Patents by Inventor Yanan Liu

Yanan Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11938222
    Abstract: The present application relates to a pregabalin sustained release composition, comprising: (a) an active ingredient; (b) a matrix-forming agent; (c) a swelling agent; (d) a gelling agent; and optionally a filler. The pregabalin sustained release composition provided in the present application can rapidly swell in volume when exposed to aqueous medium until exceeding the dimeter of human gastric pyloric (13 mm). It thereby prolongs the gastric emptying time to increase the retention time of pregabalin in the stomach and enhances absorption of pregabalin in the small intestine and ascending colon. Moreover, the pregabalin sustained release composition provided herein achieves a sustained release for 24 h, which allows QD (once a day) administration, reduces administration number, and improves patient compliance.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: March 26, 2024
    Assignee: BEIJING TIDE PHARMACEUTICAL CO., LTD.
    Inventors: Zhaolu Zhu, Yun Wu, Di Lu, Yanping Zhao, Liying Zhou, Yanan Liu
  • Patent number: 11939578
    Abstract: The present invention relates to the field of biomedicine, particularly to double-stranded RNA molecules targeting CKIP-1 and uses thereof, particularly to use of the double-stranded RNA molecules for the treatment of inflammatory diseases such as arthritis, particularly rheumatoid arthritis.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: March 26, 2024
    Assignee: BEIJING TIDE PHARMACEUTICAL CO., LTD.
    Inventors: Yanping Zhao, Hongjun Wang, Yuanyuan Jiang, Weiting Zhong, Jianmei Pang, Gong Li, Xiang Li, Yixin He, Liying Zhou, Yanan Liu
  • Publication number: 20240082833
    Abstract: The present invention provides a supported metal catalyst with synergistic sites, a preparation method therefor and an application thereof. The preparation method of this catalyst is to utilize the unsaturated cubane-like structure, M cation with catalytic activity is introduced into the cluster core unit. By using the vertex vacancy as the capturing center, and adjusting the impregnation temperature to maximize the loading of the cluster precursor, as well as depending on the electrostatic adsorption of the support and the confinement of the cluster structural unit, the number of S vacancies and the distance between S vacancies and Miso sites are effectively controlled through liquid phase reduction and atmosphere treatment at room temperature to obtain supported X3MSx/Al2O3 catalyst with Miso-Vs synergistic sites.
    Type: Application
    Filed: August 18, 2023
    Publication date: March 14, 2024
    Inventors: Yanan Liu, Dianqing Li, He Yu, Ning Li
  • Publication number: 20240084114
    Abstract: A method for preparing a rubber for an elastomer of a flexible joint, includes: weighing hydrogenated nitrile raw rubber, a silica reinforcing agent, aramid fiber pulp, carbon black, liquid nitrile rubber, zinc oxide, stearic acid, an antioxidant, and a peroxide crosslinking agent; plasticating the hydrogenated nitrile raw rubber in a first internal mixer at 125-135° C., collecting a resulting product and cooling, to yield a plasticized rubber; preheating the liquid nitrile rubber; adding the plasticized rubber to a second internal mixer, further adding the aramid fiber pulp, the zinc oxide, the stearic acid, and the antioxidant to the second internal mixer for first mixing; adding the carbon black to the second internal mixer for second mixing; adding the silica reinforcing agent and the preheated liquid nitrile rubber to the second internal mixer for third mixing; and collecting a discharged product when a temperature of the second internal mixer is 140° C.
    Type: Application
    Filed: November 22, 2023
    Publication date: March 14, 2024
    Inventors: Jianbo JI, Changqing YE, Jing FENG, Yanan HOU, Bo SUN, Gui ZHANG, Rui LIU
  • Patent number: 11919918
    Abstract: A P2X3 and/or P2X2/3 receptor antagonist of formula (I), a pharmaceutical composition comprising the same, and a use thereof in preparing a drug for preventing or treating a disease mediated by the P2X3 and/or P2X2/3 receptor antagonist.
    Type: Grant
    Filed: May 27, 2022
    Date of Patent: March 5, 2024
    Assignee: BEIJING TIDE PHARMACEUTICAL CO., LTD.
    Inventors: Yanping Zhao, Hongjun Wang, Gong Li, Xiang Li, Yuanyuan Jiang, Kai Liu, Yeming Wang, Liying Zhou, Yanan Liu, Ning Shao, Fengping Xiao
  • Patent number: 11905274
    Abstract: The present invention discloses a receptor inhibitor of formula (I), a composition comprising the same and the usage thereof.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: February 20, 2024
    Assignee: BEIJING TIDE PHARMACEUTICAL CO., LTD.
    Inventors: Yanping Zhao, Hongjun Wang, Gong Li, Xiang Li, Yuanyuan Jiang, Yeming Wang, Huai Huang, Liying Zhou, Yanan Liu, Ning Shao, Fengping Xiao, Zhenguang Zou
  • Publication number: 20230390753
    Abstract: The present invention discloses a hollow spherical catalyst for a fixed bed with internal fluidization of particles and a method for preparing the same. The preparation method used in the present invention is characterized in: fully mixing precious metal nanopowder with an organic oil phase to form an internal oil phase; preparing a gel ball of an oil-in-water structure by taking an aluminum oxide molding solution as an outer aqueous phase using an independently researched and developed coaxial dual-dropper forming apparatus; and then preparing a hollow aluminum oxide catalyst containing precious metal powder from the gel ball through processes of aging, calcination, and reduction. The resulting catalyst is expressed as X@Al2O3, where the precious metal nanopowder X is wrapped inside hollow Al2O3, and the catalyst has an outer diameter of 1.5-5.0 mm, a shell pore diameter (aluminum oxide) of 10-50 nm, and the precious metal nanopowder sized 200-500 nm.
    Type: Application
    Filed: May 12, 2023
    Publication date: December 7, 2023
    Inventors: YUFEI HE, XINGYE LIN, DIANQING LI, SHUAI CHEN, YANAN LIU, JUNTING FENG
  • Publication number: 20230259245
    Abstract: The prevent disclosure provides a method and apparatus for adjusting a perspective of a direction indicator, an electronic device, and a storage medium, which includes that: a first area and a second area corresponding to a first direction indicator are acquired, where the first direction indicator is configured to indicate a forward direction in a panorama display scene, the first area is a visible area of the first direction indicator in a graphical user interface, and the second area is an invisible area of the first direction indicator outside the graphical user interface; an initial perspective range corresponding to the second area is acquired; a target perspective range to which a first perspective belongs is determined from the initial perspective range, and a second direction indicator corresponding to the target perspective range is displayed; and the first perspective is adjusted to a second perspective based on the second direction indicator.
    Type: Application
    Filed: July 18, 2022
    Publication date: August 17, 2023
    Inventors: Yanan LIU, Da QU
  • Publication number: 20230212160
    Abstract: Provided are compounds represented by general formula (I), which can be used for treating ATR kinase-mediated diseases, such as proliferative diseases, such as cancer. Further provided are a pharmaceutical composition of the compound represented by general formula (I), a use thereof in treating ATR kinase-mediated diseases, and a preparation thereof.
    Type: Application
    Filed: May 20, 2021
    Publication date: July 6, 2023
    Inventors: Yanping Zhao, Bin Liu, Yuanyuan Jiang, Weiting Zhong, Huifen Xu, Hongjun Wang, Li Mao, Jingtao Li, Honglei Zhang, Chuangchuang Huang, Jing .. Li, Jing Zhao, Weina Liu, Nana Tian, Liying Zhou, Yanan Liu
  • Patent number: 11691138
    Abstract: Cuy/MMgOx interfacial catalyst for selective alkyne hydrogenation and its preparation method are disclosed. The preparation method of the catalyst includes: the mixture of salt and alkali solution is nucleated momentarily by nucleation/crystallization isolation method, preparing the composite metal hydroxide CuyMMg4-LDHs as precursor, which has typical hexagonal morphology of the double hydroxide; the precursor is topologically transformed by heat treatment to produce unsaturated oxide; the catalyst with Cuy-MMgOx interface structure is prepared by separating and electronically modifying Cu particles. By adjusting the ratio of Cu2+/M3+ in LDHs, the electronic and geometric structure of Cuy-MMgOx interface can be flexibly controlled, thus enhancing the reaction activity, product selectivity and stability. The catalyst can be used in the selective hydrogenation of various alkynes in the fields of petrochemical and fine chemical industry, with the outstanding catalytic activity and C?C double bond selectivity.
    Type: Grant
    Filed: May 31, 2021
    Date of Patent: July 4, 2023
    Assignee: Beijing University of Chemical Technology
    Inventors: Yanan Liu, Junting Feng, Fengzhi Fu, Dianqing Li, Yufei He
  • Publication number: 20230191373
    Abstract: The present invention discloses a catalyst for in-situ CO2 capture and coupling reduction with biomass oxidation, a preparation method therefor and an application thereof. The catalyst is applied to the coupling reaction of photocatalytic CO2 reduction and biomass oxidation. The preparation of the catalyst is to synthesize layered double hydroxides (LDHs) containing CO32? between layers by using coprecipitation method, hydrothermal method, sol-gel method and the like, wherein the chemical formula is [M1-x2+Mx3+(OH)2]x+(An?)x/n·mH2O, which has a thickness of 20-30 nm and an average particle diameter of 60-90 nm. Then metal ion vacancy defects are produced on LDHs laminate by using a NaOH/KOH selective etching to obtain the corresponding catalyst.
    Type: Application
    Filed: December 4, 2022
    Publication date: June 22, 2023
    Inventors: Junting Feng, Dianqing LI, Qian Wang, Jiaxuan Fan, Xiaoxue Yue, Yufei He, Yanan Liu
  • Publication number: 20230030115
    Abstract: The present invention relates to a Rho-associated protein kinase inhibitor of formula (I), a pharmaceutical composition comprising the same, a preparation method thereof, and a use of the same in preventing or treating a disease mediated by Rho-associated protein kinase (ROCK).
    Type: Application
    Filed: July 6, 2021
    Publication date: February 2, 2023
    Inventors: Yanping ZHAO, Hongjun WANG, Gong LI, Yuanyuan JIANG, Xiang LI, Bin LIU, Weiting ZHONG, Kai LIU, Fajie LI, Liying ZHOU, Yanan LIU
  • Publication number: 20230001393
    Abstract: A catalyst for pyrolysis of 1,2-dichloroethane (1,2-DCE) to prepare vinyl chloride monomer (VCM), a preparation method, a use, and a regeneration method thereof are provided. The catalyst for pyrolysis of 1,2-DCE to prepare VCM includes a silicon-aluminum molecular sieve. The catalyst for pyrolysis of 1,2-DCE to prepare VCM has high reaction activity and excellent selectivity and solves the problem that the pyrolysis of 1,2-DCE to prepare VCM in the prior art involves high reaction temperature and large energy consumption and is prone to coking and carbon deposition.
    Type: Application
    Filed: December 12, 2019
    Publication date: January 5, 2023
    Applicant: DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Guangye LIU, Danhua YUAN, Yunpeng XU, Zhongmin LIU, Yanan LIU, Changmin BAI, Wei HUANG, Zhaoan CHEN, Shiying LI
  • Publication number: 20220416167
    Abstract: An osmium-containing conjugated polymer and methods thereof. A structural formula of the osmium-containing conjugated polymer is formula I, a reaction formula of the osmium-containing conjugated polymer is a formula II.
    Type: Application
    Filed: July 8, 2022
    Publication date: December 29, 2022
    Inventors: Haiping Xia, Shiyan Chen, Xiang Gao, Ying Zhang, Yanan Liu, Yongfa Zhu, Lixia Peng, Yapeng Cai, Qingde Zhuo, Liulin Yang, Xumin He, Hong Zhang
  • Publication number: 20220389039
    Abstract: A P2X3 and/or P2X2/3 receptor antagonist of formula (I), a pharmaceutical composition comprising the same, and a use thereof in preparing a drug for preventing or treating a disease mediated by the P2X3 and/or P2X2/3 receptor antagonist.
    Type: Application
    Filed: May 27, 2022
    Publication date: December 8, 2022
    Inventors: Yanping ZHAO, Hongjun WANG, Gong LI, Xiang LI, Yuanyuan JIANG, Kai LIU, Yeming WANG, Liying ZHOU, Yanan LIU, Ning SHAO, Fengping XIAO
  • Publication number: 20220378799
    Abstract: Compounds of general formula (A) can be used for treating ATR kinase-mediated diseases, for example, hyperplastic diseases such as cancers. Also provided are a pharmaceutical composition of the compounds of general formula (A), a use of the pharmaceutical composition for treating the ATR kinase-mediated diseases and a preparation method for the pharmaceutical composition.
    Type: Application
    Filed: June 5, 2020
    Publication date: December 1, 2022
    Inventors: Yanping Zhao, Hongjun Wang, Bin Liu, Yuanyuan Jiang, Weiting Zhong, Huifen Xu, Honglei Zhang, Chuangchuang Huang, Nana Tian, Jing Zhao, Jing Li, Weina Liu, Liying Zhou, Yanan Liu
  • Publication number: 20220378743
    Abstract: The present invention falls within the field of biological medicine, and specifically relates to a method for preventing, alleviating and/or treating fatty liver disease and/or steatohepatitis. The method comprises administering, to an individual in need thereof, an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt, an ester, a stereoisomer, a polymorph, a solvate, an N-oxide, an isotopically labeled compound, a metabolite or a prodrug thereof.
    Type: Application
    Filed: February 26, 2020
    Publication date: December 1, 2022
    Applicant: BEIJING TIDE PHARMACEUTICAL CO., LTD.
    Inventors: Yuanyuan JIANG, Weiting ZHONG, Yanping ZHAO, Hongjun WANG, Jing ZHAO, Jing Li, Weina LIU, Liying ZHOU, Yanan LIU
  • Publication number: 20220332714
    Abstract: Disclosed are a P2X3 and/or P2X2/3 receptor antagonist of formula (I), a pharmaceutical composition containing same, and the use thereof for preventing or treating a disease regulated by the P2X3 and/or P2X2/3 receptor antagonist.
    Type: Application
    Filed: June 5, 2020
    Publication date: October 20, 2022
    Inventors: Yanping ZHAO, Hongjun WANG, Yeming WANG, Liying ZHOU, YANAN LIU
  • Patent number: 11414444
    Abstract: A P2X3 and/or P2X2/3 receptor antagonist of formula (I), a pharmaceutical composition comprising the same, and a use thereof in preparing a drag for preventing or treating a disease mediated by the P2X3 and/or P2X2/3 receptor antagonist.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: August 16, 2022
    Assignee: BEIJING TIDE PHARMACEUTICAL CO., LTD.
    Inventors: Yanping Zhao, Hongjun Wang, Gong Li, Xiang Li, Yuanyuan Jiang, Kai Liu, Yeming Wang, Liying Zhou, Yanan Liu, Ning Shao, Fengping Xiao
  • Publication number: 20220249478
    Abstract: A method for treating, resisting and alleviating endometriosis-associated pain, relating to the field of biological medicine, comprising administering, to an individual in need thereof, a therapeutically effective amount of a diaminopyrimidine compound of formula (I) or a pharmaceutically acceptable salt, an ester, a stereoisomer, a polymorph, a solvate, an N-oxide, an isotopically labeled compound, a metabolite or a prodrug thereof.
    Type: Application
    Filed: April 29, 2020
    Publication date: August 11, 2022
    Inventors: Yanping ZHAO, Huai HUANG, Hongjun WANG, Yuanyuan JIANG, Huining LIANG, Ran AN, Zhou LAN, Jin WANG, Liying ZHOU, Yanan LIU