Abstract: A balloon catheter includes an elongated main body extending in an axial direction and a balloon connected to the elongated main body. The balloon is inflatable and deflatable in the radial direction. The outer surface of the balloon includes a plurality of recesses that are spaced apart from one another. The balloon catheter also includes a plurality of elongate bodies on the outer surface of the balloon. The elongate bodies are crystals of a water-insoluble drug extending in the radial direction of the balloon away from the interior of the balloon. The elongate bodies each possess an independent long axis. At least two elongate bodies of the elongate bodies are positioned in one of the recesses in the outer surface of the balloon. These two elongate bodies extend from within the recess to a surrounding environment in the radial direction of the balloon.

Abstract: A balloon catheter that includes an elongated main body, a balloon connected to the elongated main body, and a base layer on the outer surface of the balloon. The base layer includes a water-soluble low-molecular weight compound. The balloon catheter also includes a plurality of elongate bodies extending radially away from the outer surface of the balloon. The elongate bodies are crystals of a water-insoluble drug. The elongate bodies each possesses an independent longitudinal axis. At least part of at least some of the elongate bodies are located in the interior of the base layer on the outer surface of the balloon.

Abstract: A long-lasting, controlled-release local anesthetic liposome preparation is produced by: providing a liposome composition, which is obtained by mixing, in a water-miscible organic solvent, a first aqueous phase solution with a water-miscible organic solution, in which a phospholipid and cholesterol are contained at a defined total concentration, at a defined ratio by volume thereby obtaining an emulsion wherein a total concentration of the phospholipid and cholesterol in the mixed phase is at 15 w/v % to 50 w/v %, followed by subjecting the emulsion to external solution exchange with a second aqueous phase solution to obtain a liposome composition wherein an ion gradient is formed between an internal-region aqueous phase of a liposome membrane made of the first aqueous phase solution and an external-region aqueous phase of the liposome membrane made of the second aqueous phase solution; and encapsulating a local anesthetic in the internal-region aqueous phase according to a remote loading method.

Abstract: A positioning method for balloon coating by which the thickness and morphological form of a drug in a coating formed on a balloon can be suitably set. This method is a positioning method for balloon coating for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The positioning method includes a positioning step in which a dispensing tube is moved, from a state of non-contact with the balloon, in a direction intersecting the extending direction of the dispensing tube, and an opening portion-formed end portion side of the dispensing tube formed at its end portion with an opening portion for discharging a coating solution is thereby placed in contact with the outer surface of the balloon.

Abstract: A balloon coating method is disclosed, which includes an application step in which, where a flexible dispensing tube for supplying a coating solution containing the water-insoluble drug and a solvent is formed at its end portion with an opening portion for discharging the coating solution therethrough and when the opening portion-formed end portion side of the dispensing tube is kept in contact with the outer surface of the balloon in such a manner as to be oriented in a direction opposite to a rotating direction of the balloon while the balloon is rotated about an axis of the balloon, the coating solution is discharged through the opening portion and applied to the outer surface of the balloon while the dispensing tube is moved relative to the balloon in an axial direction X of the balloon.

Abstract: A positioning method for balloon coating by which the thickness, morphological form and the like of a drug in a coating formed on a balloon can be suitably set. This method is a positioning method for balloon coating for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The positioning method includes a positioning step in which the dispensing tube is positioned in such a manner that a virtual position at which an opening portion would be located if the dispensing tube is assumed to be non-flexible is located within the range of 0 degrees to 40 degrees from the reference plane toward the rotating direction side of the balloon, in a region extending from the reference plane in a direction opposite to the discharge direction of the dispensing tube.

Abstract: A balloon coating method is disclosed for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The balloon coating method includes an application step in which, where a pipe-shaped dispensing tube formed from a polyolefin for supplying a coating solution containing the water-insoluble drug and a solvent is formed at its end portion with an opening portion for discharging the coating solution therethrough and when the end portion side of the dispensing tube is placed in contact with the outer surface of the balloon while the balloon is rotated about an axis of the balloon, the coating solution is discharged through the opening portion and applied to the outer surface of the balloon while the dispensing tube is moved relative to the balloon in an axial direction of the balloon.

Abstract: The file management server refers, when file information on at least two files targeted for association is acquired, to a storing unit that stores therein condition information, in which conditions for determining whether association between files is permitted are set, and determines whether the two files in the file information satisfy a condition that is set in the condition information and associates, when the condition is satisfied, the two files.

Abstract: A balloon coating method for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter includes: fixing a connection portion between the balloon and an inner tube penetrating an inside of the balloon in such a manner as to clamp the connection portion by at least two clamping portions each having a groove-shaped curved surface extending along an axis of the inner tube; pulling the balloon in an axial direction of the balloon by the clamping portions to thereby straighten a bend of the balloon; and moving a dispensing tube for supplying a coating liquid containing the drug relative to the balloon in the axial direction of the balloon, while rotating the balloon about an axis of the balloon, to thereby coat the outer surface of the balloon with the coating liquid.

Abstract: A balloon coating method for forming a coating layer containing a water-insoluble drug on the outer surface of a balloon of a balloon catheter, wherein the balloon catheter includes an elongate shaft possessing a distal portion at which is provided the balloon which is inflatable. The balloon coating method includes: holding the shaft on a support part capable of rotating about an axis of the balloon; and moving a dispensing tube for supplying a coating liquid containing the drug relative to the balloon in an axial direction of the balloon, while rotating the balloon together with the support part, thereby to coat the outer surface of the balloon with the coating liquid.

Abstract: A balloon coating method for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter includes: inserting a core member into a guide wire lumen penetrating the balloon, disposing a proximal portion of the core member on a proximal side of a region of inflation of the balloon, with a distal portion of the core member protruded distally beyond a distal opening portion of the guide wire lumen, and fixing by clamping together with the core member a part of the balloon catheter that is on a distal side of the region of inflation; and moving a dispensing tube for supplying a coating liquid containing the drug relative to the balloon in an axial direction of the balloon, while rotating the balloon about an axis of the balloon, thereby to apply the coating liquid to the outer surface of the balloon.

Abstract: Disclosed herein is a balloon coating method for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter, the balloon catheter including the balloon which is inflatable and provided on a distal portion of an elongate shaft. The balloon coating method includes: accommodating the shaft in a groove portion formed in a support base to extend rectilinearly, and closing at least part of the groove portion with a lid portion, thereby to support the shaft such that the shaft can be rotated within the groove portion; and moving a dispensing tube for supplying a coating liquid containing the drug relative to the balloon in an axial direction of the balloon, while rotating the balloon about an axis of the balloon, thereby to coat the outer surface of the balloon with the coating liquid.

Abstract: There is provided a sealing apparatus for a cryopreservation bag, with which a sealing treatment of an inlet/outlet of the cryopreservation bag is carried out automatically and anyone can safely and properly carry out the sealing treatment. The sealing apparatus includes: a bag clamping device 56; a laser device 57; and a scanning structure 58 for moving the bag clamping device 56, for example. The bag clamping device 56 includes a fixed pinching block 67, a movable pinching block 69, and a clamp actuator 70. The laser device 57 includes a laser oscillator 104 and a condensing lens 107. The fixed pinching block 67 includes a block base 73, a heat radiator 74, and a heat radiator holder 75. An infrared laser beam is radiated to a sealed portion 55 of the bag to form a seal bead 125 for sealing in a state in which the sealed portion 55 is pinched and fixed by the heat radiator 74 and the movable pinching block 69 and while the bag clamping device 56, for example, is moved by the scanning structure 58.

Abstract: A balloon coating method and a balloon coating apparatus are disclosed by which the thickness and/or morphological form of a drug in a coating formed on a balloon can be appropriately set. The balloon coating method can include moving a coating section for applying a coating liquid containing a drug relative to the balloon in the direction of an axis, while rotating the balloon about the axis of the balloon, thereby to apply the coating liquid to an outer surface of the balloon; detecting the distance of a dried part where the coating liquid applied to the outer surface of the balloon has been dried from the coating section; and controlling moving velocity of the coating section relative to the balloon in such a manner that the distance of the dried part from the coating section is maintained at a preliminarily set designated distance.

Abstract: A balloon coating method and apparatus are disclosed which can perform coating while freely controlling, for example, the thickness of a coating layer and/or the morphological form of a drug. The balloon coating method and the balloon coating apparatus are for forming a coating layer on a surface of a balloon. The balloon coating method includes a pulling step of pulling the balloon in the direction of an axis of the balloon to thereby straighten a bend of the balloon, and a coating step of rotating the balloon about the axis of the balloon, with the balloon maintained in the bend-straightened state, and coating an outer surface of the balloon with a coating liquid containing a drug.

Abstract: A computer-readable recording medium stores a program causing a computer to execute an association process that includes identifying a second storage location associated with a first storage location by referring to a memory unit configured to store storage location association information indicating relevance between the first storage location and the second storage location where data prepared at a second operation stage associated with a first operation stage is stored. The second storage location is identified when new data is stored to the first storage location where data prepared at the first operation stage among multiple stages for manufacture of a product is stored. The association process further includes creating and recording in the memory unit, data association information indicating the relevance between the new data stored in the first storage location and the latest data among the data that is stored in the second storage location.

Abstract: A long-lasting, controlled-release local anesthetic liposome preparation is produced by: providing a liposome composition, which is obtained by mixing, in a water-miscible organic solvent, a first aqueous phase solution with a water-miscible organic solution, in which a phospholipid and cholesterol are contained at a defined total concentration, at a defined ratio by volume thereby obtaining an emulsion wherein a total concentration of the phospholipid and cholesterol in the mixed phase is at 15 w/v % to 50 w/v %, followed by subjecting the emulsion to external solution exchange with a second aqueous phase solution to obtain a liposome composition wherein an ion gradient is formed between an internal-region aqueous phase of a liposome membrane made of the first aqueous phase solution and an external-region aqueous phase of the liposome membrane made of the second aqueous phase solution; and encapsulating a local anesthetic in the internal-region aqueous phase according to a remote loading method.

Abstract: A non-transitory computer-readable recording medium stores a data management program that causes a computer to execute a process. The computer is configured to store data, which is a development deliverable of a product, in one of folders included in a storage folder group having a hierarchal structure. The process includes referring to a storage unit storing a plurality of items constituting an ISO (International Organization for Standardization) specification defining a development process of the product; outputting one or more items as options among the plurality of items constituting the ISO specification defining the development process of the product, when applying an attribute to the one of the folders included in the storage folder group; and implementing control to store the attribute corresponding to a selected item among the one or more items that have been output in association with the one of the folders.

Abstract: A computer stores connection information with respect to data items that are management targets. The connection information identifies connection sources and connection destinations. The computer executes a process including performing analysis based on the connection information with respect to first and second data, which are specified as output targets of information indicating connections; outputting first connection information as information indicating a connection between first and second data, when one or a plurality of data items that are connection destinations are traced from the first data set as a connection source, and the second data is reached as a connection destination; and outputting second connection information as information indicating a connection between third and fourth data, when one or a plurality of data items that are connection destinations are traced from the second data set as a connection source, and the fourth data is reached as a connection destination.

Abstract: Provided are a syringe and a mounting fixture by which it can be facilitated to perform delivery of a target amount of a liquid selectively only when necessary. A syringe is provided with: an external cylinder which is fillable with a liquid; a plunger which is translatable within the external cylinder along the longitudinal direction of the external cylinder and which is formed with a plurality of concave portions and convex portions aligned in the longitudinal direction; and an annular mounting fixture which is mountable to the external cylinder. The mounting fixture is provided with: protruding portions which contact at least the convex portions sequentially in a slidable manner as the plunger is translated; and a rotation limiting member which contacts the plunger to limit a rotation of the plunger relative to the external cylinder.