Patents by Inventor Yasuhiko Hirayama

Yasuhiko Hirayama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200338218
    Abstract: The present invention addresses the problem of providing: a hydrogel particle which can be taken into a cell by the action of the cell and can control the release of a magnetic particle enclosed therein into the cell so as to retain the magnetic particle in the cell for a long period; a method for producing the hydrogel particle; a cell or a cell structure each enclosing the hydrogel particle therein; and a method for evaluating the activity of a cell using the hydrogel particle. The present invention solves the problem by a hydrogel particle including: a domain which is composed of a first hydrogel; a matrix which encloses the domain and is composed of a second hydrogel having a different crosslinking degree or composition from that of the first hydrogel; and a magnetic particle which is supported by at least the first hydrogel.
    Type: Application
    Filed: November 5, 2018
    Publication date: October 29, 2020
    Inventors: Makoto MOCHIZUKI, Chie INUI, Natsumi HIRAYAMA, Akihiro MAEZAWA, Yasuhiko TABATA
  • Publication number: 20200268912
    Abstract: The purpose of the present invention is to provide composite particles for imaging that have high biodegradability after imaging. To achieve the above purpose, the composite particles for imaging according to the present invention are configured such that the ratio (long-term residual amount/short-term residual amount) of a long-term residual amount, which is the average value of the contrast rate after six days in a cell and the contrast rate after 11 days in a cell of the same type, and a short-term residual amount, which is the contrast rate after two days in a cell of the same type, is less than 99%.
    Type: Application
    Filed: October 19, 2018
    Publication date: August 27, 2020
    Inventors: Chie INUI, Yasuhiko TABATA, Akihiro MAEZAWA, Makoto MOCHIZUKI, Natsumi HIRAYAMA
  • Publication number: 20200030248
    Abstract: Disclosed herein are gelatin particles that have been crosslinked without using a crosslinking agent and are easily taken up by cells themselves, and a method for producing such gelatin particles. The gelatin particles are made of self-crosslinked gelatin and have a particle diameter of 0.010 ?m or more but 5.0 ?m or less. The gelatin particles can be produced by discharging droplets of a liquid containing melted gelatin into air in a heating tube or a drying chamber and drying the droplets to form the gelatin into particles under conditions where a difference between the temperature in the heating tube or the drying chamber and the temperature of the liquid is 235° C. or less and further by crosslinking the gelatin forming the particles.
    Type: Application
    Filed: October 4, 2019
    Publication date: January 30, 2020
    Inventors: Chie INUI, Akihiro MAEZAWA, Yasuhiko TABATA, Natsumi HIRAYAMA
  • Patent number: 5128146
    Abstract: An apatite coated article comprising a substrate having thereon an apatite layer which is formed by flame spraying apatite powder at from about 2,000.degree. to 4,000.degree. C., and a process for producing such an apatite coated article.
    Type: Grant
    Filed: November 13, 1991
    Date of Patent: July 7, 1992
    Assignee: Asahi Kogaku Kogyo K.K.
    Inventors: Yasuhiko Hirayama, Haruko Ikata, Satoshi Ojima
  • Patent number: 5089195
    Abstract: A method for producing a calcium phosphate-based material comprising:(a) molding a calcium phosphate powder;(b) preliminarily calcining the resulting molding in a vacuum or under a reduced pressure until the relative density is 95% or more; and(c) firing the molding in air, an inert gas, or nitrogen gas.
    Type: Grant
    Filed: June 22, 1990
    Date of Patent: February 18, 1992
    Assignee: Asahi Kogaku Kogyo K.K.
    Inventors: Takeshi Ichitsuka, Yasuhiko Hirayama, Tetsuro Ogawa
  • Patent number: 5017518
    Abstract: A process for producing calcium phosphate ceramics having a porous surface is described, which comprise the steps of:a) preparing untreated calcium phosphate ceramics, which comprises a mixture of hydroxyapatite and tricalcium phosphate, andb) treating said untreated ceramics with an acidic solution to selectively dissolve the tricalcium phosphate in the surface of the ceramics.
    Type: Grant
    Filed: April 18, 1990
    Date of Patent: May 21, 1991
    Assignee: Asahi Kogaku Kogyo K.K.
    Inventors: Yasuhiko Hirayama, Tetsuro Ogawa, Satoshi Ojima
  • Patent number: 4957674
    Abstract: A method for producing a calcium phosphate-based material comprising:(a) molding a calcium phosphate powder;(b) preliminarily calcining the resulting molding in a vacuum or under a reduced pressure until the relative density is 95% or more; and(c) firing the molding in air, an inert gas, or nitrogen gas.
    Type: Grant
    Filed: May 11, 1988
    Date of Patent: September 18, 1990
    Assignee: Asahi Kogaku Kogyo Kabushiki Kaisha
    Inventors: Takeshi Ichitsuka, Yasuhiko Hirayama, Tetsuro Ogawa
  • Patent number: 4946378
    Abstract: An artificial intervertebral disc comprises a pair of end bodies which are provided, on their outer surfaces, with apatite layers. The disc includes a medical synthetic polymeric intermediate which is held between the end bodies through connecting members.
    Type: Grant
    Filed: November 22, 1988
    Date of Patent: August 7, 1990
    Assignee: Asahi Kogaku Kogyo Kabushiki Kaisha
    Inventors: Yasuhiko Hirayama, Haruko Ikata, Satoshi Ojima, Hiromi Matsuzaki
  • Patent number: 4798585
    Abstract: A support for a biomedical implant device in which the support has a surface layer composed of a biocompatible calcium phosphate material such as sintered hydroxyapatite with a porosity of 50-60% and pore size of 0.5-500 micrometers. Preferably, the surface layer is formed with projections or recesses of a few hundred micrometers size.
    Type: Grant
    Filed: June 8, 1987
    Date of Patent: January 17, 1989
    Assignee: Asahi Kogaku Kogyo Kabushiki Kaisha
    Inventors: Masahide Inoue, Takeshi Ichitsuka, Yasuhiko Hirayama, Shozo Koshikawa, Tateki Kitaoka, Nobuo Nakabayashi, Tatsumichi Takeda, Osamu Minoo
  • Patent number: RE34037
    Abstract: A support for a biomedical implant device in which the support has a surface layer composed of a biocompatible calcium phosphate material such as sintered hydroxyapatite with a porosity of 50-60% and pore size of 0.5-500 micrometers. Preferably, the surface layer is formed with projections or recesses of a few hundred micrometers size.
    Type: Grant
    Filed: January 17, 1991
    Date of Patent: August 18, 1992
    Assignee: Asahi Kogaku Kogyo K.K.
    Inventors: Masahide Inoue, Takeshi Ichitsuka, Yasuhiko Hirayama, Shozo Koshikawa, Tateki Kitaoka, Nobuo Nakabayashi, Tatsumichi Takeda, Osamu Minoo