Patents by Inventor Yao-Chung Weng

Yao-Chung Weng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8899102
    Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: December 2, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Scott Manalis, Andrea K. Bryan, Philip Dextras, Sungmin Son, Thomas Burg, William Grover, Yao-Chung Weng
  • Publication number: 20140096604
    Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.
    Type: Application
    Filed: December 17, 2013
    Publication date: April 10, 2014
    Applicant: Massachusetts Institute of Techno;ogy
    Inventors: Scott Manalis, Andrea K. Bryan, Philip Dextras, Sungmin Son, Thomas Burg, William Grover, Yao-Chung Weng
  • Patent number: 8635911
    Abstract: Method for determining buoyant mass and deformability of a cell. The method includes introducing the cell into a suspended microchannel resonator that includes a constriction near a distal location in the resonator. A first frequency shift in the resonator is monitored as a cell moves to the distal location in the resonator, the first frequency shift being related to the buoyant mass of the cell. Transit time of the cell through the constriction is measured by monitoring a second frequency shift as a result of a change in cell location as it passes through the constriction, whereby deformability is determined from the measured buoyant mass and transit time.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: January 28, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Sungmin Son, Sangwon Byun, Andrea Kristine Bryan, Thomas Burg, Amneet Gulati, Jungchul Lee, Scott Manalis, Yao-Chung Weng
  • Patent number: 8631685
    Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods and for changing the fluid properties within the SMR during the extended periods. Methods include techniques to provide for cell growth over time and over time in response to changing fluid properties to aid in determining parameters such as drug resistance and drug susceptibility.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: January 21, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Scott Manalis, Andrea K. Bryan, Michel Godin, Philip Dextras, Sungmin Son, Thomas Burg, William Grover, Yao-Chung Weng
  • Patent number: 8312763
    Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Susppended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: November 20, 2012
    Assignee: Massachusetts Institute of Technology
    Inventors: Scott R. Manalis, Andrea K. Bryan, Philip Dextras, Thomas P. Burg, William H. Grover, Yao-Chung Weng, Sungmin Son
  • Publication number: 20120118063
    Abstract: Method for determining buoyant mass and deformability of a cell. The method includes introducing the cell into a suspended microchannel resonator that includes a constriction near a distal location in the resonator. A first frequency shift in the resonator is monitored as a cell moves to the distal location in the resonator, the first frequency shift being related to the buoyant mass of the cell. Transit time of the cell through the constriction is measured by monitoring a second frequency shift as a result of a change in cell location as it passes through the constriction, whereby deformability is determined from the measured buoyant mass and transit time.
    Type: Application
    Filed: April 28, 2011
    Publication date: May 17, 2012
    Applicant: Massachusetts Institute of Technology
    Inventors: Sungmin Son, Sangwon Byun, Andrea Kristine Bryan, Thomas Burg, Amneet Gulati, Jungchul Lee, Scott Manalis, Yao-Chung Weng
  • Publication number: 20100297747
    Abstract: Microsystem for monitoring cell growth. A microfluidic structure is designed to allow cells to circulate therethrough and the microfluidic structure includes modules to monitor mass, mass density and fluorescence of the cell.
    Type: Application
    Filed: October 24, 2008
    Publication date: November 25, 2010
    Inventors: Scott R. Manalis, Andrea K. Bryan, Yao-Chung Weng, Thomas Burg, William H. Grover, Marc W. Kirschner, Paul Jorgensen, Michel Godin
  • Publication number: 20100288043
    Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Suspended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods and for changing the fluid properties within the SMR during the extended periods. Methods include techniques to provide for cell growth over time and over time in response to changing fluid properties to aid in determining parameters such as drug resistance and drug susceptibility.
    Type: Application
    Filed: March 23, 2010
    Publication date: November 18, 2010
    Inventors: Scott Manalis, Andrea K. Bryan, Michel Godin, Philip Dextras, Sungmin Son, Thomas Burg, William Grover, Yao-Chung Weng
  • Publication number: 20100154535
    Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Susppended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.
    Type: Application
    Filed: October 14, 2009
    Publication date: June 24, 2010
    Inventors: Scott R. Manalis, Andrea K. Bryan, Philip Dextras, Thomas P. Burg, William H. Grover, Yao-Chung Weng, Sungmin Son