Patents by Inventor Yasuhide Naito
Yasuhide Naito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11961728Abstract: A surface-assisted laser desorption/ionization method according to an aspect includes: a first process of preparing a sample support (2) having a substrate (21) in which a plurality of through-holes (S) passing from one surface (21a) thereof to the other surface (21b) thereof are provided and a conductive layer (23) that covers at least the one surface (21a); a second process of placing a sample (10) on a sample stage (1) and arranging the sample support (2) on the sample (10) such that the other surface (21b) faces the sample (10); and a third process of applying a laser beam (L) to the one surface (21a) and ionizing the sample (10) moved from the other surface (21b) side to the one surface (21a) side via the through-holes (S) due to a capillary phenomenon.Type: GrantFiled: March 6, 2023Date of Patent: April 16, 2024Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide Naito, Masahiro Kotani, Takayuki Ohmura
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Publication number: 20230207296Abstract: A surface-assisted laser desorption/ionization method according to an aspect includes: a first process of preparing a sample support (2) having a substrate (21) in which a plurality of through-holes (S) passing from one surface (21a) thereof to the other surface (21b) thereof are provided and a conductive layer (23) that covers at least the one surface (21a); a second process of placing a sample (10) on a sample stage (1) and arranging the sample support (2) on the sample (10) such that the other surface (21b) faces the sample (10); and a third process of applying a laser beam (L) to the one surface (21a) and ionizing the sample (10) moved from the other surface (21b) side to the one surface (21a) side via the through-holes (S) due to a capillary phenomenon.Type: ApplicationFiled: March 6, 2023Publication date: June 29, 2023Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide NAITO, Masahiro KOTANI, Takayiki OHMURA
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Publication number: 20230170201Abstract: A sample support is a sample support used for ionizing components of a sample, and includes: a substrate including a first surface, a second surface on a side opposite to the first surface, and a plurality of through holes opening to the first surface and the second surface; a conductive layer provided at least on the first surface; and a derivatizing agent provided to the plurality of through holes to derivatize the components.Type: ApplicationFiled: April 15, 2021Publication date: June 1, 2023Applicants: HAMAMATSU PHOTONICS K.K., TAIYO NIPPON SANSO CORPORATION, NATIONAL UNIVERSITY CORPORATION FUKUSHIMA UNIVERSITYInventors: Masahiro KOTANI, Takayuki OHMURA, Akari WAKIMURA, Tsutomu TERAUCHI, Shu TAIRA, Yasuhide NAITO
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Publication number: 20230042588Abstract: An imaging unit includes a MCP, a fluorescent body, and an imager. The MCP is provided on a flight route of an ionized sample that is a component of a sample ionized and emits electrons in accordance with the ionized sample. The fluorescent body is disposed in a subsequent stage of the MCP and emits fluorescent light in accordance with the electrons emitted from the MCP. The imager is disposed in a subsequent stage of the fluorescent body and has a shutter mechanism configured to be capable of switching an open state in which the fluorescent light is imaged by allowing the fluorescent light from the fluorescent body to pass through and a close state in which the fluorescent light is not imaged by blocking the fluorescent light from the fluorescent body. An afterglow time of the fluorescent body is 12 ns or shorter.Type: ApplicationFiled: April 7, 2020Publication date: February 9, 2023Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide NAITO, Tsuyoshi HIRAO, Minoru KONDO
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Publication number: 20230042476Abstract: A mass spectrometry device includes a sample stage, an irradiator, a MCP, a fluorescent body, an imager, and a controller. The irradiator irradiates a sample with an energy beam to ionize a plurality of components of the sample while maintaining position information of the plurality of components. The MCP emits electrons in accordance with an ionized sample. The fluorescent body emits fluorescent light in accordance with the electrons. The imager has a shutter mechanism configured to be capable of switching an open state and a close state. The controller controls an opening and closing operation of the shutter mechanism. The controller allows the imager to image the fluorescent light corresponding to each of the plurality of components by performing the opening and closing of the shutter mechanism at a timing for each of the components.Type: ApplicationFiled: April 7, 2020Publication date: February 9, 2023Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide NAITO, Tsuyoshi HIRAO, Minoru KONDO
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Patent number: 11442039Abstract: Provided is a sample support body that includes: a substrate having a first surface and a second surface opposite to each other; and a conductive layer provided on at least the first surface. A plurality of through-holes, which open to the second surface and a third surface of the conductive layer which is located on a side opposite to the substrate, are formed in the substrate and the conductive layer. At least one of the second surface and the third surface is subjected to surface treatment for providing a difference in an affinity with water between a surface close to the second surface and a surface close to the third surface.Type: GrantFiled: January 8, 2019Date of Patent: September 13, 2022Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide Naito, Takayuki Ohmura, Masahiro Kotani
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Patent number: 11393667Abstract: A sample support body includes: a substrate having a first surface and a second surface opposite to each other; and a conductive layer provided on at least the first surface. A plurality of through-holes, which open to the second surface and to a third surface of the conductive layer which is locate at a side opposite to the substrate, are provided in the substrate and the conductive layer. A protective film having a higher affinity with water than the substrate is provided on the second surface, the third surface, and each inner surface of the plurality of through-holes.Type: GrantFiled: January 8, 2019Date of Patent: July 19, 2022Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide Naito, Takayuki Ohmura, Masahiro Kotani
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Patent number: 11335546Abstract: A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which a plurality of through holes opening to a first surface and a second surface facing each other are formed, a conductive layer provided on at least the first surface, and a solvent provided in the plurality of through holes with refractoriness in a vacuum; a second step of mounting a sample on a mounting surface of a mounting portion, and of disposing the sample support body on the sample such that the second surface is in contact with the sample; and a third step of ionizing a component of the sample that is mixed with the solvent and is moved to the first surface side from the second surface side through the through hole by irradiating the first surface with laser beam while applying a voltage to the conductive layer.Type: GrantFiled: October 5, 2018Date of Patent: May 17, 2022Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide Naito, Takayuki Ohmura, Masahiro Kotani
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Patent number: 11170985Abstract: A surface-assisted laser desorption/ionization method according to an aspect includes: a first process of preparing a sample support (2) having a substrate (21) in which a plurality of through-holes (S) passing from one surface (21a) thereof to the other surface (21b) thereof are provided and a conductive layer (23) that covers at least the one surface (21a); a second process of placing a sample (10) on a sample stage (1) and arranging the sample support (2) on the sample (10) such that the other surface (21b) faces the sample (10); and a third process of applying a laser beam (L) to the one surface (21a) and ionizing the sample (10) moved from the other surface (21b) side to the one surface (21a) side via the through-holes (S) due to a capillary phenomenon.Type: GrantFiled: May 1, 2020Date of Patent: November 9, 2021Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide Naito, Masahiro Kotani, Takayuki Ohmura
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Patent number: 11139155Abstract: A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which a plurality of through holes opening to a first surface and a second surface facing each other are formed, and a conductive layer provided on at least the first surface; a second step of introducing a sample and a solvent having refractoriness in a vacuum into the plurality of through holes; and a third step of ionizing a component of the sample by irradiating the first surface with laser beam while applying a voltage to the conductive layer.Type: GrantFiled: October 5, 2018Date of Patent: October 5, 2021Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide Naito, Takayuki Ohmura, Masahiro Kotani
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Patent number: 11127577Abstract: A laser desorption/ionization method includes a first process of preparing a sample support body. The sample support body includes a substrate, an ionization substrate, and a support that supports the ionization substrate with respect to the substrate such that a first surface of the ionization substrate is separated from the substrate. A plurality of through-holes are formed at least in measurement regions of the ionization substrate. A conductive layer is provided on peripheral edges of the through-holes at least on the second surface. Further, the laser desorption/ionization method includes a second process of dropping the sample on the measurement regions of the ionization substrate, and a third process of, after the sample has infiltrated into the ionization substrate, ionizing components of the sample by applying a laser beam to the second surface while applying a voltage to the conductive layer.Type: GrantFiled: August 3, 2018Date of Patent: September 21, 2021Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide Naito, Takayuki Ohmura, Masahiro Kotani
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Patent number: 11101122Abstract: A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which plurality of through holes opening to a first surface and a second surface facing each other are formed, and a conductive layer provided on at least the first surface; a second step of mounting a sample on a mounting surface of a mounting portion, and of disposing the sample support body on the sample such that the second surface is in contact with the sample; a third step of introducing a matrix solution into the plurality of through holes; and a fourth step of ionizing a component of the sample that is mixed with the matrix solution and is moved to the first surface side from the second surface side through the through hole by irradiating the first surface with laser light while a voltage is applied to the conductive layer.Type: GrantFiled: August 6, 2018Date of Patent: August 24, 2021Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide Naito, Masahiro Kotani, Takayuki Ohmura
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Patent number: 11031228Abstract: A mass spectrometry device according to one aspect of the invention includes: a sample stage on which a sample is placed and on which a sample support having a substrate, in which a plurality of through-holes passing from one surface thereof to the other surface thereof are provided, and a conductive layer, which covers at least a portion of the one surface which is not provided with the through-holes, is placed such that the other surface faces the sample; a laser beam application unit that controls application of a laser beam such that the laser beam is applied to an imaging target region on the one surface; and a detector that detects the sample ionized by the application of the laser beam in a state where a positional relation of the sample in the imaging target region is maintained.Type: GrantFiled: March 1, 2018Date of Patent: June 8, 2021Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide Naito, Masahiro Kotani, Takayuki Ohmura
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Publication number: 20210033564Abstract: A sample support body includes: a substrate having a first surface and a second surface opposite to each other; and a conductive layer provided on at least the first surface. A plurality of through-holes, which open to the second surface and to a third surface of the conductive layer which is locate at a side opposite to the substrate, are provided in the substrate and the conductive layer. A protective film having a higher affinity with water than the substrate is provided on the second surface, the third surface, and each inner surface of the plurality of through-holes.Type: ApplicationFiled: January 8, 2019Publication date: February 4, 2021Applicant: Hamamatsu Photonics K.K.Inventors: Yasuhide NAITO, Takayuki OHMURA, Masahiro KOTANI
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Publication number: 20200386712Abstract: Provided is a sample support body that includes: a substrate having a first surface and a second surface opposite to each other; and a conductive layer provided on at least the first surface. A plurality of through-holes, which open to the second surface and a third surface of the conductive layer which is located on a side opposite to the substrate, are formed in the substrate and the conductive layer. At least one of the second surface and the third surface is subjected to surface treatment for providing a difference in an affinity with water between a surface close to the second surface and a surface close to the third surface.Type: ApplicationFiled: January 8, 2019Publication date: December 10, 2020Applicant: Hamamatsu Photonics K.K.Inventors: Yasuhide NAITO, Takayuki OHMURA, Masahiro KOTANI
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Publication number: 20200279729Abstract: A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which a plurality of through holes opening to a first surface and a second surface facing each other are formed, a conductive layer provided on at least the first surface, and a solvent provided in the plurality of through holes with refractoriness in a vacuum; a second step of mounting a sample on a mounting surface of a mounting portion, and of disposing the sample support body on the sample such that the second surface is in contact with the sample; and a third step of ionizing a component of the sample that is mixed with the solvent and is moved to the first surface side from the second surface side through the through hole by irradiating the first surface with laser beam while applying a voltage to the conductive layer.Type: ApplicationFiled: October 5, 2018Publication date: September 3, 2020Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide NAITO, Takayuki OHMURA, Masahiro KOTANI
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Publication number: 20200273689Abstract: A laser desorption/ionization method includes a first process of preparing a sample support body. The sample support body includes a substrate, an ionization substrate, and a support that supports the ionization substrate with respect to the substrate such that a first surface of the ionization substrate is separated from the substrate. A plurality of through-holes are formed at least in measurement regions of the ionization substrate. A conductive layer is provided on peripheral edges of the through-holes at least on the second surface. Further, the laser desorption/ionization method includes a second process of dropping the sample on the measurement regions of the ionization substrate, and a third process of, after the sample has infiltrated into the ionization substrate, ionizing components of the sample by applying a laser beam to the second surface while applying a voltage to the conductive layer.Type: ApplicationFiled: August 3, 2018Publication date: August 27, 2020Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide NAITO, Takayuki OHMURA, Masahiro KOTANI
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Publication number: 20200273691Abstract: A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which a plurality of through holes opening to a first surface and a second surface facing each other are formed, and a conductive layer provided on at least the first surface; a second step of introducing a sample and a solvent having refractoriness in a vacuum into the plurality of through holes; and a third step of ionizing a component of the sample by irradiating the first surface with laser beam while applying a voltage to the conductive layer.Type: ApplicationFiled: October 5, 2018Publication date: August 27, 2020Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide NAITO, Takayuki OHMURA, Masahiro KOTANI
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Publication number: 20200266043Abstract: A laser desorption/ionization method, includes: a first step of preparing a sample support body including a substrate on which plurality of through holes opening to a first surface and a second surface facing each other are formed, and a conductive layer provided on at least the first surface; a second step of mounting a sample on a mounting surface of a mounting portion, and of disposing the sample support body on the sample such that the second surface is in contact with the sample; a third step of introducing a matrix solution into the plurality of through holes; and a fourth step of ionizing a component of the sample that is mixed with the matrix solution and is moved to the first surface side from the second surface side through the through hole by irradiating the first surface with laser light while a voltage is applied to the conductive layer.Type: ApplicationFiled: August 6, 2018Publication date: August 20, 2020Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide NAITO, Masahiro KOTANI, Takayuki OHMURA
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Publication number: 20200258730Abstract: A surface-assisted laser desorption/ionization method according to an aspect includes: a first process of preparing a sample support (2) having a substrate (21) in which a plurality of through-holes (S) passing from one surface (21a) thereof to the other surface (21b) thereof are provided and a conductive layer (23) that covers at least the one surface (21a); a second process of placing a sample (10) on a sample stage (1) and arranging the sample support (2) on the sample (10) such that the other surface (21b) faces the sample (10); and a third process of applying a laser beam (L) to the one surface (21a) and ionizing the sample (10) moved from the other surface (21b) side to the one surface (21a) side via the through-holes (S) due to a capillary phenomenon.Type: ApplicationFiled: May 1, 2020Publication date: August 13, 2020Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Yasuhide NAITO, Masahiro KOTANI, Takayuki OHMURA