Patents by Inventor Yasushi Nemoto

Yasushi Nemoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190040359
    Abstract: The present disclosure aims to provide a method of efficiently manufacturing a cell mass, a cell structure, or a three-dimensional tissue body using a culturing surface coated with a temperature-responsive polymer or a temperature-responsive polymer composition. The manufacturing method of a cell mass, a cell structure, or a three-dimensional tissue body of the present disclosure includes seeding and culturing cells on a culturing surface coated with a temperature-responsive polymer or a temperature-responsive polymer composition.
    Type: Application
    Filed: January 27, 2017
    Publication date: February 7, 2019
    Applicant: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER
    Inventors: Yasuhide NAKAYAMA, Ryosuke IWAI, Yasushi NEMOTO
  • Publication number: 20180355296
    Abstract: The present disclosure aims to provide a cell culture container capable of easily producing large quantities of minute cellular structures. A cell culture container includes a plurality of first coated regions, on a culture surface of the cell culture container, coated by a temperature-responsive polymer or a temperature-responsive polymer composition. The surface zeta potential of the first coated regions is from 0 mV to 50 mV.
    Type: Application
    Filed: June 24, 2016
    Publication date: December 13, 2018
    Applicant: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER
    Inventors: Yasuhide NAKAYAMA, Ryosuke IWAI, Yasushi NEMOTO
  • Patent number: 9206441
    Abstract: A method for producing a cell having nucleic acid introduced therein and having low cytotoxicity is useful in primary cells and slowly dividing cells, for which nucleic acid introduction is difficult with conventional techniques. A method for introducing nucleic acid into a cell includes the steps of mixing a nucleic acid with a temperature sensitive material at a temperature lower than the cloud point of the temperature sensitive material, the temperature sensitive material being formed by adding 2-amino-2-hydroxymethyl-1,3-propanediol to a temperature-sensitive polymer material having 2-N,N-dimethylaminoethyl methacrylate and/or a derivative thereof as the main polymer component, flow coating a culture vessel with the resulting mixed liquid, and culturing a cell suspension provided to the culture vessel at a temperature higher than the cloud point.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: December 8, 2015
    Assignees: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, BRIDGESTONE CORPORATION
    Inventors: Yasuhide Nakayama, Ryosuke Iwai, Yasushi Nemoto
  • Publication number: 20150011005
    Abstract: A method for producing a cell having nucleic acid introduced therein and having low cytotoxicity is useful in primary cells and slowly dividing cells, for which nucleic acid introduction is difficult with conventional techniques. A method for introducing nucleic acid into a cell includes the steps of mixing a nucleic acid with a temperature sensitive material at a temperature lower than the cloud point of the temperature sensitive material, the temperature sensitive material being formed by adding 2-amino-2-hydroxymethyl-1,3-propanediol to a temperature-sensitive polymer material having 2-N,N-dimethylaminoethyl methacrylate and/or a derivative thereof as the main polymer component, flow coating a culture vessel with the resulting mixed liquid, and culturing a cell suspension provided to the culture vessel at a temperature higher than the cloud point.
    Type: Application
    Filed: December 26, 2012
    Publication date: January 8, 2015
    Applicants: BRIDGESTONE CORPORATION, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER
    Inventors: Yasuhide Nakayama, Ryosuke Iwai, Yasushi Nemoto
  • Patent number: 8591782
    Abstract: A stent comprising a tubular stent matrix of which diameter is extendable and a flexible polymer layer covering the stent matrix. The polymer layer is closely attached to and covers the entire surface of the stent matrix. Since the flexible polymer layer closely covers the entire surface of the stent matrix not only the outer periphery of the stent matrix, the stent has no problem of causing allergic to metal, stimulus of tissues due to metal, and rust development. Since the inner periphery of the stent is a flat and smooth surface covered by the polymer layer without convexes and concaves, the formation of thrombus can be inhibited well. There is no problem of drift between the polymer layer and the stent matrix, thereby maintaining the positional relationship between the stent matrix and the polymer layer before and after the expansion of the stent.
    Type: Grant
    Filed: August 20, 2003
    Date of Patent: November 26, 2013
    Assignees: National Cerebral and Cardiovascular Center, Japan Stent Technology Co., Ltd.
    Inventors: Yasuhide Nakayama, Shogo Nishi, Yasushi Nemoto, Yoshihiro Okamoto
  • Publication number: 20070198053
    Abstract: A cuff member that enhances the invasion and engraftment of cells from subcutaneous tissue of a living body and robustly adheres to the subcutaneous tissue through the vascularization of capillary vessels, and can consequently isolate a wound from the outside, block exacerbating factors such as bacterial infection during healing, inhibit the downgrowth, and reduce infection problems including tunnel infection. A cuff member 2 includes a flange 3 and a tubular portion 4. The cuff member 2 includes a three-dimensional network open-cell porous structure, which is formed of a thermoplastic resin or a thermosetting resin and has an average pore size of 100 to 1000 ?m and an apparent density of 0.01 to 0.5 g/cm3. A pad 5 overlies the flange 3. A tube 6 passes through the pad 5 and the flange 3.
    Type: Application
    Filed: August 21, 2006
    Publication date: August 23, 2007
    Inventors: Eisuke Tatsumi, Toshihide Mizuno, Yoshiyuki Taenaka, Yasushi Nemoto, Yoshihiro Okamoto, Hare Tazawa
  • Patent number: 7063733
    Abstract: A filter member which comprises one layer of deodorizing filter 1, which is composed of a reticulated filter substrate and a deodorizing agent adhering to the surface of its skeletons, and one or two layers of dust collecting filter 2a and 2b laminated on any one side or both sides thereof, with the resulting laminate being pleated.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: June 20, 2006
    Assignee: Bridgestone Corporation
    Inventors: Hisashi Mori, Tadashi Kuwahara, Yasushi Nemoto
  • Publication number: 20060036311
    Abstract: A stent comprising a tubular stent matrix of which diameter is extendable and a flexible polymer layer covering the stent matrix. The polymer layer is closely attached to and covers the entire surface of the stent matrix. Since the flexible polymer layer closely covers the entire surface of the stent matrix not only the outer periphery of the stent matrix, the stent has no problem of causing allergic to metal, stimulus of tissues due to metal, and rust development. Since the inner periphery of the stent is a flat and smooth surface covered by the polymer layer without convexes and concaves, the formation of thrombus can be inhibited well. There is no problem of drift between the polymer layer and the stent matrix, thereby maintaining the positional relationship between the stent matrix and the polymer layer before and after the expansion of the stent.
    Type: Application
    Filed: August 20, 2003
    Publication date: February 16, 2006
    Inventors: Yasuhide Nakayama, Shogo Nishi, Yasushi Nemoto, Yoshihiro Okamoto
  • Publication number: 20050107868
    Abstract: The invention provides a porous scaffold for tissue engineering which allows easy cell engraftment and cell culture and thus enables stable organization and an artificial blood vessel which exhibits high patency rate even if the inner diameter is small. The scaffold for tissue engineering is made of thermoplastic resin which forms a porous three-dimensional network structure having communication property, wherein the porous three-dimensional network structure has an average pore diameter of from 100 to 650 ?m and an apparent density of from 0.01 to 0.5 g/cm3. The artificial blood vessel is composed of this scaffold.
    Type: Application
    Filed: September 28, 2004
    Publication date: May 19, 2005
    Inventors: Yasuhide Nakayama, Eisuke Tatsumi, Yasushi Nemoto
  • Patent number: 6890373
    Abstract: An adsorbent includes core particles containing an adsorbing material; a porous coating layer including a polymer material that coats the core particles; and an underlying layer containing a metal compound and disposed between the core particles and the porous coating layer. The porous coating layer is formed by spraying and applying a suspension or a solution containing the polymer material over the adsorbing material, or by immersing the adsorbing material into the suspension or the solution.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: May 10, 2005
    Assignee: Bridgestone Corporation
    Inventors: Yasushi Nemoto, Hisashi Mori, Tadashi Kuwahara
  • Publication number: 20040163540
    Abstract: A filter member which comprises one layer of deodorizing filter 1, which is composed of a reticulated filter substrate and a deodorizing agent adhering to the surface of its skeletons, and one or two layers of dust collecting filter 2a and 2b laminated on any one side or both sides thereof, with the resulting laminate being pleated.
    Type: Application
    Filed: December 17, 2003
    Publication date: August 26, 2004
    Inventors: Hisashi Mori, Tadashi Kuwahara, Yasushi Nemoto
  • Publication number: 20030153457
    Abstract: An adsorbent of free of the dust emission derived from an adsorbing material is provided. The surface of the adsorbing material such as activated carbon is coated by a porous coating layer of a polymer material. The porous coating layer is formed by spraying and applying a suspension or a solution containing the polymer material over the adsorbing material, or by immersing the adsorbing material into the suspension or the solution. The polymer material may preferably be fluororesins, polyamide resins, polyimide resins, polyester resins, polystyrene resins, polyolefin resins, polycarbonate resins, polysulfone resins, acrylic resins, cellulose resins, vinyl chloride resins, polyacetal resins, and polyurethane resins. The adsorbent can be employed for indoor ambient air cleaning members, methods for cleaning air, air cleaning devices, dehumidifying materials for inner gas of dual-glass window, drying agents for organic solvents, adsorbents for hard disk drives and freshness keeping member.
    Type: Application
    Filed: January 17, 2003
    Publication date: August 14, 2003
    Inventors: Yasushi Nemoto, Hisashi Mori, Tadashi Kuwahara
  • Publication number: 20020119801
    Abstract: A portable telephone apparatus of folding type, having a upper side housing 1 and a lower side housing 2, and the first one being rotatable to second one through a hinge 91, wherein an antenna containing device 213 is provided in parallel beside the lower side body 2, and an antenna 3 is inserted into the antenna containing device 213 in a direction, crossing at a right angle with a line extending in an axial line of the hinge 91, and the antenna 3 is held by the antenna containing device 213, thereby enabling to attach the antenna onto the lower side housing but without increase in the thickness thereof.
    Type: Application
    Filed: February 28, 2001
    Publication date: August 29, 2002
    Inventors: Yasushi Nemoto, Takashi Tobita, Chuuji Chigisaki, Takashi Ishikawa
  • Publication number: 20020111796
    Abstract: There is provided a voice processing technology and device utilizing the voice processing technology, capable of making the voice on the telephone receiver easy to hear according to the frequency. This invention utilizes a frequency conversion means capable of converting the input voice frequency to a desired frequency. The frequency conversion level or frequency shift can be optionally set for each frequency. The frequency is not changed if the input voice frequency is low. The higher the voice frequency, the greater the frequency conversion shift to a low frequency range for an easy to hear voice.
    Type: Application
    Filed: February 28, 2001
    Publication date: August 15, 2002
    Inventor: Yasushi Nemoto
  • Patent number: 5279856
    Abstract: A hydrophilic porous membrane is obtained by covering porous membrane substrate with a non-ionic, amino-acid-based or non-ionic fluorine-based surface active agent. For the covering, the porous membrane substrate is immersed in a solution containing the surface active agent and then drying the membrane substrate. A different hydrophilic porous membrane is obtained by providing the surfaces of a porous membrane substrate and inner pore surfaces with a polar group and then covering the membrane substrate with a hydrophilic polymer film. For this covering, after introduction of the polar group to the surfaces of the porous membrane substrate and inner pore surfaces, the membrane substrate is immersed in a solution containing a hydrophilic substance and then dried.
    Type: Grant
    Filed: December 23, 1992
    Date of Patent: January 18, 1994
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Noriyuki Koyama, Shinsuke Yokomachi, Yasushi Nemoto, Makoto Ohnishi
  • Patent number: 5203997
    Abstract: A hydrophilic porous membrane is obtained by covering porous membrane substrate with a non-ionic, amino-acid-based or non-ionic fluorine-based surface active agent. For the covering, the porous membrane substrate is immersed in a solution containing the surface active agent and then drying the membrane substrate. A different hydrophilic porous membrane is obtained by providing the surfaces of a porous membrane substrate and inner pore surfaces with a polar group and then covering the membrane substrate with a hydrophilic polymer film. For this covering, after introduction of the polar group to the surfaces of the porous membrane substrate and inner pore surfaces, the membrane substrate is immersed in a solution containing a hydrophilic substance and then dried.
    Type: Grant
    Filed: May 1, 1989
    Date of Patent: April 20, 1993
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Noriyuki Koyama, Shinsuke Yokomati, Yasushi Nemoto, Makoto Ohnishi
  • Patent number: 5120440
    Abstract: There is disclosed a hydrophilic porous membrane in which a mixture composed of a surfactant, a hydrophilic polymer which is insoluble to water and alcohol, and a water soluble polymer is retained on the surface of a hydrophobic porous membrane material and/or at inner surface of pores and the surfactant is retained by the hydrophilic polymer.By taking the above constitution, a hydrophilic porous membrane which is restrained in dissolution and generation of foaming and is excellent in safety can be obtained.
    Type: Grant
    Filed: May 14, 1990
    Date of Patent: June 9, 1992
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Yasushi Nemoto, Shinsuke Yokomachi, Hideaki Kito