Patents by Inventor Xuechao Xie

Xuechao Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered Hansenula fungi efficiently expressing CA10 virus-like particles and uses thereof
    Patent number: 12251435
    Abstract: The present disclosure provides an engineered Hansenula fungus that efficiently expresses CA10 (Coxsackievirus A10) virus-like particles and uses thereof. The engineered fungus includes a recombinant vector carrying the P1 and 3CD genes of the CA10 virus optimized according to preferred codons of Hansenula. The present disclosure also provides a preparation method for CA10 virus-like particles and vaccines prepared therefrom.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: March 18, 2025
    Assignee: Beijing Minhai Biotechnology Co., Ltd.
    Inventors: Guoshun Li, Meirong Gu, Lin Guo, Wei Jian, Junjie Liu, Haifeng Xiao, Gaimei Zhang, Lili Zhao, Xuechao Xie, Lei Chen, Yingzhi Xu, Jiankai Liu
  • HANSENULA ENGINEERING FUNGI EFFICIENTLY EXPRESSING CA10 VIRUS-LIKE PARTICLES AND USE THEREOF
    Publication number: 20220118075
    Abstract: The present invention provides a Hansenula engineering fungus that efficiently expresses CA10 virus-like particles and use thereof. The engineering fungus comprises a recombinant vector carrying P1 and 3CD genes of the CA10 virus, and the starting strain of the engineering fungus is uracil auxotroph. The Hansenula AU-0501, P1 and 3CD genes are optimized according to preferred codons of Hansenula. The present invention also provides a preparation method of CA10 virus-like particles, comprising: culturing engineering fungi, expressing CA10 virus-like particles, and separating and purifying virus-like particles by ultrafiltration and three-step chromatography.
    Type: Application
    Filed: September 3, 2020
    Publication date: April 21, 2022
    Inventors: Guoshun Li, Meirong Gu, Lin Guo, Wei Jian, Junjie Liu, Haifeng Xiao, Gaimei Zhang, Lili Zhao, Xuechao Xie, Lei Chen, Yingzhi Xu, Jiankai Liu