Patents by Inventor Xin Linghu
Xin Linghu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240034739Abstract: Processes are provided herein for the preparation of a bicyclic ketone compound of formula (I), or a stereoisomer thereof: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and n are as defined herein; and compounds prepared by these processes.Type: ApplicationFiled: October 2, 2023Publication date: February 1, 2024Applicants: Genentech, Inc., Hoffmann-La Roche Inc.Inventors: Allen Yu HONG, Nicholas WONG, Sean M. KELLY, Lauren Elizabeth SIROIS, Sara SCHWEGLER, Xin LINGHU, Francis GOSSELIN, Katarzyna Aleksandra PIECHOWICZ, Carmela MOLINARO, Dennis WETZL
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Publication number: 20230303556Abstract: Provided herein are compounds of Formula (I): or a pharmaceutically acceptable salt thereof. The provided compounds are useful Poly ADP-ribose glycohydrolase (PARG) inhibitors. Additional utilities and advantages are described herein.Type: ApplicationFiled: March 22, 2023Publication date: September 28, 2023Inventors: Paul A. BARSANTI, Michael Patrick DILLON, Firoz Ali JAIPURI, Ying-Zi XU, Xin LINGHU, Monah ABED
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Patent number: 11702452Abstract: Methods for making an arylomycin ring of formula t or salts or solvates thereof, wherein R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R5, R10 and Pg1 are as defined herein.Type: GrantFiled: November 2, 2021Date of Patent: July 18, 2023Assignee: Genentech, Inc.Inventors: Filip Petronijevic, Ngiap-Kie Lim, Nicholas Wong, Allen Hong, Haiyun Hou, Xin Linghu, Francis Gosselin
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Publication number: 20220056078Abstract: Methods for making an arylomycin ring of formula t or salts or solvates thereof, wherein R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R5, R10 and Pg1 are as defined herein.Type: ApplicationFiled: November 2, 2021Publication date: February 24, 2022Applicant: Genentech, Inc.Inventors: Filip PETRONIJEVIC, Ngiap-Kie LIM, Nicholas WONG, Allen HONG, Haiyun HOU, Xin LINGHU, Francis GOSSELIN
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Patent number: 11192924Abstract: Methods for making an arylomycin ring of formula t or salts or solvates thereof, wherein R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R5, R10 and Pg1 are as defined herein.Type: GrantFiled: September 24, 2019Date of Patent: December 7, 2021Assignee: Genentech, Inc.Inventors: Filip Petronijevic, Ngiap-Kie Lim, Nicholas Wong, Allen Hong, Haiyun Hou, Xin Linghu, Francis Gosselin
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Patent number: 11098028Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acidType: GrantFiled: August 8, 2019Date of Patent: August 24, 2021Assignee: Genentech, Inc.Inventors: Jinguang Lin, Alexandra Chestakova, Wei Gu, Hans Iding, Jing Li, Xin Linghu, Patrik Meier, Chunbo Sha, Jeffrey Stults, Youchu Wang, Haiming Zhang, Jianqian Zhang, Tao Zhang
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Patent number: 11066389Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acidType: GrantFiled: December 18, 2019Date of Patent: July 20, 2021Assignee: Genentech, Inc.Inventors: Jinguang Lin, Alexandra Chestakova, Wei Gu, Hans Iding, Jing Li, Xin Linghu, Patrik Meier, Chunbo Sha, Jeffrey Stults, Youchu Wang, Haiming Zhang, Jianqian Zhang, Tao Zhang
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Publication number: 20200255476Abstract: Methods for making an arylomycin ring of formula t or salts or solvates thereof, wherein R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R5, R10 and Pg1 are as defined herein.Type: ApplicationFiled: September 24, 2019Publication date: August 13, 2020Applicant: Genentech, Inc.Inventors: Filip PETRONIJEVIC, Ngiap-Kie LIM, Nicholas WONG, Allen HONG, Haiyun HOU, Xin LINGHU, Francis GOSSELIN
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Patent number: 10689325Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.Type: GrantFiled: May 17, 2019Date of Patent: June 23, 2020Assignee: Genentech, Inc.Inventors: Stephan Bachmann, Serena Maria Fantasia, Michael Jansen, Stefan Koenig, Xin Linghu, Sebastian Rieth, Nathaniel L. Segraves, Andreas Zogg
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Publication number: 20200190061Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acidType: ApplicationFiled: December 18, 2019Publication date: June 18, 2020Applicant: Genentech, Inc.Inventors: JINGUANG LIN, ALEXANDRA CHESTAKOVA, WEI GU, HANS IDING, JING LI, XIN LINGHU, PATRIK MEIER, CHUNBO SHA, JEFFREY STULTS, YOUCHU WANG, HAIMING ZHANG, JIANQIAN ZHANG, TAO ZHANG
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Patent number: 10611753Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acidType: GrantFiled: January 10, 2018Date of Patent: April 7, 2020Assignee: Genentech, Inc.Inventors: Jinguang Lin, Alexandra Chestakova, Wei Gu, Hans Iding, Jing Li, Xin Linghu, Patrik Meier, Chunbo Sha, Jeffrey Stults, Youchu Wang, Haiming Zhang, Jianqian Zhang, Tao Zhang
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Publication number: 20190367484Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acidType: ApplicationFiled: August 8, 2019Publication date: December 5, 2019Applicant: Genentech, Inc.Inventors: JINGUANG LIN, ALEXANDRA CHESTAKOVA, WEI GU, HANS IDING, JING LI, XIN LINGHU, PATRIK MEIER, CHUNBO SHA, JEFFREY STULTS, YOUCHU WANG, HAIMING ZHANG, JIANQIAN ZHANG, TAO ZHANG
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Publication number: 20190270695Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.Type: ApplicationFiled: May 17, 2019Publication date: September 5, 2019Applicant: Genentech, Inc.Inventors: Stephan Bachmann, Serena Maria Fantasia, Michael Jansen, Stefan Koenig, Xin Linghu, Sebastian Rieth, Nathaniel L. Segraves, Andreas Zogg
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Patent number: 10336683Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.Type: GrantFiled: March 3, 2017Date of Patent: July 2, 2019Assignee: Genentech, Inc.Inventors: Stephan Bachmann, Serena Maria Fantasia, Michael Jansen, Stefan Koenig, Xin Linghu, Sebastian Rieth, Nathaniel L. Segraves, Andreas Zogg
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Publication number: 20180134685Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acidType: ApplicationFiled: January 10, 2018Publication date: May 17, 2018Applicant: Genentech, Inc.Inventors: Jinguang Lin, Alexandra Chestakova, Wei Gu, Hans Iding, Jing Li, Xin Linghu, Patrik Meier, Chunbo Sha, Jeffrey Stults, Youchu Wang, Haiming Zhang, Jianqian Zhang, Tao Zhang
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Publication number: 20170252457Abstract: Processes are described for the preparation of F-benzoxazinorifamycin I: and intermediates for conjugation with an antibody.Type: ApplicationFiled: March 3, 2017Publication date: September 7, 2017Applicant: Genentech, Inc.Inventors: Stephan Bachmann, Serena Maria Fantasia, Michael Jansen, Stefan Koenig, Xin Linghu, Sebastian Rieth, Nathaniel L. Segraves, Andreas Zogg
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Publication number: 20170022183Abstract: The present invention provides a process for the manufacture of a compound of formula VIIIa and salts forms of VIIIa where Rc is an aryl sulfonic acidType: ApplicationFiled: October 5, 2016Publication date: January 26, 2017Applicant: Genentech, Inc.Inventors: Jinguang Lin, Alexandra Chestakova, Wei Gu, Hans Iding, Jing Li, Xin Linghu, Patrik Meier, Chunbo Sha, Jeffrey Stults, Youchu Wang, Haiming Zhang, Jianqian Zhang, Tao Zhang
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Publication number: 20100234603Abstract: The present invention relates to novel substituted aryl sulfone intermediates and processes for preparing the same. An aspect of this invention relates to a process for making substituted aryl sulfone intermediates utilizing a one-pot deacylation-carbon/sulfur bond formation step. The invention also relates to a process for preparing intermediates that are used to make the compounds of formula I. Some of the advantages of the present invention include manufacturing flexibility and efficiency, high yield synthesis using a one pot deacylation and carbon-sulfur bond formation step of a thioester intermediate and the like. This and other aspects of the invention will be realized upon review of the specification as a whole.Type: ApplicationFiled: March 12, 2010Publication date: September 16, 2010Inventors: Xin Linghu, Kathleen Linn, Kevin M. Maloney, Mark McLaughlin, Gang Qian
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Publication number: 20100234604Abstract: The present invention relates to novel substituted aryl sulfone intermediates and processes for preparing the same. An aspect of this invention relates to a process for making substituted aryl sulfone intermediates utilizing a one-pot deacylation-carbon/sulfur bond formation step. The invention also relates to a process for preparing intermediates that are used to make the compounds of formula I. Some of the advantages of the present invention include manufacturing flexibility and efficiency, high yield synthesis using a one pot deacylation and carbon-sulfur bond formation step of a thioester intermediate and the like. This and other aspects of the invention will be realized upon review of the specification as a whole.Type: ApplicationFiled: March 12, 2010Publication date: September 16, 2010Inventors: Xin Linghu, Kathleen Linn, Kevin M. Maloney, Mark McLaughlin, Gang Qian
