Patents by Inventor XIAOLEI YIN

XIAOLEI YIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220339154
    Abstract: Method and compositions for inducing the self-renewal of stem/progenitor supporting cells comprised by a cochlear cell population, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Application
    Filed: June 27, 2022
    Publication date: October 27, 2022
    Inventors: Jeffrey M. KARP, Robert S. LANGER, Xiaolei YIN, Nitin JOSHI
  • Patent number: 11369607
    Abstract: Method and compositions for inducing the self-renewal of stem/progenitor supporting cells comprised by a cochlear cell population, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: June 28, 2022
    Assignees: The Brigham and Women's Hospital, Inc., Massachusetts Institute of Technology
    Inventors: Jeffrey M. Karp, Robert S. Langer, Xiaolei Yin, Nitin Joshi
  • Publication number: 20210363491
    Abstract: A population of enteroendocrine cells (EEC) is obtained from a mammalian post-natal cell population, such as a population including post-natal stem cells, by treating the population with a plurality of small molecules that upregulate ChgA and promote differentiation of the cells to form the enteroendocrine cells. The upregulation of ChgA is such that the fraction of cells expressing CGA in the obtained cell population, as measured by a ChgA Immunostaining Assay, is at least about 1.5%. Small molecules that can be used to differentiate the post-natal cells into the enteroendocrine cells can include at least one of a Wnt activator, a Notch inhibitor, a Wnt inhibitor, a MEK/ERK inhibitor, a growth factor, a HDAC inhibitor, a Histone Methylation Inhibitor, a Tgf-? inhibitor, and a NeuroD1 activator. Also, the insulin expression of a population of mammalian cells is increased by treating the population with a plurality of small molecules that increase the insulin expression.
    Type: Application
    Filed: May 31, 2021
    Publication date: November 25, 2021
    Inventors: Jeffrey Michael Karp, Robert Samuel Langer, Xiaolei Yin
  • Publication number: 20210301254
    Abstract: Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation.
    Type: Application
    Filed: March 22, 2021
    Publication date: September 30, 2021
    Inventors: Jeffrey Michael Karp, Xiaolei Yin, Marc David Succi, Robert Samuel Langer
  • Patent number: 11021687
    Abstract: A population of enteroendocrine cells (EEC) is obtained from a mammalian post-natal cell population, such as a population including post-natal stem cells, by treating the population with a plurality of small molecules that upregulate ChgA and promote differentiation of the cells to form the enteroendocrine cells. The upregulation of ChgA is such that the fraction of cells expressing CGA in the obtained cell population, as measured by a ChgA Immunostaining Assay, is at least about 1.5%. Small molecules that can be used to differentiate the post-natal cells into the enteroendocrine cells can include at least one of a Wnt activator, a Notch inhibitor, a Wnt inhibitor, a MEK/ERK inhibitor, a growth factor, a HDAC inhibitor, a Histone Methylation Inhibitor, a Tgf-? inhibitor, and a NeuroD1 activator. Also, the insulin expression of a population of mammalian cells is increased by treating the population with a plurality of small molecules that increase the insulin expression.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: June 1, 2021
    Assignees: The Brigham And Women's Hospital, Inc., Massachusetts Institute Of Technology
    Inventors: Jeffrey Michael Karp, Robert Samuel Langer, Xiaolei Yin
  • Patent number: 10954490
    Abstract: Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: March 23, 2021
    Assignees: The Brigham and Women's Hospital, Inc., Massachusetts Institute of Technology
    Inventors: Jeffrey Michael Karp, Xiaolei Yin, Marc David Succi, Robert Samuel Langer
  • Publication number: 20200323853
    Abstract: Method and compositions for inducing the self-renewal of stem/progenitor supporting cells comprised by a cochlear cell population, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Application
    Filed: January 24, 2020
    Publication date: October 15, 2020
    Inventors: Jeffrey M. Karp, Robert S. Langer, Xiaolei Yin, Nitin Joshi
  • Patent number: 10568883
    Abstract: Method and compositions for inducing the self-renewal of stem/progenitor supporting cells comprised by a cochlear cell population, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: February 25, 2020
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Jeffrey M. Karp, Robert S. Langer, Xiaolei Yin, Nitin Joshi
  • Publication number: 20190247395
    Abstract: Method and compositions for inducing the self-renewal of stem/progenitor supporting cells comprised by a cochlear cell population, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Application
    Filed: September 3, 2015
    Publication date: August 15, 2019
    Inventors: Jeffrey M. Karp, Robert S. Langer, Xiaolei Yin, Nitin Joshi
  • Patent number: 10246983
    Abstract: A method for the subsea transport of a multi-phase production fluid from a wellhead to a point remote from the wellhead, the multi-phase production fluid comprising a water phase, an oil phase and a gas phase. The method includes introducing the multi-phase production fluid into a pipeline, the pipeline extending from proximate the wellhead to a point remote from the wellhead; imparting rotational motion to the multi-phase production fluid; wherein the rotational motion of the multi-phase production fluid separates the water phase from the oil phase and the gas phase and reduces the pressure drop along the pipeline. A system for the subsea transport of a multi-phase production fluid from a wellhead to a point remote from the wellhead and a method for reducing hydrate formation during the subsea transport of a multi-phase production fluid from a wellhead to a point remote from the wellhead are also provided.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: April 2, 2019
    Assignee: ExxonMobil Upstream Research
    Inventors: Timothy J. Nedwed, Xiaolei Yin
  • Publication number: 20190017015
    Abstract: Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation.
    Type: Application
    Filed: July 6, 2018
    Publication date: January 17, 2019
    Inventors: Jeffrey Michael Karp, Xiaolei Yin, Marc David Succi, Robert Samuel Langer
  • Patent number: 10041046
    Abstract: Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation. A single layer of epithelial cells that actively self-renews and is organized into crypts and villi clothes the intestine. It has been recently shown that the renewal of intestinal epithelium is driven by Lgr5+ intestinal stem cells (ISC) that reside at the base of these crypts (Barker et al., 2007). Lgr5+ stem cells can be isolated and cultured in vitro to form organoids containing crypt-vcllus structures that recapitulates the native intestinal epithelium (Sato et al., 2009).
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: August 7, 2018
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Jeffrey Michael Karp, Xiaolei Yin, Marc David Succi, Robert Samuel Langer
  • Patent number: 10041047
    Abstract: Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: August 7, 2018
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Jeffrey Michael Karp, Xiaolei Yin, Marc David Succi, Robert Samuel Langer
  • Publication number: 20180030823
    Abstract: A method for the subsea transport of a multi-phase production fluid from a wellhead to a point remote from the wellhead, the multi-phase production fluid comprising a water phase, an oil phase and a gas phase. The method includes introducing the multi-phase production fluid into a pipeline, the pipeline extending from proximate the wellhead to a point remote from the wellhead; imparting rotational motion to the multi-phase production fluid; wherein the rotational motion of the multi-phase production fluid separates the water phase from the oil phase and the gas phase and reduces the pressure drop along the pipeline. A system for the subsea transport of a multi-phase production fluid from a wellhead to a point remote from the wellhead and a method for reducing hydrate formation during the subsea transport of a multi-phase production fluid from a wellhead to a point remote from the wellhead are also provided.
    Type: Application
    Filed: June 6, 2017
    Publication date: February 1, 2018
    Inventors: TIMOTHY J. NEDWED, Xiaolei Yin
  • Publication number: 20170349884
    Abstract: A population of enteroendocrine cells (EEC) is obtained from a mammalian post-natal cell population, such as a population including post-natal stem cells, by treating the population with a plurality of small molecules that upregulate ChgA and promote differentiation of the cells to form the enteroendocrine cells. The upregulation of ChgA is such that the fraction of cells expressing CGA in the obtained cell population, as measured by a ChgA Immunostaining Assay, is at least about 1.5%. Small molecules that can be used to differentiate the post-natal cells into the enteroendocrine cells can include at least one of a Wnt activator, a Notch inhibitor, a Wnt inhibitor, a MEK/ERK inhibitor, a growth factor, a HDAC inhibitor, a Histone Methylation Inhibitor, a Tgf-? inhibitor, and a NeuroD1 activator. Also, the insulin expression of a population of mammalian cells is increased by treating the population with a plurality of small molecules that increase the insulin expression.
    Type: Application
    Filed: January 6, 2017
    Publication date: December 7, 2017
    Inventors: Jeffrey Michael Karp, Robert Samuel Langer, Xiaolei Yin
  • Publication number: 20170226477
    Abstract: Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation.
    Type: Application
    Filed: April 21, 2017
    Publication date: August 10, 2017
    Inventors: Jeffrey Michael Karp, Xiaolei Yin, Marc David Succi, Robert Samuel Langer
  • Publication number: 20170174530
    Abstract: An oil-in-water monitoring (OIWM) system for monitoring an oil-in-water concentration of treated water in a subsea processing system. The system includes a first OIWM portion including a separation component configured to separate the treated water stream into a separated oil portion and a separated water portion which has a plenum including the separated oil portion and the separated water portion. A separation component instrument is operatively coupled to the plenum. The system also includes at least two of: an oil line instrument operatively coupled to an oil line, a water line instrument operatively coupled to a water line, and an inlet line instrument operatively coupled to the inlet line. A computational device is configured to output an oil-in-water concentration of the inlet treated water stream using the parameters measured by the separation component instrument and at least two of the other instruments. Methods using such systems are also disclosed.
    Type: Application
    Filed: December 1, 2016
    Publication date: June 22, 2017
    Inventors: Xiaolei Yin, Michael D. Olson, Edward J. Grave, Kamran Ahmed Gul
  • Publication number: 20170071937
    Abstract: Method and compositions for inducing the self-renewal of stem/progenitor supporting cells comprised by a cochlear cell population, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Application
    Filed: September 3, 2015
    Publication date: March 16, 2017
    Inventors: Jeffrey M. Karp, Robert S. Langer, Xiaolei Yin, Nitin Joshi
  • Publication number: 20160194604
    Abstract: Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation. A single layer of epithelial cells that actively self-renews and is organized into crypts and villi clothes the intestine. It has been recently shown that the renewal of intestinal epithelium is driven by Lgr5+ intestinal stem cells (ISC) that reside at the base of these crypts (Barker et al., 2007). Lgr5+ stem cells can be isolated and cultured in vitro to form organoids containing crypt-vcllus structures that recapitulates the native intestinal epithelium (Sato et al., 2009).
    Type: Application
    Filed: March 11, 2014
    Publication date: July 7, 2016
    Inventors: Jeffrey Michael Karp, Xiaolei Yin, Marc David Succi, Robert Samuel Langer
  • Publication number: 20100093090
    Abstract: The present invention relates to method or kit for efficient reprogramming of somatic cells.
    Type: Application
    Filed: September 28, 2009
    Publication date: April 15, 2010
    Applicants: PEKING UNIVERSITY, BEIJING HUA YUAN BO CHUANG TECHNOLOGY CO., LTD.
    Inventors: HONGKUI DENG, YANG ZHAO, XIAOLEI YIN, QIANG ZHANG, FANGFANG ZHU, HAISONG LIU, WEIFENG YANG, CHENGANG XIANG, HAN QIN