is added to the fourth mixture to produce a fifth mixture. The fifth mixture is filtered to produce filtrate. The filtrate is concentrated. Crystallization of the concentrated filtrate is induced. Methylene chloride is added to the crystallized filtrate to produce a solid product.Type: GrantFiled: May 7, 2018Date of Patent: October 15, 2019Assignee: Medtronic, Inc.Inventors: Satish Pulapura, Fatima Buevich, Xiangji Chen, Suping Lyu
-
Publication number: 20190292302Abstract: A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.Type: ApplicationFiled: March 20, 2019Publication date: September 26, 2019Inventors: Kimberly A. CHAFFIN, Xiangji CHEN, Matthew JOLLY, SuPing LYU, Peter L. THOR, Darrel F. UNTEREKER, Zhaoxu WANG
-
Publication number: 20190292327Abstract: A poly(ether-carbonate)-based polymer and a medical device that includes such polymer, wherein the poly(ether-carbonate)-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments include poly(ether-carbonate) residues and at least one of polyisobutylene (PIB) residues and hydrogenated polybutadiene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.Type: ApplicationFiled: March 20, 2019Publication date: September 26, 2019Inventors: Kimberly A. CHAFFIN, Xiangji CHEN, Matthew JOLLY, SuPing LYU, Peter L. THOR, Darrel F. UNTEREKER, Zhaoxu WANG
-
Publication number: 20190262510Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.Type: ApplicationFiled: May 9, 2019Publication date: August 29, 2019Applicant: Medtronic, Inc.Inventors: Xiangji Chen, Satish Pulapura
-
Patent number: 10314951Abstract: A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.Type: GrantFiled: April 26, 2018Date of Patent: June 11, 2019Assignee: Medtronic, Inc.Inventors: Xiangji Chen, Satish Pulapura, Fatima Buevich