Abstract: Embodiments of various aspects described herein are directed to amplification of biological entities, for example, for phage display. In one aspect, members of a library of biological entities are encapsulated in separate compartments (e.g., in separate microfluidic droplets) and amplified. For example, by putting members of a phage display library into microfluidic droplets such that no droplet contains more than one member of the library, the library can be amplified without any substantial changes in population distributions, or other artifacts created due to differences in growth rates or amplification between different members of the library. In some cases, the volume of the compartments can be used to control the copy number of a biological entity during amplification. This can be advantageous, for example, in preserving diversity within a library by preventing rapidly amplifying biological entities from outcompeting slowly amplifying biological entities.

Abstract: A product packaging is disclosed, including a rear panel, a front panel coupled to the rear panel, and an intermediate panel between the front panel and the rear panel. The intermediate panel may include a spacing segment that spaces a lip portion of the front panel away from the rear panel, and the intermediate panel may define a product-receiving recess of the packaging.

Abstract: The subject multimodal surgical gas delivery system configured to couple to one or more surgical devices providing access into a patient body cavity includes a computer-controlled control unit configured and adapted to provide at least one of the following modes of operation. A first mode of operation for providing a pressurized insufflation fluid from an insufflation gas source into a surgical device for providing and maintaining sealable access to the body cavity in a surgical device. A second mode of operation for performing smoke evacuation in a filter element from insufflation fluid caused to recycle through the multimodal system from the body cavity via a surgical device. A third mode of operation for providing insufflation fluid from the insufflation gas source into the body cavity for creating and maintaining insufflation of the body cavity.

Abstract: A surgical gas delivery system is disclosed that includes a device housing supporting a control unit and a filter interface having a seat for receiving a filter cartridge, the filter cartridge having a filter housing defining an interior reservoir, wherein sensors are coupled to the control unit for sensing a level of liquid within the reservoir of the filter cartridge to prevent contamination of the device, and wherein a set of blocking valves are provided in the device housing for interacting with the filter cartridge when it is received in the filter interface to control flow through suction and pressure lines of the device, and wherein the control unit is adapted to recognize a characteristic of the filter cartridge received in the filter interface.

Abstract: A surgical gas delivery system is disclosed that includes a device housing supporting a control unit and a filter interface having a seat for receiving a filter cartridge, the filter cartridge having a filter housing defining an interior reservoir, wherein sensors are coupled to the control unit for sensing a level of liquid within the reservoir of the filter cartridge to prevent contamination of the device, and wherein a set of blocking valves are provided in the device housing for interacting with the filter cartridge when it is received in the filter interface to control flow through suction and pressure lines of the device, and wherein the control unit is adapted to recognize a characteristic of the filter cartridge received in the filter interface.

Abstract: A surgical gas delivery system is disclosed that includes a device housing supporting a control unit and a filter interface having a seat for receiving a filter cartridge, the filter cartridge having a filter housing defining an interior reservoir, wherein sensors are coupled to the control unit for sensing a level of liquid within the reservoir of the filter cartridge to prevent contamination of the device, and wherein a set of blocking valves are provided in the device housing for interacting with the filter cartridge when it is received in the filter interface to control flow through suction and pressure lines of the device, and wherein the control unit is adapted to recognize a characteristic of the filter cartridge received in the filter interface.

Abstract: A surgical gas delivery system is disclosed that includes a device housing supporting a control unit and a filter interface having a seat for receiving a filter cartridge, the filter cartridge having a filter housing defining an interior reservoir, wherein sensors are coupled to the control unit for sensing a level of liquid within the reservoir of the filter cartridge to prevent contamination of the device, and wherein a set of blocking valves are provided in the device housing for interacting with the filter cartridge when it is received in the filter interface to control flow through suction and pressure lines of the device, and wherein the control unit is adapted to recognize a characteristic of the filter cartridge received in the filter interface.

Abstract: A valve assembly and method are provided for selectively controlling a flow of pressurized fluid from a fluid source to trocar assemblies.

Abstract: A valve assembly and method are provided for selectively controlling a flow of pressurized fluid from a fluid source to trocar assemblies. The valve assembly includes a first coupling configured and adapted to couple to a primary trocar assembly for directing pressurized fluid and a second coupling to couple to a secondary trocar assembly. A third coupling is provided to couple to a source of pressurized fluid for directing pressurized fluid from the source to the first and second couplings. Also provided is at least one valve member adapted and configured to be operable in at least first and second operating positions.

Abstract: A valve assembly and method are provided for selectively controlling a flow of pressurized fluid from a fluid source to trocar assemblies. The valve assembly includes a first coupling configured and adapted to couple to a primary trocar assembly for directing pressurized fluid and a second coupling to couple to a secondary trocar assembly. A third coupling is provided to couple to a source of pressurized fluid for directing pressurized fluid from the source to the first and second couplings. Also provided is at least one valve member adapted and configured to be operable in at least first and second operating positions.

Abstract: Systems and methods for assisting/performing image-guided transjugular intrahepatic portosystemic shunt (TIPS) procedures in a portion of an anatomy of a patient include a guide needle portion having a hollow tube with a bend toward its distal tip, and a puncture needle portion that includes at least one position indicating element at its tip. The puncture needle is slidably mounted within the hollow tube of the guide needle such that a distal tip of the puncture needle can be extended from an opening in the distal tip of the guide needle and used to place a shunt between the portal and hepatic veins of a patient. The position indicating element of the puncture needle is used to produce a display of the puncture needle relative to a target vessel, including a projected path of the puncture needle that can be adjusted to accurately locate a shunt.

Abstract: The present invention generally relates to amplification of biological entities, for example, for phage display. In one aspect, members of a library of biological entities are encapsulated in separate compartments (e.g., in separate microfluidic droplets) and amplified. As a specific example, by putting members of a phage display library into microfluidic droplets such that no droplet contains more than one member of the library, the library can be amplified without any substantial changes in growth rates or population distributions, or other artifacts created due to differences in growth rates or amplification between different members of the library. In some cases, the volume of the compartments can be used to control the copy number of a biological entity during amplification. In certain cases, biological entities with different amplification rates can be amplified independently of each other.

Abstract: A high bandwidth, low latency middle-mile core communications network providing low-cost and high-speed communications among the users of the network. Embodiments of the invention include a number of network access points located at a number of spaced apart sites. At least some of these network access points in the network are in communication with each other via millimeter radio links with microwave backup links. In preferred embodiments the millimeter radio links include two millimeter radios, one transmitting in the frequency range of 71-76 GHz and receiving in the frequency range if 81 to 86 GHz and the other radio transmitting in the frequency range of 81-86 GHz and receiving in the frequency range if 71 to 76 GHz.

Abstract: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.

Abstract: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.

Abstract: The subject multimodal surgical gas delivery system configured to couple to one or more surgical devices providing access into a patient body cavity includes a computer-controlled control unit configured and adapted to provide at least one of the following modes of operation. A first mode of operation for providing a pressurized insufflation fluid from an insufflation gas source into a surgical device for providing and maintaining sealable access to the body cavity in a surgical device. A second mode of operation for performing smoke evacuation in a filter element from insufflation fluid caused to recycle through the multimodal system from the body cavity via a surgical device. A third mode of operation for providing insufflation fluid from the insufflation gas source into the body cavity for creating and maintaining insufflation of the body cavity.

Abstract: A high bandwidth, low latency middle-mile core communications network providing low-cost and high-speed communications among the users of the network. Embodiments of the invention include a number of network access points located at a number of spaced apart sites. At least some of these network access points in the network are in communication with each other via millimeter radio links with microwave backup links. In preferred embodiments the millimeter radio links include two millimeter radios, one transmitting in the frequency range of 71-76 GHz and receiving in the frequency range if 81 to 86 GHz and the other radio transmitting in the frequency range of 81-86 GHz and receiving in the frequency range if 71 to 76 GHz. In these preferred embodiments each millimeter wave radio is equipped with an antenna designed to produce a millimeter wave beam with an angular spread of less than two degrees. A high-speed switch is located at each network access point.

Abstract: The invention provides novel GlyT2 inhibiting compounds useful in modulating, treating, or preventing: anxiolytic disorders; a condition requiring treatment of injured mammalian nerve tissue; a condition amenable to treatment through administration of a neurotrophic factor; a neurological disorder; or obesity; an obesity-related disorder.

Abstract: Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.