Patents by Inventor Xiangping Zhu
Xiangping Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240101698Abstract: Provided are stable formulations of anti-CD73 antibodies, which include 5-50 mM histidine, 2%-20% (w/v) trehalose, and 0.015%-0.05% (w/v) polysorbate 80 (PS80), at pH 5.6-6.4. Also provided are lyophilized compositions that can be obtained by drying the aqueous formulations and methods for treating diseases.Type: ApplicationFiled: May 8, 2021Publication date: March 28, 2024Inventors: Jing ZHU, Zheru ZHANG, Xiangping ZHU, Yali YU
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Publication number: 20230257007Abstract: The present invention relates to a contactless intelligent customer-service system applied to rail transit and an application method thereof. The system includes: an intelligent customer-service platform server, an intelligent customer-service interface server, a system switch, a station maintenance workstation, and an intelligent passenger service terminal, where the system switch is connected to each of the intelligent customer-service platform server, the intelligent customer-service interface server, the station maintenance workstation, and the intelligent passenger service terminal; and the intelligent passenger service terminal provides, through AI interaction and intelligent speech, a passenger with intelligent services that include information inquiry and display of various facilities inside a station, information inquiry of convenient surrounding facilities, information inquiry of a train operation status, and emergency help.Type: ApplicationFiled: September 23, 2021Publication date: August 17, 2023Applicant: CASCO SIGNAL LTD.Inventors: Shuanglei YANG, Enhua HU, Bingjian ZHANG, Jiafu PEI, Li LIN, Xiangping ZHU, Ning ZHENG, Dewei LIU
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Publication number: 20220317673Abstract: The present invention relates to a system for coordinating operation control and operation maintenance for an urban rail transit and a method using the same, where the system includes: an intelligent operation maintenance subsystem and an intelligent operation control subsystem, the intelligent operation maintenance subsystem and the intelligent operation control subsystem include coordination linkage engine modules respectively, and the intelligent operation maintenance subsystem synchronizes, by using the coordination linkage engine modules, a fault handling plan to the intelligent operation control subsystem. Compared with the prior art, the present invention has the advantages of scientific and reasonable dispatching decision-making, high efficiency and high intelligence.Type: ApplicationFiled: October 19, 2020Publication date: October 6, 2022Inventors: Jiafu PEI, Enhua HU, Li LIN, Bingfeng ZHANG, Xiangping ZHU, Ning ZHENG, Shuanglei YANG, Jiafeng GUO
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Patent number: 10160992Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.Type: GrantFiled: January 3, 2018Date of Patent: December 25, 2018Assignee: Momenta Pharmaceuticals, Inc.Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
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Publication number: 20180127801Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.Type: ApplicationFiled: January 3, 2018Publication date: May 10, 2018Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
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Publication number: 20160312264Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.Type: ApplicationFiled: July 5, 2016Publication date: October 27, 2016Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
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Patent number: 9410964Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.Type: GrantFiled: November 13, 2015Date of Patent: August 9, 2016Assignee: Momenta Pharmaceuticals, Inc.Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
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Patent number: 9395374Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.Type: GrantFiled: July 9, 2015Date of Patent: July 19, 2016Assignee: Momenta Pharmaceuticals, Inc.Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
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Publication number: 20160069892Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.Type: ApplicationFiled: November 13, 2015Publication date: March 10, 2016Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
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Publication number: 20150376334Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.Type: ApplicationFiled: July 9, 2015Publication date: December 31, 2015Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
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Patent number: 8927292Abstract: The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture.Type: GrantFiled: September 6, 2013Date of Patent: January 6, 2015Assignee: Momenta Pharmaceuticals, Inc.Inventors: Zachary Shriver, Ganesh V. Kaundinya, Jonathan C. Lansing, Corinne Bauer, Xiangping Zhu
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Patent number: 8921116Abstract: The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture.Type: GrantFiled: June 24, 2013Date of Patent: December 30, 2014Assignee: Momenta Pharmaceuticals, Inc.Inventors: Zachary Shriver, Ganesh V. Kaundinya, Jonathan C. Lansing, Corinne Bauer, Xiangping Zhu
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Publication number: 20140080218Abstract: The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture.Type: ApplicationFiled: September 6, 2013Publication date: March 20, 2014Applicant: Momenta Phamaceuticals, Inc.Inventors: Zachary Shriver, Ganesh V. Kaundinya, Jonathan C. Lansing, Corinne Bauer, Xiangping Zhu
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Publication number: 20140065652Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.Type: ApplicationFiled: September 5, 2013Publication date: March 6, 2014Applicant: Momenta Pharmaceuticals, Inc.Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
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Publication number: 20140011727Abstract: The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying. isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture.Type: ApplicationFiled: June 24, 2013Publication date: January 9, 2014Inventors: Zachary Shriver, Ganesh V. Kaundinya, Jonathan C. Lansing, Corinne Bauer, Xiangping Zhu
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Patent number: 8592142Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.Type: GrantFiled: December 10, 2012Date of Patent: November 26, 2013Assignee: Momenta Pharmaceuticals, Inc.Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
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Patent number: 8470603Abstract: The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture.Type: GrantFiled: April 30, 2007Date of Patent: June 25, 2013Assignee: Momenta Pharmaceuticals, Inc.Inventors: Zachary Shriver, Ganesh Venkataraman, Jonathan Lansing, Corinne Bauer, Xiangping Zhu
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Patent number: 8338088Abstract: The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.Type: GrantFiled: April 15, 2008Date of Patent: December 25, 2012Assignee: Momenta Pharmaceuticals, Inc.Inventors: Brian Edward Collins, Carlos J. Bosques, Xiangping Zhu, Dorota A. Bulik, Lakshmanan Thiruneelakantapillai, Ian Christopher Parsons, Zachary Shriver, Rajeev Chillakuru, Ganesh Venkataraman
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Patent number: 8329391Abstract: Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard. In some cases, the methods entail treating the co-polymer with pyro-glutamate aminopeptidase to cleave N-terminal pyro-glutamate residues.Type: GrantFiled: March 20, 2009Date of Patent: December 11, 2012Assignee: Momenta Pharmaceuticals, Inc.Inventors: Xiangping Zhu, Zachary Shriver, Yanjie Jiang, Corinne Bauer, James Eric Anderson, Peter James Ahern
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Patent number: 8043863Abstract: The present disclosure provides, among other things, methods for the identification of sulfated glycans in a mixture of glycans.Type: GrantFiled: April 15, 2008Date of Patent: October 25, 2011Assignee: Momenta Pharmaceuticals, Inc.Inventors: Carlos J. Bosques, Nathaniel J. Washburn, Xiangping Zhu, Ian Christopher Parsons