Patents by Inventor Yanan Zhang

Yanan Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7468033
    Abstract: The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
    Type: Grant
    Filed: September 8, 2004
    Date of Patent: December 23, 2008
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Nannette M. Van Antwerp, Bradley J. Enegren, John J. Mastrototaro, Rajiv Shah, Udo Hoss, Yanan Zhang, Jenn-Hann Wang, Kent L. Clark
  • Patent number: 7435569
    Abstract: A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: October 14, 2008
    Assignee: Medtronic Minimed, Inc.
    Inventors: Rajiv Shah, Bahar Reghabi, Rudy Montalvo, Yanan Zhang
  • Patent number: 7384397
    Abstract: A system and method for calibrating a sensor. The method may include, without limitation, compiling an array of data relating to the sensor; adjusting a sensor parameter a first time based on data in the array; adjusting a curve representing the sensor output based on data in the array; and adjusting the sensor parameter a second time based on data in the array. The sensor may be an in vivo glucose sensor and the sensor parameter adjusted may be a current. The array may include historical as well as recent data, such as, for example, blood glucose readings and sensor electrode readings.
    Type: Grant
    Filed: December 30, 2003
    Date of Patent: June 10, 2008
    Assignee: Medtronic Minimed, Inc.
    Inventors: Yanan Zhang, Lu Wang, Rajiv Shah
  • Publication number: 20080039822
    Abstract: An implantable sensing system that includes a sensor for sensing a biological parameter, a processor connected to the sensor for processing the parameter and a drug delivery unit connected to the processor for responding to the processor based on the parameter. The processor is programnmed to adjust an output of the sensor by compiling an array of data relating to the sensor, adjusting a sensor parameter a first time based on data in the array, adjusting a curve representing the sensor output based on data in the array and adjusting the sensor parameter a second time based on data in the array.
    Type: Application
    Filed: August 22, 2007
    Publication date: February 14, 2008
    Inventors: Yanan Zhang, Lu Wang, Rajiv Shah
  • Publication number: 20080033269
    Abstract: Electrochemical biosensors consisting of two or more needle-shaped electrodes for monitoring of molecules such as glucose in the subcutaneous tissue are provided. The two electrodes are parallel to each other, and are fixed perpendicularly to the planar side of a sensor base which provides skin fixation and electric connection. The needle electrodes are made of rigid conducting materials, capable of inserting into the skin without the need of catheters. One electrode is the sensing electrode and the other, the reference electrode. A compound sensing membrane is attached onto the sensing electrode surface to detect analyzed molecules.
    Type: Application
    Filed: October 29, 2005
    Publication date: February 7, 2008
    Inventor: Yanan Zhang
  • Publication number: 20070078319
    Abstract: A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.
    Type: Application
    Filed: November 30, 2006
    Publication date: April 5, 2007
    Inventors: Rajiv Shah, Yanan Zhang, Rebecca Gottlieb, Bahar Reghabi, Michael Miller
  • Patent number: 7192766
    Abstract: A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.
    Type: Grant
    Filed: December 27, 2001
    Date of Patent: March 20, 2007
    Assignee: Medtronic Minimed, Inc.
    Inventors: Rajiv Shah, Bahar Reghabi, Rudy Montalvo, Yanan Zhang
  • Patent number: 7162289
    Abstract: A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.
    Type: Grant
    Filed: December 31, 2002
    Date of Patent: January 9, 2007
    Assignee: Medtronic Minimed, Inc.
    Inventors: Rajiv Shah, Yanan Zhang, Rebecca Gottlieb, Bahar Reghabi, Michael Miller
  • Publication number: 20060052745
    Abstract: The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.
    Type: Application
    Filed: September 8, 2004
    Publication date: March 9, 2006
    Inventors: Nannette Van Antwerp, Bradley Enegren, John Mastrototaro, Rajiv Shah, Udo Hoss, Yanan Zhang, Jenn-Hann Wang, Kent Clark
  • Publication number: 20050214741
    Abstract: A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.
    Type: Application
    Filed: May 4, 2005
    Publication date: September 29, 2005
    Inventors: Rajiv Shah, Bahar Reghabi, Rudolph Montalvo, Yanan Zhang
  • Patent number: 6915147
    Abstract: A sensing apparatus with a connector, a sensor lead and a sensor module with a spacer placed over electrodes that have been deposited on a substrate. The spacer may have a space for receiving an enzyme. End portions of the sensor module may be encapsulated, such as with molded beads. A sensor lead may attach to the sensor module and may have an outer tubing that passes over the module and attaches to the beads at the end of the sensor module. The sensor lead may also attach to the connector such that the sensing apparatus may be electrically coupled to a pump, electronics or other devices. The sensing apparatus may be implanted into a vein or artery.
    Type: Grant
    Filed: December 28, 2001
    Date of Patent: July 5, 2005
    Assignee: Medtronic Minimed, Inc.
    Inventors: Ronald J. Lebel, Rajiv Shah, Yanan Zhang, Edward Chernoff, Rudolph A. Montalvo
  • Publication number: 20050143636
    Abstract: A system and method for calibrating a sensor. The method may include, without limitation, compiling an array of data relating to the sensor; adjusting a sensor parameter a first time based on data in the array; adjusting a curve representing the sensor output based on data in the array; and adjusting the sensor parameter a second time based on data in the array. The sensor may be an in vivo glucose sensor and the sensor parameter adjusted may be a current. The array may include historical as well as recent data, such as, for example, blood glucose readings and sensor electrode readings.
    Type: Application
    Filed: December 30, 2003
    Publication date: June 30, 2005
    Inventors: Yanan Zhang, Lu Wang, Rajiv Shah
  • Publication number: 20050049641
    Abstract: A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.
    Type: Application
    Filed: August 26, 2004
    Publication date: March 3, 2005
    Inventors: Rajiv Shah, Yanan Zhang, Rebecca Gottlieb, Bahar Reghabi, Michael Miller
  • Publication number: 20050006807
    Abstract: A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.
    Type: Application
    Filed: August 3, 2004
    Publication date: January 13, 2005
    Inventors: Rajiv Shah, Bahar Reghabi, Rudolph Montalvo, Yanan Zhang
  • Publication number: 20040236201
    Abstract: A sensing apparatus with a connector, a sensor lead and a sensor module with a spacer placed over electrodes that have been deposited on a substrate. The spacer may have a space for receiving an enzyme. End portions of the sensor module may be encapsulated, such as with molded beads. A sensor lead may attach to the sensor module and may have an outer tubing that passes over the module and attaches to the beads at the end of the sensor module. The sensor lead may also attach to the connector such that the sensing apparatus may be electrically coupled to a pump, electronics or other devices. The sensing apparatus may be implanted into a vein or artery.
    Type: Application
    Filed: June 29, 2004
    Publication date: November 25, 2004
    Applicant: MEDTRONIC MINIMED, INC.
    Inventors: Ronald J. Lebel, Rajiv Shah, Yanan Zhang, Edward Chernoff, Rudolph A. Montalvo
  • Publication number: 20040074785
    Abstract: Embodiments of the invention provide analyte sensors having stabilized coating compositions and methods for making such sensors. Illustrative embodiments include electrochemical glucose sensors having stabilized glucose oxidase coatings that are generated for example, via spin coating processes.
    Type: Application
    Filed: October 18, 2002
    Publication date: April 22, 2004
    Inventors: James D. Holker, John J. Mastrototaro, Glenn Noronha, Rajiv Shah, Yanan Zhang, Udo Hoss, Kevin D. Branch
  • Publication number: 20040064156
    Abstract: A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.
    Type: Application
    Filed: December 31, 2002
    Publication date: April 1, 2004
    Applicant: MEDTRONIC MINIMED, INC.
    Inventors: Rajiv Shah, Yanan Zhang, Rebecca Gottlieb, Bahar Reghabi, Michael E. Miller
  • Publication number: 20030077772
    Abstract: A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.
    Type: Application
    Filed: December 27, 2001
    Publication date: April 24, 2003
    Inventors: Rajiv Shah, Bahar Reghabi, Rudolph A. Montalvo, Yanan Zhang
  • Publication number: 20030050547
    Abstract: A sensing apparatus with a connector, a sensor lead and a sensor module with a spacer placed over electrodes that have been deposited on a substrate. The spacer may have a space for receiving an enzyme. End portions of the sensor module may be encapsulated, such as with molded beads. A sensor lead may attach to the sensor module and may have an outer tubing that passes over the module and attaches to the beads at the end of the sensor module. The sensor lead may also attach to the connector such that the sensing apparatus may be electrically coupled to a pump, electronics or other devices. The sensing apparatus may be implanted into a vein or artery.
    Type: Application
    Filed: December 28, 2001
    Publication date: March 13, 2003
    Inventors: Ronald J. Lebel, Rajiv Shah, Yanan Zhang, Edward Chernoff, Rudolph A. Montalvo
  • Patent number: 5165407
    Abstract: Implantable enzymatic sensors (25, 43, 44) for biochemicals such as glucose are provided having an ideal size and geometry for optional long term implantation and linear responses over the concentration ranges of interest. The sensors (25, 43, 44) include an elongated body (10, 26, 46) supporting an indicating electrode section having an appropriate enzyme immobilized thereon to present an enzymatic indicating surface (21, 33, 54). A permeable synthetic polymer membrane (24, 42, 56) is applied over the sensor body (10, 26, 46) to protect the enzyme and regulate diffusion of analyte therethrough, to ensure linearity of sensor response. The sensors (25, 43) are of flexible design and can be implanted using a catheter. Alternately, the sensor (44) includes an internal indicating electrode body (46) housed within an apertured, hollow needle (48). A holder (66) affixed to the needle (48) allows for easy manipulation and implantation of the sensor (44).
    Type: Grant
    Filed: April 9, 1991
    Date of Patent: November 24, 1992
    Assignee: The University of Kansas
    Inventors: George S. Wilson, Dilbir S. Bindra, Brian S. Hill, Daniel R. Thevenot, Robert Sternberg, Gerard Reach, Yanan Zhang