Patents by Inventor Xianhai Chen

Xianhai Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10442819
    Abstract: The present invention is directed to tricyclic compounds of formula (I) which are inhibitors of one or more mutant IDH enzymes: (I). The present invention is also directed to uses of the tricyclic compounds described herein in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: October 15, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Christian Fischer, Stephane L. Bogen, Matthew L. Childers, Francesc Xavier Fradera Llinas, J. Michael Ellis, Sara Esposite, Qingmei Hong, Chunhui Huang, Alexander J. Kim, John W. Lampe, Michelle R. Machacek, Daniel R. McMasters, Ryan D. Otte, Dann L. Parker, Jr., Michael Reutershan, Nunzio Sciammetta, Pengcheng P. Shao, David L. Sloman, Feroze Ujjainwalla, Catherine White, Zhicai Wu, Yang Yu, Kake Zhao, Craig Gibeau, Tesfaye Biftu, Purakkattle Biju, Lei Chen, Joshua Close, Peter H. Fuller, Xianhai Huang, Min K. Park, Valdimir Simov, David J. Witter, Hongjun Zhang
  • Patent number: 8801964
    Abstract: Polymer network liquid crystal materials have improved mechanical properties such as rigidity and hardness and substantially improved electro-optical performance. The PNLC material can be manufactured with an emulsion process so as to simplify substantially the manufacturing process. Each LC droplet can be configured with the polymer network extending substantially across the LC droplet, and the polymer network may comprise a material to lower substantially the switching voltage, such as a fluorinated acrylate that may interact with the liquid crystal so as to lower the surface tension of the LC droplet. The PNLC material may comprise an interfacial layer combined with the polymer network so as to decrease substantially the driving voltage.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: August 12, 2014
    Assignee: Photon Dynamics, Inc.
    Inventor: Xianhai Chen
  • Publication number: 20120162596
    Abstract: Polymer network liquid crystal materials have improved mechanical properties such as rigidity and hardness and substantially improved electro-optical performance. The PNLC material can be manufactured with an emulsion process so as to simplify substantially the manufacturing process. Each LC droplet can be configured with the polymer network extending substantially across the LC droplet, and the polymer network may comprise a material to lower substantially the switching voltage, such as a fluorinated acrylate that may interact with the liquid crystal so as to lower the surface tension of the LC droplet. The PNLC material may comprise an interfacial layer combined with the polymer network so as to decrease substantially the driving voltage.
    Type: Application
    Filed: December 22, 2010
    Publication date: June 28, 2012
    Applicant: Photon Dynamics, Inc.
    Inventor: Xianhai Chen
  • Patent number: 7916382
    Abstract: A PDLC modulator is fabricated using at least one of a selection of specially-formulated UV curable organic hard coatings as a protective layer on the exposed side of polyester (Mylar) film. The hard coatings of various related types show good adhesion on a polyester film substrate, superior hardness and toughness, and have a slippery top surface, which minimizes unnecessary wear. The coating as applied on the modulator surface significantly reduces scratch damage on modulators caused by unexpected particles on the panels under test. In addition, the slip surface will reduce stickiness to particles and therefore also reduce the possibility of panel damage.
    Type: Grant
    Filed: November 9, 2005
    Date of Patent: March 29, 2011
    Assignee: Photon Dynamics, Inc.
    Inventor: Xianhai Chen
  • Patent number: 7817333
    Abstract: An electro-optic modulator assembly includes a sensor layer made from an electro-optic modulator material that comprises liquid crystal droplets encapsulated within a polymer matrix. The sensor layer material comprises an interfacial agent, for example a defoaming agent, in an amount sufficient to lower an intrinsic operating voltage at which the sensor layer transmits light. The defoaming agent can comprise from about 1 to about 10 percent by weight of the electro-optic modulator material, and the defoaming agent may comprise a reactive component to react with the polymer matrix, for example at least one of a siloxane with a reactive end group, a reactive fluorinated polymer or a non-ionic block copolymer to react with the polymer matrix. The assembly can also include a hard coating layer to protect the sensor layer.
    Type: Grant
    Filed: February 6, 2007
    Date of Patent: October 19, 2010
    Assignee: Photon Dynamics, Inc.
    Inventor: Xianhai Chen
  • Patent number: 7639319
    Abstract: Embodiments of polymer dispersed liquid crystals (PDLCs) in accordance with the present invention comprise TL-series liquid crystal materials and a polymer matrix comprising polyacrylate resins having hydroxyl groups. These hydroxyl groups allow crosslinking by using isocyanate, improving mechanical properties and heat resistance. Typical ratios of liquid crystal to polymer range between about 50/50 to 70/30 (wt/wt). The PDLC materials exhibit enhanced sensitivity to driving voltages and higher transmission˜voltage (T-V) curve slope. In testing thin film transistors (TFTs), these PDLC materials can be used to compensate for an increased air gap accommodating flatness variation in the TFT substrate, and to reduce electrostatic forces between modulator and panel. Embodiments of PDLC materials in accordance with the present invention form solid films upon evaporation of the solvent.
    Type: Grant
    Filed: April 7, 2005
    Date of Patent: December 29, 2009
    Assignee: Photon Dynamics, Inc.
    Inventor: Xianhai Chen
  • Publication number: 20080239208
    Abstract: Embodiments of polymer dispersed liquid crystals (PDLCs) in accordance with the present invention comprise TL-series liquid crystal materials and a polymer matrix comprising polyacrylate resins having hydroxyl groups. These hydroxyl groups allow crosslinking by using isocyanate, improving mechanical properties and heat resistance. Typical ratios of liquid crystal to polymer range between about 50/50 to 70/30 (wt/wt). The PDLC materials exhibit enhanced sensitivity to driving voltages and higher transmission˜voltage (T-V) curve slope. In testing thin film transistors (TFTs), these PDLC materials can be used to compensate for an increased air gap accommodating flatness variation in the TFT substrate, and to reduce electrostatic forces between modulator and panel. Embodiments of PDLC materials in accordance with the present invention form solid films upon evaporation of the solvent.
    Type: Application
    Filed: April 7, 2005
    Publication date: October 2, 2008
    Applicant: Photon Dynamics, Inc.
    Inventor: Xianhai Chen
  • Publication number: 20080206489
    Abstract: A PDLC modulator is fabricated using at least one of a selection of specially-formulated UV curable organic hard coatings as a protective layer on the exposed side of polyester (Mylar) film. The hard coatings of various related types show good adhesion on a polyester film substrate, superior hardness and toughness, and have a slippery top surface, which minimizes unnecessary wear. The coating as applied on the modulator surface significantly reduces scratch damage on modulators caused by unexpected particles on the panels under test. In addition, the slip surface will reduce stickiness to particles and therefore also reduce the possibility of panel damage.
    Type: Application
    Filed: November 9, 2005
    Publication date: August 28, 2008
    Applicant: Photon Dynamics, Inc.
    Inventor: Xianhai Chen
  • Publication number: 20080186563
    Abstract: An electro-optic modulator assembly includes a sensor layer made from an electro-optic modulator material that comprises liquid crystal droplets encapsulated within a polymer matrix. The sensor layer material comprises an interfacial agent, for example a defoaming agent, in an amount sufficient to lower an intrinsic operating voltage at which the sensor layer transmits light. The defoaming agent can comprise from about 1 to about 10 percent by weight of the electro-optic modulator material, and the defoaming agent may comprise a reactive component to react with the polymer matrix, for example at least one of a siloxane with a reactive end group, a reactive fluorinated polymer or a non-ionic block copolymer to react with the polymer matrix. The assembly can also include a hard coating layer to protect the sensor layer.
    Type: Application
    Filed: February 6, 2007
    Publication date: August 7, 2008
    Applicant: Photon Dynamics, Inc.
    Inventor: Xianhai Chen
  • Patent number: 7385751
    Abstract: This invention relates to the field of electrophoretic displays. In particular, it relates to imagewise opening, filling and sealing multicolor display components and the manufacture of multicolor displays.
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: June 10, 2008
    Assignee: SiPix Imaging, Inc.
    Inventors: Xianhai Chen, HongMei Zang, Zarng-Arh George Wu, Rong-Chang Liang
  • Patent number: 7099067
    Abstract: A PDLC modulator is fabricated using at least one a selection of specially-formulated UV curable organic hard coatings as a protective layer on the exposed side of polyester (Mylar) film. The hard coatings of various related types show good adhesion on a polyester film substrate, superior hardness and toughness, and have a slippery top surface, which minimizes unnecessary wear. The coating as applied on the modulator surface significantly reduces scratch damage on modulators caused by unexpected particles on the panels under test. In addition, the slip surface will reduce stickiness to particles and therefore also reduce the possibility of panel damage.
    Type: Grant
    Filed: November 10, 2004
    Date of Patent: August 29, 2006
    Assignee: Photon Dynamics, Inc.
    Inventor: Xianhai Chen
  • Publication number: 20060132897
    Abstract: This invention relates to the field of electrophoretic displays. In particular, it relates to imagewise opening, filling and sealing multicolor display components and the manufacture of multicolor displays.
    Type: Application
    Filed: December 2, 2005
    Publication date: June 22, 2006
    Inventors: Xianhai Chen, HongMei Zang, Zarng-Arh Wu, Rong-Chang Liang
  • Publication number: 20060098268
    Abstract: A PDLC modulator is fabricated using at least one of a selection of specially-formulated UV curable organic hard coatings as a protective layer on the exposed side of polyester (Mylar) film. The hard coatings of various related types show good adhesion on a polyester film substrate, superior hardness and toughness, and have a slippery top surface, which minimizes unnecessary wear. The coating as applied on the modulator surface significantly reduces scratch damage on modulators caused by unexpected particles on the panels under test. In addition, the slip surface will reduce stickiness to particles and therefore also reduce the possibility of panel damage.
    Type: Application
    Filed: November 10, 2004
    Publication date: May 11, 2006
    Applicant: Photon Dynamics, Inc.
    Inventor: Xianhai Chen
  • Patent number: 6972893
    Abstract: This invention relates to the field of electrophoretic displays. In particular, it relates to imagewise opening, filling, and sealing multicolor display components and the manufacture of multicolor displays.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: December 6, 2005
    Assignee: SiPix Imaging, Inc.
    Inventors: Xianhai Chen, HongMei Zang, Zarng-Arh George Wu, Rong-Chang Liang
  • Patent number: 6933013
    Abstract: In order to allow application of any coating under a vacuum over a volatile gelatinous layer, such as polymer dispersed liquid crystal (PDLC) on an optical glass substrate with a transparent electrode, such as indium tin oxide (ITO) on its surface, a layer of an intermediate stress absorbing polymeric material is first applied to cover the volatile gelatinous layer to prevent evaporation and escape of volatiles, thereafter the coating is applied under a very high vacuum using for example a technique called Physical Vapor Deposition (PVD) or sputtering.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: August 23, 2005
    Assignee: Photon Dynamics, Inc.
    Inventors: Rajiv Pethe, Pramod Gupta, Xianhai Chen, Alexander Nagy
  • Patent number: 6933098
    Abstract: This invention relates to an electrophoretic display or a liquid crystal display and novel processes for its manufacture. The electrophoretic display (EPD) of the present invention comprises microcups of well-defined shape, size and aspect ratio and the microcups are filled with charged pigment particles dispersed in an optically contrasting dielectric solvent. The liquid crystal display (LCD) of this invention comprises well-defined microcups filled with at least a liquid crystal composition having its ordinary refractive index matched to that of the isotropic cup material. A novel roll-to-roll process and apparatus of the invention permits the display manufacture to be carried out continuously by a synchronized photo-lithographic process.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: August 23, 2005
    Assignee: SiPix Imaging Inc.
    Inventors: Mary Chan-Park, Xianhai Chen, Zarng-Arh George Wu, Xiaojia Wang, Hong-Mei Zang, Rong-Chang Liang
  • Patent number: 6914714
    Abstract: This invention relates to the field of electrophoretic displays. In particular, it relates to imagewise opening, filling, and sealing multicolor display components and the manufacture of multicolor displays.
    Type: Grant
    Filed: March 9, 2004
    Date of Patent: July 5, 2005
    Assignee: SiPix Imaging Inc.
    Inventors: Xianhai Chen, HongMei Zang, Zarng-Arh George Wu, Rong-Chang Liang
  • Patent number: 6906779
    Abstract: This invention relates to an electrophoretic display or a liquid crystal display and novel processes for its manufacture. The electrophoretic display (EPD) of the present invention comprises microcups of well-defined shape, size and aspect ratio and the microcups are filled with charged pigment particles dispersed in an optically contrasting dielectric solvent. The liquid crystal display (LCD) of this invention comprises well-defined microcups filled with at least a liquid crystal composition having its ordinary refractive index matched to that of the isotropic cup material. A novel roll-to-roll process and apparatus of the invention permits the display manufacture to be carried out continuously by a synchronized photo-lithographic process.
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: June 14, 2005
    Assignee: SiPix Imaging, Inc.
    Inventors: Mary Chan-Park, Xianhai Chen, Zarng-Arh George Wu, Xiaojia Wang, Hong-Mei Zang, Rong-Chang Liang
  • Publication number: 20050077005
    Abstract: In an electro-optic light modulator requiring an electro-optical sensor material such as polymer dispersed liquid crystal, or PDLC is directly coated on an optical glass substrate with a transparent electrode, such as indium tin oxide (ITO) and an optional layer of passivation coating such as silicon dioxide (SiO2) on its surface. A thin layer of polymeric adhesive is coated on top of PDLC layer and then this two-layer coating is laminated with a dielectric mirror on a polyester film (Mylar™) preferably with the assistance of a vacuum.
    Type: Application
    Filed: October 14, 2003
    Publication date: April 14, 2005
    Applicant: Photon Dynamics, Inc.
    Inventors: Xianhai Chen, David Baldwin, Alexander Nagy
  • Publication number: 20050079281
    Abstract: In order to allow application of any coating under a vacuum over a volatile gelatinous layer, such as polymer dispersed liquid crystal (PDLC) on an optical glass substrate with a transparent electrode, such as indium tin oxide (ITO) on its surface, a layer of an intermediate stress absorbing polymeric material is first applied to cover the volatile gelatinous layer to prevent evaporation and escape of volatiles, thereafter the coating is applied under a very high vacuum using for example a technique called Physical Vapor Deposition (PVD) or sputtering.
    Type: Application
    Filed: October 14, 2003
    Publication date: April 14, 2005
    Applicant: Photon Dynamics, Inc.
    Inventors: Rajiv Pethe, Pramod Gupta, Xianhai Chen, Alexander Nagy