Patents by Inventor Yasuhide Nakayama

Yasuhide Nakayama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10471179
    Abstract: The present invention provides a connective tissue body formation substrate which can form a film connective tissue having a desired thickness and both surfaces in a desired surface condition without prolonging the time required for formation of the connective tissue. Specifically, two tissue formation surfaces 2a and 2b are faced with each other with a tissue formation space 3 being interposed therebetween. A slit 9 is formed in the tissue formation surface 2b so that the tissue formation space 3 communicates with an outside of the substrate. A connective tissue body formation substrate 1 is installed in an environment where a biological tissue material is present. A connective tissue intrudes into the tissue formation space 3 from the slit 9. Both surfaces of the film connective tissue are formed so as to match the substrate surface.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: November 12, 2019
    Assignee: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER
    Inventors: Yasuhide Nakayama, Tomonori Oie, Takeshi Moriwaki
  • Publication number: 20190221788
    Abstract: An object of the invention is to provide a lid for storage battery, an injection molding method of the lid, a storage battery with the lid, and a terminal section for storage battery, which can save trouble of inserting a nut into a cavity portion of a terminal, and can prevent falling of the nut at the time of connection of an external leading wire. In a lid for storage battery in which a terminal section for storage battery 8 made up of a terminal 4 having a cavity portion, a bushing 6, and a conductive portion 7 joining both is insert-molded in a lid made of synthetic resin, and a storage battery with the lid for storage battery, an anchor portion 4T is projected at a location excluding at least a central portion of a bottom portion 4F of the terminal 4, and a nut is inserted into the cavity portion of the terminal to be fixed.
    Type: Application
    Filed: February 12, 2019
    Publication date: July 18, 2019
    Inventors: Shin Osaki, Hiroshi Haruyama, Eiji Hojo, Yasuhide Nakayama
  • Publication number: 20190201583
    Abstract: The present invention provides a method for forming a connective tissue body, which enables extending the ranges of design values in terms of shape, dimension, etc., of the connective tissue body. This method comprises: a fat treatment step for removing fat contained in a connective tissue body, which is formed in an environment where a biological tissue material is present, from the interior of the connective tissue body while the connective tissue body is being set in a molding tool, and for causing the shape of the connective tissue body to follow the shape of the molding tool; and a bioinert solution treatment step for immersing the connective tissue body, together with the molding tool, in a bioinert solution while the connective tissue body is being shaped so as to follow the shape of the molding tool after the fat treatment step.
    Type: Application
    Filed: August 30, 2017
    Publication date: July 4, 2019
    Applicants: BIOTUBE CO., LTD., NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER
    Inventors: Yasuhide NAKAYAMA, Takeshi MORIWAKI, Tomonori OIE
  • Patent number: 10297799
    Abstract: An object of the invention is to provide a lid for storage battery, an injection molding method of the lid, a storage battery with the lid, and a terminal section for storage battery, which can save trouble of inserting a nut into a cavity portion of a terminal, and can prevent falling of the nut at the time of connection of an external leading wire. In a lid for storage battery in which a terminal section for storage battery 8 made up of a terminal 4 having a cavity portion, a bushing 6, and a conductive portion 7 joining both is insert-molded in a lid made of synthetic resin, and a storage battery with the lid for storage battery, an anchor portion 4T is projected at a location excluding at least a central portion of a bottom portion 4F of the terminal 4, and a nut is inserted into the cavity portion of the terminal to be fixed.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: May 21, 2019
    Assignee: GS Yuasa International Ltd.
    Inventors: Shin Osaki, Hiroshi Haruyama, Eiji Hojo, Yasuhide Nakayama
  • Publication number: 20190083225
    Abstract: A tissue body formation device for forming a connective tissue body in an environment where a living tissue material is present is provided with: an inner member having a tissue body formation surface that serves as a surface for forming a connective tissue body; and a covering member which is provided with a covering surface that constitutes an external surface of the tissue body formation device, and that covers a part of the tissue body formation surface. The covering member further has a plurality of connection parts that connect the outer side of the tissue body formation device to the tissue body formation surface. Each of the connection parts has an opening in the covering surface. Each of the openings has a minimum dimension of at least 0.5 mm in a direction along the covering surface. The openings account for 20-40% per unit area of the covering surface.
    Type: Application
    Filed: May 11, 2017
    Publication date: March 21, 2019
    Applicants: SHINKAN KOGYO K.K., NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER
    Inventors: Yasuhide NAKAYAMA, Takeshi MORIWAKI, Tomonori OIE
  • Publication number: 20190040359
    Abstract: The present disclosure aims to provide a method of efficiently manufacturing a cell mass, a cell structure, or a three-dimensional tissue body using a culturing surface coated with a temperature-responsive polymer or a temperature-responsive polymer composition. The manufacturing method of a cell mass, a cell structure, or a three-dimensional tissue body of the present disclosure includes seeding and culturing cells on a culturing surface coated with a temperature-responsive polymer or a temperature-responsive polymer composition.
    Type: Application
    Filed: January 27, 2017
    Publication date: February 7, 2019
    Applicant: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER
    Inventors: Yasuhide NAKAYAMA, Ryosuke IWAI, Yasushi NEMOTO
  • Publication number: 20180355296
    Abstract: The present disclosure aims to provide a cell culture container capable of easily producing large quantities of minute cellular structures. A cell culture container includes a plurality of first coated regions, on a culture surface of the cell culture container, coated by a temperature-responsive polymer or a temperature-responsive polymer composition. The surface zeta potential of the first coated regions is from 0 mV to 50 mV.
    Type: Application
    Filed: June 24, 2016
    Publication date: December 13, 2018
    Applicant: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER
    Inventors: Yasuhide NAKAYAMA, Ryosuke IWAI, Yasushi NEMOTO
  • Patent number: 10135049
    Abstract: A vehicular lead storage battery according to the present invention includes a battery container provided with at least one cell chamber; and a cover plate 1 for covering an upper opening of the battery container. A guide path 8 for discharging gases within a cell chamber to the outside is formed in the cover plate 1. The guide path 8 includes a first guide portion 9B for horizontally guiding gases from the cell chamber; a second guide portion 9C connected to the first guide portion 9B to downwardly guide the gases from the first guide portion 9B; and a third guide portion 10A connected to the second guide portion 9C to horizontally guide the gases from the second guide portion 9C and discharge the gases from an exhaust vent 4K formed in the cover plate 1 to the outside. A corner portion 9K is formed by the first guide portion 9B and the second guide portion 9C, and a corner portion 10K is formed by the second guide portion 9C and the third guide portion 10A.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: November 20, 2018
    Assignees: GS Yuasa International Ltd., HONDA MOTOR CO., LTD.
    Inventors: Yasuhide Nakayama, Eiji Hojo, Katsuhiro Ouchi, Hidehiko Shibata
  • Publication number: 20180256311
    Abstract: A substrate for forming an artificial valve and that allows connective tissue to easily enter a leaflet forming space and can thereby shorten the time required to form a leaflet, and also provides an artificial valve. Specifically, a columnar substrate main body is provided. A plurality of recesses are formed on the outer peripheral surface of the substrate main body. A cover substrate is mounted on the substrate main body. The recesses are covered with the cover substrate to define leaflet forming spaces. An entry opening for connective tissue is defined between an edge of the cover substrate and an outer edge of the recesses. Slits are formed in the cover substrate to allow communication between the leaflet forming spaces and the outside of the substrate. Each slit is formed parallel to the substrate central axis and has a length that extends to the edge of the cover substrate.
    Type: Application
    Filed: December 18, 2015
    Publication date: September 13, 2018
    Inventors: Yasuhide NAKAYAMA, Tomonori OIE
  • Patent number: 9956074
    Abstract: The present invention provides a valved stent that can provide a valve function without blocking a branch blood vessel, and also can provide a valve function with minimum covering of blood vessel tissue in a stent indwelling section. Specifically, a cylindrical stent body 4 is provided. A leaflet 5 that can open/close a blood vessel 2 in a blood flow direction is provided. The leaflet 5 is composed of connective tissue and protrudes radially inward from the stent body 4. An inside and an outside of the stent body 4 radially communicate with each other. The stent does not block a branch blood vessel 8. An area of the blood vessel covered with the stent is reduced.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: May 1, 2018
    Assignees: SHINKAN KOGYO K.K., NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER
    Inventors: Yasuhide Nakayama, Tomonori Oie
  • Publication number: 20180013103
    Abstract: An object of the invention is to provide a lid for storage battery, an injection molding method of the lid, a storage battery with the lid, and a terminal section for storage battery, which can save trouble of inserting a nut into a cavity portion of a terminal, and can prevent falling of the nut at the time of connection of an external leading wire. In a lid for storage battery in which a terminal section for storage battery 8 made up of a terminal 4 having a cavity portion, a bushing 6, and a conductive portion 7 joining both is insert-molded in a lid made of synthetic resin, and a storage battery with the lid for storage battery, an anchor portion 4T is projected at a location excluding at least a central portion of a bottom portion 4F of the terminal 4, and a nut is inserted into the cavity portion of the terminal to be fixed.
    Type: Application
    Filed: July 20, 2017
    Publication date: January 11, 2018
    Inventors: Shin Osaki, Hiroshi Haruyama, Eiji Hojo, Yasuhide Nakayama
  • Publication number: 20170319745
    Abstract: The present invention provides a connective tissue body formation substrate which can form a film-like connective tissue having a desired thickness and both surfaces in a desired surface condition without prolonging the time required for formation of the connective tissue. Specifically, two tissue formation surfaces 2a and 2b are faced with each other with a tissue formation space 3 being interposed therebetween. A slit 9 is formed in the tissue formation surface 2b so that the tissue formation space 3 communicates with an outside of the substrate. A connective tissue body formation substrate 1 is installed in an environment where a biological tissue material is present. A connective tissue intrudes into the tissue formation space 3 from the slit 9. Both surfaces of the film-like connective tissue are formed so as to match the substrate surface.
    Type: Application
    Filed: November 13, 2015
    Publication date: November 9, 2017
    Applicant: National Cerebral and Cardiovascular Center
    Inventors: Yasuhide NAKAYAMA, Tomonori OIE, Takeshi MORIWAKI
  • Patent number: 9748530
    Abstract: An object of the invention is to provide a lid for storage battery, an injection molding method of the lid, a storage battery with the lid, and a terminal section for storage battery, which can save trouble of inserting a nut into a cavity portion of a terminal, and can prevent falling of the nut at the time of connection of an external leading wire. In a lid for storage battery in which a terminal section for storage battery 8 made up of a terminal 4 having a cavity portion, a bushing 6, and a conductive portion 7 joining both is insert-molded in a lid made of synthetic resin, and a storage battery with the lid for storage battery, an anchor portion 4T is projected at a location excluding at least a central portion of a bottom portion 4F of the terminal 4, and a nut is inserted into the cavity portion of the terminal to be fixed.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: August 29, 2017
    Assignee: GS Yuasa International Ltd.
    Inventors: Shin Osaki, Hiroshi Haruyama, Eiji Hojo, Yasuhide Nakayama
  • Publication number: 20170229695
    Abstract: A vehicular lead storage battery according to the present invention includes a battery container provided with at least one cell chamber; and a cover plate 1 for covering an upper opening of the battery container. A guide path 8 for discharging gases within a cell chamber to the outside is formed in the cover plate 1. The guide path 8 includes a first guide portion 9B for horizontally guiding gases from the cell chamber; a second guide portion 9C connected to the first guide portion 9B to downwardly guide the gases from the first guide portion 9B; and a third guide portion 10A connected to the second guide portion 9C to horizontally guide the gases from the second guide portion 9C and discharge the gases from an exhaust vent 4K formed in the cover plate 1 to the outside. A corner portion 9K is formed by the first guide portion 9B and the second guide portion 9C, and a corner portion 10K is formed by the second guide portion 9C and the third guide portion 10A.
    Type: Application
    Filed: February 28, 2017
    Publication date: August 10, 2017
    Inventors: Yasuhide Nakayama, Eiji Hojo, Katsuhiro Ouchi, Hidehiko Shibata
  • Publication number: 20170128244
    Abstract: The present invention provides a stent that can obtain sufficient strength while an inner side of the stent is easily endothelialized and moreover, can prevent occlusion of a branch blood vessel. Specifically, a stent body capable of diameter expansion is provided. A tubular film 3 is held by the stent body. In the tubular film 3, a plurality of communication holes 4 communicating between an inside and an outside are formed. Band-shaped portions 7 and 8 are formed between the communication holes 4 adjacent to each other. A wide-width portion and a narrow portion are not generated in the band-shaped portions 7 and 8. Strength of a part of the band-shaped portions 7 and 8 is not lowered. Generation of the wide-width portion in the band-shaped portions 7 and 8 is prevented.
    Type: Application
    Filed: June 11, 2015
    Publication date: May 11, 2017
    Applicants: National Cerebral and Cardiovascular Center, THE SCHOOL CORPORATION KANSAI UNIVERSITY
    Inventors: Yasuhide NAKAYAMA, Tetsu SATO, Takeshi MORIWAKI, Tsutomu TAJIKAWA
  • Publication number: 20160329548
    Abstract: A storage battery includes a terminal portion for storage batteries having a plurality of bolt insertion holes bored in one or a plurality of directions, a nut insertion opening through which a nut is inserted, a hollow in communication with the bolt insertion holes and the nut insertion opening and the nut having at least one screw hole threaded in a direction coincident with at least one or the plurality of directions. A fixation portion is formed to fix the nut by deforming the terminal portion with the nut being inserted through the nut insertion opening into the hollow and the at least one screw hole of the nut being in communication respectively with the at least one of the plurality of bolt insertion holes.
    Type: Application
    Filed: April 12, 2016
    Publication date: November 10, 2016
    Applicant: GS Yuasa International Ltd.
    Inventors: Aya Harada, Eiji Hojo, Yasuhide Nakayama, Shin Osaki, Hiroshi Okumura, Katsuya Noguchi
  • Publication number: 20160270912
    Abstract: The present invention provides a base material for forming a connective tissue structure which can accurately cut the connective tissue structure to a predetermined shape and a method for producing the connective tissue structure. A cutting-line forming groove (28) is formed in a surface of a base material (19). The base material (19) is placed under an environment in which a biological tissue material is present. A membranous connective tissue structure (20) is formed on the surface of the base material (19). At that time, a connective tissue (30) is made to invade into the cutting-line forming groove (28). A cutting line (31) for cutting is formed in the connective tissue structure (20). The connective tissue structure (20) is accurately cut along the cutting line (31) to a predetermined shape.
    Type: Application
    Filed: August 22, 2014
    Publication date: September 22, 2016
    Applicant: National Cerebral and Cardiovascular Center
    Inventors: Yasuhide NAKAYAMA, Tomonori OIE
  • Patent number: 9368781
    Abstract: A storage battery includes a terminal portion for storage batteries having a plurality of bolt insertion holes bored in one or a plurality of directions, a nut insertion opening through which a nut is inserted, a hollow in communication with the bolt insertion holes and the nut insertion opening and the nut having at least one screw hole threaded in a direction coincident with at least one or the plurality of directions. A fixation portion is formed to fix the nut by deforming the terminal portion with the nut being inserted through the nut insertion opening into the hollow and the at least one screw hole of the nut being in communication respectively with the at least one of the plurality of bolt insertion holes.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: June 14, 2016
    Assignee: GS Yuasa International Ltd.
    Inventors: Aya Harada, Eiji Hojo, Yasuhide Nakayama, Shin Osaki, Hiroshi Okumura, Katsuya Noguchi
  • Patent number: 9206441
    Abstract: A method for producing a cell having nucleic acid introduced therein and having low cytotoxicity is useful in primary cells and slowly dividing cells, for which nucleic acid introduction is difficult with conventional techniques. A method for introducing nucleic acid into a cell includes the steps of mixing a nucleic acid with a temperature sensitive material at a temperature lower than the cloud point of the temperature sensitive material, the temperature sensitive material being formed by adding 2-amino-2-hydroxymethyl-1,3-propanediol to a temperature-sensitive polymer material having 2-N,N-dimethylaminoethyl methacrylate and/or a derivative thereof as the main polymer component, flow coating a culture vessel with the resulting mixed liquid, and culturing a cell suspension provided to the culture vessel at a temperature higher than the cloud point.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: December 8, 2015
    Assignees: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, BRIDGESTONE CORPORATION
    Inventors: Yasuhide Nakayama, Ryosuke Iwai, Yasushi Nemoto
  • Publication number: 20150342724
    Abstract: The present invention provides a membranous connective tissue-forming substrate on which a membranous connective tissue having a sufficient thickness and strength can be formed and a method for producing a membranous connective tissue by using the substrate. Specifically, a connective tissue-forming section 2 is provided on the surface of the substrate. The connective tissue-forming section 2 is surrounded by a thickness-increasing section 3 to enlarge a membranous connective tissue-forming substrate 1 as a whole. The membranous connective tissue-forming substrate 1 is placed under an environment in which a biological tissue material is present to form a membranous connective tissue on the surface of the substrate. In proportion as the size of the membranous connective tissue-forming substrate 1 increases, the thickness of the membranous connective tissue increases. A surplus portion formed on the surface of the thickness-increasing section 3 is removed from the connective tissue.
    Type: Application
    Filed: May 30, 2013
    Publication date: December 3, 2015
    Applicant: National Cerebral and Cardiovascular Center
    Inventors: Yasuhide NAKAYAMA, Tomonori OIE