Abstract: Systems and methods for detecting a live human face in an image are disclosed. The methods and systems are capable of receiving multispectral image data that includes a human face. The multispectral image data can comprise visible light image data and near-infrared (NIR) image data. The multispectral image data can be processed to detect the human face. The detected human face in the visible light image data can be associated with the detected human face in the NIR image data to determine whether the detected human face is a live human face.

Abstract: A preparation method of adiposomes, and use thereof. Provided is a method for preparing adiposomes consisting of neutral lipids and a monolayer phospholipid membrane, comprising a1) vortexing phospholipid and neutral lipids in a buffer, centrifuging the resulting mixture, and collecting an upper liquid phase; a2) purifying the upper liquid phase twice or more by uniformly mixing the upper liquid phase with the buffer, layering the mixture, and collecting an upper liquid phase; and a3) uniformly mixing the upper liquid phase obtained in step a2) with the buffer, layering the mixture, and collecting a lower liquid phase in containing adiposomes. For the adiposomes prepared by the method, one or more resident proteins and/or functional proteins can be recruited to obtain artificial lipid droplets, and one or more apolipoproteins can be recruited to obtain artificial lipoproteins; and they all play important roles in preparing drugs and/or drug carriers.

Abstract: Techniques are provided for using instrumentation code to detect bots or malware. Data corresponding to requests from a plurality of client devices for a web resource comprising web code is obtained. The web resource is hosted by a first web server system. For a first client device of the plurality of client devices, instrumentation code is served. The instrumentation code is configured to execute on the first client device to monitor execution of the web code of the web resource at the first client device. One or more responses generated by the instrumentation code at the first client device are received from the first client device. The one or more responses are based one or more interactions with the web code at the first client device.

Abstract: A data analytics platform system includes a first database including economic forecast, house pricing, unemployment, and interest rate data object structures. A second database includes data object structures associated with attributes of mortgage loans and borrowers. A first module performs projections for predicting a monthly status on performing and modified performing mortgage loans. A second module performs projections of lifetime outcomes for delinquent mortgage loans. A third module performs calculations of mortgage loan level credit losses and timing parameters of loan loss recognition attributes. A fourth module performs calculations of forecasted mortgage loan performance attributes, mortgage loan contract terms, and interest rates to generate mortgage loan level cash flow data analytics. A fifth module summarizes projections of data performance analytics over a forecasted period of time, and creates an electronic summary report of the projections.

Abstract: Techniques are provided for using instrumentation code to detect bots or malware. Data corresponding to requests from a plurality of client devices for a web resource comprising web code is obtained. The web resource is hosted by a first web server system. For a first client device of the plurality of client devices, instrumentation code is served. The instrumentation code is configured to execute on the first client device to monitor execution of the web code of the web resource at the first client device. One or more responses generated by the instrumentation code at the first client device are received from the first client device. The one or more responses are based one or more interactions with the web code at the first client device.

Abstract: A network system (100) for and a method of caching information from a resource-constrained device are provided. A resource-constrained device (110) provides via a network (130) generated data (d) that relates to a status of the resource-constrained device (110) to a controllable device (150) for controlling the controllable device (150). The controllable device (150) controls an operation of an operational component (154) in response to receiving the data (d). The controllable device (150) also comprises a cache memory (156) in which the received data (d) is stored and the controllable device (150) is configured to receive from a requesting device (170) a request (r) for the stored data (d) and is configured to provide the stored data (d) to the requesting device (170). The network system (100) provides a caching solution for the data (d) which is more transparent for the resource-constrained device (110).

Abstract: In one aspect, the invention provides compounds of Formula (I) or (II): (I) or (II) and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2a, R2b, R3, R4, Z and G are defined as set forth in the disclosure. The invention also provides compounds of Formulae A and B and pharmaceutically acceptable salts and solvates thereof. Other aspects of the invention include the use of compounds of Formulae I, II, A, and B, and pharmaceutically acceptable salts and solvates thereof for the treatment of disorders responsive to modulation of one or more opioid receptors. In certain embodiments, the Compounds of the Invention are useful for treating pain.

Abstract: The disclosure relates to Substituted Piperidin-4-amino-Type Compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof wherein R1, R2, R3, Q1, Q2, E1, E2, A, B, D, W, Z, a, b, n, and x are as defined herein, compositions comprising an effective amount of a Substituted Piperidin-4-amino-Type Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted Piperidin-4-amino-Type Compound.

Abstract: Techniques detecting the execution of alien content on a client computing device are provided. A set of web code is supplemented with a set of instrumentation code, which when executed at a client computing device, collects and reports information that describes execution of the set of web code at the client computing device, wherein the client computing device receives the set of web code and the set of instrumentation code. A set of information is received from the client computing device that is generated by the set of instrumentation code when the set of instrumentation code is executed at the client computing device. The presence of alien content interacting with the set of web code on the client computing device is determined based on the set of information.

Abstract: In an embodiment, a method comprises intercepting a first set of instructions from a server computer that define one or more objects and one or more original operations that are based, at least in part, on the one or more objects; modifying the first set of instructions by adding one or more supervisor operations that are based, at least in part, on the one or more objects; transforming the one or more original operations to produce one or more transformed operations that are based, at least in part, on the one or more supervisor operations; rendering a second set of instructions which define the one or more supervisor operations and the one or more transformed operations; sending the second set of instructions to a remote client computer.

Abstract: In an embodiment, a method comprises intercepting a first set of instructions from a server computer that define one or more objects and one or more original operations that are based, at least in part, on the one or more objects; modifying the first set of instructions by adding one or more supervisor operations that are based, at least in part, on the one or more objects; transforming the one or more original operations to produce one or more transformed operations that are based, at least in part, on the one or more supervisor operations; rendering a second set of instructions which define the one or more supervisor operations and the one or more transformed operations; sending the second set of instructions to a remote client computer.

Abstract: Techniques for code modification for automation detection are described. Web code is obtained corresponding to content to be served to a first client device in response to a first request from the first client device. Instances of a particular programmatic element in the web code are identified. In response to the first request, modified web code is generated from the web code by consistently changing the particular programmatic element to a modified programmatic element throughout the web code. The modified web code is caused to be provided to the first client device in response to the first request from the first client device. A communication is received from the first client device that is made in response to the modified web code. The communication includes an attempt to interact with the particular programmatic element that exists in the web code but not in the modified web code.

Abstract: The invention provides compounds that are useful as sodium channel blockers. In one aspect, the invention provides compounds of Formula I: and pharmaceutically acceptable salts, solvates, hydrates, or diastereomers thereof, wherein W1, W2, W3, W4, U, G, m, R1, and R2 are defined in the disclosure. In certain embodiments, the invention provides compounds of Formulae II to V as set forth supra. The invention also provides the use of compounds of any of the above discussed formulae to treat a disorder responsive to blockade of sodium channels. In one embodiment, Compounds of the Invention are useful for treating pain.

Abstract: A computer-implemented method for identifying abnormal computer behavior includes receiving, at a computer server subsystem, data that characterizes subsets of particular document object models for web pages rendered by particular client computers; identifying clusters from the data that characterize the subsets of the particular document object models; and using the clusters to identify alien content on the particular client computers, wherein the alien content comprises content in the document object models that is not the result of content that is the basis of the document object model served.

Abstract: The invention provides compounds that are useful as sodium channel blockers. In one aspect, the invention provides compounds of Formula I: and pharmaceutically acceptable salts, solvates, hydrates, or diastereomers thereof, wherein W1, W2, W3, W4, U, G, m, R1, and R2 are defined in the disclosure. In certain embodiments, the invention provides compounds of Formulae II to V as set forth supra. The invention also provides the use of compounds of any of the above discussed formulae to treat a disorder responsive to blockade of sodium channels. In one embodiment, Compounds of the Invention are useful for treating pain.

Abstract: A computer-implemented method for deflecting abnormal computer interactions includes receiving, at a computer server system and from a client computer device that is remote from the computer server system, a request for web content; identifying, by computer analysis of mark-up code content that is responsive to the request, executable code that is separate from, but programmatically related to, the mark-up code content; generating groups of elements in the mark-up code content and the related executable code by determining that the elements within particular groups are programmatically related to each other; modifying elements within particular ones of the groups consistently so as to prevent third-party code written to interoperate with the elements from modifying from interoperating with the modified elements, while maintain an ability of the modified elements within each group to interoperate with each other; and recoding the mark-up code content and the executable code to include the modified elements.

Abstract: A DBMS optimizer generates a first query plan based on a first set of configuration parameters. The first query plan is executed in test mode one or more times. A first query object corresponding to the first query plan is created. The first query object includes the execution time of the first query plan. When the optimizer determines a first query plan is generated, a second query plan is generated based on a second set of configuration parameters. The second query plan is executed in test mode one or more times. A second query object corresponding to the second query plan is created. The second query object includes the execution time of the second query plan. Execution times of the first query plan and the second query plan are compared. The query plan with the shortest execution time is set as current query execution plan.

Abstract: Techniques are provided for using instrumentation code to detect bots or malware. Data corresponding to requests from a plurality of client devices for a web resource comprising web code is obtained. The web resource is hosted by a first web server system. For a first client device of the plurality of client devices, instrumentation code is served. The instrumentation code is configured to execute on the first client device to monitor execution of the web code of the web resource at the first client device. One or more responses generated by the instrumentation code at the first client device are received from the first client device. The one or more responses are based one or more interactions with the web code at the first client device.

Abstract: Methods for preparing the following compound are disclosed.

Abstract: The invention provides compounds that are useful as sodium channel blockers. In one aspect, the invention provides compounds of Formula I: and pharmaceutically acceptable salts, solvates, hydrates, or diastereomers thereof, wherein W1, W2, W3, W4, U, G, m, R1, and R2 are defined in the disclosure. In certain embodiments, the invention provides compounds of Formulae II to V as set forth supra. The invention also provides the use of compounds of any of the above discussed formulae to treat a disorder responsive to blockade of sodium channels. In one embodiment, Compounds of the Invention are useful for treating pain.