Abstract: The present invention provides a multi-drug-loading site and high drug-loading capacity ligand-drug conjugate. The ligand-drug conjugate has a structure of general formula (I). The ligand-drug conjugate has the characteristics of high loading capacity, high drug efficacy, low toxicity, and low risks. The ligand-drug conjugate can be used particularly to connect to a low toxicity chemical molecule, thereby extending a therapeutic window. Furthermore, the present invention provides an antibody-drug conjugate molecule. The antibody-drug conjugate molecule has the characteristics of multiple drug-loading ability and high drug-loading capacity, such that the antibody-drug conjugate can carry a large amount of a low toxicity chemical molecule and achieve a therapeutic effect without depending on antibody targeting or high toxicity chemicals.

Abstract: A cross reality system that provides an immersive user experience by storing persistent spatial information about the physical world that one or multiple user devices can access to determine position within the physical world and that applications can access to specify the position of virtual objects within the physical world. Persistent spatial information enables users to have a shared virtual, as well as physical, experience when interacting with the cross reality system. Further, persistent spatial information may be used in maps of the physical world, enabling one or multiple devices to access and localize into previously stored maps, reducing the need to map a physical space before using the cross reality system in it. Persistent spatial information may be stored as persistent coordinate frames, which may include a transformation relative to a reference orientation and information derived from images in a location corresponding to the persistent coordinate frame.

Abstract: An apparatus configured to be worn on a head of a user, includes: a screen configured to present graphics to the user; a camera system configured to view an environment in which the user is located; and a processing unit configured to determine a map based at least in part on output(s) from the camera system, wherein the map is configured for use by the processing unit to localize the user with respect to the environment; wherein the processing unit of the apparatus is also configured to obtain a metric indicating a likelihood of success to localize the user using the map, and wherein the processing unit is configured to obtain the metric by computing the metric or by receiving the metric.

Abstract: Disclosed in the present invention is a method for preparing a Y-branched hydrophilic polymer carboxylic acid derivative, in particular a method for preparing a Y-branched polyethylene glycol carboxylic acid derivative having a high purity and high molecular weight. The preparation steps are simple, the product of the reaction is easy to be separated, the cost for separation is low, and the purity and yield of the product are high, facilitating the subsequent preparation of other derivatives and medicament conjugates based on the preparation of the carboxylic acid derivative, which is advantageous for industrial scale-up and commercial applications. The prepared Y-branched hydrophilic polymer carboxylic acid derivative (in particular the Y-branched polyethylene glycol carboxylic acid derivative having a high molecular weight) product has a high purity and high commercial application value, in particular in the use of the preparation of medicaments for preventing and/or treating diseases.

Abstract: The present invention provides a composition of a polyethylene glycol maleimide derivative and a polymerization inhibitor. In particular, the present invention provides a composition of an 8-arm polyethylene glycol maleimide derivative and a phenolic polymerization inhibitor. The ingredient and content of the polymerization inhibitor in the composition are reasonably chosen, thereby significantly increasing stability of the polyethylene glycol maleimide derivative, effectively avoiding the undesirable effect of gel solidifying due to polymerization during storage and transportation, and extending a pot life and shelf life of a product thereof.

Abstract: Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.

Abstract: A conjugate represented by general formula (I), wherein R0 is a C1-6 alkyl, B is an anesthetic, and A is a linking group, and a quaternary ammonium salt is formed at the linking position between B and R0. The conjugate has a prolonged analgesic effect, and can be used in postoperative analgesia or treatment for chronic pain.

Abstract: Aspects of the disclosure provide an apparatus that includes interface circuitry with a serializer/deserializer (SERDES) circuit. The interface circuitry includes a receiving circuit that receives a signal that carries a sequence of digital values. The receiving circuit includes sampler circuit and a feedback equalization circuit. The sampler circuit includes an amplifying portion and a latch portion coupled at an intermediate node. The amplifying portion varies, with an amplifying gain, an intermediate signal at the intermediate node in response to an input signal to the sampler circuit, and the latch portion generates a digital output based on the intermediate signal at the intermediate node. The feedback equalization circuit is coupled to the intermediate node to vary the intermediate signal at the intermediate node based on a previous digital output from the latch portion of the sampler circuit.

Abstract: In one respect, there is provided a system for training a machine learning model to detect malicious container files. The system may include at least one processor and at least one memory. The at least one memory may include program code that provides operations when executed by the at least one processor. The operations may include: training, based on a training data, a machine learning model to enable the machine learning model to determine whether at least one container file includes at least one file rendering the at least one container file malicious; and providing the trained machine learning model to enable the determination of whether the at least one container file includes at least one file rendering the at least one container file malicious. Related methods and articles of manufacture, including computer program products, are also disclosed.

Abstract: The present invention discloses a Y-type discrete polyethylene glycol derivative, which has the advantages of determined molecular weights and the number of chain segments, and can avoid the defect of heterogeneity of a PEG derivative. In addition, the Y-type discrete polyethylene glycol derivative of the present invention may increase the water solubility of the discrete polyethylene glycol, and solve the problem of insufficient water solubility of the discrete polyethylene glycol-modified insoluble drug caused by an increase of the loading capacity.

Abstract: Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.

Abstract: An endpoint computer system can harvest data relating to a plurality of events occurring within an operating environment of the endpoint computer system and can add the harvested data to a local data store maintained on the endpoint computer system. A query response can be generated, for example by identifying and retrieving responsive data from the local data store. The responsive data are related to an artifact on the endpoint computer system and/or to an event of the plurality of events. In some examples, the local data store can be an audit log and/or can include one or more tamper resistant features. Systems, methods, and computer program products are described.

Abstract: The present invention relates to the technical field of medicine, in particular to a conjugate of dezocine and polyethylene glycol and a pharmaceutical composition thereof. The conjugate of dezocine and water-soluble oligomer provided by the present invention has better pharmacokinetic properties and a high drug absorption degree, may reduce the side effects of the drug, and achieve a smaller administration dosage and a more diverse mode of administration, such as oral administration, in clinic. Compared with dezocine, the conjugate of the present invention has a stronger analgesic effect and a longer analgesic duration, may reduce the frequency of drug administration, improve patient compliance, and has advantages in effectiveness and safety of the drug, as well as drug tolerance, etc.

Abstract: An endpoint computer system can harvest data relating to a plurality of events occurring within an operating environment of the endpoint computer system and can add the harvested data to a local data store maintained on the endpoint computer system. In some examples, the local data store can be an audit log and/or can include one or more tamper resistant features. Systems, methods, and computer program products are described.

Abstract: In one respect, there is provided a system for training a neural network adapted for classifying one or more scripts. The system may include at least one processor and at least one memory. The memory may include program code that provides operations when executed by the at least one memory. The operations may include: extracting, from an icon associated with a file, one or more features; assigning, based at least on the one or more features, the icon to one of a plurality of clusters; and generating, based at least on the cluster to which the icon is assigned, a classification for the file associated with the icon. Related methods and articles of manufacture, including computer program products, are also provided.

Abstract: A pharmaceutical composition of a polyethylene glycol-modified camptothecin derivative and a preparation method thereof. The pharmaceutical composition is prepared mainly from following components: a camptothecin derivative modified by polyethylene glycol, a pH value adjustment agent and water for injection. The pharmaceutical composition has high stability.

Abstract: Differing from the fact that the amount of register units and adder units arranged in conventional moving average filter must be increased for processing more number of reference input signals, the present invention particularly discloses a moving average low-pass filtering device. The moving average low-pass filtering device comprises a register unit and a filtering and processing unit, and is able to use identical circuit architecture to successfully treat reference input signals with a filtering process even if the number of the reference input signals is alternatively increased. Moreover, after finishing a verification experiment by a simulator, simulation results have proved that, this novel moving average low-pass filtering device still can use identical circuit architecture to complete the filtering process under nearly the same calculation efficiency even though the number of the reference input signals is alternatively increased.

Abstract: An endpoint computer system can harvest data relating to a plurality of events occurring within an operating environment of the endpoint computer system and can add the harvested data to a local data store maintained on the endpoint computer system. In some examples, the local data store can be an audit log and/or can include one or more tamper resistant features. Systems, methods, and computer program products are described.

Abstract: An endpoint computer system can harvest data relating to a plurality of events occurring within an operating environment of the endpoint computer system and can add the harvested data to a local data store maintained on the endpoint computer system. A query response can be generated, for example by identifying and retrieving responsive data from the local data store. The responsive data are related to an artifact on the endpoint computer system and/or to an event of the plurality of events. In some examples, the local data store can be an audit log and/or can include one or more tamper resistant features. Systems, methods, and computer program products are described.

Abstract: In one respect, there is provided a system for training a neural network adapted for classifying one or more scripts. The system may include at least one processor and at least one memory. The memory may include program code that provides operations when executed by the at least one memory. The operations may include: extracting, from an icon associated with a file, one or more features; assigning, based at least on the one or more features, the icon to one of a plurality of clusters; and generating, based at least on the cluster to which the icon is assigned, a classification for the file associated with the icon. Related methods and articles of manufacture, including computer program products, are also provided.