Patents by Inventor Y.-W Lee

Y.-W Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Natriuretic polypeptides
    Patent number: 10344068
    Abstract: This document provides methods and materials related to natriuretic polypeptides and the use of natriuretic polypeptides to treat cardiovascular and/or renal conditions. For example, chimeric polypeptides having at least one amino acid segment (e.g., N-terminus tail, ring structure, C-terminus tail, or a combination thereof) of a natriuretic peptide (e.g., ANP, BNP, CNP, URO, or DNP) and an amino acid segment of an angiotensin polypeptide (e.g., Ang-(1-7)) are provided.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: July 9, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Candace Y. W. Lee, John C. Burnett, Jr.
  • Nucleic acids encoding for chimeric natriuretic polypeptides with unique pharmacologic profiles
    Patent number: 9771405
    Abstract: This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity. In some cases, a polypeptide provided herein can have natriuretic activities without inducing excessive hypotension. This document also provides methods and materials for inducing natriuretic activities within a mammal.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: September 26, 2017
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: John C. Burnett, Jr., Candace Y. W. Lee
  • NATRIURETIC POLYPEPTIDES
    Publication number: 20170129934
    Abstract: This document provides methods and materials related to natriuretic polypeptides and the use of natriuretic polypeptides to treat cardiovascular and/or renal conditions. For example, chimeric polypeptides having at least one amino acid segment (e.g., N-terminus tail, ring structure, C-terminus tail, or a combination thereof) of a natriuretic peptide (e.g., ANP, BNP, CNP, URO, or DNP) and an amino acid segment of an angiotensin polypeptide (e.g., Ang-(1-7)) are provided.
    Type: Application
    Filed: January 20, 2017
    Publication date: May 11, 2017
    Inventors: Candace Y.W. Lee, John C. Burnett, JR.
  • Natriuretic polypeptides
    Patent number: 9587004
    Abstract: This document provides methods and materials related to natriuretic polypeptides and the use of natriuretic polypeptides to treat cardiovascular and/or renal conditions. For example, chimeric polypeptides having at least one amino acid segment (e.g., N-terminus tail, ring structure, C-terminus tail, or a combination thereof) of a natriuretic peptide (e.g., ANP, BNP, CNP, URO, or DNP) and an amino acid segment of an angiotensin polypeptide (e.g., Ang-(1-7)) are provided.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: March 7, 2017
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Candace Y. W. Lee, John C. Burnett, Jr.
  • NATRIURETIC POLYPEPTIDES
    Publication number: 20160362468
    Abstract: This document provides methods and materials related to natriuretic polypeptides and the use of natriuretic polypeptides to treat cardiovascular and/or renal conditions. For example, chimeric polypeptides having at least one amino acid segment (e.g., N-terminus tail, ring structure, C-terminus tail, or a combination thereof) of a natriuretic peptide (e.g., ANP, BNP, CNP, URO, or DNP) and an amino acid segment of an angiotensin polypeptide (e.g., Ang-(1-7)) are provided.
    Type: Application
    Filed: August 9, 2016
    Publication date: December 15, 2016
    Inventors: Candace Y.W. Lee, John C. Burnett, Jr.
  • Natriuretic polypeptides
    Patent number: 9441027
    Abstract: This document provides methods and materials related to natriuretic polypeptides and the use of natriuretic polypeptides to treat cardiovascular and/or renal conditions. For example, chimeric polypeptides having at least one amino acid segment (e.g., N-terminus tail, ring structure, C-terminus tail, or a combination thereof) of a natriuretic peptide (e.g., ANP, BNP, CNP, URO, or DNP) and an amino acid segment of an angiotensin polypeptide (e.g., Ang-(1-7)) are provided.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: September 13, 2016
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Candace Y.W. Lee, John C. Burnett, Jr.
  • NATRIURETIC POLYPEPTIDES WITH UNIQUE PHARMACOLOGIC PROFILES
    Publication number: 20160244500
    Abstract: This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity. In some cases, a polypeptide provided herein can have natriuretic activities without inducing excessive hypotension. This document also provides methods and materials for inducing natriuretic activities within a mammal.
    Type: Application
    Filed: May 13, 2016
    Publication date: August 25, 2016
    Inventors: John C. Burnett, JR., Candace Y.W. Lee
  • Method of increasing natriuretic activity by administering natriuretic polypeptides with unique pharmacologic profiles
    Patent number: 9365631
    Abstract: This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity. In some cases, a polypeptide provided herein can have natriuretic activities without inducing excessive hypotension. This document also provides methods and materials for inducing natriuretic activities within a mammal.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: June 14, 2016
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: John C. Burnett, Jr., Candace Y. W. Lee
  • NATRIURETIC POLYPEPTIDES WITH UNIQUE PHARMACOLOGIC PROFILES
    Publication number: 20150322127
    Abstract: This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity. In some cases, a polypeptide provided herein can have natriuretic activities without inducing excessive hypotension. This document also provides methods and materials for inducing natriuretic activities within a mammal.
    Type: Application
    Filed: July 28, 2015
    Publication date: November 12, 2015
    Inventors: John C. Burnett, Jr., Candace Y.W. Lee
  • NATRIURETIC POLYPEPTIDES
    Publication number: 20150299284
    Abstract: This document provides methods and materials related to natriuretic polypeptides and the use of natriuretic polypeptides to treat cardiovascular and/or renal conditions. For example, chimeric polypeptides having at least one amino acid segment (e.g., N-terminus tail, ring structure, C-terminus tail, or a combination thereof) of a natriuretic peptide (e.g., ANP, BNP, CNP, URO, or DNP) and an amino acid segment of an angiotensin polypeptide (e.g., Ang-(1-7)) are provided.
    Type: Application
    Filed: July 2, 2015
    Publication date: October 22, 2015
    Inventors: Candace Y.W. Lee, John C. Burnett, JR.
  • Method of treatment of cardiovascular or renal conditions with natriuretic polypeptides with unique pharmacologic profiles
    Patent number: 9115209
    Abstract: This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity. In some cases, a polypeptide provided herein can have natriuretic activities without inducing excessive hypotension. This document also provides methods and materials for inducing natriuretic activities within a mammal.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: August 25, 2015
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: John C. Burnett, Jr., Candace Y. W. Lee
  • Natriuretic polypeptides
    Patent number: 9102707
    Abstract: This document provides methods and materials related to natriuretic polypeptides and the use of natriuretic polypeptides to treat cardiovascular and/or renal conditions. For example, chimeric polypeptides having at least one amino acid segment (e.g., N-terminus tail, ring structure, C-terminus tail, or a combination thereof) of a natriuretic peptide (e.g., ANP, BNP, CNP, URO, or DNP) and an amino acid segment of an angiotensin polypeptide (e.g., Ang-(1-7)) are provided.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: August 11, 2015
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Candace Y. W. Lee, John C. Burnett, Jr.
  • Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia
    Patent number: 9056136
    Abstract: The present invention incorporates weakly basic substituents (pKa about 8 or greater) such as pyrrolidine, piperidine, piperazine and azapane moieties in halogenated 2-nitromidazoles for the non-invasive detection of cellular hypoxia in normal and malignant tissues. The compounds of the invention can be used in 18F positron emission tomography, 19F magnetic resonance spectroscopy, and 19F magnetic resonance imaging.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: June 16, 2015
    Assignee: Natural Pharmacia International, Inc.
    Inventors: James A. Raleigh, David Y-W Lee, Xiaoshen Ji
  • NATRIURETIC POLYPEPTIDES WITH UNIQUE PHARMACOLOGIC PROFILES
    Publication number: 20140228294
    Abstract: This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity. In some cases, a polypeptide provided herein can have natriuretic activities without inducing excessive hypotension. This document also provides methods and materials for inducing natriuretic activities within a mammal.
    Type: Application
    Filed: April 21, 2014
    Publication date: August 14, 2014
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: John C. Burnett, JR., Candace Y.W. Lee
  • Chimeric natriuretic polypeptides with unique pharmacologic profiles
    Patent number: 8741842
    Abstract: This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity. In some cases, a polypeptide provided herein can have natriuretic activities without inducing excessive hypotension. This document also provides methods and materials for inducing natriuretic activities within a mammal.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: June 3, 2014
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: John C. Burnett, Jr., Candace Y. W. Lee
  • NATRIURETIC POLYPEPTIDES
    Publication number: 20140005358
    Abstract: This document provides methods and materials related to natriuretic polypeptides and the use of natriuretic polypeptides to treat cardiovascular and/or renal conditions. For example, chimeric polypeptides having at least one amino acid segment (e.g., N-terminus tail, ring structure, C-terminus tail, or a combination thereof) of a natriuretic peptide (e.g., ANP, BNP, CNP, URO, or DNP) and an amino acid segment of an angiotensin polypeptide (e.g., Ang-(1-7)) are provided.
    Type: Application
    Filed: August 21, 2012
    Publication date: January 2, 2014
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Candace Y.W. Lee, John C. Burnett, Jr.
  • Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
    Patent number: 8518371
    Abstract: The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: August 27, 2013
    Assignee: Natural Pharmacia International, Inc.
    Inventors: David Y-W Lee, Xiao-Shen Ji, James A. Raleigh
  • NATRIURETIC POLYPEPTIDES WITH UNIQUE PHARMACOLOGIC PROFILES
    Publication number: 20110152191
    Abstract: This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity. In some cases, a polypeptide provided herein can have natriuretic activities without inducing excessive hypotension. This document also provides methods and materials for inducing natriuretic activities within a mammal.
    Type: Application
    Filed: June 16, 2009
    Publication date: June 23, 2011
    Applicant: National Institutes of Health (NIH)
    Inventors: John C. Burnett, Jr., Candace Y.W. Lee
  • HYPOXIA-SELECTIVE, WEAKLY BASIC 2-NITROIMIDAZOLE DELIVERY AGENTS AND METHODS OF USE THEREOF
    Publication number: 20110085975
    Abstract: The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.
    Type: Application
    Filed: November 29, 2010
    Publication date: April 14, 2011
    Applicant: NATURAL PHARMACIA INTERNATIONAL, INC.
    Inventors: David Y-W Lee, Xiao-Shen Ji, James A. Raleigh
  • Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
    Patent number: 7842278
    Abstract: The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: November 30, 2010
    Assignee: Natural Pharmacia International, Inc.
    Inventors: David Y-W Lee, Xiao-Shen Ji, James A. Raleigh