Patents by Inventor Xuan Zhao

Xuan Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200040682
    Abstract: The present invention discloses a method for lowering an oil pipe in a gas well without well-killing, a soluble bridge plug and a material preparation method thereof, wherein, the method comprises the steps of: lowering a bridge plug in a wellbore such that the bridge plug blocks the wellbore at a predetermined location in the wellbore; injecting water in the wellbore after the pressure in the wellbore has been relieved so as to replace gases in the wellbore; and lowering an oil pipe in the wellbore to the location of the bridge plug. The method for lowering an oil pipe in a gas well without well-killing, the soluble bridge plug and the material preparation method thereof provided in the present invention successfully solve the problem of high cost for lowering an oil pipe under pressure after a fracturing fluid has been injected into the casing.
    Type: Application
    Filed: April 4, 2018
    Publication date: February 6, 2020
    Inventors: Xianwen Li, Qiaorong Han, Yanming Zhang, Xu Ma, Zhanguo Ma, Yangming Hu, Changjing Zhou, Yuanxiang Xiao, Huaqiang Shi, Baochun Chen, Yonghong Gu, Xiaoyong Wen, Xuan'ang Lai, Yong Ding, Liang Ye, Qianyun Zhao, Xinxing Ma, Yajuan Wang, Man Bi, Hua Shi, Mingfang He, Xiaorui Liu, Wei Gao, Hongying Li, Yun Ling, Ruifen Hao, Lei Shen, Guohui Su, Shaowei Zhou, Shusheng Li, Zhe Li
  • Publication number: 20200034624
    Abstract: An apparatus configured to be worn on a head of a user, includes: a screen configured to present graphics to the user; a camera system configured to view an environment in which the user is located; and a processing unit configured to determine a map based at least in part on output(s) from the camera system, wherein the map is configured for use by the processing unit to localize the user with respect to the environment; wherein the processing unit of the apparatus is also configured to obtain a metric indicating a likelihood of success to localize the user using the map, and wherein the processing unit is configured to obtain the metric by computing the metric or by receiving the metric.
    Type: Application
    Filed: July 24, 2019
    Publication date: January 30, 2020
    Applicant: MAGIC LEAP, INC.
    Inventors: Divya SHARMA, Ali SHAHROKNI, Anush MOHAN, Prateek SINGHAL, Xuan ZHAO, Sergiu SIMA, Benjamin LANGMANN
  • Publication number: 20200022908
    Abstract: A method for treating myopia and an application in preparation of a medicament are provided, where the volume of choroidal blood flow is increased by expanding the choroid via a drug or a surgical method, so as to achieve treatment of the myopia caused by scleral hypoxia, which provides a new idea and method for treating myopia.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 23, 2020
    Inventors: Xiangtian ZHOU, Sen ZHANG, Jia QU, Guoyun ZHANG, Fei ZHAO, Xuan ZHOU
  • Publication number: 20200024374
    Abstract: The present invention provides a composition of a polyethylene glycol maleimide derivative and a polymerization inhibitor. In particular, the present invention provides a composition of an 8-arm polyethylene glycol maleimide derivative and a phenolic polymerization inhibitor. The ingredient and content of the polymerization inhibitor in the composition are reasonably chosen, thereby significantly increasing stability of the polyethylene glycol maleimide derivative, effectively avoiding the undesirable effect of gel solidifying due to polymerization during storage and transportation, and extending a pot life and shelf life of a product thereof.
    Type: Application
    Filed: September 30, 2019
    Publication date: January 23, 2020
    Inventors: Hui ZHU, Meina LIN, Zhen WEI, Xuan ZHAO
  • Publication number: 20200024446
    Abstract: Disclosed in the present invention is a method for preparing a Y-branched hydrophilic polymer carboxylic acid derivative, in particular a method for preparing a Y-branched polyethylene glycol carboxylic acid derivative having a high purity and high molecular weight. The preparation steps are simple, the product of the reaction is easy to be separated, the cost for separation is low, and the purity and yield of the product are high, facilitating the subsequent preparation of other derivatives and medicament conjugates based on the preparation of the carboxylic acid derivative, which is advantageous for industrial scale-up and commercial applications. The prepared Y-branched hydrophilic polymer carboxylic acid derivative (in particular the Y-branched polyethylene glycol carboxylic acid derivative having a high molecular weight) product has a high purity and high commercial application value, in particular in the use of the preparation of medicaments for preventing and/or treating diseases.
    Type: Application
    Filed: September 30, 2019
    Publication date: January 23, 2020
    Inventors: Xiaomeng CHEN, Meina LIN, Rujun ZHANG, Xuan ZHAO
  • Publication number: 20200016149
    Abstract: Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.
    Type: Application
    Filed: September 25, 2019
    Publication date: January 16, 2020
    Inventors: Xuan Zhao, Michael D. Bentley, Zhongxu Ren, Tacey X. Viegas
  • Patent number: 10525143
    Abstract: A conjugate represented by general formula (I), wherein R0 is a C1-6 alkyl, B is an anesthetic, and A is a linking group, and a quaternary ammonium salt is formed at the linking position between B and R0. The conjugate has a prolonged analgesic effect, and can be used in postoperative analgesia or treatment for chronic pain.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: January 7, 2020
    Assignee: JENKEM TECHNOLOGY CO., LTD. (TIANJIN)
    Inventors: Jinliang Wang, Zewang Feng, Hui Zhu, Meina Lin, Yan Liu, Xuan Zhao
  • Patent number: 10523472
    Abstract: Aspects of the disclosure provide an apparatus that includes interface circuitry with a serializer/deserializer (SERDES) circuit. The interface circuitry includes a receiving circuit that receives a signal that carries a sequence of digital values. The receiving circuit includes sampler circuit and a feedback equalization circuit. The sampler circuit includes an amplifying portion and a latch portion coupled at an intermediate node. The amplifying portion varies, with an amplifying gain, an intermediate signal at the intermediate node in response to an input signal to the sampler circuit, and the latch portion generates a digital output based on the intermediate signal at the intermediate node. The feedback equalization circuit is coupled to the intermediate node to vary the intermediate signal at the intermediate node based on a previous digital output from the latch portion of the sampler circuit.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: December 31, 2019
    Assignee: Marvell International Ltd.
    Inventors: Xuan Zhao, Zhong Yu, Xin Ma, Jackson Tek Kon Ding, Jacky Cheuk Yin Liu, Yihui Li
  • Patent number: 10503901
    Abstract: In one respect, there is provided a system for training a machine learning model to detect malicious container files. The system may include at least one processor and at least one memory. The at least one memory may include program code that provides operations when executed by the at least one processor. The operations may include: training, based on a training data, a machine learning model to enable the machine learning model to determine whether at least one container file includes at least one file rendering the at least one container file malicious; and providing the trained machine learning model to enable the determination of whether the at least one container file includes at least one file rendering the at least one container file malicious. Related methods and articles of manufacture, including computer program products, are also disclosed.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: December 10, 2019
    Assignee: Cylance Inc.
    Inventors: Xuan Zhao, Matthew Wolff, John Brock, Brian Wallace, Andy Wortman, Jian Luan, Mahdi Azarafrooz, Andrew Davis, Michael Wojnowicz, Derek Soeder, David Beveridge, Yaroslav Oliinyk, Ryan Permeh
  • Publication number: 20190349255
    Abstract: This disclosure provides a computer-implemented method. The method may comprise obtaining a character of first-direction communications and a character of second-direction communications in a network environment, the first-direction communications being network communications from a first node to a second node, and the second-direction communications being network communications from the second node to the first node. The method may further comprise determining a dependency between the first node and the second node based on the character of first-direction communications and the character of second-direction communications, the dependency between the first node and the second node indicating whether the first node depends on the second node or the second node depends on the first node.
    Type: Application
    Filed: May 10, 2018
    Publication date: November 14, 2019
    Inventors: Peng Hui Jiang, Han Lin Wang, Jiang Xuan, Cheng Xu, Hong Mei Zhao
  • Patent number: 10464882
    Abstract: The present invention discloses a Y-type discrete polyethylene glycol derivative, which has the advantages of determined molecular weights and the number of chain segments, and can avoid the defect of heterogeneity of a PEG derivative. In addition, the Y-type discrete polyethylene glycol derivative of the present invention may increase the water solubility of the discrete polyethylene glycol, and solve the problem of insufficient water solubility of the discrete polyethylene glycol-modified insoluble drug caused by an increase of the loading capacity.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: November 5, 2019
    Assignee: JENKEM TECHNOLOGY CO., LTD. (BEIJING)
    Inventors: Hui Zhu, Meina Lin, Xiaomeng Chen, Zhen'gang Zhu, Xuan Zhao
  • Patent number: 10463659
    Abstract: Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: November 5, 2019
    Assignee: Nektar Therapeutics
    Inventors: Xuan Zhao, Michael D. Bentley, Zhongxu Ren, Tacey X. Viegas
  • Publication number: 20190303570
    Abstract: An endpoint computer system can harvest data relating to a plurality of events occurring within an operating environment of the endpoint computer system and can add the harvested data to a local data store maintained on the endpoint computer system. A query response can be generated, for example by identifying and retrieving responsive data from the local data store. The responsive data are related to an artifact on the endpoint computer system and/or to an event of the plurality of events. In some examples, the local data store can be an audit log and/or can include one or more tamper resistant features. Systems, methods, and computer program products are described.
    Type: Application
    Filed: May 30, 2019
    Publication date: October 3, 2019
    Inventors: Ryan Permeh, Matthew Wolff, Samuel John Oswald, Xuan Zhao, Mark Culley, Steven Polson
  • Publication number: 20190298845
    Abstract: The present invention relates to the technical field of medicine, in particular to a conjugate of dezocine and polyethylene glycol and a pharmaceutical composition thereof. The conjugate of dezocine and water-soluble oligomer provided by the present invention has better pharmacokinetic properties and a high drug absorption degree, may reduce the side effects of the drug, and achieve a smaller administration dosage and a more diverse mode of administration, such as oral administration, in clinic. Compared with dezocine, the conjugate of the present invention has a stronger analgesic effect and a longer analgesic duration, may reduce the frequency of drug administration, improve patient compliance, and has advantages in effectiveness and safety of the drug, as well as drug tolerance, etc.
    Type: Application
    Filed: June 20, 2019
    Publication date: October 3, 2019
    Inventors: Zewang FENG, Jinliang WANG, Yanli XIONG, Xuan ZHAO
  • Publication number: 20190294789
    Abstract: An endpoint computer system can harvest data relating to a plurality of events occurring within an operating environment of the endpoint computer system and can add the harvested data to a local data store maintained on the endpoint computer system. In some examples, the local data store can be an audit log and/or can include one or more tamper resistant features. Systems, methods, and computer program products are described.
    Type: Application
    Filed: May 29, 2019
    Publication date: September 26, 2019
    Inventors: Ryan Permeh, Matthew Wolff, Samuel John Oswald, Xuan Zhao, Mark Culley, Steve Polson
  • Publication number: 20190286952
    Abstract: In one respect, there is provided a system for training a neural network adapted for classifying one or more scripts. The system may include at least one processor and at least one memory. The memory may include program code that provides operations when executed by the at least one memory. The operations may include: extracting, from an icon associated with a file, one or more features; assigning, based at least on the one or more features, the icon to one of a plurality of clusters; and generating, based at least on the cluster to which the icon is assigned, a classification for the file associated with the icon. Related methods and articles of manufacture, including computer program products, are also provided.
    Type: Application
    Filed: May 31, 2019
    Publication date: September 19, 2019
    Inventors: Matthew Wolff, Pedro Silva do Nascimento Neto, Xuan Zhao, John Brock, Jian Luan
  • Patent number: 10391063
    Abstract: A pharmaceutical composition of a polyethylene glycol-modified camptothecin derivative and a preparation method thereof. The pharmaceutical composition is prepared mainly from following components: a camptothecin derivative modified by polyethylene glycol, a pH value adjustment agent and water for injection. The pharmaceutical composition has high stability.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: August 27, 2019
    Assignee: JENKEM TECHNOLOGY CO., LTD. (TIANJIN)
    Inventors: Zewang Feng, Wen Li, Zhenguo Wang, Xuan Zhao
  • Publication number: 20190236132
    Abstract: Systems, methods, and a computer readable medium are provided for generating natural language recommendations based on an industrial language model. Input data, including a plurality of natural language input units is received from a first computing device and transmitted to a second computing device. The second computing device can determine an output including a plurality of natural language outputs using a predictive model trained to generate the output corresponding to an energy exploration lexicon. The second computing device can provide the output to the first computing device for display.
    Type: Application
    Filed: January 24, 2019
    Publication date: August 1, 2019
    Inventors: Xuan Zhu, Arun Karthi Subramaniyan, Haiming Zhao, Zhengjie Xu
  • Patent number: 10361681
    Abstract: Differing from the fact that the amount of register units and adder units arranged in conventional moving average filter must be increased for processing more number of reference input signals, the present invention particularly discloses a moving average low-pass filtering device. The moving average low-pass filtering device comprises a register unit and a filtering and processing unit, and is able to use identical circuit architecture to successfully treat reference input signals with a filtering process even if the number of the reference input signals is alternatively increased. Moreover, after finishing a verification experiment by a simulator, simulation results have proved that, this novel moving average low-pass filtering device still can use identical circuit architecture to complete the filtering process under nearly the same calculation efficiency even though the number of the reference input signals is alternatively increased.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: July 23, 2019
    Assignee: Chung Yuan Christian University
    Inventors: Shih-Lun Chen, Ting-Lan Lin, Wen-Xuan Zhao
  • Patent number: 10354173
    Abstract: In one respect, there is provided a system for training a neural network adapted for classifying one or more scripts. The system may include at least one processor and at least one memory. The memory may include program code that provides operations when executed by the at least one memory. The operations may include: extracting, from an icon associated with a file, one or more features; assigning, based at least on the one or more features, the icon to one of a plurality of clusters; and generating, based at least on the cluster to which the icon is assigned, a classification for the file associated with the icon. Related methods and articles of manufacture, including computer program products, are also provided.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: July 16, 2019
    Assignee: Cylance Inc.
    Inventors: Matthew Wolff, Pedro Silva do Nascimento Neto, Xuan Zhao, John Brock, Jian Luan