Patents by Inventor Yasuhiro Funahashi

Yasuhiro Funahashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20040132783
    Abstract: A method for testing influence of a drug on integrin expression, which comprises the step of measuring an integrin expression amount in platelets of a patient to which the drug is administered and the step of determining influence of the drug on integrin expression in cells other than platelets based on the measured expression amount.
    Type: Application
    Filed: January 20, 2004
    Publication date: July 8, 2004
    Inventors: Naoto Ono, Taro Senba, Naoko Hata, Yasuhiro Funahashi, Toshiaki Wakabayashi
  • Publication number: 20040053908
    Abstract: Compounds represented by the following general formula: 1
    Type: Application
    Filed: April 18, 2003
    Publication date: March 18, 2004
    Inventors: Yasuhiro Funahashi, Akihiko Tsuruoka, Masayuki Matsukura, Toru Haneda, Yoshio Fukuda, Junichi Kamata, Keiko Takahashi, Tomohiro Matsushima, Kazuki Miyazaki, Ken-ichi Nomoto, Tatsuo Watanabe, Hiroshi Obaishi, Atsumi Yamaguchi, Sachi Suzuki, Katsuji Nakamura, Fusayo Mimura, Yuji Yamamoto, Junji Matsui, Kenji Matsui, Takako Yoshiba, Yasuyuki Suzuki, Itaru Arimoto
  • Publication number: 20040018192
    Abstract: The present invention provides an integrin expression inhibitor, and an agent for treating arterial sclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinopathy or inflammatory diseases, an anticoagulant, or a cancer metastasis suppressor on the basis of an integrin inhibitory action. Namely, it provides an integrin expression inhibitor comprising, as an active ingredient, a sulfonamide compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate of them.
    Type: Application
    Filed: July 18, 2002
    Publication date: January 29, 2004
    Inventors: Toshiaki Wakabayashi, Yasuhiro Funahashi, Naoko Hata, Taro Semba, Yuji Yamamoto, Toru Haneda, Takashi Owa, Akihiko Tsuruoka, Junichi Kamata, Tadashi Okabe, Keiko Takahashi, Kazumasa Nara, Shinichi Hamaoka, Norihiro Ueda
  • Patent number: 6673787
    Abstract: The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof. In the formula, R1 represents hydrogen atom, a halogen atom or cyano group; R2 and R3 are the same as or different from and each represents hydrogen atom, a C1-C4 lower alkyl group or a halogen atom; R4 represents hydrogen atom or a C1-C4 lower alkyl group; and the ring A represents cyanophenyl group, aminosulfonylphenyl group, aminopyridyl group, aminopyrimidyl group, a halopyridyl group or cyanothiophenyl group, provided that the case where all of R1, R2 and R3 are hydrogen atoms, where both R2 and R3 are hydrogen atoms or where the ring A is aminosulfonyl group and both R1 and R2 are halogen atoms is excluded.
    Type: Grant
    Filed: March 18, 2002
    Date of Patent: January 6, 2004
    Assignee: Eisai Co., Ltd.
    Inventors: Toru Haneda, Akihiko Tsuruoka, Junichi Kamata, Tadashi Okabe, Keiko Takahashi, Kazumasa Nara, Shinichi Hamaoka, Norihiro Ueda, Takashi Owa, Toshiaki Wakabayashi, Yasuhiro Funahashi, Taro Semba, Naoko Hata, Yuji Yamamoto, Yoichi Ozawa, Noako Tsukahara
  • Patent number: 6649367
    Abstract: A method for producing a cell to which angiogenesis-inducing ability has been imparted, comprising the steps of introducing a gene of an angiogenic factor into a human or animal cell having low angiogenesis-inducing ability, and selecting a cell that overexpresses the angiogenic factor; and a method for screening for an angiogenesis inhibitor or a substance having anticancer activity by using the produced cell.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: November 18, 2003
    Assignee: Eisai Co., Ltd
    Inventors: Yuji Yamamoto, Yasuhiro Funahashi, Kenichi Nomoto, Tatsuo Watanabe
  • Patent number: 6645996
    Abstract: The present invention provides a novel bioactive substance having an antiangiogenic effect. The chemical compound represented by the formula (1) (wherein, R1 represents hydrogen atom, aldehyde group or a lower acyl group, R2 and R3 are the same as or different from each other and represent hydrogen atom or a lower alkoxy group or are combined to represent oxygen atom, R4 represents a lower alkyl group and R5 represents hydrogen atom or a lower alkyl group, provided that compounds in which R1 is aldehyde group, R2 and R3are different from each other and are hydrogen atom or methoxy group, R4 is ethyl group and R5 is hydrogen atom are excluded), a salt thereof or a hydrate thereof was isolated from the culture broth of genus Streptomyces and the structure thereof was analyzed.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: November 11, 2003
    Assignee: Mercian Corporation and Eisai Co., Ltd.
    Inventors: Toshiaki Wakabayashi, Rena Kawase, Nobuaki Naruse, Masanori Fujita, Tomohiro Sameshima, Yoshio Watanabe, Kazuyuki Dobashi, Yasuhiro Funahashi, Taro Semba
  • Patent number: 6638964
    Abstract: The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof: In the formula, R1 represents hydrogen atom, a halogen atom or cyano group; R2 and R3 are the same as or different from and each represents hydrogen atom, a C1˜C4 lower alkyl group or a halogen atom; R4 represents hydrogen atom or a C1˜C4 lower alkyl group; and the ring A represents cyanophenyl group, aminosulfonylphenyl group, aminopyridyl group, aminopyrimidyl group, a halopyridyl group or cyanothiophenyl group, provided that the case where all of R1, R2 and R3 are hydrogen atoms, where both R2 and R3 are hydrogen atoms or where the ring A is aminosulfonyl group and both R1 and R2 are halogen atoms is excluded.
    Type: Grant
    Filed: March 18, 2002
    Date of Patent: October 28, 2003
    Assignee: Eisai Co., Ltd.
    Inventors: Toru Haneda, Akihiko Tsuruoka, Junichi Kamata, Tadashi Okabe, Keiko Takahashi, Kazumasa Nara, Shinichi Hamaoka, Norihiro Ueda, Takashi Owa, Toshiaki Wakabayashi, Yasuhiro Funahashi, Taro Semba, Naoko Hata, Yuji Yamamoto, Yoichi Ozawa, Noako Tsukahara
  • Publication number: 20030144507
    Abstract: The present invention provides a sulfonamide- or sulfonylurea-containing heterocyclic compounds. Specifically, it provides a heterocyclic compound represented by the formula (I), a pharmacologically acceptable salt thereof or a hydrate of them.
    Type: Application
    Filed: June 10, 2002
    Publication date: July 31, 2003
    Inventors: Toru Haneda, Akihiko Tsuruoka, Junichi Kamata, Tadashi Okabe, Keiko Takahashi, Kazumasa Nara, Shinichi Hamaoka, Norihiro Ueda, Toshiaki Wakabayashi, Yasuhiro Funahashi, Taro Semba, Naoko Hata, Yuji Yamamoto, Yoichi Ozawa, Naoko Tsukahara, Takashi Owa
  • Publication number: 20030003580
    Abstract: A method for producing a cell to which angiogenesis-inducing ability has been imparted, comprising the steps of introducing a gene of an angiogenic factor into a human or animal cell having low angiogenesis-inducing ability, and selecting a cell that overexpresses the angiogenic factor; and a method for screening for an angiogenesis inhibitor or a substance having anticancer activity by using the produced cell.
    Type: Application
    Filed: February 26, 2002
    Publication date: January 2, 2003
    Inventors: Yuji Yamamoto, Yasuhiro Funahashi, Kenichi Nomoto, Tatsuo Watanabe
  • Patent number: 6469043
    Abstract: The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof. In the formula, R1 represents hydrogen atom, a halogen atom or cyano group; R2 and R3 are the same as or different from and each represents hydrogen atom, a C1˜C4 lower alkyl group or a halogen atom; R4 represents hydrogen atom or a C1˜C4 lower alkyl group; and the ring A represents cyanophenyl group, aminosulfonylphenyl group, aminopyridyl group, aminopyrimidyl group, a halopyridyl group or cyanothiophenyl group, provided that the case where all of R1, R2 and R3 are hydrogen atoms, where both R2 and R3 are hydrogen atoms or where the ring A is aminosulfonyl group and both R1 and R2 are halogen atoms is excluded.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: October 22, 2002
    Assignee: Eisai Co., Ltd.
    Inventors: Toru Haneda, Akihiko Tsuruoka, Junichi Kamata, Tadashi Okabe, Keiko Takahashi, Kazumasa Nara, Shinichi Hamaoka, Norihiro Ueda, Takashi Owa, Toshiaki Wakabayashi, Yasuhiro Funahashi, Taro Semba, Naoko Hata, Yuji Yamamoto, Yoichi Ozawa, Noako Tsukahara
  • Publication number: 20020128483
    Abstract: The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof.
    Type: Application
    Filed: March 18, 2002
    Publication date: September 12, 2002
    Applicant: Eisai Co., Ltd.
    Inventors: Toru Haneda, Akihiko Tsuruoka, Junichi Kamata, Tadashi Okabe, Keiko Takahashi, Kazumasa Nara, Shinichi Hamaoka, Norihiro Ueda, Takashi Owa, Toshiaki Wakabayashi, Yasuhiro Funahashi, Taro Semba, Naoko Hata, Yuji Yamamoto, Yoichi Ozawa, Noako Tsukahara
  • Publication number: 20020128480
    Abstract: The present invention creates a novel antiangiogenic agent and provides an antitumor agent which shows high safety as compared with conventional antitumor agents, has a sure effect and is able to be administered for a long period. That is, it provides an indole compound represented by the following formula (I), its pharmacologically acceptable salt or hydrates thereof.
    Type: Application
    Filed: March 18, 2002
    Publication date: September 12, 2002
    Applicant: Eisai Co., Ltd.
    Inventors: Toru Haneda, Akihiko Tsuruoka, Junichi Kamata, Tadashi Okabe, Keiko Takahashi, Kazumasa Nara, Shinichi Hamaoka, Norihiro Ueda, Takashi Owa, Toshiaki Wakabayashi, Yasuhiro Funahashi, Taro Semba, Naoko Hata, Yuji Yamamoto, Yoichi Ozawa, Noako Tsukahara
  • Patent number: 6321383
    Abstract: The first auxiliary memory 11a stores background image information in the form of digital data, and the second auxiliary memory 11b stores sound information in the form of digital data. When a request is transmitted from the terminal 36 to the information supplying device 28, a background image information of a genre, to which the requested song belongs, is retrieved from the first auxiliary memory 11a, packetized by the video packetizer 5, and outputted to the multiplexer 9. A sound information for the requested song is retrieved from the second auxiliary memory 11b, packetized by the audio packetizer 6, and outputted to the multiplexer 9. The background image information and the sound information are combined into a single packet data train and outputted to the terminal 36.
    Type: Grant
    Filed: July 29, 1996
    Date of Patent: November 20, 2001
    Assignee: Brother Kogyo Kabushiki Kaisha
    Inventors: Yasuhiro Funahashi, Takuma Kuno
  • Patent number: 5931679
    Abstract: An information provision system including: a plurality of information provision devices, each information provision device including: a memory for storing data; and an information processor for using the data stored in the memory to prepare external-output information; a transmission unit for conveying external-output information provided by the information provision devices; a plurality of output terminals in a number greater than the plurality of information provision devices, each output terminal including: a keyboard by which requests are inputted; request transmission unit for transmitting, according to commands inputted via the keyboard, requests; and output device for outputting information based on external-output information; and a central control device including: request receiver for receiving requests transmitted from the request transmitter; a priority storage unit for storing, for each output terminal, a priority level at which external-output information is to be provided; and command unit for
    Type: Grant
    Filed: March 7, 1996
    Date of Patent: August 3, 1999
    Assignees: Brother Kogyo Kabushiki Kaisha, Xing Inc.
    Inventor: Yasuhiro Funahashi
  • Patent number: 5781683
    Abstract: A video reproducing apparatus includes a video data memory for storing video data and a video data table for storing information about whether or not given items of the video data in the video data memory have been reproduced. A backup power supply unit backs up the information in the video data table when power is removed. A song category designation input unit is provided for inputting the song category designated, a video reproducing unit is provided for reproducing video data, and a background video control unit is provided for controlling the component units configured. On the basis of the information held in the video data table, the background video control unit determines whether or not any unreproduced video data remains in the video data belonging to the song category designated by the song category designation input unit. If unreproduced video data is found to exist, the control unit instructs the video reproducing unit to reproduce that unreproduced video data.
    Type: Grant
    Filed: April 18, 1994
    Date of Patent: July 14, 1998
    Assignee: Brother Kogyo Kabushiki Kaisha
    Inventors: Iwao Sakoguchi, Yasuhiro Funahashi, Yoshiko Sakoguchi
  • Patent number: 5774672
    Abstract: In the karaoke system 1, a center 3 is connected to a plurality of karaoke terminals 5 by a coaxial cable 7. The center 3 divides the karaoke song data stored in the memory device 13 over several channels and transmits all the karaoke song data within a fixed time period in succession to the karaoke terminals 5 via the coaxial cable 7. This operation is performed regardless of whether or not a song is requested from one of the karaoke terminals 5. Whether the karaoke data transmitted in succession is data of a requested song is determined by the control portion 41 of a karaoke terminal 5. If so, karaoke performance processes are performed wherein the karaoke data is reproduced and the orchestral accompaniment and lyric image is outputted.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: June 30, 1998
    Assignees: Brother Kogyo Kabushiki Kaisha, Xing Inc.
    Inventors: Yasuhiro Funahashi, Kazunori Ikami, Osamu Nishimura, Yuji Kiyohara, Yoshihiko Hibino, Yuichi Yasutomo
  • Patent number: 5725383
    Abstract: In a karaoke system, a central terminal and a plurality of karaoke terminals are connected by a coaxial cable. A polling modem modulates a polling signal to a predetermined channel signal and transmits it to a karaoke terminal and also receives a response signal (signal for responding as to whether a song has been requested) transmitted from the karaoke terminal in response to the polling signal. When a song is requested, the data transmission control portion retrieves the karaoke song data of the requested song from the memory, modulates it via the data transmission modem into an alternating current signal that differs from the channel of the polling signal, and transmits it to the karaoke terminal.
    Type: Grant
    Filed: September 26, 1996
    Date of Patent: March 10, 1998
    Assignees: Brother Kogyo Kabushiki Kaisha, Xing Inc.
    Inventors: Yasuhiro Funahashi, Kazunori Ikami, Osamu Nishimura, Yuji Kiyohara, Yoshihiko Hibino, Yuichi Yasutomo
  • Patent number: 5691915
    Abstract: When the terminal 5 requests a partial access of a desired karaoke song to the center 3 in S380, only the climactic passage data of the karaoke song is transmitted from the center 3 to the terminal 5. The terminal 5 reproduces the climactic passage in S400. Then, the terminal 5 determines whether or not the user will pay for the karaoke song in S410. When the payment is confirmed, the terminal 5 requests total access to the center 3 in S340, receives the entire data of the karaoke song in S350, and reproduces the data in S360. It is possible to prevent the user from erroneously requesting a total access of a karaoke song which the user does not want to sing. It is ensured that the user can obtain karaoke songs which he/she really wants to sing, within a short period of time.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: November 25, 1997
    Assignees: Brother Kogyo Kabushiki Kaisha, Xing, Inc.
    Inventors: Yasuhiro Funahashi, Kazunori Ikami, Yukie Hasegawa
  • Patent number: 5675509
    Abstract: Each of the data transmission devices 15a-15d serially and cyclically transmits all the song data over a corresponding channel, by a time cycle corresponding to the number of the song data. The four data transmission devices 15a-15d transmit the song data, at timings shifted from one another by (1/the number of channels) of the time cycle. Each terminal determines one channel out of the four channels that can most rapidly supply desired song data. Each terminal then picks up the desired song data from the determined channel.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: October 7, 1997
    Assignee: Brother Kogyo Kabushiki Kaisha and Xing, Inc.
    Inventors: Kazunori Ikami, Yasuhiro Funahashi, Yukie Hasegawa
  • Patent number: 5654690
    Abstract: Disclosed is an improved fire alarm system for an information providing system having a plurality of terminal devices for providing information to a plurality of operators, respectively. The fire alarm system is provided with a fire detecting sensors. If a fire is detected, a predetermined signal is transmitted to a controller. The controller controls each of the plurality of terminal devices to indicate an alarm information to the operator when the predetermined signal is received.
    Type: Grant
    Filed: December 13, 1994
    Date of Patent: August 5, 1997
    Assignees: Brother Kogyo Kabushiki Kaisha, Xing Inc., Intec Inc.
    Inventors: Seiko Ishikawa, Takayoshi Urano, Kazunori Ikami, Yoshihiko Hibino, Masaru Yasuda, Yasuhiro Funahashi, Naomi Moriguchi, Hiroshi Matsuhashi, Tatsuo Matsuda, Kazuhiro Fujii