Patents by Inventor Xiangxu Kong

Xiangxu Kong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FRET-labeled compounds and uses therefor
    Patent number: 11807904
    Abstract: Reaction mixtures are provided having at least a first nucleotide analog and a second nucleotide analog that produce signals in response to excitation illumination. The signals produced by the analogs have peaks at the same wavelengths, but have distinct signal intensities. The distinct intensities allow for identification of the analogs in nucleic acid sequencing. In some embodiments, FRET-labeled compounds are provided. In certain embodiments, FRET-labeled nucleotide analogs are used, for example, in DNA sequencing or RNA sequencing.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: November 7, 2023
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Xiangxu Kong, Gene Shen
  • FRET-LABELED COMPOUNDS AND USES THEREFOR
    Publication number: 20220251637
    Abstract: Reaction mixtures are provided having at least a first nucleotide analog and a second nucleotide analog that produce signals in response to excitation illumination. The signals produced by the analogs have peaks at the same wavelengths, but have distinct signal intensities. The distinct intensities allow for identification of the analogs in nucleic acid sequencing. In some embodiments, FRET-labeled compounds are provided. In certain embodiments, FRET-labeled nucleotide analogs are used, for example, in DNA sequencing or RNA sequencing.
    Type: Application
    Filed: October 25, 2021
    Publication date: August 11, 2022
    Inventors: Xiangxu Kong, Gene Shen
  • FRET-labeled compounds and uses therefor
    Patent number: 11186870
    Abstract: FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: November 30, 2021
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Xiangxu Kong, Gene Shen
  • FRET-LABELED COMPOUNDS AND USES THEREFOR
    Publication number: 20200318178
    Abstract: FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions.
    Type: Application
    Filed: January 27, 2020
    Publication date: October 8, 2020
    Inventors: Xiangxu Kong, Gene Shen
  • Fret-labeled compounds and uses therefor
    Patent number: 10570445
    Abstract: FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: February 25, 2020
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Xiangxu Kong, Gene Shen
  • FRET-LABELED COMPOUNDS AND USES THEREFOR
    Publication number: 20190032117
    Abstract: FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions.
    Type: Application
    Filed: July 30, 2018
    Publication date: January 31, 2019
    Inventors: Xiangxu Kong, Gene Shen
  • FRET-labeled compounds and uses therefor
    Patent number: 10066258
    Abstract: FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: September 4, 2018
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Xiangxu Kong, Gene Shen
  • Photodamage mitigation compounds and systems
    Patent number: 9732382
    Abstract: Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photoprotective compounds to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced damage threshold period.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: August 15, 2017
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Stephen Yue, Robert Weber, Xiangxu Kong, Andrei Fedorov, John Lyle
  • FRET-LABELED COMPOUNDS AND USES THEREFOR
    Publication number: 20170159111
    Abstract: FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions.
    Type: Application
    Filed: December 14, 2016
    Publication date: June 8, 2017
    Inventors: Xiangxu Kong, Gene Shen
  • Method for detecting reactants using fluorescent signal intensity
    Patent number: 9551660
    Abstract: FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: January 24, 2017
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Xiangxu Kong, Gene Shen
  • CIS reactive oxygen quenchers integrated into linkers
    Patent number: 9200311
    Abstract: The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: December 1, 2015
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Geoffrey Otto, Gene Shen, Xiangxu Kong, Robin Emig
  • PHOTODAMAGE MITIGATION COMPOUNDS AND SYSTEMS
    Publication number: 20150079603
    Abstract: Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photoprotective compounds to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced damage threshold period.
    Type: Application
    Filed: August 11, 2014
    Publication date: March 19, 2015
    Inventors: Stephen Yue, Robert Weber, Xiangxu Kong, Andrei Fedorov, John Lyle
  • FRET-labeled compounds and uses therefor
    Patent number: 8927212
    Abstract: FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: January 6, 2015
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Xiangxu Kong, Gene Shen
  • Photodamage mitigation compounds and systems
    Patent number: 8834847
    Abstract: Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photoprotective compounds to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced damage threshold period.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: September 16, 2014
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Stephen Yue, Robert Weber, Xiangxu Kong, Andrei Fedorov, John Lyle
  • CIS Reactive Oxygen Quenchers Integrated into Linkers
    Publication number: 20140038178
    Abstract: The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates.
    Type: Application
    Filed: July 1, 2013
    Publication date: February 6, 2014
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Geoffrey OTTO, Gene SHEN, Xiangxu KONG, Robin EMIG
  • CIS reactive oxygen quenchers integrated into linkers
    Patent number: 8501922
    Abstract: The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: August 6, 2013
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Geoffrey Otto, Gene Shen, Xiangxu Kong, Robin Emig
  • FRET-LABELED COMPOUNDS AND USES THEREFOR
    Publication number: 20130071849
    Abstract: FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions.
    Type: Application
    Filed: March 22, 2012
    Publication date: March 21, 2013
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Xiangxu Kong, Gene Shen
  • Photo-induced damage mitigating agents and preparation and methods of use thereof
    Patent number: 8388982
    Abstract: Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photo-induced damage mitigating agents to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced damage threshold period.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: March 5, 2013
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Xiangxu Kong, Gene Shen, Andrei Fedorov, John Lyle, Grace Lee, Lubomir Sebo, Duc Do, Robert Weber, Stephen Dudek
  • PHOTODAMAGE MITIGATION COMPOUNDS AND SYSTEMS
    Publication number: 20120052488
    Abstract: Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photoprotective compounds to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced damage threshold period.
    Type: Application
    Filed: August 11, 2011
    Publication date: March 1, 2012
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Stephen Yue, Robert Weber, Xiangxu Kong, Andrei Fedorov, John Lyle
  • FRET-LABELED COMPOUNDS AND USES THEREFOR
    Publication number: 20100255488
    Abstract: FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions.
    Type: Application
    Filed: March 30, 2010
    Publication date: October 7, 2010
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Xiangxu Kong, Gene Shen