Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

Abstract: A system for controlling power consumption of a network includes at least one terminal to receive a plurality of requests to route data from a plurality of data sources to a plurality of data sinks, where the data sources and the data sinks are connected to each other through a plurality of network nodes forming the network, and a network configuration unit. The network configuration unit includes a selection module configured to select a configuration of the network nodes that allows the network to have a lowest overall power consumption of the network among a plurality of configurations of the network, and an output module configured to output a plurality of instruction signals to the network nodes to perform the network configuration. A network path for transmitting a network flow is selected that does not allow the network flow to be split and flow through another network path.

Abstract: A power model that relates the settings of resource actuators to power consumption levels of the resource actuators and a condition model that relates the settings of the resource actuators to an environmental condition at the location of the at least one entity and a power consumption level of the at least one entity are developed. A constraint optimization problem having an objective function and at least one constraint is formulated, where the objective function computes at least a proportional quantity of a total power consumption level of the resource actuators and the at least one constraint comprises a setpoint environmental condition at a location of the at least entity. A solution to the constraint optimization problem is determined, where the solution provides optimal values for the resource actuator settings.

Abstract: Interconnects containing ruthenium and methods of forming can include utilization of a sacrificial protective material. Planarization or other material removal operations can be performed on a substrate having a recess, the recess containing a ruthenium containing material along with the sacrificial protective material. The protective material is later removed, and a conductor can be filled in the remaining recess.

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

Abstract: Power consumption of a group of computer systems is managed based on a maximum power consumption for the group. A power budget is determined from the power consumption of each computer system and the maximum power consumption for the group. The power budget identifies a power cap for each computer system in the group. The power caps in the power budget are distributed to the computer systems in the group.

Abstract: The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15R?) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15R? domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

Abstract: In a method of determining status assignments for a plurality of entities that substantially optimizes a total power consumption of the plurality of entities and a plurality of resource actuators, at least one entity power model for the entities and at least one resource power model for the resource actuators are developed. In addition, a constraint optimization problem having an objective function and at least one constraint is formulated and the problem is solved by employing a search tool, the at least one entity power model, and the at least one resource power module on the objective function to identify status assignments for the entities that results in the optimized total power consumption.

Abstract: A method and system for governing resources in a computing utility receives a demand profile associated with an application that identifies the resources required from a pool of resources during one or more demand cycles, admits an application to the computing utility facility if resources required for the application can be provided from the pool of resources in accordance with the demand profile and associated one or more demand cycles and assigns available resources from the pool of resources in response to a request from the application admitted to the computing utility facility.

Abstract: A method and system for policing resources in a computing utility facility includes policing resources in a computing utility facility includes intercepting a request for resources from an application admitted to access a pool of resources associated with the computing utility facility, acquiring an entitlement profile associated with the application to determine if application is entitled to requested resources over a time period, identifying an entitlement value and corresponding sliding window of the time period from the entitlement profile, determining if the request for resources exceeds the entitlement value associated with the sliding window and indicating application entitlement to the request for resources in response to the determining if the request is excessive.

Abstract: Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured is methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes.

Abstract: A system for controlling power consumption of a network includes at least one terminal to receive a plurality of requests to route data from a plurality of data sources to a plurality of data sinks, where the data sources and the data sinks are connected to each other through a plurality of network nodes forming the network, and a network configuration unit. The network configuration unit includes a selection module configured to select a configuration of the network nodes that allows the network to have a lowest overall power consumption of the network among a plurality of configurations of the network, and an output module configured to output a plurality of instruction signals to the network nodes to perform the network configuration. A network path for transmitting a network flow is selected that does not allow the network flow to be split and flow through another network path.

Abstract: Embodiments of the present invention relate to a system and method for allocating resources to applications. One embodiment of the present invention may include identifying a plurality of applications and a plurality of application components, and determining available resources of a networked computing system for potentially storing the applications and application components. Additionally, the embodiment may include determining required resources for each application component, assigning a subset of available resources for each application component based on the required resources of the application component and the available resources. The embodiment may also include associating the application components with the subsets of available resources and storing more than one application component of the plurality of application components on a single available resource.

Abstract: A power management system for providing a unified power management of at least one electronic system in a selected environment is provided, wherein the at least one electronic system includes a plurality of electronic components.

Abstract: Embodiments of the present invention relate to a system and method for assigning resources to an application component. One embodiment of the present invention includes identifying an application component, and determining available resources of a networked computing system for running the application component. Additionally, the embodiment includes determining required resources for the application component, assigning a subset of available resources for the application component taking into account the required resources of the application component, the available resources, and one or more operator policies. These operator policies generally include preferences of operators, administrators, users, or the like, and could also include business rules. Additionally, the embodiment includes associating the application component with the subset of available resources.

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

Abstract: A method, system, and apparatus is disclosed for allocating resources to applications. Available resources of a networked computing system may be determined. For each application, required resources of the application may be determined. An assigned subset of the available resources for each application is determined as a function of the required resources of the application and the available resources. The function reduces communication delays between resources of the subset of the available resources in conformance with bandwidth capacity requirements of the application and in conformance with network bandwidth limitations. The applications may then be associated with the assigned subsets of resources.

Abstract: A power model that relates the settings of resource actuators to power consumption levels of the resource actuators and a condition model that relates the settings of the resource actuators to an environmental condition at the location of the at least one entity and a power consumption level of the at least one entity are developed. A constraint optimization problem having an objective function and at least one constraint is formulated, where the objective function computes at least a proportional quantity of a total power consumption level of the resource actuators and the at least one constraint comprises a setpoint environmental condition at a location of the at least entity. A solution to the constraint optimization problem is determined, where the solution provides optimal values for the resource actuator settings.

Abstract: Power consumption of a group of computer systems is managed based on a maximum power consumption for the group. A power budget is determined from the power consumption of each computer system and the maximum power consumption for the group. The power budget identifies a power cap for each computer system in the group. The power caps in the power budget are distributed to the computer systems in the group.