Abstract: The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A1, A2, L1, L2, L3, Z1, Z2, W1, W2, R1, R2, R3, R4, R5, R6 and R7 are defined herein.

Abstract: The present disclosure provides a copy area identification method and device, which relates to the technical field of image processing. A copy area identification method according to the present disclosure includes: extracting feature information of multiple layers from an image to be processed; encoding the feature of the multiple layers information respectively, and jointly decoding according to encoded information of the multiple layers to acquire a jointly decoded output; acquiring information of pixels according to the jointly decoded output, wherein the information of the pixels comprises rotation angle information of the copy area, and a distance between each of the pixels and a border of the copy area; and determining a position of a border of the copy area according to the information of the pixels.

Abstract: A soft turn-off active clamp protection circuit and a power system are disclosed. The circuit includes a gate connection terminal, a drain connection terminal, a source connection terminal, a discharge capacitor, an overvoltage signal acquisition module, a negative feedback module, a discharge current control module and a turn-off control module.

Abstract: A magnetic element includes at least one primary winding, at least one secondary winding, a magnetic core, and an auxiliary winding. A winding segment or an entire of the primary winding or a winding segment or an entire of the secondary winding is defined as a parallel-connected winding set. The magnetic core includes a plurality of winding legs, two lateral legs, and two connection parts. The at least one primary winding and the at least one secondary winding are wound around each winding leg. The directions of magnetic fluxes through every two adjacent winding legs are opposite. The auxiliary winding is wound on one of two lateral legs, and electrically connected with the parallel-connected winding set. A direction of a magnetic flux generated by the auxiliary winding is opposite to a direction of the magnetic flux through the adjacent winding leg.

Abstract: A magnetic element includes a magnetic core, at least one excitation winding and an auxiliary winding. The magnetic core includes at least one first magnetic leg, a second magnetic leg and a third magnetic leg. Each of the at least one magnetic leg is wound with an excitation winding, wherein a vector sum of magnetic flux passing through each of the at least one first magnetic leg is a first magnetic flux, a second magnetic flux is passing through the second magnetic leg, and a third magnetic flux is passing through the third magnetic leg. The auxiliary winding is partially or completely wound on the second magnetic leg, wherein the auxiliary winding is used to clamp the second magnetic flux.

Abstract: Disclosed are a compound containing a fused ring, a use thereof and a pharmaceutical composition containing same. Provided are a compound as shown in formula I-A, a pharmaceutically acceptable salt thereof, a solvate thereof, a solvate of the pharmaceutically acceptable salt thereof or a crystal form thereof. The compound can significantly reduce the levels of HBsAg, HBeAg and HBV DNA, and can be used for preparing a drug for treating hepatitis B, and has good market prospects.

Abstract: The invention discloses a bionic human esophagus and stomach digestive system including a bionic stomach assembly and a bionic esophagus assembly. The bionic stomach assembly includes a bionic stomach including a stomach body provided with a pylorus and a cardia, a rolling compression apparatus disposed outside the stomach body for performing rolling compression on the bionic stomach, and a gastric juice tube in fluid communication with the stomach body. The bionic esophagus assembly includes a bionic esophagus in fluid communication with the cardia, a first and second esophagus clamp which are respectively clamped at two ends of the bionic esophagus for controlling the esophagus to be opened or closed, and a vibrator disposed between the first and second esophagus clamps for driving the bionic esophagus to vibrate. In the application, the bionic stomach and esophagus are subject to mechanical compression and vibration, thereby simulating a real stomach digestive system.

Abstract: A sensor comprising a support and a flexible structure arranged on the support is provided. The flexible structure comprises a frustum-shaped portion having a wider end and a narrower end, wherein the wider end of the frustum-shaped portion is arranged proximal to the support, and an elongated portion extending from the narrower end of the frustum-shaped portion, wherein the flexible structure further comprises a stretchable conducting film arranged on the frustum-shaped portion. A method of preparing such a sensor is also provided.

Abstract: In an embodiment an over the air (OTA )system software upgrade control method includes accessing, by a terminal device, an OTA server, and obtaining version information of a target system software upgrade package that is on the OTA server and whose version is later than a current system software version of the terminal device, requesting, by the terminal device, from a management device, authorization information corresponding to the version information of the target system software upgrade package, determining, by the terminal device in response to the authorization information that is received from the management device and that corresponds to the version information of the target system software upgrade package, that the target system software upgrade package is obtainable from the OTA server, and obtaining the target system software upgrade package from the OTA server, wherein the authorization information indicates whether the terminal device is allowed to obtain the target system software upgrade packag

Abstract: A stacking system is disclosed and includes a circuit board, an integrated circuit, a voltage regulation module and a heat dissipation module. The integrated circuit and the voltage regulation module are opposite disposed on a first side and a second side of the circuit board. The heat dissipation module includes a first heat dissipation component and a second heat dissipation component located at a top surface of the integrated circuit and the bottom surface of the voltage regulation module. The second heat dissipation component includes a base and an extended arm. The base is in thermal contact with bottom surface of the voltage regulation module. The extended arm is extended from the base to the first heat dissipation component and in thermal contact with the first heat dissipation component.

Abstract: A switch-mode power supply waste heat recovery and utilization system includes a switch-mode power supply unit, an air conditioner and a water storage tank that are all connected with pipes. The switch-mode power supply unit, the air conditioner and the water storage tank are in communication with each other through the pipes. The switch-mode power supply unit includes a cabinet. Fixed plates are fixedly connected to an inner side wall of the cabinet and arranged at equal intervals. A top and a bottom of the cabinet and respective interiors of the fixed plates are formed with cavities. The pipes are in communication with the cavities. A fan is fixedly connected to a side wall of the water storage tank, and is matched with the water storage tank. A filter screen is insertedly connected to an inner side wall of the water storage tank. A filter cotton is horizontally provided under the filter screen.

Abstract: An information processing method includes establishing, in response to a distance between a first electronic device and a second electronic device being less than a distance value, a communication connection between a first communication assembly of the first electronic device and a second communication assembly of the second electronic device; obtaining, by the first electronic device, information of the second electronic device through the first communication assembly and the second communication assembly; and connecting the first electronic device to a network based on the information.

Abstract: A mobile device management method includes: a first electronic device sends a request message including an identifier of at least one second electronic device to a first server. The first electronic device receives a DM service APP from the first server and installs the DM service APP. After the DM service APP is installed, the first electronic device can provide the MDM service. The first electronic device provides the MDM service for the second electronic device, to implement management and device system upgrade of the second electronic device.

Abstract: A power conversion module is disclosed. The power conversion module includes a circuit board, an adapter board, a first component and a second component. The second surface of the circuit board includes a concave region. The circuit board has four sidewalls. The first surface of the adapter board is attached to the second surface of the circuit board. The first surface of the adapter board includes a component disposing region, and the component disposing region is corresponding to the concave region. The first component is disposed in the concave region. A height of the first component is less than or equal to a depth of the concave region. The second component is disposed in the component disposing region and accommodated in the corresponding one of the concave region. A height of the second component is less than or equal to the depth of the concave region.

Abstract: Disclosed are a compound containing a fused ring, a use thereof and a pharmaceutical composition containing same. Provided are a compound as shown in formula I-A, a pharmaceutically acceptable salt thereof, a solvate thereof, a solvate of the pharmaceutically acceptable salt thereof or a crystal form thereof. The compound can significantly reduce the levels of HBsAg, HBeAg and HBV DNA, and can be used for preparing a drug for treating hepatitis B, and has good market prospects.

Abstract: Disclosed herein is an electrode material comprising: a non-woven silk-fibroin mesh substrate; glycerol; and a conductive polymeric material, wherein 40-65% of the silk-fibroin in the non-woven mesh substrate is in the form of ?-sheets, and the electrode material is stretchable. Also disclosed herein is a method of forming said electrode material.

Abstract: The present disclosure describes an electrolyte for an electrochemical cell comprising Solvent A selected from cyclic carbonates, Solvent Group B comprising at least four solvents, each organic solvent having a Highest Occupied Molecular Orbital (HOMO) level between about ?9 eV to about ?7 eV, and an energy band gap of at least about 5 eV between the HOMO and Lowest Unoccupied Molecular Orbital (LUMO). Also provided herein is an electrochemical cell comprising the electrolyte disclosed herein.

Abstract: A magnetic element includes at least one primary winding, at least one secondary winding, a magnetic core, and an auxiliary winding. A winding segment or an entire of the primary winding or a winding segment or an entire of the secondary winding is defined as a parallel-connected winding set. The magnetic core includes a plurality of winding legs, two lateral legs, and two connection parts. The at least one primary winding and the at least one secondary winding are wound around each winding leg. The directions of magnetic fluxes through every two adjacent winding legs are opposite. The auxiliary winding is wound on one of two lateral legs, and electrically connected with the parallel-connected winding set. A direction of a magnetic flux generated by the auxiliary winding is opposite to a direction of the magnetic flux through the adjacent winding leg.