Abstract: Disclosed herein are biodegradable scaffolds for in situ tissue engineering. In some examples, biodegradable vascular grafts and methods of fabricating and uses of such are disclosed. In some examples, a vascular graft includes a biodegradable scaffold including a biodegradable polyester tubular core, a biodegradable polyester electrospun outer sheath surrounding the biodegradable polyester tubular core and/or a thromboresistant agent, such as heparin, coating the biodegradable scaffold. The disclosed vascular grafts can be used for forming a blood vessel of less than 6 mm, including, but not limited to a coronary or peripheral arterial.

Abstract: A vascular graft that includes a biodegradable polyester electrospun tubular core; a biodegradable polyester outer sheath surrounding the biodegradable polyester tubular core; and a biodegradable poly(lactide) copolymer adhesive composition (i) disposed between the polyester electrospun tubular core and the polyester outer sheath, (ii) disposed between the polyester electrospun tubular core and the polyester outer sheath and on an outer surface of the polyester outer sheath, (iii) or disposed on an outer surface of the polyester outer sheath.

Abstract: In various embodiments, a subtitle application generates a subtitle list for a trailer. In operation, the subtitle application performs matching operation(s) between trailer audio associated with a trailer and source audio associated with an audiovisual program. The subtitle application then maps a subtitle associated with the source audio from a source timeline associated with the source audio to a trailer timeline associated with the trailer audio to generate a mapped subtitle. Subsequently, the subtitle application generates a trailer subtitle list based on the mapped subtitle and at least one additional mapped subtitle. Because the subtitle application generates the trailer subtitle list based on audio comparisons, the subtitle application ensures that the proper subtitles are included in the trailer subtitle list without requiring a subtitler to view the trailer.

Abstract: A vascular graft that includes a biodegradable polyester electrospun tubular core; a biodegradable polyester outer sheath surrounding the biodegradable polyester tubular core; and a biodegradable poly(lactide) copolymer adhesive composition (i) disposed between the polyester electrospun tubular core and the polyester outer sheath, (ii) disposed between the polyester electrospun tubular core and the polyester outer sheath and on an outer surface of the of the polyester outer sheath, (iii) or disposed on an outer surface of the polyester outer sheath.

Abstract: Disclosed herein are biodegradable scaffolds for in situ tissue engineering. In some examples, biodegradable vascular grafts and methods of fabricating and uses of such are disclosed. In some examples, a vascular graft includes a biodegradable scaffold including a biodegradable polyester tubular core, a biodegradable polyester electrospun outer sheath surrounding the biodegradable polyester tubular core and/or a thromboresistant agent, such as heparin, coating the biodegradable scaffold. The disclosed vascular grafts can be used for forming a blood vessel of less than 6 mm, including, but not limited to a coronary or peripheral arterial.

Abstract: Disclosed are a small-molecule AURKB inhibitor and applications thereof. The invention is directed to a diindolylmethane compound of formula (I) or a stereoisomer, a tautomer, a solvate, a prodrug, a N-oxide or a pharmaceutically acceptable salt thereof. The invention also provides an application of the small-molecule inhibitor and a modified derivative thereof (such as a stereoisomer, a tautomer, a solvate, a prodrug, an N-oxide or a pharmaceutically acceptable salt) in the preparation of an antitumor drug. The small-molecule AURKB inhibitor identified herein is slightly toxic to those normal cells and can significantly inhibit the expression of a downstream gene E2F2 mediated in the phosphorylation of an AURKB substrate histone H3S10. Therefore, the small-molecule inhibitor, as an anti-tumor drug, can effectively inhibit the proliferation of various tumor cells and induce the apoptosis of tumor cells.

Abstract: In various embodiments, a subtitle application generates a subtitle list for a trailer. In operation, the subtitle application performs matching operation(s) between trailer audio associated with a trailer and source audio associated with an audiovisual program. The subtitle application then maps a subtitle associated with the source audio from a source timeline associated with the source audio to a trailer timeline associated with the trailer audio to generate a mapped subtitle. Subsequently, the subtitle application generates a trailer subtitle list based on the mapped subtitle and at least one additional mapped subtitle. Because the subtitle application generates the trailer subtitle list based on audio comparisons, the subtitle application ensures that the proper subtitles are included in the trailer subtitle list without requiring a subtitler to view the trailer.

Abstract: A shear-thinning therapeutic composition is provided along with methods of making and using the therapeutic composition.

Abstract: In one embodiment, a drug is administered to a subject using a transdermal patch that includes a substrate and a layer of pressure-sensitive adhesive provided on the substrate, the pressure-sensitive adhesive comprising a blend of an adhesive compound and a carrier-drug compound, the carrier-drug compound comprising a drug transport compound and a drug that is to be delivered to the skin of the subject, wherein the drug transport compound transports the drug through the pressure-sensitive adhesive to the skin.

Abstract: In various embodiments, a subtitle timing application detects timing errors between subtitles and shot changes. In operation, the subtitle timing application determines that a temporal edge associated with a subtitle does not satisfy a timing guideline based on a shot change. The shot change occurs within a sequence of frames of an audiovisual program. The subtitle timing application then determines a new temporal edge that satisfies the timing guideline relative to the shot change. Subsequently, the subtitle timing application causes a modification to a temporal location of the subtitle within the sequence of frames based on the new temporal edge. Advantageously, the modification to the subtitle improves a quality of a viewing experience for a viewer. Notably, by automatically detecting timing errors, the subtitle timing application facilitates proper and efficient re-scheduling of subtitles that are not optimally timed with shot changes.

Abstract: A shock-absorbing and energy-collecting roller cage shoe including a base, a main energy-collecting module, two auxiliary energy-collecting modules, and a roller is provided. The base is provided with three containing spaces for containing the main energy-collecting module and the two auxiliary energy-collecting modules. In the three containing spaces, the main energy-collecting module and the two auxiliary energy-collecting modules are respectively connected fixedly to the base through wire rope shock absorbers, the main energy-collecting module and the two auxiliary energy-collecting modules are respectively pressed on the left side, the upper side and the lower side of the roller, and the right side of the roller is pressed on a cage guide. The energy-collecting modules collect vibrational energy generated by vibration in the operation process of a lifting container, and convert the vibrational energy into collectable piezoelectric energy.

Abstract: A method is provided for preparing an ECM material, including an ECM gel, from regenerative or regenerating tissue. ECM material prepared from regenerative or regenerating materials also is provided.

Abstract: Compositions are provided herein comprising a coacervate of a polycationic polymer, a polyanionic polymer, and platelet-rich plasma and/or serum, or a fraction or concentrate thereof. The composition is useful in wound healing. Compositions also are provided that comprise a hydrogel comprising TIMP-3; and a complex of a polycationic polymer, a polyanionic polymer, FGF-2 and SDF-1? embedded in the hydrogel, which is useful in treating a myocardial infarction.

Abstract: Provided herein are coacervate compositions including cytokines, and methods of making and using the same. The coacervate can be formed by the mixing of an active agent, such as a drug or protein with the polyanion, such as heparin or heparan sulfate, and a custom-made polycation (e.g., PEAD or PELD). The coacervates can be used in the treatment of diseases and disorders where targeted treatment is desired, for example in treatment of cancers.

Abstract: In one embodiment, a transdermal patch includes a substrate and a layer of pressure-sensitive adhesive provided on the substrate, the pressure-sensitive adhesive comprising a blend of an adhesive compound and a carrier-drug compound, the carrier-drug compound comprising a drug transport compound and a drug that is to be delivered to the skin of a subject, wherein the drug transport compound transports the drug through the pressure-sensitive adhesive to the skin

Abstract: Disclosed herein are methods of electrospinning poly(glycerol sebacate) (PGS) which allow stable PGS fibers and fibrous PGS constructs, scaffolds and grafts to be formed. In one example, a disclosed method includes generating PGS fibers by blending PGS prepolymer with a heat resistant synthetic carrier polymer, wherein the blend is electrospun into micro- or nano-fibers, and the PGS prepolymer is cross-linked into PGS with heat without using chemical cross-linkers. In another example, a disclosed method includes electrospinning a PGS and gelatin blend, wherein the PGS and gelatin composition are cross-linked by heat curing without using chemical cross-linkers. In another example, the method includes preparing an electrospinning precursor solution comprising blending PGS prepolymer with poly(lactic-co-glycolic acid) (PLGA) and a chemical cross-linker; electrospinning the prepared blend; and exposing the electrospun blend to an organic solvent to remove the PLGA.

Abstract: A vascular graft, comprising a biodegradable scaffold comprising: a biodegradable polyester electrospun tubular core; a biodegradable polyester outer sheath surrounding the biodegradable polyester tubular core; and a biodegradable poly(lactide) copolymer adhesive composition (i) disposed between the polyester electrospun tubular core and the polyester outer sheath, (ii) disposed between the polyester electrospun tubular core and the polyester outer sheath and on an outer surface of the polyester outer sheath, (iii) or disposed on an outer surface of the polyester outer sheath.

Abstract: Techniques, described herein, may enable a computing device (e.g., a set-top-box, a user equipment (UE), etc.) with an array of sensors (e.g., microphones, antennas, etc.) to engage in beamforming in a manner that optimizes the signal strength of the target signal. For example, the computing device may create an optimized beam pattern by applying a pre-selected band width to a steering direction of the target signal. The beam width may include steering vectors at equal, angular distances from the steering direction, enabling steep transition slopes to be applied to the optimized beam pattern. In some implementations, the beam width and transition slopes may be standardized, such that the optimized beam pattern for any signal may be uniform, regardless of variables such as frequency and time.

Abstract: Techniques, described herein, may enable a computing device (e.g., a set-top-box, a user equipment (UE), etc.) with an array of sensors (e.g., microphones, antennas, etc.) to engage in beamforming in a manner that optimizes the signal strength of the target signal. For example, the computing device may create an optimized beam pattern by applying a pre-selected band width to a steering direction of the target signal. The beam width may include steering vectors at equal, angular distances from the steering direction, enabling steep transition slopes to be applied to the optimized beam pattern. In some implementations, the beam width and transition slopes may be standardized, such that the optimized beam pattern for any signal may be uniform, regardless of variables such as frequency and time.

Abstract: A shock-absorbing and energy-collecting roller cage shoe including a base, a main energy-collecting module, two auxiliary energy-collecting modules, and a roller is provided. The base is provided with three containing spaces for containing the main energy-collecting module and the two auxiliary energy-collecting modules. In the three containing spaces, the main energy-collecting module and the two auxiliary energy-collecting modules are respectively connected fixedly to the base through wire rope shock absorbers, the main energy-collecting module and the two auxiliary energy-collecting modules are respectively pressed on the left side, the upper side and the lower side of the roller, and the right side of the roller is pressed on a cage guide. The energy-collecting modules collect vibrational energy generated by vibration in the operation process of a lifting container, and convert the vibrational energy into collectable piezoelectric energy.