Patents by Inventor Xiaoguang Lei

Xiaoguang Lei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180263934
    Abstract: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
    Type: Application
    Filed: May 22, 2018
    Publication date: September 20, 2018
    Applicant: National Institute of Biological Sciences, Beijing
    Inventors: Zhiyuan Zhang, Xiaodong Wang, Xiaoguang Lei, Yaning Su, Sudan He, Hanying Ruan, Liming Sun
  • Patent number: 9974762
    Abstract: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: May 22, 2018
    Assignee: National Institute of Biological Sciences, Beijing
    Inventors: Zhiyuan Zhang, Xiaodong Wang, Xiaoguang Lei, Yaning Su, Sudan He, Hanying Ruan, Liming Sun
  • Publication number: 20170290790
    Abstract: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
    Type: Application
    Filed: June 26, 2017
    Publication date: October 12, 2017
    Applicant: National Institute of Biological Sciences, Beijing
    Inventors: Zhiyuan Zhang, Xiaodong Wang, Xiaoguang Lei, Yaning Su, Sudan He, Hanying Ruan, Liming Sun
  • Patent number: 9670226
    Abstract: The invention provides novel compounds and compositions for inhibiting IKK?/?, including treating disorders associated with IKK?/? activity, including cancer, autoimmune and inflammatory disorders, with a compound of structure:
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: June 6, 2017
    Assignee: National Institute of Biological Sciences, Beijing
    Inventors: Xiaoguang Lei, Sudan He, Chao Li, Ting Dong
  • Publication number: 20170044180
    Abstract: The invention provides novel compounds and compositions for inhibiting IKK?/?, including treating disorders associated with IKK?/? activity, including cancer, autoimmune and inflammatory disorders, with a compound of structure:
    Type: Application
    Filed: October 24, 2016
    Publication date: February 16, 2017
    Applicant: National Institute of Biological Sciences, Beijing
    Inventors: Xiaoguang Lei, Sudan He, Chao Li, Ting Dong
  • Patent number: 9006439
    Abstract: Disclosed are novel camptothecin derivatives having anti-tumor activity (the basic structure thereof is as shown in the figure) and compositions of such compounds and use thereof. The compounds according to the present invention exhibit very good water solubility and stability, show good selectivity among drugs of the same category, and have a very high therapeutic index. Such compounds are promising as therapeutic agents for treating tumors.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: April 14, 2015
    Assignee: Ningbo Team Pharmaceutical Co., Ltd
    Inventors: Xiaoguang Lei, Xiuguo Zhang
  • Patent number: 8859615
    Abstract: The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I).
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: October 14, 2014
    Inventors: Samuel J. Danishefsky, Ting-Chao Chou, Xiaoguang Lei, Heedong Yun, Fay Ng, John Hartung, Dalibor Sames
  • Publication number: 20140011833
    Abstract: Disclosed are novel camptothecin derivatives having anti-tumor activity (the basic structure thereof is as shown in the figure) and compositions of such compounds and use thereof. The compounds according to the present invention exhibit very good water solubility and stability, show good selectivity among drugs of the same category, and have a very high therapeutic index. Such compounds are promising as therapeutic agents for treating tumors.
    Type: Application
    Filed: April 6, 2012
    Publication date: January 9, 2014
    Applicant: Ningbo Team Pharmaceutical Co., Ltd
    Inventors: Xiaoguang Lei, Xiuguo Zhang
  • Publication number: 20130254139
    Abstract: Systems and methods disclosed herein relates to building an intelligent assistant that can take in human requests/commands in simple text form, especially in natural language format, and perform tasks for users. Systems and methods are disclosed herein in which knowledge of how to interpret users' requests and carry out tasks, including how to find and manipulate information on the Internet, can be learned from users by the designed assistant, and the knowledge can be subsequently used by the assistant to perform tasks for users.
    Type: Application
    Filed: March 18, 2013
    Publication date: September 26, 2013
    Inventor: Xiaoguang Lei
  • Publication number: 20110312904
    Abstract: The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I).
    Type: Application
    Filed: August 27, 2009
    Publication date: December 22, 2011
    Applicants: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH, TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Samuel J. Danishefsky, Ting-Chao Chou, Xiaoguang Lei, Heedong Yun, Fay Ng, John Hartung, Dalibor Sames
  • Publication number: 20110124690
    Abstract: The present invention relates to compositions comprising an effective amount of a Panaxytriol Compound and a tubulin-binding drug, methods for treating or preventing cancer or a neurotrophic disorder comprising administering to a subject in need thereof an effective amount of a Panaxytriol Compound and a tubulin-binding drug, and methods for making a Panaxytriol Compound.
    Type: Application
    Filed: February 22, 2008
    Publication date: May 26, 2011
    Inventors: Samuel J. Danishefsky, Heedong Yun, Ting-Chao Chou, Xiaoguang Lei, Dalibor Sames
  • Publication number: 20100234348
    Abstract: The present invention provides compounds that potentiate the activity of antibiotic agents, particularly quinolones such as norflaxin. The invention further provides compositions, e.g., pharmaceutical compositions, comprising the inventive compounds. The invention also provides compositions comprising an antibiotic (e.g., a quinolone) and a compound that potentiates activity of the antibiotic. The invention further provides methods of treating a subject comprising administering any of the inventive compounds or compositions to the subject. The invention also provides screening methods to identify compounds that potentiate the activity of an antibiotic, e.g., a quinolone.
    Type: Application
    Filed: August 2, 2007
    Publication date: September 16, 2010
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Guillaume Cottarel, Timothy S. Gardner, Xiaoguang Lei, John Porco, Scott E. Schaus, Jamey Wierzbowski, Kollol Pal