Abstract: A liquid outlet device and a liquid outlet system are provided. The liquid outlet device includes an outer housing assembly provided with a liquid inlet flow channel and a liquid outlet member installed to the outer housing assembly. The liquid inlet flow channel can form a liquid discharge opening on the outer housing assembly. The liquid outlet member can be enclosed with the outer housing assembly to form a liquid outlet flow channel. A protrusion part of the liquid outlet member can elastically abut against the outer housing assembly, and seal the liquid discharge opening disposed opposite to the protrusion part, so that the liquid can act positively on the protrusion part under the action that the liquid pressure of the liquid inlet flow channel exceeds a preset value. The protrusion part can further reset against the liquid pressure less than or equal to the preset value.

Abstract: Provided herein are bioassays to measure the synergistic antibody-dependent enhancement (ADE) effect of SARS-CoV-2 neutralizing antibodies. In particular, the disclosure relates to a method for determining whether two or more SARS-CoV-2 neutralizing antibodies have synergistic ADE effect comprising contacting a combination of said two or more SARS-CoV-2 neutralizing antibodies with Fc?R-expressing cells infected with a pseudovirus pseudotyped with SARS-CoV-2 antigen; and determining whether the combination increases the internalization of the pseudovirus into the Fc?R-expressing cells synergistically.

Abstract: Provided herein are 3D bioassays to measure antibody-dependent cell-mediated cytotoxicity (ADCC). In particular, provided is a method for assessing ADCC comprising contacting an antibody or a functional antibody fragment thereof with a target cell and an effector cell expressing FcR, in a 3D cell culture under a condition allowing the interactions between those substances; and detecting the changes in the expression levels of biomarkers CXCL9, CXCL10 and CXCL11 and 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 of the biomarkers selected from UBD, IDOL, STEAP4, JAG1, APOL4, GBP4, CD274, GBP5, CCL3 and CCL4; and assessing ADCC of the antibody based on the expression results. Also provided are the use and product relate to the method.

Abstract: An apparatus control method includes: acquiring one or more facial images; performing eye behavior recognition based on at least one of the facial images to obtain eye behavior information on at least one of the facial images; determining a target control instruction based on eye behavior information on the one or more facial images; and performing apparatus control based on the target control instruction.

Abstract: The ultrasonic quality sensor includes a probe assembly, a control module, an ultrasonic probe base, a probe filter, a temperature sensor, and a probe top cover; The probe assembly consists of a transmitting and a receiving transducer to form a face-to-face layout and the ultrasonic flight distance h, h?(V0*V50)*T0/(V50?V0), where T0 is the pulse width, V0 is the ultrasonic speed at 4° C. in water, V50 is the ultrasonic speed at 50% urea and 70° C. Sampling timing tb?[t0, t0+C], where C=(N+1)*T0, t0=h/V0, N is the number of ultrasonic actuating pulses. tr and td are first rising edge trigger timing and first falling edge trigger timing; As long as td?tr exceeds a certain percentage of T0, the chip can catch timing tf after tb of wave rising edge crosses zero. The cylindrical ring has small holes to carry away bubbles during high-temperature stages.

Abstract: The invention provides a method for preventing super large-scale floods and debris flows. First, the scale corresponding to certain standard floods in the watershed is evaluated based on field investigations and historical data. Second, the design standards of the system are chosen based on the prevention of super large-scale floods, and the design standard of critical control engineering is further determined. Finally, the design methods of check dams with different functional zones are proposed according to the design standards of critical control engineering. The invention allows part of the key control dam to fail under safe operating conditions of the entire system by increasing the cross-sectional areas and the flow discharges. The unbroken foundation of the dam can effectively control the channel entrainment and regulate the cross-sectional discharge. The design is helpful in mitigating giant floods and debris flows, thus protecting downstream infrastructures.

Abstract: Implementations of the present disclosure relate to setting a system time of an access point (AP) for server certificate validation. A method comprises obtaining a default time as a system time of the AP after an AP boots up. The method also comprises obtaining a memory time from a flash memory of the AP. The method also comprises updating the system time with the memory time obtained from the flash memory. The method also comprises validating a server certificate received from an authentication server based on the system time. The system time is synchronized with a network time if the server certificate is successfully validated based on the system time. The synchronized system time is then written into the flash memory. In this way, the authentication can be performed based on a reasonable system time even if the AP reboots.

Abstract: The method for preventing and controlling glacial lake outbreak flood and related debris flows by the present invention is mainly controlling the scale of the floods by separating water and rocks and dispersing its energy step by step. The cascading amplification effects of floods can be reduced by controlling the initiation of source material with energy dissipation by using ground sills, groups of piles, and placed large stones and prefabricated artificial structures. The diversion dam built in the downstream area discharge floods in different layers, which can quickly guide water to the main river. The preconstructed engineering system can be used in a timely manner to prevent and control floods and debris flows induced by a sudden outburst of glacial lakes in areas with important facilities and inhabitants enduring the risk of natural hazards. Prevention and control systems can separate floods and debris flows and dissipate their energy.

Abstract: Disclosed is a genetically modified oncolytic herpes simplex virus (oHISV) encoding a truncated nonsignaling variant of at least one tumor associated/specific antigen, and at least one chemokine. The expression of the truncated nonsignaling variant and the chemokine is under the control of an immediate-early gene promoter of HSV, and the truncated nonsignaling variant is expressed and presented on a tumor cell surface as a biomarker upon replication of the oHSV in the tumor cell, and the chemokine is expressed and released to induce chemotaxis of an immune cell towards the tumor cell. The genetically modified oHSV can be used in combination with CAR-T, ADC, and/or BiTE therapies.

Abstract: Implementations of the present disclosure relate to setting a system time of an access point (AP) for server certificate validation. A method comprises obtaining a default time as a system time of the AP after an AP boots up. The method also comprises obtaining a memory time from a flash memory of the AP. The method also comprises updating the system time with the memory time obtained from the flash memory. The method also comprises validating a server certificate received from an authentication server based on the system time. The system time is synchronized with a network time if the server certificate is successfully validated based on the system time. The synchronized system time is then written into the flash memory. In this way, the authentication can be performed based on a reasonable system time even if the AP reboots.

Abstract: A cam-driven wire mesh-type electrospinning apparatus and a use method therefor are provided. The cam-driven wire mesh-type electrospinning apparatus includes the following components: a high-voltage (HV) power supply unit, a wire mesh-type spinneret, a fiber receiving device, a cam unit, and a solution supply unit. The positions and connection relationships of all the components are as follows: any end of the wire mesh-type spinneret is connected to the HV power supply unit, and the other end of the wire mesh-type spinneret is connected to the cam unit; the wire mesh-type spinneret is installed on the solution supply unit; and the fiber receiving device is positioned right above the wire mesh-type spinneret. The cam-driven wire mesh-type electrospinning apparatus may induce a solution to be uniformly distributed on a wire mesh plane, and adjust the density of jet flow and the distribution position of the jet flow.

Abstract: The present disclosure provides a cleaning brush, which includes a brush holder and a cleaning assembly connected with the brush holder, the brush holder includes a main body, a grip end, and a cleaning end, the grip end and the cleaning end are arranged at two opposite ends of the main body respectively, the holding end can be held by the user, and the cleaning end can be used to clean target objects, the mounting seat of the cleaning assembly is detachably connected to the cleaning end, the bristles and the scraper are connected to the mounting seat, a side of an cutting edge of the scraper towards the mounting seat is recessed to form a profile cleaning groove.

Abstract: The present application relates to the technical field of circuit board fabricating, and provides a method for fabricating an asymmetric board, the method includes fabricating a master board, fabricating a second sub-board, thermal compression bonding the master board and the second sub-board, and milling an asymmetric board; further includes at least one of the following three steps: laying copper on the connection areas of the master board except for the second copper layer of an outermost layer to obtain laying copper area, removing copper on the connection areas of the third copper layer, and after the step of milling the asymmetric board, on each of the sub-boards, performing depth control milling at the connection areas from a side of the second sub-board on each sub-board to obtain a depth control groove.

Abstract: Disclosed herein is an oncolytic HSV-1 virus genetically engineered for treatment of brain tumors, which lacks both copies of gamma 34.5 gene and an internal inverted repeat region and is optionally incorporated with immunostimulatory and/or immunotherapeutic genes. The oncolytic HSV-1 virus exhibited superior anti-tumor activity specifically in brain tumors. A pharmaceutical composition comprising the oncolytic HSV-1 virus and a pharmaceutically acceptable carrier, and a method of treatment of a brain tumor using the same is also disclosed.

Abstract: Disclosed is an engineered exosome comprising a miRNA targeting human epidermal growth factor receptor 2 (HER2) synthesis and a ligand displayed on a membrane of the exosome for specific binding to a HER2 protein expressed on a cancer cell.

Abstract: A method for forming a test flume usable in hydraulic engineering and debris-flow hazard mitigation is provided. The test flume has a foundation flume and an expansion flume. The expansion flume has a lower edge connected to an upper edge of the foundation flume. A hydraulic radius of the test flume is determined based on a model test. A width of the foundation flume is selected based on a size of the test site of the model test. A coefficient is obtained and a width of the test flume is obtained. A cross section curve equation of the expansion flume is obtained based on the hydraulic radius of the test flume, the coefficient, the width of the test flume and the width of the foundation flume. The test flume is formed based on the cross section curve equation of the expansion flume.

Abstract: The present application provides an asymmetric board, which includes the first master board, the second master board, and the insulating dielectric layer sandwiched between the first master board and the second master board, and the depth control grooves are disposed in the connection position between the units on the asymmetric board, and located on the surface of the second master board and extending a toward the side of the first master board, the depth control grooves provide space for the expansion of the second master board, reduce the stress of the units, and reduce the warping of the second master board. When the number of the depth control grooves in the first direction and/or the second direction is greater than 0, the depths of the depth control grooves increase by X from a center to an edge of the asymmetric board, and the X is greater than or equal to 0.