Patents by Inventor Yair Reisner

Yair Reisner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5858328
    Abstract: A non-human chimeric animal is obtained by transplanting a non-human mammal host having a T cell deficiency with a human liver tissue preparation or with a liver tissue preparation from a non-human animal capable of being infected by the hepatitis virus (HV). The non-human chimeric animal is useful as an HV model for evaluating anti-HV therapy and prophylaxis.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: January 12, 1999
    Assignee: Yeda Research and Development Co. Ltd.
    Inventor: Yair Reisner
  • Patent number: 5849288
    Abstract: Non-human chimeric mammals are created from a mammal having hematopoietic cells replaced with hematopoietic cells from a hematopoietic deficient mammal donor, and in which xenogeneic hematopoietic cells and/or tissue are engrafted. The chimeric mammal can produce xenogeneic, preferably human, B and/or T cells, and can be used as a source of mammalian, preferably human, monoclonal antibodies and/or T cells.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 15, 1998
    Assignee: Yeda Research and Development Co. Ltd.
    Inventor: Yair Reisner
  • Patent number: 5849987
    Abstract: Chimeric mouse and rat models useful as models for human hepatitis virus (HV) infection are disclosed. These chimeras are made by substantially destroying the hematopoietic cells of a host mouse or rat and then transplanting into the resultant animal hematopoietic cells from SCID mice. The resultant chimera is then used as a host for transplantation of xenogeneic liver tissue, including liver tissue from humans. The liver tissue may be infected with HV either prior to or after transplantation.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: December 15, 1998
    Assignee: Yeda Research and Development Co. Ltd.
    Inventor: Yair Reisner
  • Patent number: 5806529
    Abstract: The present invention provides a method for bone marrow transplantation from an HLA-nonmatched donor to a patient which comprises conditioning the patient under a suitable regimen followed by transplant of a very large dose of stem cells which is at least about 3-fold greater than the conventional doses used in T cell-depleted bone marrow transplantation. The patient is conditioned under lethal or supralethal conditions for the treatment of malignant or non-malignant diseases, or under sublethal conditions for the treatment of non-malignant diseases. The transplant may consist of T cell-depleted bone marrow stem cells and T cell-depleted stem cell-enriched peripheral blood cells from the HLA-nonmatched donor. preferably a relative of the patient, which donor was previously treated with a drug, e.g. a cytokine such as granulocyte colony-stimulating factor (G-CSF).
    Type: Grant
    Filed: November 2, 1994
    Date of Patent: September 15, 1998
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yair Reisner, Massimo Martelli
  • Patent number: 5804160
    Abstract: A method of preparing xenogeneic anti-hepatitis virus antibodies from a chimeric mouse or rat host is taught. In this method, tissues including liver tissue of mammals that can be infected with hepatitis virus are transplanted into a mouse or rat and immune cells are subsequently recovered from the transplanted animal. These immune cells are then selected for cells or antibodies that have anti-hepatitis virus reactivity.
    Type: Grant
    Filed: April 8, 1997
    Date of Patent: September 8, 1998
    Assignee: Yeda Research and Development Co. Ltd
    Inventor: Yair Reisner
  • Patent number: 5709843
    Abstract: Non-human chimeric mammals are created from a mammal having hematopoietic cells replaced with hematopoietic cells from a hematopoietic deficient mammal donor, and optionally in which xenogeneic cells and/or tissue are engrafted. The xenogeneic, preferably human, cells or tissue may be hematopoietic cells, in which case the chimeric mammal can produce xenogeneic B and/or T cells, and can be used as a source of mammalian, preferably human, monoclonal antibodies and/or T cells. Alternatively, the xenogeneic cells or tissue may be non-hematopoietic, such as normal or pathological cells or tissue, which can form a stable transplant in the chimeric mammal and thus can be used as an animal model of various pathologies or to test therapeutic or diagnostic agents or modalities.
    Type: Grant
    Filed: November 23, 1994
    Date of Patent: January 20, 1998
    Assignee: Yeda Research and Development Co. Ltd.
    Inventor: Yair Reisner
  • Patent number: 5652373
    Abstract: Non-human chimeric mammals are created from a mammal having hematopoietic cells replaced with hematopoietic cells from a hematopoietic deficient mammal donor, and optionally in which xenogeneic cells and/or tissue are engrafted. The xenogeneic, preferably human, cells or tissue may be hematopoietic cells, in which case the chimeric mammal can produce xenogeneic B and/or T cells, and can be used as a source of mammalian, preferably human, monoclonal antibodies and/or T cells. Alternatively, the xenogeneic cells or tissue may be non-hematopoietic, such as normal or pathological cells or tissue, which can form a stable transplant in the chimeric mammal and thus can be used as an animal model of various pathologies or to test therapeutic or diagnostic agents or modalities.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: July 29, 1997
    Assignee: Yeda Research and Development Co. Ltd.
    Inventor: Yair Reisner