Patents by Inventor Yasuo Kurosaki

Yasuo Kurosaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240207492
    Abstract: Provided are a drug-eluting medical device in which drug elution is sustained release and the peeling durability of the coating layer is high, and a method for producing the same. A drug-eluting medical device including: a substrate; a first coating layer coated on the substrate and having a first polymer obtained by autoxidation polymerization of a dopamine molecule or an analog thereof; a second coating layer coated on the first coating layer having a second polymer covalently bonded to the first polymer; and a third coating layer coated on the second coating layer and having a drug and a third polymer supporting the drug, wherein the second polymer and the third polymer form an interpenetrating polymer network structure.
    Type: Application
    Filed: March 7, 2024
    Publication date: June 27, 2024
    Applicant: TERUMO KABUSHIKI KAISHA
    Inventors: Shuhei MATSUSHITA, Yasuo KUROSAKI
  • Publication number: 20230316519
    Abstract: A coating layer inspection device and a method for inspecting a coating layer are disclosed that enable highly accurate evaluation of defectiveness in a coating layer of a subject. The coating layer inspection device includes a processing unit including a digitization unit that digitizes gray level information of each pixel, an average gray level calculation unit that calculates an average gray level, a first grayscale determination unit that determines whether the average gray level is equal to or greater than a first threshold and classifies the grayscale image as a potentially acceptable quality when obtaining an affirmative result, and a first upper-limit determination unit that determines whether the number of pixels having a gray level equal to or greater than the first threshold is equal to or less than a first specified upper limit and classifies the grayscale image as a potentially acceptable quality when obtaining an affirmative result.
    Type: Application
    Filed: June 7, 2023
    Publication date: October 5, 2023
    Applicant: TERUMO KABUSHIKI KAISHA
    Inventors: Yuno KITAGAWA, Yasuo KUROSAKI
  • Patent number: 11707609
    Abstract: A balloon catheter is disclosed that can effectively deliver a drug to living body tissue, a method of manufacturing a balloon catheter, and a treatment method. A balloon catheter is disclosed, the balloon catheter is provided on an outer surface of a balloon with a plurality of elongate bodies which are independent crystals of a water-insoluble drug extending in an elongate form. The elongate bodies include fixed-side elongate bodies which are fixed to the outer surface side of the balloon, and top-side elongate bodies which are bent or broken from the fixed-side elongate bodies and are continuous with or independent of the fixed-side elongate bodies.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: July 25, 2023
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Hiroshi Goto, Yu Murata, Ryosuke Suzuki, Yasuo Kurosaki, Katsumi Morimoto
  • Patent number: 11690983
    Abstract: Provided are a drug layer applying device and a method for forming a drug layer which can quickly and easily apply or provide an appropriate amount of a drug on a surface of a medical instrument such as a balloon. A drug layer applying device that applies a drug layer on a surface of a balloon to be inserted into a living body, includes: a deformable porous body capable of holding a coating solution containing a drug and a solvent; a removal unit that is flexibly deformable and arranged alongside the porous body; and a holding base that holds the porous body and the removal unit.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: July 4, 2023
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuo Kurosaki, Hiroshi Goto, Yuno Kitagawa
  • Patent number: 11660429
    Abstract: A drug coating layer that prevents breakage of elongated drug crystals on a balloon surface while maintaining the drug crystals in an appropriate shape to act on the living body includes plural elongated bodies which are crystals of a water-insoluble drug each extending from the surface of the balloon at various lengths and angles, and a water-soluble additive layer provided in a space between an outer surface of an aggregate of the elongated bodies and the balloon surface to fill a space between the elongated bodies. The outer surface of the additive layer being located outside the aggregate, being uneven connecting a plurality of tip ends and side surfaces of the elongated bodies to each other. The tip ends of the elongated bodies slightly protrude from the additive layer, and the side surfaces and/or tip surfaces of the elongated body are exposed on the surface of the additive layer.
    Type: Grant
    Filed: February 25, 2020
    Date of Patent: May 30, 2023
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuo Kurosaki, Yu Osawa
  • Patent number: 11446475
    Abstract: A balloon catheter by which a drug can be effectively delivered to living body tissue and a method of manufacturing the balloon catheter, and a treatment method. The balloon catheter is provided on an outer surface of a balloon with a plurality of elongate bodies which are independent crystals of a water-insoluble drug that extend in an elongate form. The elongate bodies have long axes extending in directions along the outer surface of the balloon when the balloon is in a deflated state. Deformation, when the balloon is inflated from the deflated state, of portions on an outer surface side of the balloon to which end portions of the elongate bodies are fixed causes a force to act on the elongate bodies such that the long axes of the elongate bodies approach perpendicularity to the outer surface of the balloon.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: September 20, 2022
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuo Kurosaki, Katsumi Morimoto, Hiroshi Goto
  • Patent number: 11426564
    Abstract: A method and apparatus are disclosed for forming a drug coating layer capable of preventing breakage of elongated drug crystals on a surface of a balloon and maintaining the drug crystals in an appropriate shape in order to act on a living body. The method includes supplying a coating solution which contains the water-insoluble drug, a water-soluble additive, an organic solvent, and water to the surface of the balloon and evaporating the organic solvent and the water to form an additive layer containing the water-soluble additive and a protruding crystal having a tip end protruding from the additive layer, cutting a surplus portion protruding from the additive layer of the protruding crystal from a part surrounded by the additive layer and forming the part surrounded by the additive layer as the elongated body, and removing the cut-out surplus portion from the drug coating layer.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: August 30, 2022
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuo Kurosaki, Hiroshi Goto, Yuno Kitagawa
  • Patent number: 11369777
    Abstract: A balloon catheter includes an elongated main body extending in an axial direction and a balloon connected to the elongated main body. The balloon is inflatable and deflatable in the radial direction. The outer surface of the balloon includes a plurality of recesses that are spaced apart from one another. The balloon catheter also includes a plurality of elongate bodies on the outer surface of the balloon. The elongate bodies are crystals of a water-insoluble drug extending in the radial direction of the balloon away from the interior of the balloon. The elongate bodies each possess an independent long axis. At least two elongate bodies of the elongate bodies are positioned in one of the recesses in the outer surface of the balloon. These two elongate bodies extend from within the recess to a surrounding environment in the radial direction of the balloon.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: June 28, 2022
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuo Kurosaki, Katsumi Morimoto, Hiroshi Goto
  • Patent number: 11369776
    Abstract: A balloon catheter that includes an elongated main body extending in an axial direction and a balloon connected to the distal portion of the elongated main body. The balloon includes an interior and is inflatable and deflatable. The balloon catheter also includes a plurality of elongate bodies extending radially away from the outer surface of the balloon. The elongate bodies are crystals of a water-insoluble drug. The elongate bodies each possess an independent longitudinal axis. Each of the elongate bodies includes a base portion at the proximal end of the elongate body. A plurality of elongate body proximal portions extend radially inwardly from the base portion of each of the elongate bodies toward the interior of the balloon. The elongate body proximal portions are continuous extensions of the crystal of the water-insoluble drug.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: June 28, 2022
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Katsumi Morimoto, Yasuo Kurosaki, Katsunori Ebata
  • Patent number: 11369778
    Abstract: A balloon catheter that includes an elongated main body, a balloon connected to the elongated main body, and a base layer on the outer surface of the balloon. The base layer includes a water-soluble low-molecular weight compound. The balloon catheter also includes a plurality of elongate bodies extending radially away from the outer surface of the balloon. The elongate bodies are crystals of a water-insoluble drug. The elongate bodies each possesses an independent longitudinal axis. At least part of at least some of the elongate bodies are located in the interior of the base layer on the outer surface of the balloon.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: June 28, 2022
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuo Kurosaki, Katsumi Morimoto, Yu Murata, Hiroshi Goto
  • Patent number: 11331457
    Abstract: A balloon catheter is disclosed having a balloon at a distal portion of a catheter shaft and on a surface of the balloon are elongate bodies which are crystals of a water-insoluble drug having independent long axes. The balloon in a deflated state has a plurality of wing portions in a circumferential direction of the balloon, and a circumferential surface portion along a circumferential direction of the catheter shaft, the plurality of wing portions being folded along the circumferential direction of the balloon. A surface of the circumferential surface portion which faces the plurality of wing portions that are folded has a region in which tip portions are not in contact with the surface of the balloon or with other elongate bodies, and a surface which faces the plurality of wing portions that are folded which faces an outer circumferential side has a region in which the tip portions are in contact with the surface of the balloon or with the other elongate bodies.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: May 17, 2022
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Hiroshi Goto, Katsumi Morimoto, Yasuo Kurosaki
  • Publication number: 20220001147
    Abstract: A balloon catheter and a method for arranging a balloon are disclosed, which are capable of suppressing the separation of a drug with which an outer surface of a balloon is coated. A balloon catheter in which a balloon with an outer surface coated with a drug is disposed to an inside of a protective tube, in which: the balloon includes a plurality of wing portions that protrude radially outward, and a plurality of base portions that are in contact with an inner tube; each of the plurality of wing portions include a wing distal end portion that is positioned on a protruding side, a wing proximal end portion that is connected to the base portion, and a wing middle portion that is positioned between the wing distal end portion and the wing proximal end portion.
    Type: Application
    Filed: September 21, 2021
    Publication date: January 6, 2022
    Applicant: TERUMO KABUSHIKI KAISHA
    Inventors: Hiroshi GOTO, Yasuo KUROSAKI
  • Publication number: 20220001153
    Abstract: A folding method of an inflatable balloon disposed on an outer peripheral surface of an inner tube of a balloon catheter is disclosed. The method includes: disposing the balloon to an inner side of a plurality of first blade portions arranged so as to surround a reference position while maintaining a state where pressure is applied to an inside of the balloon; correcting a bend of the balloon by moving the plurality of first blade portions toward the reference position in the state where the pressure is applied to the inside of the balloon; pleating a plurality of wing portions protruding radially outward on the balloon by further moving the plurality of first blade portions toward the reference position to partially press the balloon while gradually discharging the fluid inside the balloon; and folding the balloon along the inner tube.
    Type: Application
    Filed: September 20, 2021
    Publication date: January 6, 2022
    Applicant: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuo KUROSAKI, Hiroshi GOTO
  • Publication number: 20220001148
    Abstract: A balloon catheter and a method are disclosed capable of suppressing the separation of a drug with which an outer surface of a balloon is coated. A balloon catheter in which a balloon with an outer surface coated with a drug is disposed to an inside of a protective tube, in which: the balloon includes a plurality of wing portions that are folded while protruding radially outward; the wing portions each include a wing distal end portion, a wing proximal end portion, and a wing middle portion; the wing distal end portion is pleated such that inner surfaces are separated from each other; and the wing distal end outer portion contacts an inner peripheral surface of the protective tube; the wing distal end inner portion includes a first contact portion that contacts a second contact portion of another wing portion.
    Type: Application
    Filed: September 21, 2021
    Publication date: January 6, 2022
    Applicant: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuo KUROSAKI, Hiroshi GOTO
  • Patent number: 11135409
    Abstract: A balloon wrapping apparatus for folding a balloon at a distal portion of an elongated shaft includes: a pleating section that forms the balloon with pleats; a folding section that folds the pleats formed in the balloon, along a circumferential direction; and a support base that supports the shaft and can be moved toward and away from the pleating section. The pleating section includes an insertion hole through which the balloon can be inserted, and a back surface hole provided in a back surface on the side opposite to the side on which the insertion hole is provided. The pleating section includes an assisting shaft which can be inserted into the back surface hole from the rear surface side, and an interlock portion interlocking the assisting shaft with the support base. The assisting shaft is formed with a cavity portion.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: October 5, 2021
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuo Kurosaki, Hiroshi Goto
  • Patent number: 11104056
    Abstract: A balloon wrapping apparatus and a balloon wrapping method are disclosed by which a balloon can be wrapped appropriately. The balloon wrapping apparatus for wrapping a balloon of a balloon catheter provided with the balloon at a distal portion of an elongated shaft includes: a pleating section that forms the balloon with wing shapes projecting in radial directions; a folding section that includes a plurality of blades aligned in a circumferential direction, and that folds the wing shapes formed in the balloon along the circumferential direction by moving rotationally the blades; and a rotational support portion that supports a portion of the shaft which portion is on a proximal side of the balloon, and that rotates the shaft in a direction opposite to a rotary movement direction of the blades in a state in which the balloon is positioned in relation to the folding section.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: August 31, 2021
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuo Kurosaki, Hiroshi Goto
  • Patent number: 11097460
    Abstract: A balloon wrapping apparatus is disclosed by which a balloon can be accurately positioned and inserted in relation to a pleating section. The balloon wrapping apparatus for wrapping a balloon provided at a distal portion of an elongated shaft includes: a pleating section that forms the balloon with wing shapes; a folding section that folds the wing shapes formed in the balloon along a circumferential direction; a support base that supports a portion other than the distal portion of the shaft, and that makes the distal portion of the shaft insertable into the pleating section and the folding section; and a core metal member to be inserted in the shaft. The core metal member is inserted in the shaft from a distal end position of the balloon to at least the proximal side of a proximal end position of the balloon.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: August 24, 2021
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuo Kurosaki, Hiroshi Goto
  • Patent number: 10869995
    Abstract: A balloon wrapping apparatus and a balloon wrapping method are disclosed by which a balloon can be accurately positioned in relation to a pleating section and to a folding section. The balloon wrapping apparatus for wrapping a balloon of a balloon catheter provided with the balloon at a distal portion of an elongated shaft includes: a pleating section having a plurality of blades aligned with space parts therebetween in a circumferential direction, and forms the balloon with wing shapes projecting in radial directions by clamping the balloon in the space parts by moving rotationally the blades; and a folding section having a plurality of blades aligned in a circumferential direction, and that folds the wing shapes formed in the balloon in the circumferential direction by moving rotationally the blades; and a support base that supports a part of the shaft which part is on a proximal side of the balloon.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: December 22, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuo Kurosaki, Hiroshi Goto
  • Patent number: 10806912
    Abstract: A balloon coating method for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The method includes moving a drive shaft relative to at least one of a hub of the balloon catheter and an interlocking member. The drive shaft is configured to rotate the balloon catheter about an axis of the balloon. The method fixing the drive shaft to the proximal end of the hub or to the opening of the interlocking member by frictional force, and applying a coating solution containing the drug to the outer surface of the balloon from a dispensing tube while gradually moving the dispensing tube in the axial direction and simultaneously rotating the drive shaft to rotate the balloon catheter around the axis of the balloon catheter.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: October 20, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Hiroshi Goto, Yasuo Kurosaki, Eisuke Furuichi
  • Patent number: 10799909
    Abstract: A balloon coating method is disclosed for forming a coating layer on an outer surface of a balloon of a balloon catheter. The method includes an application step where a vertically extending dispensing tube for supplying a coating solution containing the water-insoluble drug and a solvent is formed at its end portion with an opening portion for discharging the coating solution therethrough and when an opening portion-formed end portion side of the dispensing tube is kept in contact with the outer surface of the balloon in such a manner as to be oriented to a rotating direction of the balloon while the balloon is rotated about an axis of the balloon, the coating solution is discharged through the opening portion and applied to the outer surface of the balloon while the dispensing tube is moved relative to the balloon in an axial direction of the balloon.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: October 13, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Yasuo Kurosaki, Hiroshi Goto, Eisuke Furuichi